Articles tagged with Opioids
A study published in JAMA Health Forum found that nonfatal opioid overdose visits have more than doubled during the pandemic, while few patients who overdosed on opioids had received a prescription for naloxone. The number of individuals filling naloxone prescriptions fell by over 25% throughout the pandemic.
During the COVID-19 pandemic, naloxone prescriptions decreased in the US, while overall prescriptions and opioid prescriptions remained relatively stable. Researchers analyzed changes in prescription trends to better understand the impact of the pandemic on opioid use.
Researchers at Hospital for Special Surgery found that duloxetine reduced cumulative opioid use by 30% in patients undergoing total knee arthroplasty compared to those receiving placebo. Patients who received duloxetine also reported higher pain management satisfaction and less pain interference with daily activities.
Researchers found gaps in patients' understanding of opioid use, pain management, and proper storage/disposal. Patients may benefit from educating them on multimodal analgesia and safe opioid use practices.
A study at Hospital for Special Surgery found that older age, female sex, and higher comorbidities are associated with persistent opioid use in pediatric patients. The research aims to inform clinicians about risk factors for opioid dependence in this vulnerable population.
A Penn Medicine study reveals that opioid supply shortages in emergency departments can lead to a decrease in opioid use, but no significant change in dosing. The shortage led to a shift from IV opioid use to oral formulations.
A patient support program for people with autoimmune diseases and complex medication regimens can help them avoid using opioids or reduce their use. The study found that patients in the program were 13% less likely to start taking opioid pain medications and 26% less likely to fill two or more opioid prescriptions.
A novel CBD analog, KLS-13019, has been shown to effectively alleviate pain and reverse sensitivity in mice with chemotherapy-induced peripheral neuropathy. The study suggests that KLS-13019 may have an additional mechanism of action beyond pain relief, potentially disrupting opioid-seeking behavior.
A study presented at the AATS Annual Meeting found that modifying the ERATS protocol significantly reduced in-hospital and post-discharge opioid consumption, particularly Schedule II opioids. The optimized protocol included replacing saline with 0.25% bupivacaine and switching tramadol to as-needed scheduling.
A new study from the University of Michigan shows that overdose rates were two and a half times higher among patients who filled a prescription for an opioid medication after a dental procedure compared to those who didn
A study found that kratom use is relatively rare in the general US population, affecting only 0.7% of adults and adolescents, but more prevalent among people with opioid use disorder, who report a 10.3% rate of kratom use. Kratom use is also associated with depression, serious mental illness, and other factors.
A new study by Henry Ford Health System has found that a non-opioid approach to managing pain after knee surgery is just as effective as traditional opioid-based methods. The novel multimodal pain management protocol, developed at Henry Ford, brings immediate pain relief without the use of powerful opioids.
A study in cells and mice finds a positive allosteric modulator can boost endorphins' ability to activate the mu-opioid receptor, producing analgesia with reduced side effects. The compound shows promise as an alternative to traditional opioid drugs for pain relief.
A recent study analyzed claims data to examine opioid use among adolescents and young adults who received their first opioid prescription. The study found that a significant proportion of this population developed opioid use disorder within three years.
A new study from Boston Medical Center reveals a significant association between back pain and elevated mortality risk in women. Mild back pain is unlikely to impact life expectancy, but more severe cases are linked to an increased risk of mortality.
During COVID-19, prescribing of opioids and buprenorphine for opioid use disorder changed significantly. The study found that buprenorphine prescriptions increased, while opioid analgesic prescriptions decreased.
Researchers found that percutaneous peripheral nerve stimulation significantly reduced postoperative pain scores by over 50% and opioid consumption by 80%. The technique, which delivers mild electrical stimulation to the nerve, could be a safe and effective adjunct for pain management after surgery.
The pandemic led to a sharp drop in new opioid prescriptions and a decline in buprenorphine treatment for opioid dependency among new patients. This reduced access to treatment may have increased overdose deaths.
Researchers investigated prenatal opioid exposure and its impact on infant mortality, discovering a significant association between the two. Infants exposed to opioids in utero are at higher risk of death, with neonatal opioid withdrawal syndrome also increasing mortality rates.
A recent study found that nurse practitioners' buprenorphine prescribing has been limited by state restrictions and inadequate training. The researchers recommend relaxing scope-of-practice requirements and addressing practice-level barriers to improve treatment access for those with substance use disorders.
The American Academy of Otolaryngology has published a new clinical practice guideline to reduce opioid use disorder risks. The guideline focuses on multimodal analgesia and judicious use of opioids, aiming to improve postoperative pain control while minimizing the risk of chronic opioid use.
A targeted opioid called NFEPP selectively activates opioid receptors in acidic tissues, relieving pain from colitis without causing severe side effects. Researchers are now collecting tissue samples to test NFEPP's ability to inhibit pain in the human gut and plan clinical trials.
A new study by researchers at the University of Pennsylvania School of Medicine found that more than 60% of opioid tablets prescribed for patients undergoing orthopaedic or urologic procedures went unused. The study used an automated text messaging system to track patient pain and opioid use, revealing that most opioids are taken withi...
A recent study found a significant increase in heart infections and strokes in the US, primarily due to IV drug use during the national opioid epidemic. Medical costs associated with these cases were also significantly higher, translating to over $100,000 per patient.
A new analysis by Carnegie Mellon University professor Jonathan Caulkins explores the effects of reduced production costs on cannabis and opioid use. Sharp declines in prices may alter consumption patterns and lead to changes in drug markets, including reduced violence and disruption of criminal organizations.
Research on opioid use among Black people is scarce due to historical exclusion and underrepresentation. The review identifies key disparities in overdose risk, treatment access, and prescription opioid use, emphasizing the importance of culturally informed care.
The project aims to understand the impact of peer recovery coaches on outcomes for individuals in medication-assisted recovery (MAR) housing. It will compare residents with and without peer recovery coaches to those in non-MAR housing, evaluating how culture, services, and camaraderie affect their recovery.
A new study published in Psychopharmacology found that frustration is a significant contributor to addiction. Researchers at UTMB used a rat model to demonstrate how frustration can lead to increased drug intake and escalation of opioid use disorder.
A recent study estimates that 858,000 Americans use opioids for knee pain, resulting in $0.5 billion annual costs and nearly $14 billion lifetime costs. The study suggests substantial savings from preventing opioid use for knee osteoarthritis pain management.
A new guideline for reducing opioid use post-surgery has led to a high pain management satisfaction rate of over 90%, with 83% of patients properly disposing of unused pills. The guideline takes into account individual patients' perception of pain, setting expectations and prescribing non-opioid analgesics to minimize opioid use.
The opioid and HIV epidemics in West Virginia are deeply interconnected, requiring a comprehensive approach to address both issues simultaneously. Stigma is a significant barrier to combating these epidemics, particularly in rural areas with limited resources.
A study at the University of Pennsylvania found that 61% of opioids prescribed to patients after orthopedic procedures went unused. The text message system showed high patient uptake, with 88% responding on the fourth day and 95% on the 21st day. Patients reported a decrease in pain levels without using most of the prescribed opioids.
A new study by RAND Corporation found that low-value healthcare spending among Medicare recipients decreased marginally from 2014 to 2018, but three services - opioid prescriptions for back pain, preoperative laboratory testing, and antibiotic use for upper respiratory infections - accounted for two-thirds of the wasteful care. The fin...
A new study from the University of Michigan School of Dentistry confirms that low-dose naltrexone is a good option for patients with orofacial and chronic pain, reducing pain intensity and improving quality of life. Low-dose naltrexone works by targeting sensitized nervous cells to reduce pain threshold and sensitivity.
A landmark animal study reveals that exposure to opioids during pregnancy can cause long-lasting impairments in the brain's ability to process sensory information. The study found that newborn mice exposed to fentanyl developed withdrawal symptoms and sensory processing disorders that lasted until adolescence.
Two studies published in The BMJ found no associations between prescription opioids or macrolide antibiotics and major birth defects during pregnancy. Researchers did find a small increased risk of cleft palate associated with opioid use, but overall risks were deemed minimal. The findings provide reassurance for women and inform clini...
A new prediction model has identified 10 preoperative characteristics that may predict persistent high-dose opioid use after knee replacement surgery. Certain patient demographics and medication history, including substance abuse and benzodiazepine use, were found to be risk factors.
A nationwide study found that nearly 11% of ICU patients in Sweden received opioid prescriptions for at least 6 months and up to 2 years after discharge. Chronic opioid use was linked to a 70% higher risk of death, with pre-admission history and certain medical conditions being major risk factors.
Researchers found that an enriched diet and companionship can reduce pain in mice with sickle cell disease by increasing serotonin levels. Duloxetine, an antidepressant boosting serotonin, also showed similar pain-reducing effects.
A study of 620 patients who had surgery found that those counseled to use opioids only as backup experienced less pain and similar patient satisfaction compared to standard care. The approach took a middle ground between controlling pain and reducing the risk of long-term opioid use or addiction.
A recent study found that over half of primary care clinics in nine states refuse to accept opioid patients due to perceived stigma. Clinics gave more favorable responses when patients mentioned their last doctor had retired, suggesting systemic biases influence decision-making.
A study found that fatal opioid overdoses increased by over 50% among Black individuals in Philadelphia during the COVID-19 pandemic. Meanwhile, white residents experienced a 31% drop in fatal overdoses during the same period. The research suggests that racial inequities worsened the opioid crisis, with factors such as economic hardshi...
The study found that a multimodal pain regimen (MMPR) reduced opioid exposure and pain scores in trauma patients. The MMPR, which includes generic medications such as acetaminophen and tramadol, was shown to be an effective alternative to traditional opioid treatments.
A new study by physician-researchers at the University of Texas Health Science Center at Houston found that a modified pain management strategy reduced opioid exposure in trauma patients while maintaining equal levels of pain control. The MAST regimen, a multi-modal analgesic approach using over-the-counter medications, achieved this o...
Researchers found that using medical terminology can reduce certain types of stigma but increase others. Non-medical terms, on the other hand, may boost confidence in recovery and perceptions of danger. The study suggests tailoring language to specific purposes is key to reducing stigma.
Research suggests that physical and social pain share common processing in the brain, increasing the risk of addiction with long-term opioid therapy. The authors advocate for integrating physical and social pain care models to provide more effective treatment.
A retrospective cohort study of 251 primary care physicians found significant variation in medical practice patterns across different doctors, but relatively stable patterns within an individual's practice over time. Researchers propose that personal behavioral characteristics may explain these variations.
A new polymer patch provides controlled release of a drug blocking COX-2 enzyme, driving pain and inflammation. The patch can provide three to four days of localized pain control for critical post-surgical period.
A team-based approach to treating opioid use disorder with community pharmacists shows promise in improving medication adherence and participant satisfaction. The study found nearly 90% of participants remained in the program and 95.3% adhered to their daily medication regimen.
Researchers at Rush University Medical Center found a potential link between opioid use and increased risk of pancreatic cancer. The study, which analyzed data from 1999-2016, suggests that opioid consumption may be an unidentified risk factor contributing to the rising incidence of pancreatic cancer in the US.
Chronic pain and emotional pain are intertwined, with opioids making things worse in the long term. Researchers recommend tapering down or switching to buprenorphine for high-dose long-term opioid users without improvement in pain and function.
A national study found significant sex and age-based differences in nonfatal opioid overdoses among youth, with female youth between 11-16 having a higher incidence. The study highlights specific risk factors that could inform targeted interventions to prevent opioid overdoses in adolescents and young adults.
During the COVID-19 pandemic, buprenorphine prescription filling increased in the US, indicating improved access to opioid use disorder treatment. Researchers found that retail pharmacy sales of buprenorphine products surged during this time.
This study compared opioid use disorder treatment during early COVID-19 pandemic months with 2019 data, focusing on medication fills, outpatient visits, and urine tests among privately insured individuals. The findings highlight the challenges of treating OUD during a global health crisis.
Despite telehealth visits, fewer people began new medication treatment and less urine testing was conducted across all patients during the early months of the pandemic. The study found that established patients continued to receive needed care, but new patients who needed help might not have been getting it.
Opioid prescribing rates vary hugely across England, even in similarly deprived areas. Higher prescribing rates are associated with a higher prevalence of rheumatoid arthritis, urban areas, and socioeconomic deprivation.
Only 1.8% of US obstetrician-gynecologists have an X-waiver, allowing them to prescribe buprenorphine for opioid addiction. Rural areas and cities with high neonatal abstinence syndrome rates have higher X-waiver rates among OB-GYNs.
A trial found that listening to soothing words and music during surgery reduced postoperative pain levels by 25% and decreased opioid consumption by 16%. This non-invasive technique could offer a safe and inexpensive way to reduce pain and opioid use after surgery.
Women who receive mastectomy and reconstructive surgery are at increased risk of developing persistent use of opioids and sedative-hypnotic drugs. The study found that 13.1% of patients become new persistent opioid users after surgery, while 6.6% develop persistent sedative-hypnotic use.
The University of Oklahoma Health Sciences Center is developing a comprehensive approach to managing chronic pain in older adults by reducing opioid use and promoting non-opioid alternatives. The grant aims to establish standards for pain management that prioritize non-opioid medications, treatments, and physical therapy options.