Research on opioids, addiction, and treatment. Covers traditional care practices, opioid treatment in pregnancy, illicit fentanyl, and treatment disparities.
A multilevel program improved the awareness and adoption of buprenorphine treatment for opioid use disorder in rural Colorado. The program increased the proportion of practices providing or referring patients for treatment from 18.8% to 74.4%, with a significant increase in buprenorphine prescriptions over four years.
Researchers found that exposure to addiction medicine consult teams led to a significantly reduced risk of death within three months of discharge. Medication played a key role in reducing mortality for patients with opioid use disorders, while other components may be crucial for those with alcohol use disorder.
A new study in Ohio finds that neighborhoods with more opioid overdoses have higher rates of child welfare investigations and confirmed cases of child maltreatment. Concentrated disadvantage measures, such as poverty levels, are particularly associated with severe issues with child maltreatment.
A new study from the University of Pennsylvania School of Nursing found that patients with acute painful admitting diagnoses were almost twice as likely to have a self-directed discharge than those without. Inadequate pain assessment may be a motivator for this behavior, leading to poorer health outcomes and preventable financial costs.
A study analyzing opioid overdose deaths among adults aged 55 and older found disparities by sex, race, and ethnicity. The research revealed that Black and Native American women had higher rates of opioid overdose deaths compared to their white female counterparts.
A new study found a 1,886% increase in opioid-related overdose deaths among U.S. adults aged 55 and older between 1999 and 2019. Contributing factors include ageism, social isolation, depression, and declining cognitive function.
Research suggests that some heart surgery patients can effectively manage postoperative pain with non-opioid medications at home. A study of 1,924 patients found that nearly one-fourth did not receive an opioid prescription at discharge.
A new study suggests that combining two drugs can reduce postoperative opioid use and side effects in adolescents with scoliosis. The combination of intrathecal morphine and oral gabapentin provides more effective pain control, resulting in fewer side effects and lower narcotic consumption.
Researchers found that buprenorphine providers are less likely to discriminate between Medicaid and privately insured patients, but patients face numerous barriers to obtaining an initial appointment. Despite this, disparities persist in access to OUD treatment.
A Colorado State University study analyzed global health data to identify the leading causes of deaths and disabilities in the state from 1990 to 2019. Cardiovascular disease and cancers accounted for half of the deaths, while musculoskeletal disorders and tobacco use were also significant contributors.
Per capita morphine milligram equivalents (MME) volume declined most in metropolitan counties and counties with higher fatal opioid overdoses. Clinical specialties showed significant declines, except for some states' counties with both increases and decreases.
A program at the University of Pennsylvania School of Medicine increased buprenorphine treatment rates in emergency departments by sixfold, from 3% to 23%, and sustained the changes. The program used behavioral design tactics and automated connections to peer recovery specialists to overcome barriers to treatment.
A Salk Institute team has uncovered a neural network in the brain that connects breathing rhythm with feelings of pain and fear. This discovery could lead to the development of an analgesic that prevents opioid-induced respiratory depression, a major cause of overdose deaths.
The study found that buprenorphine use for opioid use disorder increased substantially in US jails and prisons over the past five years. Despite being rare among incarcerated individuals with opioid use disorder, this increase suggests potential improvements in treatment access.
During the COVID-19 pandemic, access to nonpharmacologic therapies like physical therapy was limited, leading to an increase in opioid prescriptions for pain management. The study found that prescription opioids replaced nonpharmacologic therapies as a primary means of pain control.
A new study found that childhood trauma is a significant risk factor for prescription opioid misuse among young adults. Participants who reported four or more adverse childhood experiences were nearly three times more likely to be at risk for opioid misuse, with a 13% higher likelihood compared to those with zero to three ACEs.
A new smartwatch sensor uses machine learning to detect opioid cravings and provide personalized interventions, showing 80% accuracy in real-time monitoring. The technology has the potential to prevent relapse, overdose, and dependency.
A LSU Health New Orleans study reports a nearly 70% decrease in morphine milligram equivalent (MME) per discharge opioid prescriptions for patients who underwent common lower extremity surgical procedures. The study also found a significant decline in new opioid prescriptions, from 50% in 2013 to 19.3% in 2018.
A new study by NYU School of Global Public Health found racial disparities in opioid prescribing, with Blacks and Hispanics less likely to be prescribed opioids in the late 1990s. By the mid 2000s, prescription opioid use among Blacks matched that of whites, despite the focus on white populations during the opioid crisis.
A study by the University of Pennsylvania School of Nursing explores the effectiveness of telehealth in treating opioid use disorder (OUD) in low-barrier clinic settings. The research highlights how telehealth can facilitate treatment for many patients, but also notes digital divide limitations and clinician comfort issues.
A new study by the Keck School of Medicine of USC finds that Medicaid expansion is associated with a significant reduction in mortality rates. The study, which tracked data from 2014-2018, found that expanding Medicaid coverage resulted in an estimated 3.8% decrease in adult deaths per year.
A new study found that emergency physicians are missing opportunities to prescribe life-saving medications like naloxone and buprenorphine after opioid overdose visits. The study analyzed over 149,000 visits between 2019-2021 and discovered that naloxone was prescribed only in 7.4% of cases, while buprenorphine was prescribed in only 8...
Pharmacy standing orders led to a significant increase in naloxone dispensing in Massachusetts, but gaps in access persist in rural communities and Hispanic neighborhoods. Communities with higher rates of opioid overdose deaths and buprenorphine treatment also dispensed more naloxone.
A new study by researchers at the University of Pennsylvania School of Medicine found that 12.4% of patients who received implantable cardiac devices and filled an opioid prescription within two weeks of surgery developed persistent opioid use. Higher initial prescriptions were associated with a higher risk of persistent opioid use.
A Michigan Medicine study found that only 7.4% of patients received naloxone and 8.5% received buprenorphine prescriptions within 30 days of an opioid overdose. The low rates highlight missed opportunities for equipping patients with rescue medicines to use in case of future overdoses.
Scientists at Scripps Research have created new compounds that activate opioid receptors without inducing tolerance, allowing for sustained pain relief. These 'biased agonists' also avoid respiratory suppression and constipation, making them a promising alternative to traditional opioids.
Experts suggest expanding treatment options for hospital patients with opioid withdrawal symptoms, potentially allowing more individualized and patient-centered care. Randomized controlled trials are needed to determine the efficacy of short-acting opioids in this context.
A wearable device has been developed to detect and reverse opioid overdoses by injecting naloxone, a lifesaving antidote. The device, which senses when a person stops breathing and moving, has shown promising results in clinical trials.
Analysis of COVID-19 pandemic policy changes found that federal and state governments have ensured opioid treatment availability, with few states adopting comprehensive approaches. The study highlights the importance of standardized policies to improve treatment access and outcomes for individuals with opioid use disorder.
A Henry Ford Health System study published in The American Journal of Sports Medicine found that a novel opioid-free pain management protocol provided the same pain relief for patients as common types of prescription opioids. This approach aims to reduce opioid misuse and promote more effective pain management after ACL knee reconstruc...
Opioid overdose deaths in Illinois increased significantly from July 2017 to June 2020, with the highest rates occurring in 2020. The study analyzed data from the Centers for Disease Control and Prevention and found a notable spike in unintentional opioid overdose deaths during the pandemic.
Researchers developed a compound that regulates a biological channel linked to pain, reducing the sensation of pain in rodents. The compound, dubbed 194, successfully targets sodium ion channels and promotes pain relief by activating the body's endogenous opioid system.
A review board comprising healthcare professionals from various disciplines has sharply reduced opioid prescribing at an OHSU internal medicine clinic. The clinic uses a systematic approach to review high-risk cases and coach primary care providers on tapering patients off opioids.
A randomized controlled trial found that CBT with yoga and education components significantly reduced pain impact and disability in patients on long-term opioid therapy. Patients receiving CBT also reported greater reductions in pain compared to those receiving usual care.
The rate of HCV in pregnant people increased from 1.8 to 5.1 per 1,000 live births between 2009 and 2019. Researchers found that rural residence, higher rates of employment, and a greater density of obstetricians were associated with a lower risk of developing HCV during pregnancy.
Boston University researchers found that even low levels of physical therapy before or after total knee replacement surgery lower the odds of chronic opioid use. Participation in six or more sessions of physical therapy post-surgery and initiation within 30 days of surgery were linked to reduced chance of chronic opioid use.
A study of 67,000 patients found that physical therapy can significantly lower the risk of long-term opioid dependence following total knee replacement surgery. The researchers suggest that this could be due to improved pain management and reduced reliance on opioids for post-operative pain relief.
A survey of US dentists found that an overwhelming majority believe nonsteroidal anti-inflammatory drug (NSAID)-acetaminophen combinations are as effective or more effective in managing dental pain as opioids. However, nearly half still prescribe opioids, highlighting a disconnect between their knowledge and prescribing habits.
Overdose deaths involving cocaine or methamphetamine increased triply in the shadow of the opioid epidemic. Most fatal overdoses (70%) involved multiple substances, with most being opioids and stimulants. The study highlights disparities in overdose risk from stimulants among Black veterans and rural residents.
A study published in JAMA Network Open found that nearly three-fourths of U.S. adults with buprenorphine use did not misuse the medication in 2019, trending downward between 2015-2019 despite increased treatment. The research highlights the need to expand access to proven treatment approaches like buprenorphine therapy to reduce misuse.
A new study maps opioid-related incidents and discards to identify high-risk neighborhoods and support targeted interventions. The research team used GIS data to highlight areas with the highest concentrations of discarded syringes and fatal overdoses.
A recent study by UCI researchers found that the extract of Corydalis yanhusuo prevents morphine tolerance, dependence, and addiction. The findings suggest that YHS may help reduce opiate overdose mortality when co-administered with morphine.
A 'think-twice' campaign for GPs has been found effective in reducing opioid prescribing in primary care, resulting in a net saving to the NHS of £700,000. The campaign led to a reduction of 15,000 fewer patients being given opioids over a year-long trial.
A recent study published in Frontiers in Immunology found that opioids can control gut immune responses, reduce colonic inflammation, and even promote the growth of regulatory T cells. The findings suggest that KNT-127 could be a promising therapeutic option for inflammatory bowel disease.
Scientists at Temple University will explore the therapeutic potential of KLS-13019, a CBD analog that shows promise as an opioid alternative. The Phase 2 SBIR grant aims to test the compound's effects on rat models of neuropathic pain, shedding light on its safety and efficacy.
Researchers analyzed two years of health data to identify trends and patterns in overdose deaths during the pandemic. Men, jobless individuals, and those with mental health diagnoses experienced the largest increases in overdose death rates, with synthetic opioids and personal residence being significant factors.
Physicians prescribed opioids more frequently to their white patients with new-onset low back pain, while prescribing non-steroidal anti-inflammatory drugs (NSAIDs) to patients of color. The study's findings suggest racial bias in pain treatment, with white patients being more likely to develop long-term opioid reliance.
A study analyzing Medicare data found that racial and ethnic minority groups received fewer opioid prescriptions for new low back pain compared to white patients. This disparity persisted during the first wave of the opioid epidemic, despite growing awareness of its adverse effects.
Researchers identified sex-dependent changes in gene expression in the brainstem during neonatal opioid withdrawal, which could lead to new therapeutic targets for preventing or mitigating Neonatal Opioid Withdrawal Syndrome symptoms. The study found that prenatal opioid exposure compromised neurodevelopmental 'wiring' of the brain and...
West Virginia University researcher Judith Feinberg is integrating services for opioid use disorder, the hepatitis C virus and HIV in 20 primary care clinics across the state. The project aims to address the intertwined opioid and HIV epidemics through efficient and comprehensive care.
Researchers reviewed 79 studies on neurocognitive impairments and brain abnormalities associated with nonfatal opioid overdoses in humans. The findings suggest a link between overdose, cognitive impairment, and brain changes, which could influence attention span, memory, and executive function.
Scientists challenge existing thinking on opioid tolerance and respiratory depression, proposing a new balanced approach to developing safer analgesics. They found that arrestin-3 engagement limits tolerance development but does not exacerbate respiratory depression.
Researchers found a spike in prescription opioid and anti-anxiety sedative consumption, while illicit drug use plummeted during the early pandemic. The study used wastewater analysis to track community-wide habits and anxiety levels.
A national study suggests that half of pediatric opioid prescriptions are considered high-risk, increasing the risk of overdose and addiction. A small group of prescribers in the top 5% account for half of these high-risk prescriptions, particularly dentists or surgeons who practice mainly in the South.
The American Heart Association highlights recommendations to safely manage pain, screen for opioid use disorder, and support treatment. The advisory aims to mitigate the devastating intersection of opioid abuse and cardiovascular disease.
A new study has found that chronic opioid use changes gene expression in the brains of people with opioid use disorder (OUD), suggesting proinflammatory signaling and synaptic remodeling. The affected genes involved in immune response and neuronal connections were also identified, offering new targets for treatment.
Researchers investigated the link between state opioid prescription duration limits and changes in opioid prescribing. The study found that limiting initial opioid prescriptions may lead to a decrease in opioid-related overdose deaths, but also increase unnecessary hospitalizations.
Research from the University of Pennsylvania School of Nursing documents essential components of hospital care models for patients with opioid use disorder. The review found that addiction medicine consult services facilitate connection to post-discharge care and improve outcomes.
An observational study examined the association between opioid dose tapering and rates of overdose and mental health crisis among patients prescribed long-term opioids. The study found a significant correlation between opioid dose reduction and increased risk of overdose and mental health crisis.
A UC Davis Health study found that patients on stable opioid therapy who had their doses tapered had significantly higher rates of overdose and mental health crisis. The study suggests that patients undergoing tapering need significant support to safely reduce or discontinue their opioids.