Articles tagged with Opioids
A new study found that hospitals can reduce excessive opioid prescribing by implementing an evidence-based default setting for opioid prescriptions written in electronic health records. The study showed that patients who received a standard prescription size with a lower default dose of opioids had similar pain control, but took home f...
This qualitative study provides consensus-level guidance to clinicians caring for patients with advanced cancer-related pain and opioid misuse or use disorder. The findings emphasize the importance of comprehensive assessment and multimodal treatment strategies.
Experts outline a framework for treating cancer pain in patients with opioid use disorder or prescription opioid misuse. The study highlights the need for better integration of addiction treatment in cancer care, particularly prescribing methadone and buprenorphine.
A new study found that low-income Canadians are nearly four times more likely to be hospitalized and end up in emergency departments due to opioid use. The study also shows a significant gap in opioid-related deaths between low-income and high-income Canadians, with those living in lower-income areas still at higher risk.
A Rutgers study reveals that racial and ethnic minority groups were less likely to obtain prescriptions to treat opioid addiction during the COVID-19 pandemic. This trend is particularly concerning, as minority groups face more barriers to healthcare and are already disproportionately affected by the pandemic.
Researchers found that 27.8% of drugs with high abuse potential successfully completed development compared to 4.7% for low-abuse potential drugs. Funding is needed to improve understanding of pain mechanisms and develop non-addictive treatments.
The COVID-19 pandemic disrupted access to addiction treatment for adolescents and young adults, particularly those with private health insurance. Prescription claims data shows a significant decline in buprenorphine prescriptions among this age group, especially among those with commercial insurance coverage.
A pan-Canadian study found that prescribing buprenorphine-naloxone at home is as effective as traditional methadone treatment in reducing opioid use. The flexible model of care offers improved access and autonomy for individuals with opioid use disorder. With over 270 participants, the OPTIMA study suggests a new approach to treating t...
A study published in the British Journal of Anaesthesia found that fentanyl can induce changes similar to autism-like behaviors in young male and female mice. The research team discovered that fentanyl induces autism-like behaviors via activating the mu-opioid receptor in the anterior cingulate cortex.
A UC Davis Health study found that patients on stable but higher-dose opioid therapy who had their doses tapered by at least 15% had significantly higher rates of overdose and mental health crisis in the second year after tapering compared to their pre-tapering period. The risks were greatest in patients with the highest baseline doses.
A recent study published in Annals of Internal Medicine found that patients who underwent spinal anesthesia for hip fracture surgery experienced more pain and were more likely to use prescription painkillers compared to those who received general anesthesia. The researchers hope to improve pain care by increasing the use of peripheral ...
Researchers at Emory University treated eight patients with chronic nerve pain using a technique called interventional cryoneurolysis, which uses imaging guidance to freeze damaged nerves and promote regeneration. The study found significant improvements in pain symptoms, with six patients experiencing dramatic reductions in pain scores.
A study by WVU researcher Ednilson Bernardes found that supplier pool pressure contributed to the oversupply of prescription opioids like oxycodone and hydrocodone. The researchers analyzed transactions from 2006-2012, revealing that over 90% of supply came from just three generics manufacturers.
A review of 25 trials found that synthetic cannabis products with high THC-to-CBD ratios improved chronic pain, but were associated with higher risks of adverse events. In contrast, products with comparable THC-to-CBD ratios showed few benefits in overall functioning.
A Mayo Clinic study found that disparities in opioid treatment access persist among women, Black and Hispanic populations. Despite increased access, these groups continue to face systemic barriers, including racism, mistrust of healthcare professionals, and lack of clinicians able to prescribe buprenorphine.
A study by Drexel University found that reduced prescribing guidelines and telemedicine visits improved patient retention in treatment, with patients staying an average of 78 days on-site and 180 days offsite. Buprenorphine helps reduce cravings and withdrawal symptoms, cutting overdose risk in half.
A Michigan study reveals that hundreds of thousands of surgical and dental opioid prescriptions are filled long after writing, but a state law helped reduce this trend. The authors suggest tightening state laws to prevent or reduce misuse associated with delayed dispensing of opioids.
The COVID-19 pandemic has been linked to increased disparities in buprenorphine and naltrexone prescriptions for opioid use disorder among racial and ethnic minority groups. The study found that these groups experienced worsened disparities compared to white patients.
A new data-driven simulation model, SOURCE, has been developed to help policymakers understand and address the nation's rampant opioid crisis. The model presents a detailed understanding of the crisis by capturing how interconnections between stages of prescription and illicit opioid use have evolved over time.
Breathing difficulties following opioid use can be fatal. Electrical pulses to the back of the neck have been found to help patients regain respiratory control and breathe independently without the need for medication or mechanical assistance.
Researchers administered epidural electrical stimulation (EES) to patients with degenerative spine diseases undergoing surgery, improving respiratory control and depth of breathing. The study provides proof of principle for using EES as an alternative treatment to combat opioid-induced respiratory depression.
Researchers found that liver transplants from drug overdose donors increased by 26% during the pandemic, while overall solid organ transplant use from overdose donors rose by 31.2%. This trend suggests that a surge in organ donations from overdose deaths helped stabilize liver transplant numbers despite COVID-19 disruptions.
A recent study found that nearly one-quarter of young sarcoma patients continue to use opioids after treatment is completed. The researchers highlight the need for monitoring and age-appropriate strategies to manage pain while minimizing opioid exposure.
A new app called HOPE, developed at UVA Health, aims to provide vital support to patients battling opioid-use disorder. The app offers a secure way to connect with care providers and an anonymous message board for sharing experiences and building healing relationships.
A Rutgers study found that individuals with opioid-use disorder who used non-prescribed buprenorphine before entering treatment were twice as likely to remain in care. Those who used the medication also had significantly lower rates of opioid use during the first six months in treatment.
Leicester researchers developed an Opioid Toolkit to reduce non-cancer pain opioids prescribed by 2024. The tool provides a theory and evidence-based approach to implementing the NHS' goal, balancing workload with patient support.
The University of Rochester Recovery Center of Excellence brings together diverse experts to discuss strategies for overcoming stigma and health inequity barriers to substance use disorder care. The summit aims to address the 'fourth wave' of the opioid epidemic, driven by synthetic opioids and multiple substances in combination.
This case series examined changes in buprenorphine prescribing waivers during COVID-19. The number of clinicians receiving waivers increased significantly before and during the pandemic, indicating a growing need for expanded access to opioid treatment.
Researchers at Scripps Research Institute have synthesized GB18, a psychotropic compound found in the bark of the Galbulimima belgraveana tree. The compound binds to opioid receptors in the brain, potentially offering new hope for treating depression and anxiety. Further studies are needed to adapt it for human use.
A new study found that most caregivers are unsure about giving their child opioids post-operatively due to concerns about addiction. The survey, which assessed demographic information and attitudes towards opioid use, revealed that caregivers who had taken opioids in the past were more likely to feel comfortable using them.
A study by researchers at the University of Pennsylvania School of Medicine found that mailing opioid disposal kits doubled the rate of safe disposal among patients who received them. The kits were provided to 235 patients after orthopedic or urologic procedures and resulted in the safe disposal of 480 unused tablets.
A mailed at-home disposal kit increased self-reported rates of disposal of unused opioids after common surgical procedures. The study found that patients who received the kit reported a higher rate of opioid disposal compared to those without access to such kits.
More than half of Michigan pharmacies offer naloxone, a life-saving medication for opioid overdose, without requiring a prescription. The standing order allows pharmacists to dispense the drug in emergency situations.
A new study found that opioid-related mortality rates in Ontario, Canada, have shifted downward to peak in the mid-30s among males and females. The study analyzed high-frequency data from 2003 to 2020 and hypothesizes that opioid-related mortality among younger adults will continue to grow.
A new study shows that personalized feedback between peers can significantly reduce opioid prescribing rates in emergency departments. The analysis found a 35% drop in opioid prescribing among physicians and a 41% drop among nurse practitioners and physician assistants.
Scientists have created a searchable atlas of distinct cell populations in the ventral tegmental area, a key brain region involved in reward-directed behavior and substance use disorders. The study identified 16 cell populations, including classic dopaminergic neurons, glutamatergic neurons, and GABAergic neurons.
A decision-support framework was developed by management science researchers to help clinicians make informed decisions about opioid prescribing. The framework incorporates multiple factors, including recovery time, pain intensity, and patient history, to provide a quantitative model of the prescribing process.
Researchers found that Massachusetts' state mandate driving staff acceptance and creating an atypical flexibility to seek innovative solutions. The program showed that medication diversion was uncommon, and protocols helped ensure correct use of the medication by detainees.
A pair of studies published by Washington State University scientists found that hyperbaric oxygen therapy can help individuals with opioid addiction reduce their methadone dose and better manage pain and withdrawal symptoms. The treatment involves breathing pure oxygen in a pressurized environment, resulting in significant dose reduct...
A systematic review and meta-analysis found that SGLT2 inhibitors reduce hospitalizations and cardiovascular deaths in heart failure patients, regardless of diabetes status. The analysis also warned of increased genital infections associated with treatment.
Research reveals nearly a third of pregnant Medicaid beneficiaries screened for hepatitis C test positive, but fewer than a fifth receive follow-up care. A sustainable pathway to treatment is crucial, especially with expanded postpartum Medicaid coverage and highly effective oral medications.
A new animal study suggests that combining marijuana compounds like CBD and THC with opioids may not increase the risk of addiction. The research found that these compounds do not enhance the rewarding effects of opioids, which could lead to a lowered risk of addiction or physical dependence.
A study found that opioid prescriptions for children undergoing common outpatient surgeries declined by up to 50% between 2014 and 2019. The trend was most pronounced in adolescents, with a decline from 78.2% to 48% of prescriptions filled within 7 days of surgery.
A new study by NIH-funded researchers shows that adolescents with severe substance use disorder symptoms are more likely to develop prescription drug misuse and overdose risks in adulthood. Screening for substance use disorder in teens may help predict adult problems and prevent overdoses.
The number of fentanyl-containing pill seizures surged nearly 50-fold between 2018 and 2021, highlighting the growing risk for people new to drug use. The rise in overdose deaths is largely driven by illicit fentanyl and other synthetic opioids.
A new wireless implant has the potential to treat neuropathic pain resistant to medical therapy, offering a minimally invasive alternative to surgery. The device uses bioelectronic therapy to stimulate peripheral nerves from within blood vessels, providing precise placement and predictable outcomes.
A study led by UCL researchers found significant disparities in opioid painkiller access between countries, with some regions reporting rates as low as 0.01 MME per 1,000/day, while others have surpassed the US in opioid sales. The findings highlight the need for global policies to improve palliative care and pain relief provision.
Researchers found that patients with psychosocial and behavioral therapy had lower risk of medication discontinuation in the first 180 days after treatment. Therapy may help reduce high attrition rates commonly observed early during treatment.
A new study from the University of Copenhagen suggests that the poison from the sea snail species Conus rolani can function as a painkiller, blocking out pain in mice for an even longer time than morphine. This discovery offers a potential alternative to addictive painkillers like morphine and opioids.
Researchers investigated buprenorphine prescribing among Medicaid beneficiaries during the first year of the pandemic. Changes in prescribing rates were observed, with significant implications for treatment access and patient outcomes.
Researchers urge federal intervention to make naloxone widely available, citing a 30% increase in fatal overdoses from 2019 to 2020. The lack of accessible distribution points and high costs are major barriers to access, with one prescription dispensed for every 70 high-dose opioid prescriptions nationwide.
A recent survey study found that many people who could benefit from treatment are going without medication for opioid use disorder. The study revealed particularly low rates of medication use among adolescents and older adults, underscoring the need for targeted interventions to address this critical public health issue.
Research found that Black females and male individuals of Other racial groups had higher odds of having a positive COVID-19 test than their White counterparts. Mortality rates were similar across sexes. Individuals with opioid use disorder presented with an opioid overdose more often than a positive COVID-19 test.
A study found that fewer than one-third of patients who fill buprenorphine prescriptions written by emergency physicians subsequently fill prescriptions from other clinicians. Researchers emphasize the need for improved systems to seamlessly transition patients from emergency settings to community treatment providers.
A new study published in Annals of Internal Medicine found that state laws regulating opioid prescriptions had no effect on prescribing patterns for commercially insured adults with chronic non-cancer pain. The study suggests that declines in opioid prescribing may be driven by shifting clinical guidance or other factors.
A study of insurance claims data found that state laws governing opioid prescribing had a negligible effect on opioid prescribing trends. The authors suggest that shifting clinical guidelines, professional norms, or other factors may be driving the decline in opioid prescribing. In contrast, a post-hoc analysis of an ASPREE trial found...
Researchers at UNC Chapel Hill are working with community-based harm reduction programs to develop systems to detect and issue public warnings about dangerous adulterants in street drugs. The team aims to use data to reduce overdose deaths and provide timely alerts to protect people's health.
During the COVID-19 pandemic, Medicaid patients in Wisconsin with opioid use disorder experienced decreased access to treatment, including buprenorphine and urine drug testing. The study highlights the need for continued support and resources for these individuals.
The US overdose death rate exceeded the white rate for the first time in 20 years, driven by synthetic opioids and highly toxic drugs. Black Americans and Native Americans had the highest overdose death rates, highlighting deep-seated inequalities in access to treatment and services.
Researchers found that blood pressure medications increase the effect of opioids in the brain, fine-tuning a specific circuit and reducing addiction risk. This discovery suggests a new strategy to boost opioid signaling with minimal dependence on pain treatment.