Articles tagged with Opioids
Researchers link fentanyl to sodium pockets in nerve cell receptors, blocking harmful side effects while reducing pain. The study offers promise for safer painkillers and potential improvements for addressing the nation's crisis of addiction and overdose.
New York State opioid prescriptions declined during the COVID-19 lockdown, with only a small transient increase in early refills. Medications for opioid use disorder (MOUD) prescriptions remained steady, thanks to policies ensuring their availability.
A novel public health intervention, virtual overdose monitoring services offer timely and anonymous access to emergency care and can develop personalized response plans for individuals using substances. High-quality research is needed to better understand the benefits and risks of these services.
A randomized Phase 3 study published in JAMA found that morphine does not improve symptoms of chronic breathlessness in patients with COPD. However, clinical experience suggests that morphine can provide relief in end-of-life situations or crisis scenarios.
A recent study found that benzodiazepine treatment for sleep disorders is associated with an increased risk of drug overdose among young people aged 10-29, particularly those with recent opioid prescriptions. This highlights the importance of considering alternative pharmacologic treatments to minimize safety risks.
A researcher at Ohio University is using a $1.4 million grant from the National Institute on Drug Abuse to develop a training program for healthcare professionals to overcome stigma surrounding Buprenorphine prescriptions. The study aims to increase access to harm reduction services in rural areas.
Researchers found cannabis users had decreased patency and were 1.25 times more likely to require amputation one year after lower extremity bypass surgery. Cannabis use was also associated with a higher risk of opioid use after discharge.
Research found racial and ethnic disparities in buprenorphine treatment duration grew between 2006 and 2020. Longer treatment durations were associated with superior clinical outcomes for patients with opioid use disorders.
The risk of death from infective endocarditis (IE) among young US residents aged 15-44 years has doubled in the last two decades. IE cases among younger patients and those who inject drugs have increased, with mortality rates increasing by 50%.
A study published in the Journal of the American Geriatrics Society found that antiepileptic prescribing to US nursing home residents with Alzheimer's Disease and dementia increased between 2015 and 2019. In contrast, antipsychotic and opioid prescribing rates declined during this period
Researchers analyzed 200 overdose events in Rhode Island city, finding police were last to arrive at scene in most incidents. Arrests were extremely rare, with only 1% of cases involving law enforcement presence due to safety concerns.
Researchers at Rutgers University found that patients who participate in multiple outpatient visits early in treatment are more likely to continue care. Nearly half of these patients remained in treatment for six months or more, compared to just 2.9% of those with less frequent visits.
A recent study found that despite no decrease in opioid prescriptions, the doses prescribed are lower for senior patients after surgery. The study analyzed over 278,000 patients and showed an increase in non-opioid prescriptions, with most patients still receiving opioid prescriptions.
Opioid abuse declined nationwide during the pandemic, yet remained higher among non-heterosexuals compared to heterosexuals. The analysis suggests a need for tailored approaches to reduce abuse in vulnerable populations.
The project aims to utilize care coordination and population health principles to maximize health outcomes for high-risk individuals with OUD. Funding will be used to coordinate care through cross-sector system collaboration and individualize treatment plans.
A University of Kansas researcher is using a $2.3 million grant to investigate the connection between DNA break-and-repair processes and opioid addiction. The study aims to understand how molecular changes in the brain contribute to addiction, with the goal of developing new therapies.
A study found that 16.5% of American adults with diabetes ration their insulin, with younger adults and the uninsured being most affected. Insulin rationing is often linked to cost concerns, with many patients delaying purchases or taking less insulin than needed.
A survey of over 1,000 physicians found that 67% of respondents favored making telehealth a permanent option for treating opioid-use disorder. The study suggests that continued flexibility in telehealth regulations could help increase access to life-saving treatment, particularly during the ongoing opioid crisis.
Discontinuing or reducing telephone access may disrupt treatment for patients with access disparities, particularly Black patients and those experiencing homelessness. Telehealth was associated with increased retention rates for both new and continuing patients.
A new study suggests that phone calls and video chats can help patients access care, especially for those with barriers to traditional in-person visits. The study found that veterans who received virtual visits were more likely to stay on buprenorphine treatment, but there were disparities by race, housing status, and age.
Rescue Biomedical's technology detects opioid overdoses and delivers naloxone to reverse them. The NIH grant will help the company complete milestones, including regulatory approval and scaling up manufacturing.
Nonadherence with buprenorphine treatment was associated with increased opioid overdose risk and higher healthcare expenditures in a study of 34,000 Medicare patients. The study found that treatment gaps led to more frequent overdoses and increased healthcare costs.
Researchers will test a new telehealth platform linking people who have overdosed with access to medication for opioid use disorder, harm reduction services, and recovery supports. The project aims to expedite access to medication and reduce overdose events and fatalities.
A McMaster University study found that switching to non-opioid painkillers after surgery can significantly reduce opioid consumption and improve patient outcomes. The six-week study enrolled 193 patients who received either standard opioid-based painkillers or a combination therapy of naproxen, acetaminophen, and pantoprazole.
Researchers found that individuals who received naloxone were nine times more likely to survive an overdose, but access to the drug varied greatly across counties. The study suggests that increasing distribution of naloxone, training emergency responders, and expanding take-home programs could help combat the opioid epidemic.
The October issues of The American Journal of Psychiatry focus on diagnosis and treatment of opioid use disorder and cannabis use disorder. Psychiatric Services features research reports on issues related to mental health services for people with serious mental illness.
A clinical trial of email alerts from pharmacists to doctors and other practitioners found no reduction in risky opioid prescribing, highlighting the need for rigorous testing of policies aimed at making opioid prescribing safer. The study tested behavioral science techniques to encourage safer prescribing practices.
A new study from North Carolina State University reveals that law enforcement is not uniformly recognizing and respecting the legal protections in place to support harm reduction programs. Despite these protections, more than half of survey participants reported negative experiences with law enforcement, including confiscation of suppl...
A prospective multicenter case-control study found that third-trimester fetuses exposed to opioids in utero exhibited smaller brain biometric measurements and altered fetal physiology. The study suggests a possible link between prenatal opioid exposure and postnatal clinical outcomes.
A new study found that medical cannabis users reported significant improvements in pain management, social functioning, and overall health. The majority of participants were able to stop or reduce their opioid use, with some experiencing a five-fold decrease in hydrocodone prescriptions.
Researchers at University of Illinois Chicago found that opioid deaths in Cook County have been undercounted by up to 15%, with the majority of missed cases occurring in hospitals. The study highlights the need for better data collection and reporting to combat the opioid crisis.
Researchers at UC Davis aim to develop monoclonal antibodies that can bind to specific ion channels in nerve cells, inhibiting pain signal transmission. The goal is to create a monthly, non-addictive pain medication to replace opioids, which can lead to addiction.
For people at high risk of overdose enrolled in a safer opioid supply program, there was a rapid decrease in emergency department visits, hospitalizations, and health care costs. The study found improved outcomes for participants compared to those not exposed to the program.
The COVID-19 pandemic has seen a significant increase in years of life lost to unintentional drug overdose among adolescents, with synthetic opioids like fentanyl contributing to the rising trend. Researchers found that mortality due to unintentional overdose in adolescents reached an all-time high in 2020.
A new poll reveals that nearly half of people over 50 experience joint pain, and many turn to prescription-based treatments despite potential health risks. The poll's authors stress the need for healthcare providers to discuss medication interactions and non-drug options with patients.
A new analysis reveals that mandatory prescription drug monitoring programs (PDMPs) do not significantly impact retail opioid sales across eight commonly prescribed opioids. The findings suggest that PDMP implementation is best considered as part of a broader policy response to the opioid crisis.
A new randomized, controlled trial demonstrates that Medasense's NOL monitoring during major abdominal surgery can reduce postoperative pain by 30% compared to standard care. The study found that personalized fentanyl dosing with NOL guidance leads to lower sympathetic activation and surgical stress, resulting in reduced PACU pain scores.
A new study by the University of Exeter found that engaging with non-drug related online communities significantly reduces the risk of relapse during remission. Participants who engaged with more online forums had a lower risk of opioid use episode, with a potential 5% reduction per forum.
Scientists have developed a soft, bioresorbable device that cools peripheral nerves to reduce pain. The device was tested in rat models and found to be effective, reversible, and non-addictive, with potential applications for treating neuropathic pain after surgery.
A newly identified link between chronic pain and lung cancer in mice suggests that old drugs such as clonidine, capsaicin, and fluphenazine may offer new treatments for chronic pain. The study found that blocking the BH4 pathway reduced pain sensitivity and decreased tumor growth in mouse models of KRAS-driven lung cancer.
A study found that expanded telehealth services for opioid use disorder care during the COVID-19 pandemic led to individuals staying in treatment longer and reducing their risk of medically treated overdose. The expansion also showed improved receipt and retention of medication-assisted treatment, suggesting a valuable approach to addr...
A new American Heart Association statement highlights the need for specialized care in people who inject drugs, a population with a complex approach to manage potentially deadly heart infections. The standard treatment includes six weeks of intravenous antibiotics, but alternative regimens and oral antibiotics may help complete treatment.
A study by Massachusetts General Hospital researchers found that fentanyl stops breathing before noticeable changes occur, leading to a high risk of death when used illicitly. The discovery could enable safer opioid administration through EEG monitoring.
Mandated PDMP use in US states reduced opioid prescriptions by 6.1% but led to a 50.1% increase in heroin-related deaths, according to researchers from the University of Texas at Dallas.
A new study from the University of Georgia found that four out of five counties with the highest opioid overdose death rates do not have a methadone clinic accessible within a 15-minute drive. Federally qualified health centers (FQHCs) may offer a possible solution to improving access to opioid treatment programs in rural communities.
A RAND Corporation study found that the out-of-pocket cost of naloxone increased by more than 500% for those without health insurance, while decreasing for those with coverage. The high cost may be a significant barrier to naloxone adoption among the uninsured, highlighting the need for policymakers to address financial barriers.
A recent observational study found that out-of-pocket naloxone costs hindered access among the uninsured population, particularly those with opioid use disorder. The study's findings suggest that cost barriers may not significantly limit naloxone use in this vulnerable group.
Researchers found that a gene called PTCHD1 plays a crucial role in opioid tolerance by altering cholesterol content in cell membranes. This discovery may lead to the development of new pain medications with lower overdose risk.
A new University of Rochester study compares two groups of patients with dental extractions, finding that a combination of non-opioid pain medications and gabapentin can minimize or eliminate opioids for dental pain. The results show promise for reducing opioid use during the COVID-19 pandemic.
A new study reveals that methamphetamine use is widespread in rural America, driving overdoses and deaths. The research found that people using both methamphetamine and opioids had a significantly higher risk of nonfatal overdose, with 22% reporting an overdose in the past six months.
A study of rural communities in the US found that people using both methamphetamine and opioids had the highest risk of nonfatal overdose. The study suggests that addressing methamphetamine use alongside opioid use is crucial for reducing overdose rates in these communities.
Researchers studied the impact of withholding nitrous oxide on labor pain and found no adverse outcomes for mothers or children. Opioid use increased significantly but no change in other measures such as epidural use or Caesarean section rates were observed.
Researchers at Houston Methodist found that injecting morphine into the tibia during knee replacement surgery reduces postoperative pain and the need for pain medication. This method, known as intraosseous infusion, may also facilitate a swifter recovery of the knee joint.
Researchers at Tufts University School of Medicine suggest improvements to the release process and treatment for individuals with opioid use disorder (MOUD) who are transitioning from jail to the community. The study identifies three critical areas for improvement: bridge doses, better communication, and phone access.
A recent study published in PLOS ONE found that opioid prescriptions declined for US patients with both cancer and non-cancer pain between 2012 and 2019. The proportion of people receiving any opioid prescription dropped from 49.7% to 30.5% for non-cancer pain and from 86.0% to 78.7% for cancer pain.
A cohort study found that reinfection rates are low after successful hepatitis C virus (HCV) treatment in people who inject drugs, suggesting a benefit of treatment in this population. The risk for reinfection was highest among those with ongoing injecting drug use and needle sharing.
A study of 482,000 children and adolescents found no link between state laws limiting opioid prescriptions and the receipt of these prescriptions. Alternative strategies, such as youth-specific guidelines, are needed to address this public health concern.
A new study found that 86.6% of people with opioid use disorder are not receiving life-saving medications like methadone, buprenorphine, and extended-release naltrexone. The researchers recommend expanding treatment access by removing barriers, eliminating stigma, and ensuring evidence-based medications are used.
A Michigan Medicine study found that patients who received preoperative education on opioid risks and nonopioid pain management options consumed significantly less oxycodone, with only 16 doses used despite similar pain scores. The results suggest a multimodal approach to managing pain can reduce harm and prevent substance use disorders.
A new study at the University of Missouri found that prenatal opioid exposure can trigger long-term neurological or behavioral effects in children. The research suggests that opioids impact the developing fetus' gut microbiome, leading to changes in metabolic pathways and potentially affecting overall health and wellness.