Research on opioids, addiction, and treatment. Covers traditional care practices, opioid treatment in pregnancy, illicit fentanyl, and treatment disparities.
A new conceptual model distinguishes between malleable and unmalleable factors, as well as pre- and post-diagnosis factors, to identify patients at risk of chemical coping with opioids. The model recommends universal screening, patient education, and mental health care to mitigate overdoses and deaths.
A recent study found that transmucosal dose of buprenorphine followed by extended-release buprenorphine injection significantly reduced Clinical Opioid Withdrawal Scale scores in individuals using fentanyl. This rapid treatment strategy may be an important potential option for addressing the growing opioid crisis.
Researchers developed injectable nanoparticles that release naloxone when triggered by blue light, potentially preventing opioid overdose deaths. The system showed effectiveness up to a month after injection and could be incorporated into a wearable device.
A new study shows a significant decline in dental opioid prescriptions, with 45% fewer opioids dispensed between 2016 and 2022. However, progress slowed significantly during the COVID-19 pandemic, which may be attributed to dentists being more cautious due to limited follow-up appointments.
A University of Missouri study found that opioid-dependent mothers experience stigma, leading to withdrawal from healthcare and negative outcomes for their infants. The research highlights the need for compassionate support and education to promote better health outcomes.
A three-year USDA grant will train healthcare and social workers in five high-risk rural Missouri counties to address childhood trauma and reduce opioid overdoses. The training covers topics such as ACEs, positive childhood experiences, and trauma-informed care.
A systematic review and meta-analysis of observational studies found 10 predictors of opioid overdose after prescription for chronic pain, including high-dose opioids, fentanyl prescription, and history of overdose. The risk of fatal and nonfatal overdose increased two- to six-fold with these factors.
A randomized clinical trial found that high-frequency electrical stimulation device reduced opioid use and prescribed opioids after cesarean delivery, suggesting a potential adjunct to decrease opioid use without compromising pain control.
A new study found that racial and ethnic disparities persist in access to chiropractic care and physical rehabilitation for adults with low back pain, with Hispanic adults being less likely to use these services. The study also found that policy changes are needed to address these gaps in access, particularly in underserved communities.
Starting buprenorphine treatment via telehealth was associated with higher treatment retention rates compared to non-telehealth settings. The study found that 48% of Kentucky patients and 32% of Ohio patients remained in treatment for 90 continuous days after starting telehealth-based care.
A new study found that people experiencing homelessness accounted for one in six fatal opioid-related deaths in Ontario, reaching 16.8% by 2021. The quarterly proportion of opioid-related overdose deaths among unhoused individuals increased from 7.2% to 16.8% over four years.
Patients from racial and ethnic minority groups receive inadequate pain treatment in the prehospital setting, according to a study of over 4.7 million encounters across the US. The results suggest a significant disparity in pain management practices based on race and ethnicity.
A new study published in JAMA Health Forum shows that implementing a five-day limit on opioid prescriptions for surgery patients did not lead to increased pain levels or decreased satisfaction. However, the amount of opioid pills patients received dropped significantly after the limit went into effect.
A new study published in Obstetrics & Gynecology found that birthing people who died during pregnancy or postpartum had received significant amounts of hospital care. The study identified factors such as severe maternal morbidity, opioid use, and prior hospitalization as linked to pregnancy-associated deaths.
A new RAND Corporation study reveals that drug overdose deaths have surged among Americans without a college education, nearly doubling over a three-year period. The findings highlight the potential association between the rise in overdose deaths and barriers to education access, a social determinant of health.
Rates of opioid prescribing to US adolescents have decreased in recent years, mainly for non-surgical procedures. Opioid prescribing for surgical indications has remained relatively stable during the same period. This analysis of Medical Expenditure Panel Surveys data from 2015-2020 reveals a significant shift in prescribing patterns.
A recent study by University of Cincinnati researchers found that a community-wide naloxone distribution program did not significantly reduce opioid overdose deaths. The study, which ran from 2017 to 2019, saw no significant change in median monthly opioid overdose rates despite widespread availability of the medication.
Researchers surveyed patients undergoing elective surgeries and found that reducing opioid prescriptions led to higher patient satisfaction with pain management. The study's results were used to develop evidence-based guidelines for prescribing opioids after surgery, aiming to balance managing pain and opioid use.
Researchers at University of Chicago identified a new pain relief pathway in the brain that produces powerful analgesic effects without tolerance or addictive risks. Targeting acetylcholine receptors, particularly alpha-7, offers a promising path to developing non-opioid painkillers.
Patients prescribed higher doses of buprenorphine (24mg) were more likely to stay in treatment for longer periods compared to those on lower doses (16mg). Higher doses may help address the challenges posed by fentanyl, a potent synthetic opioid.
The study of 6,499 patients suggests that higher buprenorphine doses can reduce time to discontinuation. This finding challenges current recommended dosages for improving treatment retention.
A study by researchers at the University of Miami Miller School of Medicine found that thoracic surgeons who treat lung cancer are helping to reduce patients' risk of opioid dependence. The ERATS protocol, which includes intercostal nerve blocks and safe pain relievers, enables earlier hospital discharge with nearly opioid-free recovery.
Researchers found that half of patients need only five tablets or fewer of morphine to manage acute pain, varying by condition. The study aims to adapt opioid prescriptions according to patient need and reduce long-term misuse.
New research from Boston Medical Center's Grayken Center for Addiction found that municipalities offering wide-ranging social services to overdose survivors saw a 21% decrease in fatal overdoses. The study suggests connections to housing, food, employment, and transportation may be key to successful post-overdose outreach programs.
An economic evaluation of extended-release buprenorphine found it was not an efficient allocation of resources when transmucosal buprenorphine was available. The study suggests improving retention rates or decreasing costs associated with extended-release buprenorphine to improve treatment outcomes.
A study of Medicare beneficiaries with chronic low back pain and opioid use disorder found that physical therapy and chiropractic care were underutilized, particularly among minority groups. The findings underscore the importance of addressing inequities in pain management to improve health outcomes.
Palliative care and addiction experts agree that clinicians should increase monitoring and continue opioids without tapering in patients with advanced cancer who use stimulants. This approach prioritizes pain control and allows for individualized harm-reduction strategies.
A new study suggests that treating insomnia can prevent opioid relapse in rats, and potentially in humans. The experimental insomnia drug DORA-12 reduced withdrawal symptoms and prevented drug-seeking behavior in rats experiencing oxycodone withdrawal.
Researchers at MD Anderson successfully reduced inpatient opioid use by 50% and median prescription volumes to zero after pancreatic cancer surgery. This approach achieved effective pain control for patients without increasing the risk of opioid dependence.
A study by University of Kansas and Georgetown University found that facilities with more religious orientation offered a wider range of services and were located in racially diverse communities. This can help service providers make better referrals and provide a roadmap for other communities to better understand their substance use se...
The American Dental Association has released a new clinical practice guideline recommending the use of acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs) as first-line treatments for managing short-term dental pain in children under 12. The guideline has been endorsed by the American Dental Association.
The series emphasizes the importance of anesthesiologists in addressing unmet needs of patients with Substance Use Disorder (SUDs) in the perioperative period. Anesthesiologists are urged to adopt a broader approach to effective disease management, incorporating trauma-informed patient care and increased collaboration with addiction me...
A Rutgers-led study found that improving prison reentry programs for highest-risk users can help reduce opioid overdose deaths in the US. Strengthening healthcare services, such as psychiatric medication and syringe services, is crucial to engage individuals in opioid use treatment after release.
A randomized clinical trial found that a preoperative augmented reality walkthrough decreased preoperative anxiety compared to traditional education and handouts. However, there was no significant impact on postoperative anxiety, pain levels, or narcotic use in patients undergoing surgery.
A French study found that recreational drug use was associated with a nearly 9-fold higher rate of death or need for emergency intervention in cardiac intensive care patients. The study detected various substances in 1 in 10 patients, with cannabis being the most frequently detected substance.
Chronic pain patients who take opioids need access to gold-standard multi-modal pain care, including physical therapy, cognitive behavioral therapy, and integrative medicine techniques. The experts recommend restructuring insurance models, enhancing provider education, and addressing racial inequities in care.
Most adults commencing treatment with prescription opioids had relatively low and time-limited opioid exposure over a 5-year period. Individuals with sustained or increasing use were older with more comorbidities, reflecting higher pain needs.
A new study published in JAMA Network Open shows that methadone use following surgery in infants can increase hospital stay and delay recovery. Babies who required methadone needed to stay in the hospital an average of 21 days longer after surgery, as well as more days on ventilators and IV nutrition.
Approximately 1 in 5 adults with past-year opioid use disorder received medication for opioid use disorder (MOUD), highlighting disparities in uptake. MOUD disparities affect Black adults, women, unemployed individuals, and those in nonmetropolitan areas.
A study found that out-of-pocket costs for medication are a significant barrier to treatment, with those facing the highest daily costs having a higher risk of discontinuing their treatment. Researchers call for buprenorphine to be added to the list of clinically approved preventive services to alleviate the opioid crisis
A human antibody that targets carfentanil, fentanyl, and related opioids has shown promising results in reversing overdose effects in a preclinical study. The antibody, developed by Scripps Research, binds tightly to the potent opioid variants and reverses respiratory depression caused by carfentanil.
A new study found that drug manufacturers, particularly competitors of Purdue Pharma, increased their opioid marketing efforts after the company's 2007 lawsuit. The study analyzed data from over 670,000 physicians and found a 160% increase in promotional spending on competing opioids.
Research found no association between oxycodone prescriptions and persistent opioid use after delivery, but those who delivered vaginally were at greater risk. Higher dosages and prescription durations also linked to increased risk of persistent opioid use.
A new study shows that earlier transfer to specialized care is associated with better outcomes for infants with NOWS, including shorter hospital stays and less exposure to medication. The study found that nonpharmacologic interventions, such as swaddling and pacifier use, are critical to clinical outcomes.
A large US veterans' study found that men and women who adopt eight healthy habits, such as regular exercise, good sleep hygiene, and positive social relationships, can expect to live up to 21 additional years. The study's findings support the role of lifestyle factors in preventing chronic diseases and promoting healthy aging.
Researchers at Indiana University have identified a new method to reverse the effects of fentanyl, which is 50 to 100 times stronger than morphine. Cannabidiol, or CBD, was found to behave as a negative allosteric modulator at the binding site, successfully reversing fentanyl effects in in vitro tests.
Opioid toxicity-related deaths in the US increased substantially during the COVID-19 pandemic, with 1 in every 22 deaths attributable to unintentional opioid toxicity. This trend highlights the urgent need for support people at risk of substance-related harm, particularly men and younger adults.
A study by Weill Cornell Medicine found that state laws allowing medical cannabis use did not reduce prescriptions for opioids or other therapies for chronic non-cancer pain. The results challenge previous studies suggesting a link between medical cannabis laws and reduced opioid prescribing.
A study of commercially insured adults with chronic noncancer pain found that state medical cannabis laws did not lead to a reduction in the use of opioid or nonopioid pain treatments. The researchers also suggested slow implementation and reluctance among healthcare leaders may have contributed to these findings.
A randomised controlled trial published in The Lancet found no significant difference in pain levels among patients with lower back or neck pain who received opioid pain relievers compared to those given a placebo. The study also showed an increased risk of opioid misuse in the long term.
A world-first trial by the University of Sydney found that opioids do not alleviate acute back and neck pain, but may cause harm. The researchers recommend updating treatment guidelines to advise against opioid use for this purpose.
A Rutgers study found that restricting access to prescription opioids can lead people to seek out unregulated opioids, increasing the risk of fatal overdoses. Restoring easier access to opioid pain medications may protect against fatal overdoses, according to researchers.
Researchers are exploring natural killer cells as a potential treatment for neuropathic pain, which is caused by nerve damage. NK cells may help prune damaged nerve cells, providing relief from chronic pain.
A recent study by the Hebrew University of Jerusalem has unveiled crucial insights into the brain's ability to regulate fentanyl consumption. The research discovered that claustral neurons can modulate fentanyl intake, suggesting a potential target for intervention in fentanyl addiction.
A study by Penn State researchers found that minority communities bore the brunt of the opioid crisis, with Black men and American Indian/Native Alaskan men and women disproportionately affected. The researchers suggest that race- and gender-specific interventions may be more effective in preventing overdose deaths.
The University of Sydney-led guidelines recommend personalized deprescribing plans and gradual dose reduction to minimize withdrawal symptoms. Clinicians should avoid abruptly stopping opioids without support or pain management plans, especially for patients with severe opioid use disorder.
Integrating MAT training into nursing programs has been shown to reduce bias and stigma associated with medication-assisted treatment. The training also improved graduate students' attitudes towards people with opioid use disorder and increased their desire to pursue careers as OUD MAT providers.
A national study launched by UNCG's Prevention Strategies aims to prevent opioid misuse among high-risk occupations. The WorkWell mobile app, featuring evidence-based educational strategies, will be tested in the construction and nursing industries.
A recent analysis of 61,249 adults who had surgery at Massachusetts General Hospital found that restricting opioid use during surgery may increase postoperative pain and opioid use. Patients administered more opioids during surgery were less likely to experience pain and used less opioids after waking up from anesthesia.
A new study found a 67% increase in hospital encounters for benzodiazepine-related toxicity among young adults and a 44% rise in youth aged 18 or below in Ontario between 2013 and 2020. The increased risk is attributed to the growing presence of non-pharmaceutical benzodiazepines in the unregulated opioid supply.