Articles tagged with Opioids
A study of Medicare beneficiaries with chronic low back pain and opioid use disorder found that physical therapy and chiropractic care were underutilized, particularly among minority groups. The findings underscore the importance of addressing inequities in pain management to improve health outcomes.
Palliative care and addiction experts agree that clinicians should increase monitoring and continue opioids without tapering in patients with advanced cancer who use stimulants. This approach prioritizes pain control and allows for individualized harm-reduction strategies.
A new study suggests that treating insomnia can prevent opioid relapse in rats, and potentially in humans. The experimental insomnia drug DORA-12 reduced withdrawal symptoms and prevented drug-seeking behavior in rats experiencing oxycodone withdrawal.
Researchers at MD Anderson successfully reduced inpatient opioid use by 50% and median prescription volumes to zero after pancreatic cancer surgery. This approach achieved effective pain control for patients without increasing the risk of opioid dependence.
A study by University of Kansas and Georgetown University found that facilities with more religious orientation offered a wider range of services and were located in racially diverse communities. This can help service providers make better referrals and provide a roadmap for other communities to better understand their substance use se...
The American Dental Association has released a new clinical practice guideline recommending the use of acetaminophen and/or non-steroidal anti-inflammatory drugs (NSAIDs) as first-line treatments for managing short-term dental pain in children under 12. The guideline has been endorsed by the American Dental Association.
The series emphasizes the importance of anesthesiologists in addressing unmet needs of patients with Substance Use Disorder (SUDs) in the perioperative period. Anesthesiologists are urged to adopt a broader approach to effective disease management, incorporating trauma-informed patient care and increased collaboration with addiction me...
A Rutgers-led study found that improving prison reentry programs for highest-risk users can help reduce opioid overdose deaths in the US. Strengthening healthcare services, such as psychiatric medication and syringe services, is crucial to engage individuals in opioid use treatment after release.
A randomized clinical trial found that a preoperative augmented reality walkthrough decreased preoperative anxiety compared to traditional education and handouts. However, there was no significant impact on postoperative anxiety, pain levels, or narcotic use in patients undergoing surgery.
A French study found that recreational drug use was associated with a nearly 9-fold higher rate of death or need for emergency intervention in cardiac intensive care patients. The study detected various substances in 1 in 10 patients, with cannabis being the most frequently detected substance.
Chronic pain patients who take opioids need access to gold-standard multi-modal pain care, including physical therapy, cognitive behavioral therapy, and integrative medicine techniques. The experts recommend restructuring insurance models, enhancing provider education, and addressing racial inequities in care.
Most adults commencing treatment with prescription opioids had relatively low and time-limited opioid exposure over a 5-year period. Individuals with sustained or increasing use were older with more comorbidities, reflecting higher pain needs.
A new study published in JAMA Network Open shows that methadone use following surgery in infants can increase hospital stay and delay recovery. Babies who required methadone needed to stay in the hospital an average of 21 days longer after surgery, as well as more days on ventilators and IV nutrition.
Approximately 1 in 5 adults with past-year opioid use disorder received medication for opioid use disorder (MOUD), highlighting disparities in uptake. MOUD disparities affect Black adults, women, unemployed individuals, and those in nonmetropolitan areas.
A study found that out-of-pocket costs for medication are a significant barrier to treatment, with those facing the highest daily costs having a higher risk of discontinuing their treatment. Researchers call for buprenorphine to be added to the list of clinically approved preventive services to alleviate the opioid crisis
A human antibody that targets carfentanil, fentanyl, and related opioids has shown promising results in reversing overdose effects in a preclinical study. The antibody, developed by Scripps Research, binds tightly to the potent opioid variants and reverses respiratory depression caused by carfentanil.
A new study found that drug manufacturers, particularly competitors of Purdue Pharma, increased their opioid marketing efforts after the company's 2007 lawsuit. The study analyzed data from over 670,000 physicians and found a 160% increase in promotional spending on competing opioids.
Research found no association between oxycodone prescriptions and persistent opioid use after delivery, but those who delivered vaginally were at greater risk. Higher dosages and prescription durations also linked to increased risk of persistent opioid use.
A new study shows that earlier transfer to specialized care is associated with better outcomes for infants with NOWS, including shorter hospital stays and less exposure to medication. The study found that nonpharmacologic interventions, such as swaddling and pacifier use, are critical to clinical outcomes.
A large US veterans' study found that men and women who adopt eight healthy habits, such as regular exercise, good sleep hygiene, and positive social relationships, can expect to live up to 21 additional years. The study's findings support the role of lifestyle factors in preventing chronic diseases and promoting healthy aging.
Researchers at Indiana University have identified a new method to reverse the effects of fentanyl, which is 50 to 100 times stronger than morphine. Cannabidiol, or CBD, was found to behave as a negative allosteric modulator at the binding site, successfully reversing fentanyl effects in in vitro tests.
Opioid toxicity-related deaths in the US increased substantially during the COVID-19 pandemic, with 1 in every 22 deaths attributable to unintentional opioid toxicity. This trend highlights the urgent need for support people at risk of substance-related harm, particularly men and younger adults.
A study by Weill Cornell Medicine found that state laws allowing medical cannabis use did not reduce prescriptions for opioids or other therapies for chronic non-cancer pain. The results challenge previous studies suggesting a link between medical cannabis laws and reduced opioid prescribing.
A study of commercially insured adults with chronic noncancer pain found that state medical cannabis laws did not lead to a reduction in the use of opioid or nonopioid pain treatments. The researchers also suggested slow implementation and reluctance among healthcare leaders may have contributed to these findings.
A randomised controlled trial published in The Lancet found no significant difference in pain levels among patients with lower back or neck pain who received opioid pain relievers compared to those given a placebo. The study also showed an increased risk of opioid misuse in the long term.
A world-first trial by the University of Sydney found that opioids do not alleviate acute back and neck pain, but may cause harm. The researchers recommend updating treatment guidelines to advise against opioid use for this purpose.
Researchers are exploring natural killer cells as a potential treatment for neuropathic pain, which is caused by nerve damage. NK cells may help prune damaged nerve cells, providing relief from chronic pain.
A Rutgers study found that restricting access to prescription opioids can lead people to seek out unregulated opioids, increasing the risk of fatal overdoses. Restoring easier access to opioid pain medications may protect against fatal overdoses, according to researchers.
A study by Penn State researchers found that minority communities bore the brunt of the opioid crisis, with Black men and American Indian/Native Alaskan men and women disproportionately affected. The researchers suggest that race- and gender-specific interventions may be more effective in preventing overdose deaths.
A recent study by the Hebrew University of Jerusalem has unveiled crucial insights into the brain's ability to regulate fentanyl consumption. The research discovered that claustral neurons can modulate fentanyl intake, suggesting a potential target for intervention in fentanyl addiction.
The University of Sydney-led guidelines recommend personalized deprescribing plans and gradual dose reduction to minimize withdrawal symptoms. Clinicians should avoid abruptly stopping opioids without support or pain management plans, especially for patients with severe opioid use disorder.
Integrating MAT training into nursing programs has been shown to reduce bias and stigma associated with medication-assisted treatment. The training also improved graduate students' attitudes towards people with opioid use disorder and increased their desire to pursue careers as OUD MAT providers.
A national study launched by UNCG's Prevention Strategies aims to prevent opioid misuse among high-risk occupations. The WorkWell mobile app, featuring evidence-based educational strategies, will be tested in the construction and nursing industries.
A recent analysis of 61,249 adults who had surgery at Massachusetts General Hospital found that restricting opioid use during surgery may increase postoperative pain and opioid use. Patients administered more opioids during surgery were less likely to experience pain and used less opioids after waking up from anesthesia.
A new study found a 67% increase in hospital encounters for benzodiazepine-related toxicity among young adults and a 44% rise in youth aged 18 or below in Ontario between 2013 and 2020. The increased risk is attributed to the growing presence of non-pharmaceutical benzodiazepines in the unregulated opioid supply.
Researchers found that morphine interacts with toll-like receptor 4 to contribute to increased bone loss and pain. Blocking TLR4 prevents these effects, suggesting a new target for reducing opioid side effects.
The Better Together trial partners with community organizations and sites to provide buprenorphine treatment, reducing distance for patients and offering peer support in familiar environments. Researchers aim to address barriers such as stigma, misunderstandings about addiction, and bias against certain treatments.
A MU study found that providing educational information about naltrexone to healthcare professionals increases patient prescriptions for the drug. The study resulted in a 36% increase in patients leaving the facility with a prescription for naltrexone, suggesting better-informed decisions by healthcare professionals.
A recent NIH-funded study found that only 1 in 4 residential addiction treatment facilities for adolescents under 18 years old offer buprenorphine to treat opioid use disorder. The study highlights a significant gap in access to evidence-based treatment among young people, with many facilities not offering this life-saving medication d...
Only one in four US adolescent residential addiction treatment facilities offer buprenorphine and one in eight offer it for ongoing treatment. Nearly two-thirds of adult residential facilities provide this medication, highlighting a significant gap in care for adolescents.
A decision analytical model study found that sustained public health interventions can reduce opioid-related overdose deaths. Implementing medications for opioid use disorder and increasing naloxone supply were key factors in reducing death rates.
A recent study published in The Journal of Orthopaedics found that patients who underwent partial meniscectomy using a needle arthroscopic technique experienced significantly less pain and improved patient-reported outcomes at two weeks after surgery. However, differences were not sustained at six weeks.
A Rutgers study found that reentry services helped reduce the risk of overdose and death related to substance use disorder after a large-scale prison release in New Jersey. Researchers attribute this finding to the state's robust reentry supports for incarcerated individuals with substance use disorders.
The June issues of The American Journal of Psychiatry and Psychiatric Services focus on substance use disorders, opioids, and youth self-harm and suicide. The articles highlight the importance of addressing these issues to improve patient outcomes and reduce stigma.
A new study reveals that over 80% of people who inject drugs in New York City test positive for fentanyl, but only 18% intend to take it intentionally. The research suggests that widespread use of fentanyl among this population may be driving overdose risk and tolerance development.
A new RAND Corporation study finds that state policies requiring additional education for buprenorphine prescribers and continuing medical education related to substance misuse significantly increase the use of anti-opioid medication. This is associated with improved quality of life and decreased fatal overdose rates.
A new treatment has been developed to help people stop needing opioid painkillers for chronic pain, with promising results in a clinical trial. The intervention programme combines one-to-one and group support to guide individuals in coming off opioids, teaching them alternative techniques to manage their pain.
Researchers warn that patients with rheumatic and musculoskeletal conditions are vulnerable to long term opioid use. The study found that up to 1 in 3 patients with rheumatoid arthritis or fibromyalgia may be at risk of transitioning to long term opioid use, highlighting the need for vigilance in practice prescribing.
A new study by Harvard T.H. Chan School of Public Health found significant racial inequalities in treatment for opioid use disorder, with White patients receiving medication up to 80% more frequently than Black and Hispanic patients. Despite similar numbers of healthcare visits, disparities persist.
A new Johns Hopkins Medicine study found that patients with low pain self-efficacy are more likely to use daily prescribed opioids before surgery. Surgeons can use pain self-efficacy scores to identify high-risk patients and provide education and counseling to improve post-surgery outcomes.
A study of 390,000 infants found that those born to mothers with opioid use disorder or neonatal opioid withdrawal syndrome had a higher risk of postneonatal infant mortality. The study highlights the need for supportive interventions during and after pregnancy to reduce adverse outcomes.
The latest May issues of American Psychiatric Association journals focus on new treatments for conditions like trichotillomania, social anxiety disorder, and opioid use disorder. Additionally, a special issue of Focus journal explores suicide preventive interventions and knowledge.
A multicentre registry study found that medicinal cannabis can safely relieve cancer pain while reducing the total number of medications and opioids taken. Products with an equal balance of THC and CBD were particularly effective in reducing pain intensity and symptoms.
Researchers found that the 'Eat, Sleep, Console' (ESC) care approach is more effective than Finnegan Neonatal Abstinence Scoring Tool (FNAST) in assessing and managing opioid-exposed newborns. Newborns cared for with ESC were medically ready for discharge approximately 6.7 days earlier and 63% less likely to receive medication.
A preclinical study found that suvorexant reduced prescription opioid intake and helped protect against relapse in rats modeling opioid use disorder. The insomnia drug could offer a promising approach for the millions of people affected by OUD.
A study published in Clinical Pharmacology & Therapeutics has identified six single nucleotide polymorphisms associated with opioid use disorder. The findings suggest that genetics play a role in the development of OUD, but environmental factors also contribute to its progression.
A new study finds that buprenorphine initiation rates and six-month retention rates remain flat despite policy changes aimed at increasing access to the medication. Only 22% of patients who started treatment kept refilling their prescriptions for at least six months, highlighting barriers to prescribing enough of the life-saving drug.
Researchers at UNIGE discovered that natural opioids cannot enter cells, whereas therapeutic opioids can, leading to differences in physiological responses. The study's findings could help develop safer medications with improved efficacy and reduced side effects.
A recent Mayo Clinic study found that prescription opioid use is associated with declines in cognitive performance, particularly in memory and attention. Older adults who received at least one opioid prescription over 7.5 years had a 20% higher chance of developing mild cognitive impairment.
A new study published in the American Journal of Psychiatry found a link between opioid prescribing patterns and suicide risk. The researchers analyzed data from 2009-2017 and discovered that regions with the greatest decrease in opioid prescriptions also experienced the greatest decline in suicide deaths. This suggests that policies a...