Articles tagged with Translational Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A clinical prediction model called the Goliat score can estimate the risk of acute complications in patients with minor and moderate traumatic brain injuries. The model, developed by researchers at UOC and IRBLleida, uses easily accessible variables to predict neurological or cardiorespiratory complications and mortality within 48 hours.
Cancer cells tap into the nervous system's power grid by forming synaptic contacts with nerve cells, promoting tumor growth and spread. Venkataramani's research aims to repurpose the drug perampanel for glioblastoma treatment and develop gene therapy approaches to disconnect tumors from the nervous system.
Researchers developed bioengineered lymphatic tissue (CeLyT) that restored functional lymph nodes in mice with secondary lymphedema. CeLyTs improved lymphedema symptoms by restoring lymphatic flow, filtration capacity, and immune cell populations.
The ISSCR has released a comprehensive roadmap for developing pluripotent stem cell-derived therapies, outlining critical scientific, manufacturing, and regulatory guidance. The Best Practices document provides a risk-based, end-to-end development strategy to support informed decision-making across seven essential areas.
A two-step genome editing method integrates large human genomic fragments into mice, mimicking human regulatory landscapes. This platform enables the creation of physiologically relevant humanized models for therapeutic targets and disease research.
Researchers at the University of Virginia Health System have discovered how the keto diet protects against epilepsy seizures by regulating brain cell activity. The team found that a specific cellular receptor, HCAR2, plays a crucial role in reducing seizures, and may be targeted for new treatments.
Dr. Noritaka Ichinohe challenges the long-held assumption that averaging away individual differences is necessary in psychiatric research. Instead, biological heterogeneity is seen as a phenomenon demanding explanation. The author's work on primate brain mapping and molecular subtyping has identified convergence points between species ...
A new study from Texas A&M University reveals that circadian disruptions change the structure of mammary glands, weaken immune defenses, and fuel aggressive breast cancer. Disabling an immune checkpoint molecule called LILRB4 helps restore the immune system's ability to fight back.
A team of researchers has identified two proteins critical to the destruction of red blood cells by the Oroya fever pathogen. This discovery paves the way for a potential novel therapy against this deadly neglected tropical disease.
The ESMO Immuno-Oncology Congress 2025 will discuss key developments in immuno-oncology, including combined approaches, AI in cancer therapy, and innovative strategies across various cancers. The congress aims to advance the field of immunotherapy and improve patient outcomes.
A new paper from the University of Kansas overturns the idea that gene PTPN22 boosts production of Type 1 interferon, a key antiviral response. Researchers found no difference in interferon production when PTPN22 was knocked out, but discovered its influence on other immune signaling pathways.
Researchers at UC Riverside and City of Hope have developed a novel Pin1 degrading compound that suppresses pancreatic cancer peritoneal metastases. The treatment targets not only cancer cells but also tumor-supporting cells, potentially overcoming treatment resistance.
Researchers at UMC Utrecht are developing a predictive model to accurately predict disease progress in juvenile dermatomyositis. The Interferon Score aims to identify which children can safely reduce medication and which require intensified treatment.
A new AI model uses machine learning to predict drug toxicity in humans by identifying biological differences between cells, mice, and humans. The model improved predictive power over existing state-of-the-art models and demonstrated practicality in predicting market withdrawal due to toxicity.
The International Society for Stem Cell Research invites you to celebrate 20 years of induced pluripotent stem cell (iPSC) discovery and chart its future. The symposium features keynote speakers, featured sessions, and presentations on cutting-edge research.
The FDA has approved elinzanetant for treating hot flashes and night sweats in postmenopausal women. The drug significantly reduces the frequency and severity of symptoms while improving sleep quality and quality of life.
A new Alliance trial is exploring the effectiveness of a combination of targeted therapy and immunotherapy for patients with advanced adrenocortical carcinoma, a rare and aggressive cancer. The study aims to improve disease control and quality of life for patients with limited treatment options.
The UC San Diego REACH Center for Translational Science on Whole Person Health aims to advance research through partnerships with complementary and integrative health institutions. The center will support at least 26 new research scholars and fund pilot grants to drive innovation in translational science.
Rebecca Richards-Kortum has been elected to the National Academy of Medicine for her major contributions to global health. She created low-cost, lifesaving technologies for underserved communities, transforming health systems worldwide through her innovations in cervical cancer diagnostics and neonatal care technologies.
A new study has identified a leptin-sensitive brain circuit in the lateral hypothalamus that helps animals overcome anxiety to perform essential behaviors such as eating, exploring, and limiting maladaptive hyperactivity. Boosting the activity of these neurons can restore adaptive choices even under conditions that cause anxiety.
Scientists found a promising candidate, pleiotrophin, which is essential for brain development and function; restoring it may improve brain circuits in individuals with Down syndrome and other neurological diseases. The study's findings suggest using modified viruses to deliver the protein directly into cells could lead to new treatments.
Researchers developed TAMENDOX to supplement (Z)-endoxifen in patients with CYP2D6 enzyme deficiency, improving drug concentration and effectiveness. The new therapy was well-tolerated, showing promise as an alternative to aromatase inhibitors for premenopausal women.
Researchers at UMass Amherst have developed a nanoparticle-based vaccine that prevents melanoma, pancreatic and triple-negative breast cancer in mice. The vaccine achieved remarkable survival rates, with up to 88% of vaccinated mice remaining tumor-free.
Colin Hill joins C-Path's Board of Directors with experience in AI, drug development, and translational acceleration. He aims to bring precision medicine focus to advance treatments worldwide.
The International Federation of Sports Medicine (FIMS) has partnered with Translational Exercise Biomedicine (TEB), the first such collaboration in Asia. This partnership aims to enhance research publication, host co-branded events, and advance global advocacy for sports medicine.
Dr. Michael Welsh's research on cystic fibrosis paved the way for a triple-drug combination therapy that has transformed CF from a fatal condition into a manageable one for over 90% of patients. His work also revealed the function and 'broken' nature of the CFTR protein, laying the foundation for targeted therapies.
A non-electronic soft robotic device guides a soft tube into the trachea, improving success rates for both expert and non-expert users. The device yields a 100% success rate with highly trained users and an 87% success rate with non-expert providers after just five minutes of training.
Researchers found that frail patients with residual intra-abdominal bacteria or fungi are at a higher risk of developing postoperative ileus and infections. The study suggests that incorporating frailty assessment and prehabilitation programs into surgical planning may help reduce complications.
The study found that increasing Piezo1 activity leads to a coordinated response, resulting in increased skin surface area and thickness. The findings could ultimately help doctors develop noninvasive therapeutic approaches to create new skin for treating burns and other injuries.
Researchers at Institute of Science Tokyo found that basophils suppress lung inflammation during ARDS recovery, suggesting potential treatment strategies. Basophils release interleukin-4, which helps immune cells coordinate responses and alleviate lung inflammation.
Researchers discovered that GLP-2 analogs reshape the intestinal environment by expanding villi and crypts, increasing regulatory T cells, and improving nutrient absorption. This breakthrough offers new hope for patients with short bowel syndrome and potentially benefits immunocompromised individuals.
Researchers at Lehigh University and the Cleveland Clinic are developing a nonsurgical therapy for pelvic organ prolapse using drug-delivering nanoparticles. The treatment aims to delay or reverse matrix degradation, reducing the severity of POP in patients with earlier stages of the disorder.
A wearable robot has been upgraded to provide personalized assistance to ALS and stroke patients. The device uses machine learning and a physics-based model to adapt to an individual user's movements, offering more nuanced help with daily tasks.
A recent study by researchers at the University of Missouri has made a groundbreaking discovery using patient's own cartilage cells to aid in healing after hip surgery. The research team successfully cultured and expanded cartilage cells, or chondrocytes, in the lab, paving the way for future clinical applications.
Scientists have created a detailed map of cell behavior in the small intestine of people with coeliac disease using single-cell RNA sequencing. The study found that immune signals from immune system proteins encourage fibroblasts to support changes in the gut lining, suggesting communication between cells plays a key role in the disease.
Researchers are developing an AI imaging approach to distinguish between tumor progression and treatment effects in glioblastoma patients, promising to improve care and outcomes. The AI approach has already shown accuracy rates of up to 74% in initial testing.
Researchers at Syracuse University have identified a new target for treating obesity and diabetes, reducing nausea and vomiting associated with existing treatments. A molecule called tridecaneuropeptide (TDN) produced by brain support cells suppresses appetite and improves glucose processing without adverse effects.
A team of scientists has discovered molecular changes in children's immune systems that determine their response to oral immunotherapy for peanut allergy. Children who respond well have lower levels of inflammatory messengers, while those who don't show increased activation of certain genes.
Researchers at the University of Illinois found that benign and cancerous breast calcifications have unique structures and formation processes. The study provides a new classification scheme and opens the possibility of treating benign calcifications using certain drugs.
Scientists found that mesenchymal stromal cells (MSC) therapy improved immune recovery in cats with FIP, a disease similar to Long COVID. The study showed reduced systemic inflammation and increased regulatory T cells, suggesting potential benefits for human patients.
Researchers at the University of Würzburg are developing a new therapy for KEAP1-mutated lung cancer using a sulfite inhibitor to block tumor cell growth. The team has identified a first-of-its-kind compound, SulfExstatin-1, which accumulates toxic sulfite in cancer cells, initiating their death.
UVA Health received two anonymous $25 million estate gifts to support the Paul and Diane Manning Institute of Biotechnology. The institute will develop new treatments for hard-to-treat diseases with a state-of-the-art biomedical research facility expected to drive economic growth in Central Virginia.
A new study reveals that Rapamycin has a comparable life-extending effect to dietary restriction in eight species of vertebrates. The compound, originally developed as an immunosuppressant, offers similar benefits without the need for caloric restriction.
Researchers developed a compact diagnostic platform that can evaluate antibody protection against COVID-19 using only a single microliter of fingertip blood. The Tip Optofluidic Immunoassay (TOI) system delivers comprehensive immune profiles in just 40 minutes, enabling rapid and accurate assessment of individual immune protection.
The ISSCR has assembled an international consortium to support the adoption of human stem cell-derived disease models for drug discovery and development. This initiative aims to reduce R&D costs and accelerate therapy development, aligning with efforts by regulatory bodies such as the FDA, NIH, and European Commission.
A new smartphone app, ECHAS, can help people determine if they are suffering from a heart attack or stroke and need medical attention. The app, developed by experts at UVA Health and other leading institutions, proved effective in identifying patients with cardiac and neurological emergencies.
Scientists have uncovered a previously unknown mechanism explaining how neurons survive botulinum neurotoxin type A exposure. The research found that specific tRNA fragments interact with key proteins and RNA molecules involved in regulating ferroptosis, supporting neuronal survival by blocking cell death pathways.
The Boston Children's Therapeutic & Medical Device Accelerator has announced its inaugural awardees, selected for their groundbreaking innovations in pediatric healthcare. The program provides targeted funding, expert mentorship, and strategic collaborations to advance hospital discoveries towards clinical impact.
Dr. Yehezkel Ben-Ari's Neuroarcheology framework links developmental mechanisms to disorders, offering new hope for previously untreatable conditions. His groundbreaking work has transformed our understanding of brain development and malfunctions.
The Buck Institute's hybrid intervention combines a daily ketone ester with ICOPE-INTENSE, a personalized approach improving Intrinsic Capacity and age-related functions. The team aims to restore muscle, cognition, and immune function by 10 years in one year or less.
A study led by the Badalona Neuromuscular Research Group found that HDAC11 deficiency reduces muscle mass loss, promotes muscle regeneration, and improves overall muscle function in aged murine models. This discovery proposes a new therapeutic strategy to slow down age-related muscular decline and promote healthier ageing.
Dr. Seymour Reichlin's remarkable career spanned five decades, marked by scientific excellence, mentorship, and generosity. His influence on neuroendocrinology has been profound, with ongoing contributions at age 100 revealing new insights into Alzheimer's disease and ecstatic mysticism.
W. Kimryn Rathmell, former NCI director, joins Ohio State as CEO of The Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. She will lead the clinical and research excellence of Ohio State's cancer program, including operational oversight of both hospitals.
Researchers identified piperacillin as an effective treatment for Lyme disease, which causes devastating symptoms in half a million individuals annually. The antibiotic works by targeting the bacteria's unique cell wall synthesis pattern, leading to its death without harming beneficial gut microbes.
A smart bandage called iCares has been developed to monitor chronic wounds in human patients, detecting biomarkers of inflammation and infection. The bandage can provide real-time data and deliver treatment, accelerating the healing process.
A novel biological pathway, the IL6 pathway, has been identified as central to calciphylaxis skin lesion initiation and progression. Blocking this pathway could prevent progression of skin ulcers and resolve pain in patients with calciphylaxis.
Researchers using multi-omics tools analyze blood-derived immune cells to chart disease heterogeneity in unprecedented detail. This approach enables exploration of pre-existing immune states shaped by past infections, environmental exposures, and genetic predisposition.
Common prescription medications can disrupt sterol biosynthesis, potentially causing developmental disorders. The editorial highlights the need for mandatory sterol biosynthesis screening in clinical practice.
Researchers have identified a potential precision medicine approach to prevent chronic kidney disease progression by targeting type 5 collagen, a minor component of scar tissue. A repurposed anti-cancer drug, Cilengitide, has been shown to slow kidney scarring and disease progression in high-risk individuals.
Dr. Romina Mizrahi's PET-based neuroimaging sheds light on brain workings, integrating genetics, environment and imaging to understand psychiatric illness as a complex biological puzzle. She advocates for precision psychiatry paradigm with customized treatments based on molecular profiles, and calls for diversity in academic leadership.