Articles tagged with Translational Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Dr. Loftus's research has had a profound impact on the administration of justice in the US and abroad, highlighting the fragility and malleability of human memories. Her work has led to the dismissal of murder charges based on repressed memories, contributing to her being recognized as a pioneer in the field.
The Neandertal genome draft sequence reveals significant genetic variants shared with present-day humans from Eurasia, indicating gene flow before population divergence. This finding supports the theory of interbreeding between Neandertals and early modern humans in Eurasia.
The AAAS has awarded four researchers with the Joshua E. Neimark Memorial Travel Assistance Award to study stem cell transplantation, sustainable growth, women in academia, and conservation science. The winners will attend the 2011 Annual Meeting of the American Association for the Advancement of Science.
Dr. J. John Cohen is recognized for his work in demystifying science for non-scientists through public programs like Mini Med School, which has inspired similar programs globally. His research on apoptosis and teaching awards have further solidified his commitment to making science accessible.
This year's AAAS/Subaru Science Books & Film competition recognizes four authors, an illustrator, and a photographer for their scientifically sound works promoting science literacy. Winners explore topics like climate change, honey bee colonies, and biomedicine.
A new foot bone from Hadar, Ethiopia, reveals Australopithecus afarensis had stiff, arched feet similar to modern humans. This finding supports the hypothesis that A. afarensis was primarily an upright walker, with its well-formed arch allowing for efficient walking and running on two feet.
A new study has found that modern humans may have reached the Arabian Peninsula as far back as 125,000 years ago. This discovery challenges current estimates of human migration out of Africa and sheds light on the technological innovations that allowed early humans to thrive in the region.
Researchers demonstrate the role of cellular bioenergetics in selectively inhibiting pathogenic lymphocytes while preserving normal immune function. Lycera's prototype compound Bz-423 induces selective apoptosis of alloreactive donor T cells, reversing graft-versus-host disease and improving survival in mice.
The American Association for the Advancement of Science (AAAS) has announced the 2011 fellowship recipients for international science journalists. The fellowships aim to promote international scientific dialogue and advance science news globally. This year's winners are from Chile, Egypt, Argentina, and China.
A mechanical device that operates in the quantum realm has been developed by researchers from the University of California at Santa Barbara. This innovation extends quantum mechanics into a whole new realm and opens up possibilities for controlling light, electrical currents, and motion.
Researchers found that silencing the TLR4 gene can prevent hyperglycemic cardiac apoptosis in diabetic mice, highlighting the potential clinical use of siRNA-based therapy. The study demonstrated that TLR4 plays a critical role in cardiac apoptosis and that its silencing can suppress apoptotic cascades.
A new study finds that a brief writing exercise can improve female students' academic performance and reduce the gender gap in college science. The exercise appears to narrow the gap by alleviating anxiety related to negative stereotypes about women in science.
Christopher Gregg's groundbreaking research reveals how parental genetic cues influence brain development and disease, providing a roadmap for future research. His findings have major relevance for understanding brain evolution, function, and disease.
A study published in Science reports that one-fifth of vertebrate species are threatened, with declines accelerating over the past few decades. Conservation measures have mitigated this trend, with certain approaches proving more effective than others, such as controlling invasive species.
Researchers at Penn Medicine measured the collaborative nature of translational medicine using network analysis, finding that ITMAT members' collaborative papers doubled since 2006. They also discovered that researchers were more likely to collaborate within their own departments and institutions rather than across them.
Researchers found that brain cells in Parkinson's patients abandon their energy-producing machinery, the mitochondria. Boosting the mitochondria with FDA-approved drugs may prevent or delay the onset of Parkinson's disease.
The new book discusses research on the impact of alcohol on the growing body and offers practical tips for parents to talk to their children about drinking. Studies show that delaying the first drink can make a big difference in reducing later-life problems.
A study published in Science has found that the anterior prefrontal cortex and white matter structure are associated with introspective ability. Researchers used MRI scans to analyze participants' brains and identified a correlation between gray matter volume and self-awareness, which could lead to better treatments for mental illness.
A new area of study called the 'science of team science' (SciTS) aims to resolve problems facing interdisciplinary research teams. The study focuses on what works and what doesn't when teams of scientists work together to achieve a common goal.
Researchers developed a titanium coating with protein 'flower bouquet' nanoclusters that strengthened implant attachment by 50% compared to standard coatings. The clusters improved bone growth around the implant, enhancing cell adhesion signals and promoting better integration of biomaterial implants into bone.
A centuries-old traditional Chinese medicine, PHY906, may reduce intestinal side effects of chemotherapy by stimulating gut cell division and reducing inflammation in cancer patients. Researchers found that PHY906 triggers Wnt signaling, which drives the replacement of damaged intestinal stem cells with healthy ones.
Researchers at the University of Texas Medical Branch have developed new techniques to identify specific asthma subtypes using protein patterns in airway lining fluid. This allows for targeted medication and potentially improved treatment outcomes. The study aims to reduce trial and error in asthma diagnosis and treatment.
A bioengineered implantable glucose sensor successfully monitored tissue glucose levels in animals for over a year, demonstrating its potential as an alternative to traditional glucose monitoring methods. The device could help people with diabetes adjust their insulin doses and reduce the risk of hypoglycemia.
Researchers found that administering antibiotics to mice infected with malaria prevents the disease and induces long-term immunity. The treatment targets the apicoplast, a bacterial organ necessary for parasite reproduction, allowing the immune system to develop robust protection.
Experts propose a bold vision of hope by translating advances in worm, mouse, and rat research into therapies for humans. The new science of aging can form the basis for a new kind of medicine that focuses on underlying changes driving age-related diseases.
A panel of experts recommends translating laboratory findings into medicines that can benefit the aging population, with a focus on regenerative therapies and lifestyle improvements.
The Wellcome-Wolfson partnership is funding £30 million of large-scale university infrastructure projects in the UK. This initiative aims to facilitate internationally competitive biomedical research, enabling scientists to make groundbreaking discoveries and turn them into clinical applications.
Researchers have developed a long and accurate chronology of ancient Egyptian dynasties using radiocarbon analysis, narrowing down historical scenarios and imposing some revisions. The study constrains previous predictions, especially for the Old Kingdom, with more accurate comparisons to surrounding areas.
Researchers found that children born to HIV-positive mothers with specific TLR9 gene variants are at a higher risk of acquiring the virus. The study confirms the relevance of innate immunity in perinatal HIV-1 infection and may lead to new therapeutic strategies.
Researchers found that colon polyp detection rates remained consistent throughout the day at Mayo Clinic, contradicting previous findings. Shorter daily shifts did not result in decreased polyp detection rates, unlike traditional half-day shifts.
A newly discovered hominid species, Australopithecus sediba, has revealed a bone structure similar to the earliest Homo species but employed it more like Australopithecus. The fossils, dated between 1.95 and 1.78 million years old, provide a wealth of information about human origins.
Researchers developed a new approach to track cancer by identifying personalized biomarkers from tumor DNA, using next-generation sequencing technology. The findings show that this method can provide accurate and specific monitoring of tumors, allowing for better assessment of treatment effectiveness.
The 2009 International Science & Engineering Visualization Challenge honored artists who use visual media to promote scientific research, highlighting complex concepts like sustainability, branching morphogenesis, and human mobility. The challenge encouraged effective communication and creativity in presenting scientific findings.
Diola Bagayoko, a Southern University professor, received the 2009 AAAS Lifetime Mentor Award for increasing African-American Ph.D. degrees in physics and chemistry. He has mentored 21 undergraduate students to receive Ph.D.s in these fields through his Timbuktu Academy.
Katepalli R. Sreenivasan, immediate past director of the International Centre for Theoretical Physics, has been recognized by AAAS for his role in promoting cutting-edge science globally. He was awarded the 2009 AAAS International Scientific Cooperation Award for mentoring students and young scholars from developing countries.
Francis S. Collins, M.D., has been selected to receive the 2009 AAAS Philip Hauge Abelson Award in recognition of his outstanding contributions to science. He is recognized for his exceptional skills as a scientist, communicator, and leader, as well as his pioneering work on the Human Genome Project.
Dr. Nancy Olivieri, a professor at the University of Toronto, was honored with the 2009 AAAS Scientific Freedom and Responsibility Award for her courage in defending patient safety and research integrity. She faced severe consequences after reporting potential life-threatening side effects of a medication during a clinical trial.
Luis Colón, a University at Buffalo chemistry professor, received the 2009 AAAS Mentor Award for his efforts to recruit and mentor Hispanic-American students in chemistry. His initiatives led to an increase in Ph.D. degrees awarded to Hispanic-Americans in chemistry.
The 2009 AAAS Newcomb Cleveland Prize was awarded to Christian Marois and colleagues for their direct imaging of multiple planets orbiting HR 8799, a distant star. The discovery, made using the Keck and Gemini North telescopes, reveals a system resembling our solar system's outer portion.
May R. Berenbaum, a renowned entomologist, has been awarded the AAAS Public Understanding of Science and Technology Award for her extraordinary ability to integrate scientific discovery with public outreach. Her work has had a significant impact on fields such as chemical ecology, agriculture, and environmental conservation.
The AAAS/Subaru Science Books & Film (SB&F) competition recognizes authors who convey the excitement of science, fostering scientific literacy in readers of all ages. The 2009 winners included books on photosynthesis, microbes, and a real-life amphibian scientist.
Three young scientists will receive financial support to attend the AAAS Annual Meeting to present their research on topics including a science teaching strategy, HIV medication synthesis, and DNA integrity analysis. The award aims to help them attain careers in their chosen fields.
The AAAS Fellowships for Science Reporters from North Africa provide recipients with a front-row seat at the unveiling of new research and opportunities to mingle with fellow science writers. The fellowship program supports excellence in communicating science worldwide, fulfilling AAAS and EurekAlert! mission goals.
Researchers at the University of California, San Diego, have discovered that HIV RNA in seminal plasma is transmitted during sex, not HIV DNA. This finding has significant implications for developing prevention strategies, including vaccines and microbicides to prevent the spread of sexually transmitted HIV.
Developed at the University of Utah's Genetic Science Learning Center, the websites are providing an excellent source of new material while educating a hugely diverse audience. They have been honored with the Science Prize for Online Resources in Education, recognizing their value as educational tools.
Researchers found that slime mold can self-organize into a nearly identical network to Tokyo's rail system, suggesting improved technological systems. The model captures the basic dynamics of network adaptability through interaction of local rules.
Dr. Kilduff recognized for his role in discovering the neuropeptide hypocretin and developing therapeutics for sleep disorders such as narcolepsy and insomnia. He has published over 200 research papers and received funding from government agencies and private foundations.
Kai W. Wucherpfennig, a Dana-Farber Cancer Institute researcher, has been named a Fellow of the American Association for the Advancement of Science (AAAS) for his contributions to immunology and T-cell activation in human autoimmune disease. The AAAS Fellowship recognizes his distinguished efforts to advance science and its applications.
Mark A. Smith, Ph.D., has been awarded the American Association for the Advancement of Science (AAAS) Fellowship for his distinguished contributions to neurodegenerative disorders and Alzheimer's disease research. He is recognized for his work on oxidative stress and cell cycle alterations in Alzheimer's disease.
The discovery of Ardipithecus ramidus, a 4.4 million-year-old hominid species from Ethiopia, revolutionizes our understanding of early human evolution. The fossils, including the partial skeleton named 'Ardi', show a mix of primitive and derived traits, challenging current models of human-chimpanzee evolution.
The University of North Carolina's Graduate Training Program in Translational Medicine has received a $700,000 HHMI grant to integrate medical knowledge into its Ph.D. programs. This program aims to train researchers to translate basic science discoveries into improved treatments for patients.
Social media pioneer Anil Dash is leading Expert Labs, an independent effort to enhance policy-making by tapping into the wisdom of crowds. The initiative will leverage social networking platforms and technology startups to provide innovative solutions for sharing expertise.
Research at Thomas Jefferson University found that inhibiting GRK2 reduces acute ischemia injury to the myocardium, protecting cardiac myocytes from damage. The absence of GRK2 activity leads to improved recovery from acute cardiac damage.
A study demonstrates the effectiveness of a gene delivery strategy producing follistatin, which inhibits myostatin, in non-human primates, showing pronounced increases in muscle size and strength. The treatment is well-tolerated and has long-term effects, paving the way for potential clinical trials.
The 2009 AAAS Kavli Science Journalism Awards honored excellence in science reporting, including a story about probability told through a drifting balloon and a series on a rare genetic disorder affecting a family in rural Montana. The winners will receive $3000 and a plaque at the 2010 AAAS Annual Meeting.
Young neurobiologist Richard Benton's research on insect odor detection has uncovered unanticipated evolutionary parallels between chemosensation, immune recognition, and synaptic transmission. His findings have significant implications for controlling disease-transmitting insects and understanding the evolution of nervous systems.
Researchers at Baylor College of Medicine have identified a potassium channel KvLQT as the molecular trigger for sudden death in epilepsy. This discovery could lead to a simple genetic screening test to identify patients at risk, offering effective treatments such as beta blockers and cardiac pacemakers.
The debut edition of Science Translational Medicine describes a microfluidics device for detecting tiny amounts of estrogen, which could improve breast cancer screening. Researchers have also identified a novel mechanism to protect patients from graft-versus-host disease after bone marrow transplants.
The study provides the first comprehensive description of Ardipithecus ramidus, revealing a mix of primitive and derived traits. The findings suggest that early hominids lived in woodland environments, climbed on all fours along tree branches, and walked upright on two legs.
Researchers found a common genetic variation associated with differences in brain structure, including reduced surface area in the cortex, in both healthy individuals and patients with neurological and psychiatric disorders. This variation may be a promising candidate gene for further study.