Articles tagged with Translational Medicine
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The AAAS has awarded grants to 10 Christian seminaries to integrate science into their core theological courses, impacting individual seminaries and ministries served by graduates. The project will provide faculty with scientist-advisers and resources, including short science-education videos.
Researchers have successfully engineered cartilage tissue using nasal septum cells, showing promising results in repairing articular cartilage defects. The treated patients' knees were replaced with the engineered cartilage grafts, demonstrating the potential of this innovative clinical treatment for cartilage damage.
Despite government promises, satellite analysis shows no significant increase in civic facilities in Sri Lanka's Valikamam High-Security Zone. The area has seen a sharp increase in residential housing-type structures and development.
A study has restored a missing repair protein in skeletal muscle of patients with muscular dystrophy. Proteasome inhibitors enabled mutated dysferlin proteins to regain function and repair damaged muscle membranes.
Researchers at Norwegian University of Science and Technology discovered that eliminating nerve signals sent to cancer stem cells can suppress gastric tumor growth. Botox, commonly used for beauty treatments, was found to be highly effective in treating stomach cancer.
A study by UCSF researchers found that hospital workers exposed to antibacterial soap had significantly higher triclosan levels in their urine compared to those using plain soap and water. Washing with antibacterial soap accounted for even higher triclosan levels than brushing with toothpaste containing triclosan.
Researchers found that fibroblastic reticular cells from lymph nodes improved survival in mouse models of sepsis, even when treatment was delayed by up to 16 hours. FRC administration prevented damage to the spleen and death of immune cells, leading to reduced bacterial levels in the bloodstream.
Researchers developed a way to coax flat sheets of composite materials into complex robots that crawl and turn. The new approach allows for rapid assembly, scalability, and high strength-to-weight ratio, making it ideal for mass production and diverse applications.
Recent advances in genetic research offer new hope for treating coronary artery disease by identifying specific genetic variants and pathways associated with cardiovascular risk. Human genetic data suggest that targeting LDL-C and triglycerides may be effective in reducing major cardiovascular events.
A Harvard-led team uses low-power laser therapy to stimulate human dental stem cells into forming dentin, a hard tissue similar to bone. The approach, led by David Mooney, could radically shift dental treatment and lead to broader clinical applications in regenerative medicine.
The Human Proteome Organization (HUPO) and Elsevier's new open-access journal, Translational Proteomics, have formed a partnership to promote translational proteomics research. The journal aims to link basic sciences to clinical research, with a focus on rapid dissemination of novel discoveries.
The center will investigate mechanisms underlying addiction and discover new treatments, focusing on the serotonin system. It will prioritize individuals with impulsivity traits, which are associated with higher relapse rates.
A team of scientists observed a supernova in 2010 and proposed it was a new type of extra-bright supernova. However, further analysis revealed the presence of a lens that amplified the supernova's light, settling an important controversy. The discovery offers a means to test cosmic expansion using future lensed supernova events.
New gravity data reveals an ocean of liquid water beneath 30-40 km of ice at Enceladus' surface, potentially creating conditions for complex chemical reactions. The sub-surface ocean may extend towards the equator in every direction, similar to Europa's ocean.
Researchers at Trinity College Dublin made a breakthrough in treating AMD by finding that IL-18 suppresses abnormal blood vessel growth behind the retina. Low doses of IL-18 have shown no adverse effects on the retina, offering a promising non-invasive treatment option.
UTSA College of Sciences faculty Andrew Tsin, Garry Cole, and Donald Kurtz were honored as AAAS Fellows for their groundbreaking research contributions. Tsin received the 2013 AAAS Mentor Award for Lifetime Achievement in promoting Hispanic American doctorates.
A study by Byoung-il Bae and colleagues found that a specific gene mutation affects the development of cortical convolutions in the human brain. The researchers discovered that the mutation impacts the production of neuroprogenitor cells around the Sylvian fissure, leading to thinner and more convoluted folds.
Researchers designed algorithms that reflect termite behavior, enabling robots to build complex structures without detailed plans. The robots use simple cues from their environment and each other to complete user-defined structures.
Strogatz has contributed widely to popularize mathematics through newspaper articles, books, radio and television appearances, documentaries, and public lectures. He has introduced the public to various mathematical concepts, including chaos theory, statistics, and group theory.
Dr. Mary Helen Immordino-Yang has been honored by the American Association for the Advancement of Science (AAAS) with the Early Career Award for Public Engagement with Science, recognizing her contributions to public engagement activities and research in neuroscience of social emotion and education.
Siegfried Hecker has been honored by AAAS for his work in nuclear security and global threat reduction. His dedication to fostering cooperation through science led to significant international partnerships, improving the control of nuclear materials.
The 2014 AAAS/Subaru Science Books & Film competition recognized four engaging science books exploring school gardens, fossil discovery, backyard bird watching, and biotechnology. Winners received $1500 and a plaque for their outstanding contributions to science writing and illustration.
Paul B. Tchounwou, associate dean of graduate studies at Jackson State University, received the 2013 AAAS Mentor Award for his significant contributions to mentoring African American students in environmental sciences. He has mentored over 75 students and has played a key role in increasing research productivity at the university.
Andrew Tsin, a professor of biology at the University of Texas at San Antonio, received the 2013 AAAS Lifetime Mentor Award for his dedication to mentoring underrepresented students. He has mentored over 130 students, including dozens of Hispanic Americans, and helped establish programs aimed at increasing diversity in science education.
Researchers reconstructed the neuronal circuits of an adult male nematode to understand how sensory neurons interpret signals from the environment and translate them into mating behavior. The comprehensive map, known as a connectome, reveals various classes of neurons involved in locomotion, posture, and insemination.
The annual challenge honored recipients who used visual media to convey scientific research and ideas, featuring award-winning entries such as 'Dynamic Earth' on climate change and 'Wearable Power' on sustainable energy. The competition received over 1,983 public votes for the People's Choice awards.
Researchers have identified a distinctive profile of cytokine activity associated with certain symptoms of endometriosis, including ovarian and rectovaginal lesions. This signature is negatively correlated with patient fertility and has previously been implicated in the disease.
A Scripps Health study suggests that a ZIO Patch, worn on the chest for up to two weeks, detects abnormal heart rhythms more effectively than a traditional Holter monitor. The patch's extended monitoring period led to significantly more arrhythmia events being detected.
Daniel G. Streicker's research using viral infections in bats aims to understand how infectious diseases jump between species and prevent disease transmission. He has developed a novel population genetic framework to determine transmission rates and shown that host biology can shape the speed of viral evolution.
Researchers at Scripps Translational Science Institute used wireless health sensors to collect data from meditators, studying the immediate effects of meditation on blood pressure and markers of stress. The study aims to guide better treatments for high blood pressure and other health conditions.
Researchers at Temple University have discovered that inhibiting a specific protein called TNNI3K can limit damage from heart attacks and protect the heart from further injury. The findings have significant potential for translation into human patients and could lead to the development of a new treatment using a TNNI3K inhibitor.
A new study published in Cell suggests that the latent reservoir of HIV-infected patients is significantly larger than previously estimated, making it a major barrier to cure. The findings highlight limitations of current treatment strategies and could lead to the development of more effective interventions.
Researchers found that a fungus, Batrachochytrium dendrobatidis, blocks the adaptive immune response in amphibians, allowing it to survive. The study suggests that the fungus targets a conserved vulnerability shared by both amphibian and mammalian lymphocytes.
A complete skull from early Homo has been discovered in Georgia, combining features like a small braincase with large teeth. The finding suggests that all Homo species may have belonged to the same evolving lineage.
Carl Nathan, MD, receives $20,000 prize for discoveries in immunology; monograph published in Molecular Medicine explores inspiration and purpose in scientific inquiry. The Anthony Cerami Award aims to document innovations and discoveries in medicine and healthcare.
A Yale-led study has identified 52 genes that significantly correlate with outcome in patients with IPF, predicting shorter survival time and guiding treatment decisions. The discovery of these biomarkers may lead to better prediction of disease presence and severity.
Voyager 1 has entered interstellar space, leaving the heliosphere and entering a region of cold, dark space. The spacecraft's plasma density measurements suggest it crossed the heliopause in August 2012, marking a significant technological achievement and a new chapter in human scientific endeavors.
A new study reveals that only 17% of Earth's land needs to be protected to satisfy the Convention on Biological Diversity's goals, but this area must contain 67% of all plant species. Protecting these hotspots could slow biodiversity loss and meet international targets
Scientists have finally mapped the brain region responsible for numerosity, distinguishing between small and large quantities. The discovery reveals a topographical layout of numerosity in the human brain, with neurons organized to facilitate communication and interaction over short distances.
A new model predicts arsenic contamination risks in China, identifying high-risk areas where millions of people live. The model could also be used to identify contaminated water sources in other arid regions worldwide.
Scientists successfully treated the Ebola virus in infected animals following onset of disease symptoms, demonstrating promise for developing therapies against the virus. The experimental treatment, known as MB-003, protected 43% of infected non-human primates.
A new mouse model study reveals that interleukin-17 can stabilize atherosclerotic plaques by promoting their stability. This discovery provides crucial information on the role of the immune system in atherosclerosis and may lead to the development of new therapies.
The Sackler Institute aims to advance understanding of neurodevelopmental disorders and develop innovative treatments through collaboration across King's and other research networks. The new institute will foster interdisciplinary training and translation of findings into patient care.
A new study reveals that the brain's representation of complex features may start earlier and be more cumulative than previously thought. Researchers analyzed nerve cell pairs in two adult macaques and found that the neuronal circuit generating pair-association was only in area TE, not in area 36.
Archaeologists uncover evidence of ancient grain cultivation between 12,000 and 9,800 years ago in eastern Fertile Crescent. Plant remains found at Chogha Golan site show simultaneous development of Neolithic culture across region.
Researchers found regions of genome associated with cholera susceptibility, including pathways regulating water loss and innate immune system responses. The findings suggest a potential fingerprint for cholera's genetic impact, such as the relative rarity of blood type O, which may confer increased risk of severe symptoms.
Researchers have developed an assay to quantify structural avidity in living T cells, a key predictor of success in adoptive transfer therapies. The technology offers advantages over previous methods, including simplicity, non-invasive measurement, and quantitative assessment of binding strength.
A new course module, ECO mission, has won the Science Prize for Inquiry-Based Instruction for its effective teaching of biology. The course uses a combination of web-based learning environments and hands-on experimentation to improve students' understanding of real research.
The BigBrain project presents a landmark three-dimensional digital reconstruction of the human brain with a spatial resolution of 20 microns. This allows for unprecedented exploration of brain microstructure and cellular level details, facilitating new insights into neurobiology, cognition, and aging.
The disappearance of large fruit-eating birds from Brazilian forests has led to smaller, less successful seeds in nearby palm trees. The study found that the absence of these birds triggered a rapid evolution of forest palms, resulting in smaller seeds.
A new study suggests that Li-ion battery disposal can lead to environmental and human health threats due to the release of toxic materials. The American Chemical Society recommends stronger government policies to encourage recovery, recycling, and reuse of lithium-ion battery materials.
A new study reveals that the ancient Maya civilization developed its unique culture and architecture through broad cultural exchanges across southern Mesoamerica. The researchers found that the plazas and pyramids at Ceibal, Guatemala, were built around 1,000 BCE, predating other comparable examples by roughly 200 years.
Researchers report success with Sirolimus treatment, minimizing seizures and improving language function in Pretzel syndrome children. The study's findings have implications for related neurodevelopmental disorders like tuberous sclerosis complex.
The article provides an evidence-based overview of pancreatic cancer diagnosis and treatment, emphasizing the importance of surgery as a curative option. Key findings also highlight the benefits of accelerated progress in understanding the disease through partnerships between clinicians and basic scientists.
The DREAM Breast Cancer Prognosis Challenge successfully predicted better breast cancer progression than existing models, using genomic and clinical information from 2000 women. The winning team, Attractor Metagenes, developed a model based on 'attractor metagenes,' gene signatures that behave similarly in multiple cancer types.
A team of scientists at Temple University School of Medicine has identified a key molecule, GRK2, in mitochondria that contributes to the death of heart cells. The researchers found that blocking this enzyme's activity can prevent its delivery to mitochondria and reduce pro-death signaling.
The Feil Family Brain and Mind Research Institute aims to develop advanced personalized therapeutic solutions for patients with devastating brain diseases, such as Alzheimer's disease and Parkinson's disease. The institute will conduct bench-to-bedside research to test novel therapeutics in cutting-edge clinical trials.
Researchers envision cell-based therapeutics as a promising approach to treat critical diseases. Cells can adapt and respond better than small-molecule drugs, offering a more predictable treatment option.
Christina Wang, a leading LA BioMed researcher, has been recognized for her outstanding contributions to the field of andrology. Her research has focused on male reproductive health and disease, with a particular emphasis on androgen replacement therapy and hormonal male contraceptive development.
Researchers propose coverage with evidence development (CED) and parallel review policies to accelerate access to molecular diagnostics, which aid in disease prediction, diagnosis, prognosis, and treatment. These policies aim to streamline regulatory processes and provide benefits for developers.