Articles tagged with Translational Medicine
A centuries-old traditional Chinese medicine, PHY906, may reduce intestinal side effects of chemotherapy by stimulating gut cell division and reducing inflammation in cancer patients. Researchers found that PHY906 triggers Wnt signaling, which drives the replacement of damaged intestinal stem cells with healthy ones.
Researchers developed a titanium coating with protein 'flower bouquet' nanoclusters that strengthened implant attachment by 50% compared to standard coatings. The clusters improved bone growth around the implant, enhancing cell adhesion signals and promoting better integration of biomaterial implants into bone.
Researchers at the University of Texas Medical Branch have developed new techniques to identify specific asthma subtypes using protein patterns in airway lining fluid. This allows for targeted medication and potentially improved treatment outcomes. The study aims to reduce trial and error in asthma diagnosis and treatment.
A bioengineered implantable glucose sensor successfully monitored tissue glucose levels in animals for over a year, demonstrating its potential as an alternative to traditional glucose monitoring methods. The device could help people with diabetes adjust their insulin doses and reduce the risk of hypoglycemia.
Researchers found that administering antibiotics to mice infected with malaria prevents the disease and induces long-term immunity. The treatment targets the apicoplast, a bacterial organ necessary for parasite reproduction, allowing the immune system to develop robust protection.
A panel of experts recommends translating laboratory findings into medicines that can benefit the aging population, with a focus on regenerative therapies and lifestyle improvements.
Experts propose a bold vision of hope by translating advances in worm, mouse, and rat research into therapies for humans. The new science of aging can form the basis for a new kind of medicine that focuses on underlying changes driving age-related diseases.
The Wellcome-Wolfson partnership is funding £30 million of large-scale university infrastructure projects in the UK. This initiative aims to facilitate internationally competitive biomedical research, enabling scientists to make groundbreaking discoveries and turn them into clinical applications.
Researchers have developed a long and accurate chronology of ancient Egyptian dynasties using radiocarbon analysis, narrowing down historical scenarios and imposing some revisions. The study constrains previous predictions, especially for the Old Kingdom, with more accurate comparisons to surrounding areas.
Researchers found that children born to HIV-positive mothers with specific TLR9 gene variants are at a higher risk of acquiring the virus. The study confirms the relevance of innate immunity in perinatal HIV-1 infection and may lead to new therapeutic strategies.
Researchers found that colon polyp detection rates remained consistent throughout the day at Mayo Clinic, contradicting previous findings. Shorter daily shifts did not result in decreased polyp detection rates, unlike traditional half-day shifts.
A newly discovered hominid species, Australopithecus sediba, has revealed a bone structure similar to the earliest Homo species but employed it more like Australopithecus. The fossils, dated between 1.95 and 1.78 million years old, provide a wealth of information about human origins.
Researchers developed a new approach to track cancer by identifying personalized biomarkers from tumor DNA, using next-generation sequencing technology. The findings show that this method can provide accurate and specific monitoring of tumors, allowing for better assessment of treatment effectiveness.
The 2009 International Science & Engineering Visualization Challenge honored artists who use visual media to promote scientific research, highlighting complex concepts like sustainability, branching morphogenesis, and human mobility. The challenge encouraged effective communication and creativity in presenting scientific findings.
The AAAS/Subaru Science Books & Film (SB&F) competition recognizes authors who convey the excitement of science, fostering scientific literacy in readers of all ages. The 2009 winners included books on photosynthesis, microbes, and a real-life amphibian scientist.
Three young scientists will receive financial support to attend the AAAS Annual Meeting to present their research on topics including a science teaching strategy, HIV medication synthesis, and DNA integrity analysis. The award aims to help them attain careers in their chosen fields.
Diola Bagayoko, a Southern University professor, received the 2009 AAAS Lifetime Mentor Award for increasing African-American Ph.D. degrees in physics and chemistry. He has mentored 21 undergraduate students to receive Ph.D.s in these fields through his Timbuktu Academy.
Katepalli R. Sreenivasan, immediate past director of the International Centre for Theoretical Physics, has been recognized by AAAS for his role in promoting cutting-edge science globally. He was awarded the 2009 AAAS International Scientific Cooperation Award for mentoring students and young scholars from developing countries.
Francis S. Collins, M.D., has been selected to receive the 2009 AAAS Philip Hauge Abelson Award in recognition of his outstanding contributions to science. He is recognized for his exceptional skills as a scientist, communicator, and leader, as well as his pioneering work on the Human Genome Project.
Dr. Nancy Olivieri, a professor at the University of Toronto, was honored with the 2009 AAAS Scientific Freedom and Responsibility Award for her courage in defending patient safety and research integrity. She faced severe consequences after reporting potential life-threatening side effects of a medication during a clinical trial.
Luis Colón, a University at Buffalo chemistry professor, received the 2009 AAAS Mentor Award for his efforts to recruit and mentor Hispanic-American students in chemistry. His initiatives led to an increase in Ph.D. degrees awarded to Hispanic-Americans in chemistry.
The 2009 AAAS Newcomb Cleveland Prize was awarded to Christian Marois and colleagues for their direct imaging of multiple planets orbiting HR 8799, a distant star. The discovery, made using the Keck and Gemini North telescopes, reveals a system resembling our solar system's outer portion.
May R. Berenbaum, a renowned entomologist, has been awarded the AAAS Public Understanding of Science and Technology Award for her extraordinary ability to integrate scientific discovery with public outreach. Her work has had a significant impact on fields such as chemical ecology, agriculture, and environmental conservation.
The AAAS Fellowships for Science Reporters from North Africa provide recipients with a front-row seat at the unveiling of new research and opportunities to mingle with fellow science writers. The fellowship program supports excellence in communicating science worldwide, fulfilling AAAS and EurekAlert! mission goals.
Researchers at the University of California, San Diego, have discovered that HIV RNA in seminal plasma is transmitted during sex, not HIV DNA. This finding has significant implications for developing prevention strategies, including vaccines and microbicides to prevent the spread of sexually transmitted HIV.
Developed at the University of Utah's Genetic Science Learning Center, the websites are providing an excellent source of new material while educating a hugely diverse audience. They have been honored with the Science Prize for Online Resources in Education, recognizing their value as educational tools.
Dr. Kilduff recognized for his role in discovering the neuropeptide hypocretin and developing therapeutics for sleep disorders such as narcolepsy and insomnia. He has published over 200 research papers and received funding from government agencies and private foundations.
Researchers found that slime mold can self-organize into a nearly identical network to Tokyo's rail system, suggesting improved technological systems. The model captures the basic dynamics of network adaptability through interaction of local rules.
Kai W. Wucherpfennig, a Dana-Farber Cancer Institute researcher, has been named a Fellow of the American Association for the Advancement of Science (AAAS) for his contributions to immunology and T-cell activation in human autoimmune disease. The AAAS Fellowship recognizes his distinguished efforts to advance science and its applications.
The discovery of Ardipithecus ramidus, a 4.4 million-year-old hominid species from Ethiopia, revolutionizes our understanding of early human evolution. The fossils, including the partial skeleton named 'Ardi', show a mix of primitive and derived traits, challenging current models of human-chimpanzee evolution.
Mark A. Smith, Ph.D., has been awarded the American Association for the Advancement of Science (AAAS) Fellowship for his distinguished contributions to neurodegenerative disorders and Alzheimer's disease research. He is recognized for his work on oxidative stress and cell cycle alterations in Alzheimer's disease.
The University of North Carolina's Graduate Training Program in Translational Medicine has received a $700,000 HHMI grant to integrate medical knowledge into its Ph.D. programs. This program aims to train researchers to translate basic science discoveries into improved treatments for patients.
Social media pioneer Anil Dash is leading Expert Labs, an independent effort to enhance policy-making by tapping into the wisdom of crowds. The initiative will leverage social networking platforms and technology startups to provide innovative solutions for sharing expertise.
Research at Thomas Jefferson University found that inhibiting GRK2 reduces acute ischemia injury to the myocardium, protecting cardiac myocytes from damage. The absence of GRK2 activity leads to improved recovery from acute cardiac damage.
A study demonstrates the effectiveness of a gene delivery strategy producing follistatin, which inhibits myostatin, in non-human primates, showing pronounced increases in muscle size and strength. The treatment is well-tolerated and has long-term effects, paving the way for potential clinical trials.
The 2009 AAAS Kavli Science Journalism Awards honored excellence in science reporting, including a story about probability told through a drifting balloon and a series on a rare genetic disorder affecting a family in rural Montana. The winners will receive $3000 and a plaque at the 2010 AAAS Annual Meeting.
Young neurobiologist Richard Benton's research on insect odor detection has uncovered unanticipated evolutionary parallels between chemosensation, immune recognition, and synaptic transmission. His findings have significant implications for controlling disease-transmitting insects and understanding the evolution of nervous systems.
Researchers at Baylor College of Medicine have identified a potassium channel KvLQT as the molecular trigger for sudden death in epilepsy. This discovery could lead to a simple genetic screening test to identify patients at risk, offering effective treatments such as beta blockers and cardiac pacemakers.
The debut edition of Science Translational Medicine describes a microfluidics device for detecting tiny amounts of estrogen, which could improve breast cancer screening. Researchers have also identified a novel mechanism to protect patients from graft-versus-host disease after bone marrow transplants.
The study provides the first comprehensive description of Ardipithecus ramidus, revealing a mix of primitive and derived traits. The findings suggest that early hominids lived in woodland environments, climbed on all fours along tree branches, and walked upright on two legs.
Researchers found a common genetic variation associated with differences in brain structure, including reduced surface area in the cortex, in both healthy individuals and patients with neurological and psychiatric disorders. This variation may be a promising candidate gene for further study.
Researchers have discovered that human fallopian tube mesenchymal stem cells can differentiate into muscle, fat, cartilage, and bone cell lines, offering a new source for regenerative medicine. The study found that these cells are abundant in fertile women's reproductive years and can be easily isolated and expanded in vitro.
Researchers identified seven ginsenosides with immune-suppressive effects and selectively inhibited expression of the inflammatory gene CXCL-10. The study uses state-of-the-art technologies to define bioactivity and opens up a methodology for studying medicinal herbs.
Researchers have found promising results with stem cells obtained from a patient's own adipose tissue in treating multiple sclerosis. The treatment, known as stromal vascular fraction (SVF) cell therapy, has shown dramatic improvement in symptoms for three patients with MS.
Two UC San Diego faculty members, Karen Christman and Seth J. Field, received $1.5 million grants from the NIH to support their cutting-edge research in tissue engineering and lipid signaling molecules. Their projects aim to improve human health through regenerative medicine approaches.
The Ohio State University Center for Clinical and Translational Science will provide support services to researchers while fostering collaboration with other medical centers. The grant will accelerate research outcomes at Ohio State and elsewhere, leading to faster development of treatments for patients.
The Center for Translational Injury Research will focus on new medical technologies to improve diagnosis, care, and survival of trauma victims. Researchers aim to tackle pressing issues like brain injuries, bleeding patients, and regenerative medicine in skin replacement therapy.
A study of first-time physician applicants reveals that those with only an M.D. degree are less likely to secure NIH research grants compared to researchers with Ph.D. degrees or both M.D. and Ph.D. degrees. The average annual funding rate for M.D.-only applicants was 28%, while it was higher for those with a Ph.D.
Researchers used Genomatix tools to identify novel cancer-associated genes in a colon cancer model. The study validated the findings using siRNA knock-down and RT-PCR, confirming the importance of these genes in cell proliferation.
A new study from CAMH and NIH demonstrates that nicotine plays a critical role in reinforcing smoking behavior in primates. The study shows that animals develop strong motivation to self-administer nicotine over time.
A study in rats reports that a specific receptor for a stress-response transmitter may play an important role in stress-induced relapse. The research found that blocking this receptor suppressed alcohol drinking and reinstatement of drinking in animals with a higher preference for alcohol.
The AACR Minority Scholar Awards program aims to increase minority participation in cancer research by providing opportunities for young scientists and clinicians. The program's 20th anniversary is being celebrated with a special session and gala, honoring past award recipients and recognizing the contributions of minority researchers.
The AACR-Gertrude B. Elion Cancer Research Award supports meritorious basic, translational, or clinical cancer research by a tenure-track scientist at an academic institution worldwide. Five Career Development Awards will be granted in 2004 to support research in various areas of cancer research.
The American Association for Cancer Research (AACR) is accepting nominations for several prestigious awards and lectureships, recognizing outstanding contributions in epidemiology, clinical cancer research, and preclinical research. The deadline for submissions is September 12, 2003.
Actor Christopher Reeve was awarded the UCSD-Salk Institute Service Award for his tireless efforts to raise awareness of the importance of basic research for human biology and disease. The award recognized his unwavering personal campaign to increase public and legislative awareness of the need to support basic research in health.