Articles tagged with Vaccination
A new study led by St. Michael's Hospital maps the potential risk of yellow fever virus spread to cities around the world, analyzing travel patterns and environmental conditions. The research highlights the need for countries to reexamine their policies to prevent yellow fever virus importation, protect travelers, and prevent exportation.
LepVax, IDRI's leprosy vaccine candidate, shows promise in pre-exposure and post-exposure prophylaxis against M. leprae infection in animals. It alleviates and delays neurologic disruptions caused by the bacteria, a major breakthrough for leprosy treatment.
The study demonstrates the efficacy of a single dose of NDV-3A in reducing recurrences of vaginitis in patients with RVVC, with younger patients showing higher efficacy rates. The vaccine also generates rapid and robust immune responses.
Purdue researchers have developed an online platform called the Social Media Analytics and Reporting Toolkit (SMART) that filters social media content according to key words and geographic regions. The tool is being used by first responders to analyze both live and historical data, helping them attend to certain areas faster.
Research presented at ECCMID found that unvaccinated patients accounted for most measles cases, with children under two years old being at higher risk of dying from the disease. The study also highlighted the impact of measles on young populations, with one in 1,000 cases resulting in death.
Researchers developed a nasal spray vaccine that shifts the immune response toward peanut tolerance in mice with established allergies. The vaccine's nano-emulsion adjuvant promotes a strong infection-fighting response that suppresses allergic reactions.
Researchers have developed a vaccine that can redirect the immune response to prevent allergic symptoms, providing extended relief from peanut allergies. The study shows promise for potential therapy of allergies in humans and may lead to long-lasting suppression of food allergies.
A new personalized vaccine has shown promise in boosting immune responses and increasing survival rates in patients with advanced ovarian cancer. The vaccine combines different immunotherapies to better tackle the disease, which is often diagnosed at later stages and lacks curative treatment options.
A study by University of Waterloo historians reveals that vaccine hesitancy, also known as immunization apathy, is rooted in social and political factors rather than bad parenting. The study shows how decades of misinformation and a lack of political priority on disease prevention contributed to the issue.
A Zika vaccine has shown significant potential in eliminating prenatal infections, with a 75% effective vaccine covering 90% of females aged 9-49 years reducing incidence by at least 94%. The vaccine's effectiveness depends on demographic and fertility patterns, local Zika attack rates, and population susceptibility.
Scientists link whooping cough resurgence in the US to incomplete adult vaccination and declining vaccine efficacy over time. School-aged children are identified as a key transmission hub for future vaccination efforts.
A new study by Kaiser Permanente researchers found that children with autism spectrum disorders and their younger siblings are less likely to receive full vaccinations. The study analyzed data from over 3,700 children with ASD and nearly 500,000 children without ASD, as well as their siblings born between 1995 and 2014.
A study of over 3,700 children with autism spectrum disorder (ASD) and 592,000 without ASD found that those with ASD and their younger siblings had lower vaccination rates. The research suggests a possible association between ASD diagnosis and undervaccination.
Scientists at NIH highlight innovations that can expedite vaccine development, shortening the timeline from decades to months. These advancements enable the application of standardized manufacturing processes to multiple vaccines, creating a collective database on safety and accelerating preclinical development.
A recent resurgence in mumps cases in the US is attributed to declining immune protection from the mumps vaccine. Researchers propose a booster dose at age 18 as a potential solution to maintain population immunity and control outbreaks.
Researchers have made groundbreaking discoveries regarding the onset of cholera, paving the way for a fast-acting antidote. The study shows that mice without a specific receptor can still get diarrhea after consuming cholera toxin, offering new possibilities for producing a drinkable antidote.
A yellow fever outbreak in Brazil highlights the need for tourists to get vaccinated before visiting affected areas, with the risk of severe illness and death being up to 60% among those who contract the disease. The Food and Drug Administration-approved vaccine is currently unavailable in the US due to manufacturing difficulties.
A new study found that people's misconceptions about the association between the MMR vaccine and autism significantly influence their willingness to receive a Zika vaccine. The study also revealed that individuals who believe in science's power to solve problems are more likely to intend to use a Zika vaccine.
A majority of US adults (59.7%) would pay at least $1 for an Ebola vaccine, according to a national survey conducted during the 2014-2016 West African outbreak. Participants who had traveled internationally and were interested in getting vaccinated were more likely to be willing to pay.
The new Shingrix vaccine has been shown to be more than 90% effective in protecting against the herpes zoster virus, which causes chickenpox and shingles. The vaccine stimulates production of immune memory cells, generating a strong and sustained protection against the virus.
A randomized trial in rural India found that educating mothers on the benefits of tetanus vaccination increased immunization coverage by 43%. The intervention also improved measles vaccination rates and reduced the cost per disability-adjusted life year averted.
A communication training program for healthcare professionals increased HPV vaccine series initiation and completion among adolescents, with higher rates seen in intervention compared to control groups. The study highlights the potential of disseminating this intervention to increase national adolescent HPV vaccination levels.
Researchers at Michigan State University are developing a new cancer vaccine using the virus-like particle Qβ, which generates anti-cancer immune responses. The vaccine aims to protect animals against cancerous cells and could translate to human use for spontaneously occurring cancers.
A proof-of-concept study reveals that mass dog vaccination can effectively eliminate human exposure to rabies in Africa. The research found that with over 65% of a city's dog population vaccinated, the risk of transmission was significantly reduced.
A new study shows that innuendo and pointing suspicion in news coverage can significantly increase belief in false facts. Researchers found that even implicit hints at conspiracy theories can lead to increased conspiracy beliefs, while debunking information can only partially reduce these levels.
A new online game aims to provide general immunity against fake news by simulating the techniques and motivations behind its spread. Players engage with fake news sites, Twitter bots, and conspiracy theories to build their critical thinking skills.
Researchers at Scripps Research Institute have created a safe and effective vaccine to block heroin's lethal effects, using an adjuvant already approved by the FDA. The vaccine, which is stable at room temperature for up to 30 days, shows promise in treating heroin addiction and preventing overdose deaths.
A new study in Ghana found that the timing of measles vaccination can significantly impact child survival rates. Measles vaccination after DTP3 increased child survival by 28% within the first year and 18% until age five. The vaccine also showed a stronger beneficial effect on boys compared to girls.
A recent study published in Annals of Internal Medicine found that consuming hot tea at high temperatures is associated with a significant increase in the risk of esophageal cancer. The research, which followed over 450,000 participants for nine years, suggests that abstaining from hot tea may be beneficial for individuals who drink al...
A new study estimates that vaccines can prevent up to 36 million deaths and 24 million cases of medical impoverishment in 41 low- and middle-income countries by 2030. The poorest populations are expected to benefit the most from vaccine programs, with a significant impact on health and economic outcomes.
Exposing the gut to chlamydia provides robust protection against subsequent genital tract and other tissue infections, according to a study published in Infection and Immunity. The discovery has significant vaccine implications for preventing genital chlamydia, particularly among young people.
Researchers developed artificial receptors called EVIR that enable dendritic cells to capture antigens from the patient's tumor, amplifying the immune response against cancer. The EVIR technology exploits pro-tumoral exosomes as selective nanocarriers of tumor antigens.
A new study by University of Waterloo researchers found that vaccines used by commercial fish farmers are not protecting fish from disease, with vaccinated fish showing more symptoms and higher death rates. The study highlights the need for veterinary pharmaceutical companies to redesign and test vaccines tailored to fish immune systems.
UAlberta researchers created a synthetic horsepox virus that can provide vaccine protection against smallpox. The discovery demonstrates the potential of synthetic DNA technology in advancing public health measures.
Research presented at the Crohn's & Colitis Congress provides guidance for physicians to enhance IBD patient care. Studies show that better management of anemia improves overall outcomes, while IBD patients need better understanding of CRC screening intervals.
Researchers at the University of Kansas have developed a method to screen millions of human antibodies for rapid therapeutic discovery, overcoming limitations of single-cell cloning. The breakthrough technology identifies highly potent antibodies and provides insights into human immune responses to vaccines and infections.
A new saliva-based diagnostic test could identify people at risk for throat cancers earlier, enabling early treatment and prevention. The test aims to detect HPV infections in a low-cost, non-invasive manner.
The Future Vaccine Manufacturing Hub aims to increase vaccine coverage worldwide, improve response to deadly outbreaks, and overcome barriers in vaccine distribution. Researchers will explore innovative approaches, including synthetic RNA vaccines and protein stabilisation, to rapidly respond to emerging threats.
Researchers found that a vaccine inducing killer T cells provides broader protection for children of vaccinated mothers. The vaccine prevents the immune system from producing antibodies specific to the virus and induces protective killer T cells that can recognize and attack the virus.
Researchers estimate that vampire bat rabies causes between 505-724 cattle deaths annually in Peru, with significant financial losses for farming communities. Enhancing vaccination programs can reduce the disease burden and increase awareness can encourage preventative measures.
A proof-of-concept study reveals that mass dog vaccination can eliminate human rabies exposure in Africa. The study, conducted in Chad, demonstrated the effectiveness of a 20-year-old strategy targeting foxes, with over 65% of the city's dog population vaccinated against rabies.
Researchers successfully interrupted rabies transmission in N'Djaména, Chad, after two mass dog vaccination campaigns. The campaigns reduced dog-to-human transmissions by less than one per million people, highlighting the effectiveness of vaccines when local communities are informed and engaged.
Researchers have identified an antibody that can block entry to the host cell, providing a basis for safe and broad-spectrum anti-dengue therapy. The study also revealed the structural basis of the antibody binding to individual dengue viruses, which could help explain why some vaccines may not work.
Research led by Queen Mary University of London predicts a shift in cervical cancer burden from young to older women. Incidence among 50-54 year olds is expected to increase by 50%, while mortality rates are projected to rise by 109% among 60-64 year olds.
A study led by UC Berkeley researchers found that a small pool of immune cells remain alive for years after vaccination, developing unique features such as methylation patterns to keep them primed and ready to respond to the same microbe. This discovery may help scientists develop better vaccines and understand differences among diseases.
Researchers found male virgins can acquire HPV despite never having engaged in penetrative sexual intercourse. Vaccination before first sex is crucial to prevent infection, according to study authors.
The Michelson Prizes aim to support young scientists developing groundbreaking approaches to defeat major global diseases. Two $150,000 prizes will be awarded in June 2018 to identify innovative projects beyond conventional approaches.
A new animal model has been developed at Texas Biomedical Research Institute to mimic key features of the Zika virus infection, including lingering presence in bodily fluids. The marmoset model is useful for testing new drugs and vaccines, and may help identify places where transmission can be blocked.
Researchers used Twitter and Google data to analyze public perceptions on vaccines and detect early warning signals of a tipping point in vaccine coverage. They successfully predicted the 2014-15 Disneyland measles outbreak by monitoring sentiment on social media.
A study analyzed Twitter and Google search data to identify trends in vaccine sentiment before the 2014-2015 Disneyland measles outbreak. The findings suggest that social media users' attitudes toward vaccines exhibit increased variability, characteristic of systems approaching a tipping point.
A high-dose live oral vaccine has been found to be more effective in rapidly protecting individuals from cholera than the standard two-dose killed vaccine approach. This breakthrough could lead to improved control of outbreaks and lower mortality rates, particularly in low-income countries.
A new Zika vaccine has demonstrated well-tolerability and induced potentially protective immune responses in three phase 1 clinical trials. The vaccine, called ZPIV, was developed by the Walter Reed Army Institute of Research and is being evaluated in several trials to determine its safety and efficacy.
A study published in the Proceedings of the National Academy of Sciences found that men infected with one type of HPV are 20 times more likely to be reinfected within a year. Vaccination before sexual contact is crucial in preventing initial infection, while vaccinating previously infected men could also reduce reinfection risk.
A gene-based Zika vaccine developed by NIH scientists has been found to be safe and immunogenic in healthy adults, with 60-89% of participants generating a neutralizing antibody response. The vaccine, which includes a small piece of DNA called a plasmid, triggers the body to mount an immune response when injected into muscle.
Researchers have developed an inactivated Zika purified virus (ZPIV) vaccine that induced an immune response in participants and was well-tolerated, according to Phase 1 clinical trial results.
A new Zika vaccine candidate has produced strong immune responses in healthy adults, with nearly all recipients mounting protective antibody responses against the virus. The vaccine was safe and caused only mild reactions, offering a promising step towards an effective Zika vaccine.
Researchers from the University of Copenhagen developed a new vaccine technique that can fight HER2-positive breast cancer in mice with a 50-100% prevention rate. The vaccine works by inducing large amounts of antibodies targeted at cancer cells, preventing tumors from developing and slowing down cancer progression.
The Human Vaccines Project has reported high-level outcomes from two concurrent clinical studies aimed at deciphering the components and mechanisms of human immunity. The findings may provide important new insights into human immunity, which will be leveraged to launch expanded studies in 2018.
A new longitudinal study from York University's OUCH Cohort found that parents' behavior during vaccinations significantly impacts their child's pain coping responses. Engaging in positive behaviors like deep breathing and distraction, while avoiding negative ones, can reduce pain-related distress. The study suggests that a preschooler...
A new study suggests that HPV vaccination can reduce the number of cervical screens needed from 12 to just three for vaccinated women. The research also recommends seven lifetime screens for unvaccinated women.