Articles tagged with Vaccination
USC scientists have made groundbreaking discoveries about a tick-borne virus, including its molecular mechanisms and potential therapeutic targets. The research could lead to the development of medications and a vaccine to prevent or treat hemorrhagic fever.
Researchers found that providing universal vaccination against meningitis B infection to college students would be too costly, as the vaccine prevents only a small number of cases. However, they suggest that if the price is lowered, universal vaccination might be worth requiring on college campuses.
Scientists have developed a new vaccine against the Zika virus, which can prevent microcephaly and other serious conditions in unborn babies. The vaccine is based on the yellow fever vaccine and offers complete protection.
Qualitative analyses suggest vaccine-based strategies can outperform antibiotic-centered approaches in certain cases, limiting AMR spread and preserving the human microbiome. Vaccine development is crucial to address growing AMR concerns, as indicated by studies highlighting vaccines' potential economic benefits.
A new microneedle patch vaccine containing the inactivated RSV virus has been shown to be effective in enhancing protection against the disease and reducing inflammation. The vaccine, combined with an immune-stimulating compound, was found to induce a stronger immune response than traditional intramuscular vaccination.
Researchers have developed monoclonal antibodies effective against several synthetic opioids, including fentanyl and carfentanil. The vaccine could help combat opioid addiction and reduce overdose deaths by blocking the analgesic effects of these potent drugs.
A new study found that cancer patients, particularly those with blood-related cancers, have a significantly higher risk of developing shingles due to the virus reactivating later in life. New shingles vaccines offer great promise as a strategy to prevent shingles and its complications in cancer patients.
A team from Osaka University has created a system to produce large numbers of human norovirus particles using intestinal epithelial cells derived from human induced pluripotent stem cells. This breakthrough allows for the study of the virus and potential vaccine development without relying on human tissue or bile.
A new study by Drexel University researchers found that while anti-vaccine bills increased nationwide between 2011 and 2017, pro-vaccine bills were more likely to be enacted into law. The majority of proposed legislation aimed to expand vaccine exemptions, but limited exemption laws were overwhelmingly passed.
Researchers at MIT have devised a new way of providing cooling on a hot sunny day using inexpensive materials and no fossil fuel-generated power. The passive system allows emission of heat at mid-infrared range, radiating into outer space and punching through greenhouse gases.
Researchers found that a fractional dose of the 17D yellow fever virus vaccine provided protective levels of antibodies for over 10 years after vaccination. This finding supports the use of fractional doses in mass vaccination campaigns before outbreaks and eliminates the need for booster shots.
Two new studies reveal that previous Dengue infection in pregnant mothers may lead to increased severity of Zika in babies. Conversely, previous Zika infection in mouse mothers may increase severity of Dengue in their pups. The research suggests a unique mechanism by which flaviviruses can cross the placental barrier.
Researchers developed a treatment for canine leishmaniasis using the LeishTec vaccine, which is already available in Brazil. The vaccine was tested on over 400 dogs and proved effective in minimizing disease symptoms.
Cornelis Melief is recognized for his life's work in studying the interactions of the immune system with cancer, leading to the development of new therapeutic cancer vaccine strategies. His research has shown clinical effectiveness in treating patients with pre-malignant lesions caused by HPV type 16.
The global disease burden of meningitis remains unacceptably high, with only a 21% reduction in deaths between 1990 and 2016. The number of cases increased during this period due to population growth.
A new study reveals how the poxvirus tricks cells into activating their own cell movement mechanism, allowing the virus to spread rapidly. The researchers found that a specific protein, vaccinia growth factor, plays a key role in this process, and that targeting this pathway could lead to new antiviral strategies.
Researchers designed a quadrivalent fusion glycoprotein vaccine against human parainfluenza viruses, inducing up to 500-fold higher neutralizing immune responses. The shape-stabilized glycoproteins may offer a general class of vaccines against widespread parainfluenzas and related pathogens.
A study by Imperial College London found that nursery vaccinations and development checks significantly lower childhood hospital admission rates. The analysis tracked 319,730 children in England from birth to 13 years old, revealing infants who didn't receive vaccinations had a higher risk of emergency admissions.
A culturally tailored multilevel strategy increased HPV vaccination rates among low-income, mostly Chinese American adolescent girls and boys. The intervention, which engaged pediatricians, parents, and adolescents through various channels, showed a significant increase in vaccine uptake compared to control groups.
A recent measles case highlights the importance of herd immunity in safeguarding those with compromised immune systems. Despite being fully vaccinated as a child, a Swiss man undergoing leukemia treatment died from severe measles complications.
A new experimental vaccine has shown to reduce the risk of secondary strokes caused by blood clots for over two months without triggering an autoimmune response. The vaccine, S100A9, provides protection against blood clot formation and works as well as oral blood thinner clopidogrel in a major artery.
A systematic review of over two million patients found the newer shingles vaccine Shingrix to be 85% more effective than Zostavax in reducing cases of shingles. However, it also carried a higher risk of injection-site adverse events such as redness or swelling.
A new study of survey data reveals that parental concerns about the human papillomavirus (HPV) vaccine tend to focus on safety worries and lack of necessity. The findings suggest that physician education and recommendation may be key factors in increasing HPV vaccination rates.
Researchers have developed a new vaccine strategy that offers partial protection against the highly contagious infectious bronchitis virus. The recombinant virus vaccine approach has potential to be more cost-effective and respond to emerging new virus strains, but further research is needed to develop a more robust vaccine.
A randomized controlled trial found that parental educational tools on pain relief during vaccinations increased use of pain interventions at future infant vaccinations, knowledge and confidence in parents' ability to manage infant pain.
A special issue by The Lancet warns that primary health care is underdeveloped and underfunded, with half the world's population lacking access to essential services. The Lancet calls for renewed leadership to revive primary health care, citing its importance in delivering better health for all.
Researchers developed a virus nanoparticle vaccine against anthrax and plague, providing complete protection in animal models. The dual vaccine was effective even when animals were exposed to lethal doses of both pathogens.
A study by the University of Exeter found that innuendo alone in news coverage can lead people to believe false information, spreading conspiracy theories. The research suggests that journalists should avoid including 'errant data' that may be misconstrued when there is uncertainty about facts.
The WRAIR is conducting a Phase 1 clinical trial of the VRC-MARADC087-00-VP vaccine candidate, developed by NIAID, in healthy adult volunteers. The vaccine aims to stimulate rapid but durable immunity against Marburg virus, which causes severe hemorrhagic fever.
Researchers analyzed data from a province-wide survey of over 300,000 girls and found no correlation between HPV vaccination and increased risky sexual behaviors. The percentage of girls reporting ever having sex decreased, while the proportion engaging in intercourse before age 14 declined and condom use increased.
A new Lassa fever and rabies vaccine has demonstrated effective protection in animal models of disease, suggesting a new way to test for protection against the virus. Researchers have also identified a new surrogate measure of protection that could aid in vaccine development.
Researchers have developed a novel vaccine that protects against both Lassa fever and rabies, with promising results in preclinical testing. The vaccine, called LASSARAB, uses a weakened rabies virus vector to elicit an immune response against both viruses.
A study by the London School of Hygiene & Tropical Medicine found a significant drop in public confidence in vaccines after the Philippines' Dengvaxia crisis. In 2015, 93% of respondents strongly agreed that vaccines are important, but this dropped to 32% in 2018.
A University of Guelph researcher has developed a novel three-in-one vaccine targeting E. coli, Shigella, and Campylobacter jejuni, providing immunity against all three pathogens in mice tests. The vaccine may save lives in developing countries where these pathogens kill over 100,000 children under age five annually.
The Johns Hopkins Center for Health Security has identified 15 emerging technologies that could help prevent future infectious disease outbreaks from becoming catastrophic events. These technologies include genomic sequencing, drone networks, and medical countermeasure manufacturing, among others.
Researchers at UTMB create DNA-based vaccine that cuts production costs and storage needs by up to 80%. The new platform has potential to serve as a universal platform for developing live-attenuated vaccines for many viral pathogens.
The BCG vaccine, used to prevent tuberculosis, can reduce blood sugar levels in people with advanced type 1 diabetes by mimicking microbial exposures. The vaccine appears to reset abnormal metabolic functions, boosting the immune system to consume sugar and reduce blood glucose levels over time.
A new cancer vaccine targeting HER2 has demonstrated clinical benefits in a phase I clinical trial, with six out of eleven evaluable patients experiencing improvements in their condition. The vaccine provided complete or partial responses and stable disease in some cases.
The HPV vaccine offers a promising approach to lowering rates of cervical cancer and HPV-related diseases worldwide, particularly in underserved populations. Research highlights disparities in cervical cancer screening among different demographic groups, emphasizing the need for targeted interventions.
Researchers from the University of Copenhagen have developed a new vaccine for hay fever that targets specific sugar molecules to improve vaccination efficacy. The vaccine has been tested on mice and in vitro tests, showing potential for increased effectiveness and reduced treatment time.
Researchers found that 86% of patients with advanced head and neck squamous cell carcinoma showed elevated T cell activity after receiving the DNA vaccine. The study also describes a patient who developed metastatic disease but achieved remission after anti-PD-1 immunotherapy.
A review of bivalent HPV vaccine data found no new or unexpected safety concerns. The majority of adverse event reports were classified as non-serious and mild.
A new study found that CD4+T cells play a crucial role in protecting against Zika-induced neurological symptoms. Mice lacking these immune cells showed more severe symptoms and increased mortality, highlighting the need for vaccines that elicit robust CD4+T cell responses.
A new study by Bocconi scholars links measles resurgence to public health expenditure cuts in Italy. The research found that each 1% reduction in per-capita real public health expenditure corresponds to a 0.5 percentage point decline in MMR vaccination coverage, highlighting the importance of investing in public health.
Researchers at the University of Colorado Anschutz Medical Campus have discovered that T cells elicited from subunit vaccines can reproduce without glucose, supporting their expansion and potentially defeating cancerous tumors. This finding has major implications for the development of immunotherapies for cancer patients.
Researchers found that implementing a standard tetanus protocol in an ICU in Tanzania did not significantly reduce mortality rates, but shifted causes of deaths to airway compromise and sepsis. The study emphasizes the need for increased vaccination coverage to eliminate this preventable disease.
Researchers found that bot accounts shared anti-vaccination messages 75% more than average users, while Russian trolls used polarizing language to promote discord. The study suggests a significant portion of online vaccine discourse may be generated by malicious actors with hidden agendas.
Researchers used genomic and epidemiological approaches to understand the mode of transmission of the South America's largest yellow fever virus outbreak. The study revealed that the virus lineage had spread through a sylvatic cycle of transmission in primates before spilling over into human populations.
Researchers at Imperial College London identified the cause of enterovirus outbreaks as linked to birth rates. The model predicts subsequent outbreaks, allowing for vaccine design and anticipation of outbreak impact.
Scientists at Garvan Institute of Medical Research have identified a new micro-organ within the immune system that helps fight reinfection fast. The structure, named SPFs, is strategically positioned to detect infection early and contains immune cells gathering to mount a rapid response.
A statistical analysis of two Phase 3 clinical trials reveals a decrease in dengue vaccine efficacy with increasing antigen amino acid mismatch in children aged 2-8. In contrast, older children showed broader protective responses with prior virus exposure.
A large study of over 80,000 children found no increased risk of autism spectrum disorder after prenatal Tdap vaccination. The study's lead author says pregnant women can be reassured that receiving the vaccine is not associated with an increased risk of autism.
A proof-of-concept study found that antibiotic treatment prior to vaccination increased viral shedding in healthy adult men, while narrow-spectrum antibiotics showed a slight increase in early vaccine boosting. The results suggest a potential correlation between the microbiome and vaccine performance.
Researchers found a broad range of cost per dose delivered across Indian states, with personnel costs accounting for 57% of total costs. The weighted average national cost per dose was $2.29, which is lower than the current allocation of $25 per child.
A recent study published in Nature Communications found that dengue immunity provides cross-protection against Zika virus in mouse models. The research shows that cytotoxic T cells mobilized by dengue infection can combat the devastating effects of Zika infection on fetal brain development.
Chiung-Yu Hung receives $1.9 million grant to develop a vaccine for fungal infections, particularly valley fever caused by Coccidioides fungus. The goal is to prevent illness and save lives by stopping the spread of the infection before it occurs.
A new study published in EcoHealth confirms that plague vaccine bait is safe for thousands of small rodents, including mice species, without apparent ill effects. The findings support the use of this vaccine bait to help recover endangered black-footed ferrets and protect prairie dog populations from plague.
A major new study published in Science Translational Medicine found that a hepatitis C vaccine would significantly reduce transmission among injecting drug users, even if it doesn't provide complete sterilizing immunity. The study estimated that the risk of transmission could decrease to between 1 and 25 percent with vaccination.
A Phase 2 study published in the NEJM found that vaccination can reduce the rate of sustained TB infections, with a 45.4% vaccine efficacy against BCG revaccination. The trial also showed promise for an investigational subunit vaccine candidate, H4:IC31, which reduced sustained infections by 30.5%.
Researchers at La Jolla Institute found that the current whooping cough vaccine primes the immune system in a way that leaves it vulnerable to future infections. The study suggests that new vaccines could be developed to improve the vaccine's efficacy, potentially applicable to other vaccines.