Articles tagged with Vaccination
A vaccine that protects against a worrisome superbug has been successfully tested in mice, providing hope for a solution to the growing global health threat of Klebsiella pneumoniae. The vaccine, developed using genetically modified E. coli, proved highly effective in preventing severe disease and death.
Scientists at MLU have developed a new method for vaccinating plants against viruses, enabling rapid identification and production of precisely tailored substances. The new method follows the modular principle, allowing for flexible combat against new pests and improving the efficiency of siRNA molecules.
Researchers have achieved a major breakthrough in developing a thermally stable TB vaccine using a technique called ensilication, which protects vaccine components from heat damage. This innovation has the potential to improve the effectiveness and accessibility of vaccines globally, particularly in remote areas.
Researchers at Boston Children's Hospital are developing an opioid vaccine to protect people with opioid use disorder against accidental fentanyl overdoses. The two-year project aims to enroll patients and test responses to candidate vaccines, with the goal of eventually testing the vaccine in humans.
Researchers at La Jolla Institute for Immunology identified the molecular properties of antibodies that neutralize Lassa virus. By understanding these properties, they can create a map for rational vaccine design, aiming to develop effective treatments or vaccines against this deadly disease.
A study published in PLOS Pathogens found that prior infection with either Zika virus or dengue virus has no apparent effect on the clinical course of subsequent infection with the other virus. This is a significant finding for the development of vaccines against both viruses.
A study of 21 macaque monkeys found that primary and secondary infections with Zika virus did not amplify symptoms, contradicting previous tissue culture and mouse findings. The study suggests that combining a Zika vaccine with a dengue vaccine may be necessary to prevent enhancement of either virus.
Researchers at Yale University have developed a promising combination immune therapy to dramatically reduce the recurrence of genital herpes. The prime-and-pull strategy involves a vaccine and medicated cream that work together to block the virus from spreading.
Scientists have created a microneedle patch based on snake fangs that can deliver therapeutic liquids and vaccines through the skin of rodents in under 15 seconds. The device uses capillary action to bypass pumping systems, making it an attractive alternative for simple and pain-free drug delivery.
A new approach from Harvard researchers uses a biomaterial scaffold and childhood vaccines to attract and activate T cells that promote revascularization of ischemic tissues. The technique increases the concentration of T cells at the ischemic site and stimulates angiogenesis, blood flow, and muscle fiber regeneration.
Research finds that general fear orientation, trust in government, and perceived exposure likelihood significantly influence vaccination willingness. The study's findings suggest that social factors play a crucial role in shaping public health responses to infectious diseases.
Researchers found that stress on immune cells and altered metabolism lead to different outcomes in individuals infected with the same virus, with potential targets for new treatments identified. Preventing conditions causing increased stress may also prevent disease from viral infections.
Researchers at MIT developed a vaccine that dramatically enhances antitumor T cell population and allows cells to invade solid tumors. The booster vaccination increased the success rate of CAR-T cell therapy from 10% to 60% in mice, eliminating tumors in 60% of animals.
A new nonlive shingles vaccine reduced shingles episodes by 75% among patients who underwent stem cell transplantation compared to placebo. Long-term protection was not assessed due to study limitations.
A statewide initiative in California resulted in a significant decrease in the rate of kindergartners entering school without up-to-date vaccinations. The study found that the rate decreased from 9.84% to 4.87% between 2013 and 2017, likely due to changes in vaccination policies.
A group of leading public health scientists calls for improved search engine and social media monitoring, as well as government support for mandatory immunization programs. They also advocate for correct dissemination of reliable vaccine information through various channels.
Researchers developed a new vaccine, NOMV-FHbp, which induced higher levels of protective antibodies than licensed vaccines against five of six bacterial strains. The vaccine has the potential to extend coverage to infants and toddlers, who are at high risk of developing meningococcal disease.
A new study by the Johns Hopkins Bloomberg School of Public Health identifies viruses as the main causes of severe childhood pneumonia in low- and middle-income countries. Respiratory syncytial virus (RSV) accounted for nearly a third of all cases, with other top causes including rhinovirus and S. pneumoniae bacteria.
Researchers found that HPV vaccination programs substantially reduced HPV infections by 83% among girls aged 13-19 and 66% among women aged 20-24. Precancerous cervical lesions also decreased by 51% among teens and 31% among women in their early twenties.
A new online game called Bad News has been shown to increase 'psychological resistance' to fake news by exposing players to disinformation tactics. The game reduces perceived reliability of fake news headlines and tweets by up to 24%, with the greatest effect on those most susceptible to fake news.
The study found that measles-vaccinated children had significantly higher scores on cognitive tests and attended better schools than their unvaccinated peers. Long-term health benefits of measles vaccination were also observed in terms of improved growth parameters, such as height and weight.
The topline Phase 3 results of ULTOMIRIS (ravulizumab) show efficacy and safety in treating aHUS. The therapy has shown promise in reducing inflammation and blood clotting, with the potential to treat patients with progressive organ damage.
Three young scientists, Murad Mamedov, et al., receive $150,000 for their novel methods in understanding the human immune system. The Michelson Prizes recognize groundbreaking research using genomics, AI, and machine learning to transform human health.
A team of scientists at Duke University Medical Center has discovered a previously unidentified route for antibodies to be transferred from the mother to the fetus, which could lead to safer and more effective vaccines. This finding provides a potential way to control when and how certain antibodies are shared.
A unique adjuvant has been identified that can prevent vaccine-enhanced respiratory disease in RSV. The study found that combining this adjuvant with RSV vaccination primes the body for protective immune responses and prevents inflammatory RSV disease after infection.
A Kaiser Permanente-led study found that routine varicella vaccine significantly lowers the likelihood of painful shingles disease in children. The study, which looked at over 6.3 million children, showed that vaccinated kids had a 78% lower risk of contracting HZ compared to unvaccinated children.
A large Kaiser Permanente study found that fully vaccinated children were still at risk of developing pertussis due to waning vaccine effectiveness over time. The study suggests that under-vaccination is only one factor contributing to recent outbreaks, and that a better vaccine that lasts longer between doses is needed.
A class of immune cells called innate lymphoid cells (ILCs) plays an unexpected role in the early defense against tuberculosis. ILCs may provide a new approach to developing treatments and vaccines against TB.
Experts argue that compulsory vaccination can increase uptake, but others recommend improving services and infrastructure instead. The UK's measles vaccination rate is currently below the required 95% for herd immunity.
Recent falls in vaccination rates and uptake of other preventative programs, such as bowel and breast cancer screenings, indicate a fragmentation of public health arrangements. Visible public health leadership is needed to address these weaknesses and prevent further deterioration.
A study models the demand, benefit, and cost of implementing a 20-year strategy for radiotherapy to treat cervical cancer in low- and middle-income countries. The research estimates that 9.4 million women will require radiotherapy, generating $151.5 billion in economic benefits.
Researchers identified a common gene signature in almost all global Strep A strains through genomic sequencing of thousands of genomes from over 20 countries. This finding has the potential to aid in the development of an effective global vaccine, which could combat the bacterial pathogen responsible for millions of deaths annually.
The partnership aims to increase HPV vaccine uptake, which causes over 33,000 cancers annually. UVA will launch a multipronged campaign to educate healthcare workers and the public on the importance of HPV vaccination.
A new study from Rockefeller University reveals that the gut is organized into compartments with different immune system functions in each segment. This discovery has potential to improve drugs for gastrointestinal disorders and inform the development of oral vaccines.
Computational modeling reveals that vaccination success increases with access to local information about disease prevalence, rather than relying solely on global data. This suggests a need for strategic dissemination of detailed incidence data to inform individual vaccination decisions.
New research from Brigham Young University finds that exposing people to the pain and suffering caused by vaccine-preventable diseases can increase support for vaccinations. Nearly 70% of students who interviewed someone with a vaccine-preventable disease moved from hesitant to pro-vaccine attitudes.
Researchers developed a statistical method to predict disease reemergence, particularly for preventable childhood infections like measles and pertussis. The model analyzes subtle changes in reported cases to identify early warning signals for emerging diseases.
Researchers used a model of measles transmission to predict the impact of vaccination campaigns in Pakistan. Conducting vaccination campaigns between May and October reduced estimated infections by 400,000 compared to January campaigns.
Researchers at the University of Texas at Austin and Johns Hopkins University have identified 25 US counties at high risk for measles outbreaks. The analysis considered international travel and vaccination rates, predicting over 1,000 cases in the US this year.
Researchers at UNC will receive up to $10.7 million to develop a chlamydia vaccine, which could help women who suffer from infertility and chronic pelvic pain due to the infection. The project aims to identify specific T-cell and antibody responses that limit infection and inform antigens and adjuvants for vaccine development.
A new analysis predicts top 25 US counties at risk for measles outbreaks in 2019, considering non-medical exemptions, international air travel, and population data. The study identifies regions with low vaccination rates and high passenger inflow from affected countries as areas of high risk.
Researchers identify predictable changes in global measles dynamics, enabling tailored vaccination and public health programs. Countries along the 'canonical path' experience declining disease incidence with increasing yearly variability, guiding informed control efforts.
A new vaccine has been shown to be effective in preventing African Swine Fever in wild boar, with 92% protection rate. The vaccine can also pass on immunity via contact with infected animals, offering a potential solution to the spread of this deadly disease.
Researchers have developed an orally administered hepatitis B vaccine that is both effective and safe. The new vaccine uses a technique called 3D imaging to understand how the vaccine behaves in the body, leading to improved efficacy and reduced side effects.
A study by Kellogg Eye Center reveals that herpes zoster ophthalmicus (HZO) cases tripled in 12 years, mostly affecting older adults. Shingles vaccination provides strong protection from HZO complications, but its use is not widespread.
A new study suggests that vaccination could reduce the impact of white-nose syndrome in bats by providing immunity against the fungus Pseudogymnoascus destructans. Bats immunized against Pd were less likely to develop WNS or die from the disease in two initial scientific trials.
Despite available safety and effectiveness, HPV vaccine coverage rates remain suboptimal. Pediatricians and nurse practitioners report using various strategies, including prompts, communication tools, and performance feedback, to improve HPV vaccination rates.
A national survey of pediatricians and family physicians reveals substantial progress in recommending HPV vaccination to adolescents over the past five years. However, significant areas for improvement exist, including physician communication style and practice-based delivery methods.
Despite the availability of a safe and effective HPV vaccine since 2006, coverage rates remain suboptimal. Pediatricians and nurse practitioners reported using various strategies to improve HPV vaccination rates, but still face challenges such as parent refusal and lack of training. The study suggests that more work is needed to overco...
A new study reveals that HPV vaccine coverage is far behind other infant vaccines, with only 13 and three US states reaching above 60% coverage by 2016. The study tracked over 7.5 million children from 2003 to 2016 and found increased uptake among girls and boys, but still fell short of the Healthy People 2020 goal of 80%.
A recent commentary warns of a preventable global resurgence of measles due to declining vaccination rates. Measles is an extremely contagious illness that can cause severe complications and death in vulnerable populations. Without renewed focus on measles vaccination efforts, the disease may rebound in full force.
A new study found that a maternal vaccine can effectively protect against HSV-1 and HSV-2 infections in mouse offspring, transferring infection-fighting antibodies to their nervous system. The vaccine has shown promise in preclinical animal models and phase 1 human trials, offering new hope for preventing neonatal herpes infections.
Measles and diphtheria have re-emerged in Venezuela with a disproportionate impact on indigenous populations, with over 7,500 measles cases reported and 100 deaths attributed to the disease. Diphtheria cases also surged, with 96% of reported cases originating from Venezuela, exposing 3 million vulnerable children to the disease.
A study highlights the importance of seeking prompt medical advice if symptoms of rabies are suspected, as delays can be fatal. Experts stress that preventive treatments are highly effective when given promptly after exposure, and encourage individuals to seek treatment immediately after a bite or scratch from an animal.
Researchers found diphtheria, tetanus, and whooping cough vaccination levels in Nigeria, DRC, Ethiopia, Mozambique, and Cambodia below the 80% threshold. Targeted campaigns can improve immunization service delivery, especially in areas with poor routine immunization coverage.
Researchers at the NIH have made progress toward developing an EBV vaccine by identifying key antibodies that block infection. The new vaccine candidates elicited potent anti-EBV antibody responses in animals, offering potential protection against EBV-associated cancers and infectious mononucleosis.
InDevR to showcase VaxArray technology at the BIO International Convention, leveraging NIH SBIR/STTR funding. The company has a proven track record of translating scientific ideas into commercial products.
Researchers at Mount Sinai have developed an innovative approach to cancer immunotherapy by injecting immune stimulants directly into a tumor. This 'in situ vaccination' teaches the immune system to destroy not only the primary tumor but also other tumor cells throughout the body, effectively turning the tumor into a vaccine factory.
A clinical trial shows promise of an immune-based therapy, which completely eliminated both the lesion and underlying HPV infection in a third of women enrolled. The shot triggers an immune system response to attack high-risk HPV types causing cervical cancer precursors.
Researchers suggest an oral dog vaccine hidden in food could vaccinate millions of stray dogs daily, reducing the risk of rabies transmission to humans. The combined injectable and oral vaccination approach is estimated to be more efficient and potentially cheaper.