Articles tagged with Vaccination
Consumers believe that life-saving products like vaccines and cancer medications are priced based on need rather than profit. This perception can lead to an increased perceived health risk when prices are low, even if the product is still necessary.
Researchers will study how maternal parasite infections affect fetal immune systems to identify effective interventions promoting healthy growth in children. The goal is to understand the causes of stunted growth and develop affordable solutions.
Researchers found that different strains of Borrelia burgdorferi respond differently to the immune system of white-footed mice, leading to variations in bacterial growth and prevalence. This knowledge can help scientists develop a vaccine by targeting specific proteins common to all strains.
A new study found that the tetanus-diphtheria-acellular pertussis (Tdap) vaccine is safe for seniors, with minor injection site reactions being the most common adverse event. The study's findings support the recommendation that older adults receive the vaccine to protect themselves and others from pertussis.
A Kaiser Permanente study found that Tdap vaccination is as safe as Td vaccination for adults 65 and older, with no increased risk of injection site reactions. The study provides empirical evidence supporting the use of Tdap in reducing pertussis infections among older adults.
A study in California found that children with pertussis had lower odds of having received all 5 doses of the DTaP vaccine series. The risk increased as the time since last vaccination lengthened, indicating a progressive decrease in estimated vaccine effectiveness each year after the final dose.
A new pneumococcal vaccine has been shown to prevent 93% of cases of invasive pneumococcal disease (IPD) in healthy infants who received at least one dose. The vaccine's effectiveness against IPD was confirmed by the Finnish Invasive Pneumococcal Disease Vaccine Trial, which tracked over 46,000 children under 19 months.
A new equine vaccine, Equivac HeV, has been developed to prevent clinical disease caused by Hendra virus in horses. The vaccine, derived from the original work of Christopher C. Broder and Katharine Bossart, is now available for use in Australia.
A new focus section discusses a new, improved shingles vaccine and alternative therapies to control symptoms. Experts emphasize the need for continued attention from public health, physicians, and researchers to address this debilitating condition.
Experts from the US FDA argue that few global initiatives focus on strengthening medical product regulatory systems in low-and middle-income countries. Strengthening these systems is crucial to assure product efficacy, safety, and quality, particularly as globalization increases access to medicines and vaccines.
Lifting age restrictions on rotavirus vaccination in low- and middle-income countries could prevent up to 203,000 rotavirus deaths while potentially causing 547 intussusception deaths. The World Health Organization supports removing age restrictions where benefits outweigh risks.
A Kaiser Permanente study found no association between HPV vaccination and increased pregnancy, sexually transmitted infections, or contraceptive counseling among girls. The study included 1,398 girls ages 11-18 who received at least one dose of the vaccine, with only 8% diagnosed with an STI or having a positive pregnancy test.
Researchers aim to improve protection against pneumonia with a higher dose of pneumococcal vaccine in older adults. The study, funded by the National Institutes of Health, will compare two dosages of a pneumococcal vaccine approved for children and adults.
Research suggests that pulmonary vaccine delivery can induce a local immune response more effectively than traditional injections, potentially combating pathogens that cause pulmonary diseases. The unique physiology of the respiratory tract makes it an attractive alternative to injections.
A recent study published in Vaccine found that HPV vaccination has no influence on sexual behavior among adolescent girls. The research, conducted in the UK, showed no difference in sexual activity between girls who received the vaccine and those who did not.
William Foege, a renowned epidemiologist and physician, received the Dean's Medal from Johns Hopkins Bloomberg School of Public Health for his pioneering work in eradicating smallpox and controlling river blindness. The award recognizes Foege's tireless efforts to save millions of lives worldwide.
Army surgeons have presented two studies highlighting the potential of a cancer vaccine in improving survival rates. The first study showed that breast cancer survivors who received a HER2 peptide vaccine had a higher likelihood of surviving disease-free compared to those without the treatment. In contrast, patients with Crohn's Diseas...
A large study found that the quadrivalent HPV vaccine was associated with fainting and skin infections in the days following vaccination. The study of over 189,000 females suggests that these side effects are relatively common but not serious, supporting the safety of routine vaccination.
A new report highlights the cognitive factors that make misinformation sticky, including the need for cognitive effort to reject information. Effective strategies for debunking or counteracting erroneous beliefs include providing alternative narratives, focusing on facts rather than myths, and considering audience beliefs. Research has...
Local African herders guided scientists to decide which animals to immunize and when, achieving higher than 80% herd immunity. The eradication of rinderpest is a triumph against a disease that has plagued animals and humankind for centuries.
A new dengue vaccine candidate, CYD-TDV, has shown promising results in a phase 2b trial with an effective rate of 60-90% against DENV 1, 3, and 4 viruses. The vaccine was also found to be safe and well-tolerated, with no serious adverse events reported.
A new vaccine for hayfever could be more effective, less invasive and cheaper than existing options. Researchers found a significant reduction in skin sensitivity to grass pollen with intradermal injections, promising results for potential allergy treatments.
A nationwide study found inconsistent standards for medical exemptions from kindergarten immunization requirements across states. The research suggests that granting more accountability to parents and physicians may ensure valid medical exemptions are used appropriately.
A $1.2 million grant will support a program providing HPV vaccine to hundreds of low-income women at UTMB's healthcare services, addressing barriers such as lack of awareness and limited access. The initiative aims to increase vaccination rates among Hispanic women at high risk for cervical cancer.
Researchers propose a novel vaccine strategy using lipidated-promiscuous-peptide vaccines to overcome limitations of existing BCG vaccine, which fails to prevent disease in adults, especially in endemic regions. This new approach has shown promise in animal models and is being tested in human clinical trials.
A recent Special Focus in Human Vaccines & Immunotherapeutics discusses the mistakes of past cancer vaccine programs and provides critical insights into the future of cancer vaccines. The study emphasizes the importance of antigen discovery and personalized approaches to overcome the challenges of tumor heterogeneity.
Researchers discovered that poxviruses can rapidly produce multiple copies of a gene to counter host defenses, allowing them to quickly adapt and evolve. The study provides new insight into the mechanisms of adaptation for large double-stranded DNA viruses.
Researchers have identified CD4 T cells as the key players in an autoimmune response that fuels inflammation in the artery wall, leading to plaque buildup. A potential vaccine could target this response, offering a new approach to preventing heart disease.
A new study found that hepatitis A vaccination in children under 2 years old is highly effective, with most retaining protection for at least 10 years. The vaccine's effectiveness was not affected by the transfer of mothers' antibodies to their child, contradicting previous concerns.
Researchers have successfully tested a vaccine against the deadly Nipah virus in monkeys, achieving a 75% fatality rate in humans. The vaccine, based on a protein from Hendra virus, has shown great efficacy in protecting animals from infection.
Researchers successfully developed a highly effective vaccine against the deadly Nipah virus, which has shown complete protection in African green monkeys with no evidence of disease. The vaccine, known as Hendra-sG, is a recombinant piece of the virus produced in the laboratory and can be used safely for human treatment.
A new line of defense against E. coli O157:H7 has been discovered through a Kansas State University study. The commercial cattle vaccine significantly reduced E. coli shedding in feces by more than 50%, making it an effective tool for improving food safety.
A new study led by a UCSF researcher shows that poor sleep can significantly reduce the effectiveness of vaccines. The study found that individuals who slept fewer than six hours per night were less likely to mount an antibody response to the vaccine and thus were more likely to be unprotected by the vaccine.
A UNC-led team studied 2228 Kenyan men and found no evidence of HPV type competition after vaccination. The study suggests that different HPV types act independently, making it unlikely for type-replacement to occur following large-scale vaccination programs.
Researchers have unraveled the mystery of a unique virus-coping mechanism, revealing a crucial role for motif D in accurately replicating genetic material. This discovery holds promise for improving existing vaccines and designing new ones against RNA viruses that eluded vaccination strategies.
A 2010 California whooping cough epidemic highlighted the importance of vaccination for adults, pregnant women, and infant contacts. The disease had the highest incidence in infants under 6 months, with Hispanics being most affected in this age group, while Whites were most affected among children and adolescents.
Researchers found that aging mice's dendritic cells accumulated oxidation-damaged proteins, impairing their function. Administering antioxidants reversed some effects, suggesting a potential therapy to improve vaccine responses in the elderly.
CSIRO will produce a large quantity of antibodies specific to rotavirus strains used in developing vaccines, aiding the project's goal of increasing access and effectiveness of existing commercial vaccines worldwide. The production facility will supply antibodies for five years, supporting the development of new, affordable rotavirus v...
A new protocol allows registries to match records on identifiers such as SIN and health card number without revealing these values. The protocol uses cryptographic techniques to provide end-to-end privacy protection for surveillance programs.
Researchers at Tufts University have discovered a way to stabilize heat-sensitive drugs in silk protein, preserving potency for months at temperatures above 110 degrees F. The technology allows for the development of single devices that can store and deliver vaccines or antibiotics without costly refrigeration.
Researchers developed two somatostatin vaccinations that reduce body weight and increase energy expenditure in diet-induced obese male mice. The vaccines induce antibodies to somatostatin, effectively removing inhibition on growth hormone and insulin-like growth factor-1.
Researchers at Brigham and Women's Hospital have discovered a new vaccine candidate for Pseudomonas aeruginosa, a bacterium that causes severe lung infections in patients with cystic fibrosis. The vaccine is based on a new mechanism of immunity mediated by T helper 17 (Th17) cells and has been shown to protect mice from lethal pneumonia.
Insufficient vaccination coverage, particularly in insecure regions, is preventing the elimination of polio in Pakistan and Afghanistan. A new study suggests that introducing bivalent oral poliovirus vaccines could eliminate polio if sufficient numbers of children are reached by vaccination programs.
Weill Cornell researchers develop a novel vaccine that protects mice against nicotine addiction, using the liver to continuously produce antibodies. The vaccine is designed to prevent nicotine chemicals from reaching the brain and heart, offering hope for smokers who struggle with addiction.
Researchers at Karolinska Institutet report positive effects of an active vaccine, CAD106, against Alzheimer's disease. The study found that 80% of patients developed protective antibodies without side effects.
A Kaiser Permanente study of over 6,000 individuals found a low short-term risk of developing shingles recurrence among those with healthy immune systems. The study's findings suggest that the risk is low regardless of vaccination status.
A 1998 medical journal publication sparked concerns about an alleged link between the MMR vaccine and autism, leading to a decline in vaccination rates. The controversy persisted even after epidemiological studies refuted the claim. Research found that higher-educated mothers were less likely to vaccinate their children.
Researchers at Albert Einstein College of Medicine have been awarded a $5.9 million NIH grant to develop a new TB vaccine against multi-drug resistant and extensively drug-resistant strains. The approach is based on genetically altered Mycobacterium smegmatis, which can generate a robust immune response in animals.
Researchers have designed specialized proteins that assemble to form tiny molecular cages, which may be used for drug delivery or as artificial vaccines. The cages are hundreds of times smaller than a single cell and can be decorated with virus-identifying proteins to stimulate an immune response.
Researchers at U of A used 3-D magnetic resonance to map the structure of Candida, a deadly pathogen with a 40% mortality rate. This breakthrough could pave the way for an effective vaccine development.
Researchers at MIT have developed a device that delivers a variety of drugs through the skin without using needles, potentially improving patient compliance and reducing accidental needle-stick injuries. The device can be programmed to deliver different doses to varying depths, addressing limitations of existing jet-injection systems.
Researchers have successfully protected laboratory animals from lethal hantavirus disease using a DNA vaccine and duck eggs. The study demonstrates the feasibility of this novel approach, which could supplement or replace existing treatments for HPS.
Researchers at Mercer University are developing an oral vaccine that can be delivered in spherical bead-like particles to enhance innate immune recognition, offering a cost-effective alternative to current options. The vaccine aims to prevent meningitis and ovarian cancer recurrence by generating immunity against specific bacteria.
Researchers have found that a combination of vitamin D therapy and the BCG vaccine greatly improves bladder cancer survival in a mouse model, with 100% of mice surviving. The study aims to improve treatment outcomes for patients who do not respond to traditional BCG immunotherapy.
Researchers created an innovative biomimetic model of the human immune system called MIMIC®, enabling faster and more effective vaccine development. The MIMIC platform provides a novel in vitro model for evaluating human immune responses against candidate drugs, adjuvants, and vaccines.
A new bivalent recombinant vaccine has been shown to be safe and immunogenic in adolescents, inducing bactericidal antibodies against 90% of invasive meningococcus serogroup B strains. The vaccine's broad protection and high seroprotection rates suggest it may help reduce the global burden of invasive meningococcal disease.
The HPV vaccine completion rate among girls has dropped significantly since 2006, with only 38.2% completing the series within 365 days. Girls who receive the first dose from a gynecologist or obstetrician are more likely to complete the series.
Scientists from the University of Bonn found over 60 new paramyxovirus species in bats and rodents, revealing that bats are the original hosts of these viruses. The study suggests that bats may be a reservoir for dangerous viruses, making it challenging to eradicate them.
Global measles mortality decreased by 74% from 535,300 deaths in 2000 to 139,300 in 2010. Despite this progress, India and Africa remain major concerns due to low vaccine coverage. The authors suggest intensified control measures are needed to achieve mortality reduction targets.
A recent Vaccine Safety Datalink study found the shingles vaccine to be generally safe and well-tolerated in adults aged 50 and older, with a small increased risk of local reactions. The study also ruled out any increased risk for serious conditions such as cerebrovascular diseases or meningitis.