Articles tagged with Vaccination
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A phase I clinical trial of cytotoxic T-lymphocyte-associated antigen 4 blockade therapy has shown promising results in boosting the immune system against cancer. The treatment enhanced the anti-tumor activity of certain vaccines and improved responses in patients with melanoma and ovarian cancer.
Researchers at University of California - San Diego develop new compound cidofovir analogs to treat poxvirus infections, showing effectiveness in preventing death and maintaining efficacy when given prior or after infection. The study found two compounds, HDP-CDV and ODE-CDV, to be most effective against lethal cowpox infection.
Researchers developed a method using bacteriophages to deliver vaccine components, offering advantages over traditional naked DNA vaccines. The technique has significant production and storage benefits, making it an attractive solution for addressing sudden vaccine demands.
Researchers genetically engineered tobacco mosaic virus to instruct spinach plants to manufacture protective antigen fragments, which can be easily purified and used in a vaccine. The resulting subunit vaccine has shown promise as a more efficacious and safer alternative to existing anthrax vaccines.
Scientific studies have found no link between vaccines and chronic diseases such as asthma and food allergies. Reducing vaccination rates can lead to increased rates of preventable infectious diseases, according to the article co-authored by Dr. Paul Offit.
Researchers have made a significant breakthrough in developing a cancer vaccine by attaching tumor material to antibodies, inducing an immune response against cancer in animal experiments. The vaccine's effectiveness may also be applied to other diseases such as arthritis and whooping cough.
The Lancet discusses the conflict between scientific openness and global security concerns, highlighting the need for defensive biological research to prevent the spread of knowledge and dangerous materials. Pneumococcal vaccines are also reviewed, showing varying effectiveness in developed countries.
AVANT Immunotherapeutics awarded subcontract to develop oral combination vaccine against anthrax and plague using proprietary technologies. The vaccine aims to offer rapid, effective protection from multiple biological agents with a single dose, eliminating the need for protracted dosing regimens.
Smallpox experts suggest limiting vaccinations to first responders to prevent complications and ensure public safety. The authors cite studies from the 1960s documenting vaccine-related complications, including spread to close contacts and increased risk of morbidity and mortality.
A study found that injecting beta-amyloid binding agents into the bloodstream reduced brain plaques and amyloid protein levels in mice with Alzheimer's disease. The researchers suggest this approach as an initial step towards developing targeted drugs with fewer side effects.
A study found no significant association between exposure to contaminated poliovirus vaccine and the incidence of pleural mesothelioma, a rare lung cancer. Incidence rates increased among older males, but remained stable or decreased in younger age groups.
A new study has found that chicken pox vaccine is safe and effective for children with chronic kidney disease. The study shows that vaccination can prevent severe complications such as pneumonia and brain inflammation in these patients.
A study analyzing Boston smallpox case records found that young patients, those unvaccinated, and those with severe disease had the lowest survival rates. In contrast, a college student study on echinacea found no effect on cold symptoms, highlighting the need for more research into its efficacy.
A large clinical trial will be conducted at 16 US sites, with Saint Louis University leading as the national coordinating site. The study aims to prevent genital herpes in women using an investigational vaccine.
Researchers have developed a new vaccine that amplifies the production of beneficial antibodies to combat IP-10, a protein responsible for autoimmune disease progression. The vaccine rapidly suppressed experimentally induced rheumatoid arthritis and MS, offering potential relief for millions.
Ethiopian wolf populations are threatened by rabies, which spreads rapidly among packs. Vaccinating surrounding dogs is a costly and difficult option, but researchers found vaccinating wolves themselves could increase survival rates. Developing an oral rabies vaccine for wolves may be a more effective solution.
A study by Cardiff University found that the British public is strong on opinions about scientific issues like climate change and biotechnology but weak on actual knowledge. The survey revealed that people's trust in sources like scientists and media outlets is low, suggesting a need for more effective communication strategies.
UT Southwestern researchers have developed a vaccine against the deadly bioterrorism toxin ricin, which can be administered in foods and water or sprayed as an aerosol. The new vaccine has shown protective effects in mice and is believed to be safe and effective in humans.
HPV vaccination has shown high safety and efficacy, inducing high antibody titers against papillomaviruses. Hepatitis B vaccination is also highly effective in preventing chronic infection, with a 95% effectiveness rate in children.
Researchers discovered that an inactivated chickenpox vaccine may prevent healthy elderly people from developing shingles and protect transplant recipients against viruses and bacteria. The vaccine boosted memory T cells to mount an attack during the transplant and recovery, reducing shingle risk.
A vaccine has been shown to delay symptoms of prion brain disease in mice by inducing an immune response and producing antibodies. This breakthrough could potentially lead to a therapeutic response and prevent the disease in animals at risk.
The company's phase I clinical trial will examine NicVAX's safety and ability to stimulate the immune system in nonsmokers. If successful, additional trials will be conducted to investigate its efficacy in smokers and ex-smokers.
Tumor vaccines via dendritic cells aim to enhance the immune response against cancer cells Researchers found that dendritic cells can stimulate the production of antibodies and T-cells specific to cancer antigens
A multi centre collaborative study found a two-thirds reduction in group C meningococci carriage after UK-wide vaccination. The programme protected both vaccinated and unvaccinated populations, providing valuable insights for future comprehensive vaccines.
Researchers have developed a new TB vaccine by fusing a Mycobacterium tuberculosis antigen with a gene that highly expresses a thiol-specific-antioxidant protein from Leishmania major. This hybrid DNA vaccine increased protein production, leading to a more robust immune response in mice.
Emory University is conducting a clinical trial to evaluate an improved anthrax vaccine regimen with reduced injections and muscle administration. The study will enroll 1,560 volunteers across six sites and aim to simplify the existing dosing schedule while providing more data on safety.
A study by Kansas State University researchers has linked anthrax vaccination to poor health outcomes in Gulf War veterans, suggesting that the combination of vaccinations and medications may have adverse effects on susceptible individuals. The research also found that falsified or destroyed medical records made it difficult to assess ...
A recent study found that people previously infected with HCV are 12 times less likely to develop persistent infection than those infected for the first time. This suggests that immunity can be acquired to protect against viral persistence, making vaccines a potential solution to reduce medical consequences of HCV infection.
Fox Chase Cancer Center researcher Glenn F. Rall is studying whether a link exists between the measles vaccine and the development of autism. He believes that maternal exposure history to measles may afford protection to offspring, but more research is needed.
A new vaccine targeting ticks' gut wall could significantly reduce their fertility and larval survival, decreasing the risk of diseases like Lyme disease and tick-borne encephalitis. The development comes as tick-borne diseases are increasing in the UK and becoming more prevalent globally.
University of Rhode Island researchers, Thomas Mather and David Nelson, are developing a new Lyme disease vaccine using tick saliva genes. They have received $2.3 million NIH grant to identify promising genes over five years.
A new NIAID study found that diluting smallpox vaccine can expand the US vaccine supply fivefold, providing more protection against a potential outbreak. The trial used a freeze-dried live vaccinia virus vaccine and resulted in high take rates with minimal side effects.
Researchers have developed a potent antiviral drug, HDP-CDV, that can block the replication of variola and orthopox viruses, including smallpox. The oral drug is 100 times more active than existing cidofovir and may be used to treat and prevent smallpox infections.
Researchers at Virginia Tech will develop plant-expressed antigens and adjuvants to create affordable, effective vaccines. The goal is to produce inexpensive, disease-fighting vaccines through plant-based delivery systems.
A new peptide-based vaccine has been shown to reduce arterial plaque formation by 60-70% in mice with high cholesterol levels, according to a study led by Cedars-Sinai's P.K. Shah and the Swedish team of Gunilla Nordick-Fredricksson. The vaccine targets the major protein component of low-density lipoprotein (LDL) cholesterol.
A new study shows that a vaccine based on a chimpanzee adenovirus possesses the immunological strengths of a human adenovirus vaccine without its drawbacks. The vaccine, developed by researchers at The Wistar Institute, has been shown to be effective in mice against rabies and other viruses.
A new protocol for administering pneumonia vaccines has shown promising results in improving vaccination rates among hospital patients. The study found that the protocol resulted in a 38% vaccination rate, compared to 4.9% in standard procedures. This intervention can potentially save lives and reduce healthcare costs.
A recent outbreak in England and Wales highlights the need for better vaccination coverage among Mecca pilgrims, with a previously rare strain causing high case-fatality rates. Enhanced surveillance and early recognition are crucial to prevent further transmission of the disease.
The Nabi experimental vaccine reduced bloodstream infections caused by Staphylococcus aureus in end-stage kidney disease patients by nearly 60%. The vaccine elicited a significant antibody response in 86% of the patients, and significantly reduced the incidence of systemic S. aureus infection in the blood.
Researchers at the University of Melbourne have developed a potential allergy vaccine using a modified rye grass protein that reduces allergenic response while boosting immune system. The vaccine, delivered in its pure form, may significantly reduce risk of anaphylactic shock and increase immunotherapy efficacy.
A new prostate cancer vaccine developed at Duke University Medical Center has shown promising results, boosting the patient's immune system to fight cancer. The vaccine, made from the patient's own dendritic cells, causes no adverse side effects and activates T cell responses against tumor cells.
A study conducted by Yale University has shown that a cocaine vaccine can significantly reduce cravings and addiction in patients who abuse the drug. The vaccine was found to be safe and effective in increasing anti-cocaine antibodies, which help prevent the uptake of cocaine across the blood-brain barrier.
A recent study found that infants can generate protective immune responses to multiple vaccines simultaneously, using only a small percentage of their immune system. Current research also shows that vaccine formulations have been refined to contain fewer antigens, reducing the risk of overwhelming the infant's immune system.
Researchers at UT Southwestern Medical Center have developed a new procedure for delivering vaccines by manipulating dendritic cells in the skin, reducing production time from 10 days to just 24 hours. This breakthrough could lead to more effective cancer treatments and broader clinical applications.
A recent yellow fever outbreak in Guinea highlights insufficient international stocks of the 17D yellow fever vaccine, which can protect for at least 10 years. WHO recommends an emergency stockpile of 1 million doses to provide a rapid response to large outbreaks.
The US government is investing in bioterrorism research through seven new initiatives, aiming to develop vaccines and treatments for diseases like anthrax and smallpox. The initiatives will also support basic research and partnerships between academia, industry, and government.
A genetic vaccine developed by the University of Nebraska Medical Center has shown promising results in mice studies, combining DNA and adenovirus to deliver a tumor suppressor factor. The vaccine improved survival rates up to 40% in mice with metastatic breast cancer.
Researchers have found that a Japanese encephalitis (JE) vaccine may also protect people from the most serious complication associated with West Nile virus infection. The study tested two vaccines in hamsters and found that they provided better protection than other options, including a yellow fever vaccine.
Researchers aim to better understand cellular immunity in fighting Alzheimer's disease using a new mouse model jointly developed by USF and the University of Pennsylvania.
Researchers at Ohio State University have developed a new DNA-based vaccine approach that successfully immunizes mice against anthrax. The vaccine uses combinations of two gene products produced by the bacteria responsible for causing anthrax, resulting in strong immune responses.
A recent study suggests that the rotavirus vaccine did not increase the risk of intussusception, a rare bowel blockage, in infants under 1 year old. The study found a 4-10% decline in hospitalizations for intussusception during the period when the vaccine was available.
A recent study found that Rotashield may trigger intussusception events in susceptible infants, but these risks are compensated for by a lower risk of intussusception later in infancy. The study analyzed hospital admissions of infants with intussusception in ten US states during the period when Rotashield was in use.
Researchers are exploring postraumatic vaccination as a potential treatment for spinal cord injuries, showing promise in promoting neural regeneration and recovery. Early studies suggest that this approach may improve functional outcomes and quality of life for affected individuals.
Researchers at The Scripps Research Institute have solved the structure of a neutralizing antibody against HIV, marking an important milestone in the development of an effective vaccine. This breakthrough demonstrates that the human immune system can produce antibodies effective against HIV and provides a template for vaccine design.
Researchers at NYU Langone Health successfully immunized mice against Alzheimer's disease using a new vaccine that reduces amyloid plaque and soluble beta levels. The vaccine, modeled on a modified peptide, appears to be non-toxic and shows great promise for the treatment of Alzheimer's disease.
A program called Operation Stop Cough reduced illness rates by 45% among Navy recruits who were ordered to wash their hands frequently. Handwashing may be especially valuable during the respiratory disease season, as it can prevent less virulent illnesses and mitigate outbreaks.
A new model for detecting early meningitis epidemics in sub-Saharan Africa has been developed, using weekly incidence thresholds to identify outbreaks. The model uses clinic-based weekly incidence of 5-10 cases per 100,000 inhabitants to detect all meningitis epidemics with high sensitivity.
Dr. Tramont takes helm of DAIDS, a successful program critical to understanding HIV causes and creating antiretroviral drugs, with a focus on building on its legacy
Two fatal cases of haemorrhagic fever associated with yellow fever 17DD substrain vaccine were reported in Brazil, highlighting the need to review the vaccine's safety. The cases led Philippe Marianneau and colleagues from Institut Pasteur to emphasize the importance of investigating mechanisms of attenuation of yellow-fever virus.
The Office of Naval Research has funded a study to develop new plasmid DNA vaccines for marine mammals, aiming to prevent epidemic disease. The studies may soon allow for better protection against infection using vaccination of individual animals within a population.