Articles tagged with Vaccination
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Researchers found that a peptide called LL-37 selectively kills the vaccinia virus in the smallpox vaccine, which could enable thousands of civilians or military personnel with atopic dermatitis to receive the vaccine. This breakthrough may lead to safer testing and better predict and control reactions to the vaccine.
A new study has shown that vaccinia transfer after smallpox immunization is extremely low if proper precautions are taken. The risk of transmission can be greatly reduced by keeping the vaccine site bandaged and practicing thorough hand-washing.
A meta-analysis of five published trials found that aluminium-containing vaccines were more likely to cause redness and induration in young children and local pain in older children. However, there was no evidence of serious or long-lasting side effects.
A new recombinant tuberculosis vaccine is being tested in a Phase I clinical trial in the United States, combining two proteins known to stimulate strong immune responses in humans. The vaccine aims to offer protection against pulmonary TB, the most contagious form of the disease.
Researchers found that parents who received a photo calendar of their baby's upcoming immunization dates were more likely to vaccinate their child. The study showed an 82% vaccination rate among babies whose parents received the calendars, compared to 65% for those without.
The use of rubella vaccine has increased globally, with 124 countries using it in their immunization programs by 2002. Surveillance for congenital rubella syndrome remains a concern, with incomplete reporting and estimated cases being only 0.1% of true total.
A study found that nearly 750 pediatricians and family practice physicians reported a rise in vaccine concerns, with many citing short-term effects and unproven allegations. Physicians must be equipped to address these concerns and provide accurate information on vaccine safety.
The National Vaccine Advisory Committee recommends strengthening routine vaccine supplies by increasing funds for stockpiles, supporting regulatory agencies, and improving communication. The committee also highlights the need for increased investment in vaccine manufacturing facilities and development of new vaccines to sustain supply.
A survey of 743 physicians found that parents' refusal of vaccines is becoming a growing concern, with many citing fears about short-term reactions and long-term complications. Pediatricians are more likely than family physicians to provide additional information and discuss concerns with parents.
The meningococcal vaccine is safe and effective in preventing invasive meningococcal disease, which can cause severe illness or death. Despite its value, many parents and teens are not informed about the vaccine due to limited public resources and high costs.
The incidence of pertussis among infants increased significantly between 1980 and 1999, with a 49% rise in reported cases. The majority of these cases occurred among infants under four months old, suggesting the need for improved vaccination strategies to control the spread of the disease.
Researchers at USAMRIID have developed Ebola virus-like particles (VLPs) that induce both cell-mediated and humoral immunity in mice, providing 100% protection against lethal challenge. The VLPs, resembling infectious viral particles without genetic material, offer a promising vaccine platform for Ebola and other viruses.
Researchers have developed a device, known as a micromechanosensor, that allows for rapid detection of botulism toxins, which can cut detection time from days to minutes. This could lead to more effective treatment and lower mortality rates among those afflicted.
A new form of coronavirus was genetically altered to resemble parts of the SARS virus, then injected into rhesus macaques. The results showed strong immune responses against SARS in all immunized animals, suggesting a potential protective vaccine.
A new investigational vaccine to prevent hepatitis C has been tested in humans for the first time, offering a promising breakthrough against the deadly virus. The study aimed to assess the safety and effectiveness of three different strengths of the Chiron Corporation's vaccine.
A Phase II clinical study of TP10 found that the complement inhibitor significantly reduced heart attacks and death in male patients undergoing open heart surgery. The study showed a significant decrease in composite endpoints for death, myocardial infarction, and prolonged intubation in males treated with TP10.
Researchers found that individuals vaccinated against smallpox maintained anti-smallpox antibodies for at least 60 years after vaccination. Memory B cells initially declined but then plateaued approximately ten times lower than their peak and remained stable for over 50 years.
Researchers have found that a new vaccine can diminish symptoms of Alzheimer's disease by increasing clearance of amyloid beta protein from the brain. The study used monkeys and showed that vaccinating them with synthetic amyloid beta peptide enhanced clearance, leading to reduced plaques and improved cognitive function.
A recent study has found a link between smallpox vaccination and rare heart diseases, including pericarditis and myocarditis. Twenty-four cases of these conditions were identified among 37,876 US civilian healthcare workers who received the vaccine as part of a bioterrorism readiness program.
A new peptide-based vaccine has shown promising results in treating advanced melanoma by inducing a strong immune response in patients. The vaccine, which includes granulocyte macrophage-colony stimulating factor (GMCSF), resulted in significant tumor regressions and stable disease in some patients.
A UK measles expert warns that major epidemics are likely to occur in the country this winter if vaccination rates do not improve rapidly. The Lancet publication cites unequivocal evidence supporting the safety of the MMR vaccine and highlights the risks associated with unvaccinated children.
Researchers at the US Army Medical Research Institute of Infectious Diseases have developed a hantavirus vaccine that elicited a potent neutralizing antibody response in rhesus macaques. The vaccine, which uses a naked DNA approach, also provided protection against hamster infection when administered after exposure.
A breakthrough discovery has been made by McMaster University researchers, who have cloned the gene that marks an important nuclear protein of the SARS virus. The team plans to test their newly engineered adenovirus vector in animals for protective effects against the deadly disease.
Researchers have developed a modified smallpox vaccine that is expected to be identical in effectiveness to the current vaccine but treatable for rare complications. The new vaccine will use genes to make the virus susceptible to common drugs, allowing doctors to effectively treat severe reactions.
Hepatitis A vaccine boosters are unnecessary for healthy individuals, according to a meeting of experts; protective antibody amounts persist beyond 10 years after primary vaccination. Further investigations are needed for special patient groups.
A study by the World Health Organization found that officially reported global vaccination coverage rates are higher than actual rates, highlighting issues with data quality. The investigation compared national data with a 'gold standard' household survey method in 45 countries between 1990 and 2000.
A new HPV vaccine targeting high-risk types could prevent up to 84% of cervical cancer cases. Testing a cocktail of these virus types could provide sufficient guidance for clinical decisions and future screening programmes.
Researchers have made significant progress towards a vaccine for pancreatic cancer, with one patient out of ten remaining disease-free after five years and two others surviving over two years. While the study's findings are promising, caution is advised due to the small sample size and potential biases in the selection process.
Researchers at Dana-Farber and other Harvard-affiliated hospitals will study the human immune system's response to the vaccinia virus and other related viruses. The goal is to develop effective alternatives with fewer risks, addressing concerns about the current vaccine's complications in people with weakened immune systems.
The Emory-led consortium aims to study the entire range of human immune responses, from laboratory to clinic, to develop new vaccines addressing emerging infections and biothreats. Scientists will use genomics and proteomics to analyze vaccine-induced innate and adaptive immune responses.
Studies presented at ICAAC reveal significant clinical outcomes, resource utilization, and infection-associated costs of Staph aureus bacteremia among hemodialysis-dependent patients. The infections are associated with substantial morbidity and mortality, underscoring the need for a vaccine to prevent these infections.
The NIH has awarded $85 million to five cooperative centers for translational research on human immunology and biodefense. Researchers will develop new ways to analyze immune cells and use imaging technologies to study vaccine responses, aiming to strengthen the immune system against diseases.
Afghanistan's Ministry of Health has made significant strides in healthcare delivery and policy planning, achieving 94% national coverage in measles vaccination. The country's example is seen as a potential blueprint for post-conflict reconstruction in other nations.
A study found that organ-transplant patients are particularly vulnerable to measles due to their compromised immune systems. Low MMR vaccine uptake in southeast London poses a significant threat to these individuals, highlighting the need for increased awareness and vigilance.
A new vaccine has shown promise in stimulating a powerful immune response against melanoma tumors, with 10 patients still alive three years after treatment and no signs of disease in four cases. The vaccine, made using a weakened cold virus, was safe and relatively easy to produce, with minimal side effects.
A new study finds that nearly 1 in 3 doctors hesitate to administer the Prevnar vaccine due to its high cost, especially among those with many uninsured patients. The vaccine protects against bacterial meningitis and other diseases, but its expense creates obstacles for families without insurance coverage.
Researchers discovered that repeated vaccinations provide short-term immunity boosts but do not sustain higher protection levels. Long-term antibody immunity can last throughout a person's lifetime, while T-cell immunity declines slowly over time.
The American College of Preventive Medicine recommends prioritizing research on improving vaccine delivery and funding for immunization programs. All children and adolescents without contraindications should receive immunizations against 11 diseases, according to ACPM's recommendations.
A recent study reports a correlation between declining vaccinations and increasing measles outbreak sizes in the UK. The reproductive number, measuring the spreadability of measles, has increased to approach endemic disease levels.
A new study published in The Lancet found that the meningococcal C conjugate vaccine (MCCV) may increase relapse rates of nephrotic syndrome in children with kidney disease. The vaccine was introduced to all UK children under 18 years old in 1999, but subsequent monitoring revealed a 30% increase in relapses post-vaccination.
Research suggests that cervical cancer vaccines may be less effective in women who are ovulating, due to fluctuations in antibody levels triggered by sex hormones. The study found higher antibody levels during the proliferative phase and lower levels around ovulation.
Researchers found that adults who received smallpox vaccinations as children showed fewer adverse reactions to diluted vaccine doses compared to those who never received the vaccine. The study's results have implications for potential future biological attacks and suggest that vaccine stocks may be more sustainable.
Researchers at Vanderbilt University Medical Center found that a generalized rash on some smallpox vaccine recipients was not due to the virus, but rather a benign reaction called folliculitis. The study aimed to clarify this previously unwell-documented phenomenon and reassure physicians about accurate diagnosis.
A new study suggests that pneumococcal vaccination can save medical costs for individuals aged 50 to 64, particularly those at high risk of pneumococcal disease. The cost-effectiveness of vaccination is comparable to other preventive services in this age group.
A phase II study of a multiepitope CD8 T-cell vaccine has demonstrated promising results, inducing an immune response in 32% of patients with metastatic melanoma. The vaccine showed significant correlations with non-progression of disease and longer survival rates.
Researchers found that CEM15 renders HIV dead by altering DNA, causing mutations and preventing replication. The virus can subvert this system, enabling it to make numerous mutations and evade the host's defense.
The VA health system saw significant improvement in quality-of-care indicators after implementing reforms, including electronic medical records and accountability measures. The system outperformed Medicare on many measures, making it an excellent model for healthcare organizations to adopt.
Researchers found that smallpox vaccine-induced antibody immunity can last a person's entire life, while T-cell immunity declines slowly over time. The study also showed that repeated vaccinations have little impact on immunity levels.
Researchers have created a new vaccine that stimulates the immune system to clear nicotine from the body, potentially aiding in smoking cessation. The vaccine induces antibodies that can neutralize nicotine before it reaches the brain.
A recent survey found that the public was misled by the media's coverage of the MMR controversy, with 53% assuming there was equal evidence for both sides. The study also revealed that journalists struggled to balance competing views on issues like climate change and genetics.
Virus researchers discovered a critical role of Z-DNA in pox virus lethality, leading to potential development of anti-viral compounds effective against smallpox. The findings may also shed light on the regulation of transcription and cellular responses to viral infections.
Researchers found nearly half of British public disagree with media coverage of MMR vaccine concerns, emphasizing the importance of balanced reporting. The study also highlights the need for journalists to approach minority voices within science with caution, particularly when dealing with alarming research.
Researchers discovered that 29% of individuals were completely resistant to the Norwalk virus, with those lacking the FUT2 gene showing no signs of infection. The study suggests that vaccination may be effective in reducing disease burden and offers new hope for developing vaccines.
Researchers at UCSD School of Medicine have demonstrated that pneumococcal vaccination can reduce the extent of atherosclerosis by 21 percent in laboratory mice. This breakthrough provides insight into the biological role of immune responses and offers potential therapeutic interventions for this complex disease.
A recent study found that people with atopic dermatitis or eczema, and their household contacts, are at increased risk of complications from smallpox vaccination. The study suggests that the screening process may not be effective in identifying individuals who should not receive the vaccine.
Scientists at University of Maryland Biotechnology Institute developed a new vaccine using recombinant DNA technology to protect fish against infectious pancreatic necrosis virus. The vaccine, composed of hollow virus-like particles, demonstrates a resistance potential against the disease and has shown promising results in experiments.
A mathematical model developed by Don Klinkenberg suggests that partial vaccinations can effectively control the spread of swine fever. The model indicates that vaccination reduces the spread of the virus but does not completely prevent it, allowing for epidemic persistence for several months.
Researchers at Memorial Sloan-Kettering Cancer Center have developed a DNA-based vaccine that triples the survival rate for dogs with advanced melanoma. The vaccine, tested in nine dogs with no side effects, shows promise for treating this aggressive cancer in humans.
A phase I clinical trial found that antibody therapy increased the effectiveness of cancer vaccines in patients with metastatic melanoma and ovarian cancer. The treatment, which blocks CTLA-4, elicited a potent immune response and killed cancer cells.
A Danish study found that individuals exposed to contaminated poliovirus vaccine had no increased risk of cancer compared to those not exposed. The findings contradict previous laboratory and epidemiologic evidence suggesting a link between SV40 contamination and human cancer.