Scientists at Johns Hopkins Medicine have overcome a major obstacle to creating large libraries of drug-like peptides. By modifying naturally occurring amino acids with a methyl group, they can produce up to 10 billion stabilized peptides in a single reaction. This breakthrough enables the rapid testing of potential medicines and has s...
Researchers at the University of Pennsylvania School of Medicine have discovered a fat cell hormone, adiponectin, that can cause weight loss in mice by increasing their metabolic rate. This finding has far-reaching potential to help treat obesity-related diseases such as diabetes and heart disease.
The four new research centers will study the effects of harmful algal blooms, marine pathogens, and ocean potential for drug discovery. The combined expertise of experts in biomedical and oceanographic sciences will accelerate scientific discovery.
Researchers Drs Sun and Arceci find that loss of PASG gene results in reduced genomic methylation and premature aging in mice. The study reveals a potential model for studying aging and epigenetic regulation, with implications for cancer predisposition and therapeutic targeting.
Researchers at HHMI argue that supplementing lectures with active learning strategies leads to better understanding and success in science courses. The study recommends revamping introductory courses, training scientists to teach, and changing the reward system to emphasize good teaching.
A study analyzing published and unpublished trials found that most SSRI antidepressants pose a higher risk than benefits in treating childhood depression. The analysis highlights the need for greater access to unpublished data from the pharmaceutical industry to ensure accurate treatment guidelines.
Researchers used satellites to create an 18-year record of global land surface temperatures, confirming that snow-free land surfaces have warmed. The satellite data provides a more detailed and comprehensive understanding of climate changes and will improve computer modeling.
A study found that tobacco smoke exposure is responsible for more than half the non-lung cancer death rate in African-American males, and up to two-thirds of their overall cancer death rate. The excess cancer burden can be clearly linked to smoking, with significant declines in mortality rates observed when smoking declined.
A multinational team of scientists has found microscopic life colonized in ancient volcanic lava dating back nearly 3.5 billion years. The discovery was made in the Barberton Greenstone Belt, a location that was previously thought to be inhospitable for life.
A research team found mineralized tubes and DNA associated with microbial activity in ancient basaltic glass samples, suggesting that microbes colonized the early oceanic crust. The discovery provides clues to the origin of life on Earth.
The EU's new eastern border raises concerns about the growth of communicable diseases in Russia, Ukraine, and Belarus. Public health systems have struggled to respond to these challenges, and a global response is needed to strengthen health systems and prevent disease spread.
A 1999 outbreak of furunculosis in rural Alaska identified individuals with MRSA who received more antibiotics, highlighting a link between antibiotic use and increased risk of skin infections. The study found that Panton-Valentine leukocidin virulence factor was present in nearly all methicillin-resistant isolates.
A Stanford study reveals a connection between archaea abundance and gum disease severity, affecting about one-third of Americans. The research found that more than one-third of patients with chronic periodontitis harbored archaea in their diseased subgingival spaces but not elsewhere.
The book Challenges for Rural America in the 21st Century examines rural social change, economic transformation, and policy implications. Key findings include unevenly spread gaming benefits, elder care challenges, and the need for rural communities to adapt to a decentralized system.
A new diagnostic test using proteomic signature analysis has been developed to accurately diagnose sleeping sickness. The test showed a sensitivity of 100% and specificity of 98.6%, offering a promising solution for early detection and treatment.
Researchers at Johns Hopkins Medicine discovered that nitric oxide attaches to parkin protein, reducing its ability to mark proteins for destruction. This process may contribute to Parkinson's disease progression, providing a potential new target for treatment.
A new investigational anthrax vaccine is being tested in a phase II human study at Saint Louis University. The vaccine aims to provide better protection, an improved safety profile and a simpler dosing schedule.
Cornell University Library will collaborate with Göttingen State and University Library in Germany to develop an online archive of digital mathematics serial publications. The project aims to provide long-term access to e-research literature and serves as a model for similar efforts in other disciplines.
A University of Florida study found that sibling violence is a predictor of dating violence, particularly among those who experienced physical abuse as children. The survey of over 500 participants revealed that siblings who were abused or perpetrated violence towards each other were more likely to engage in abusive behavior in their r...
The US President's FY 2005 budget proposes significant cuts to non-defense Research and Development (R&D) programs, with some agencies facing declines of up to 28%. The largest decreases will occur in the Department of Agriculture, Department of Commerce, and National Institutes of Health.
A new study further reinforces CellCept's cardioprotective profile, demonstrating lower rates of coronary artery disease in patients treated with CellCept compared to azathioprine. This finding could explain the superior survival benefits observed with CellCept.
A major study at Cedars-Sinai Medical Center found that a bioartificial liver significantly reduced mortality among patients with acute liver failure. The treatment showed a 44% reduction in mortality rates compared to standard supportive care, offering new possibilities for treating this life-threatening condition.
Four new research centers will bring together experts in biomedical and oceanographic sciences to study the effects of harmful algal blooms, marine pathogens, and the oceans' potential for drug discovery. The centers will accelerate scientific discovery and develop new sensors for early warning systems.
The Woods Hole COHH will research how oceanic processes affect human pathogens, focusing on temperate coastal ocean distribution and persistence. The center aims to address public health threats from harmful algal blooms and contaminated coastal waters.
A genome-wide screen reveals new functions for old genes associated with chromosome cohesion, a process keeping chromosomes together until cell division. The study identified 17 genes involved in this critical aspect of genetic material manipulation.
Scientists found that Condensin compacts DNA against a weak stretching force, but increasing the force reverses compaction. The researchers observed jumps in distance between DNA ends during compaction and decompaction.
A team of researchers has successfully corrected a genetic defect responsible for cystic fibrosis in mice using turmeric extract. Curcumin, a compound found in turmeric, was able to release the mutant CFTR protein from an inappropriate compartment inside the cell and allow it to function normally.
According to Dr. George Lister, using high-dose epinephrine in children may impair organ function and survival after cardiac arrest. Limiting doses to recommended levels can reduce errors and improve outcomes.
A new study reveals that a slowdown in ocean circulation was directly tied to sudden and dramatic changes in climate. The research found that the Atlantic Ocean's north-south overturning circulation played a crucial role in regulating regional temperatures.