Articles tagged with Xenografts
Researchers develop a new xenotransplantation model where human cells coexist with porcine cells, showing that they can live long-term without PERV infection. The study suggests that pigs may be a safer source for human transplantation due to the low risk of transmitting viruses.
Scientists have grown functional kidneys in rats using embryonic tissue transplants, demonstrating their ability to filter blood and excrete waste. The research marks a critical step towards developing animal-to-human transplants to address chronic organ donation shortages.
Researchers at Immerge have identified that human-tropic PERV is acquired during life, rather than being present in the germ-line DNA of mini-swine. The study found no viruses in the germ-line DNA that could infect human cells, paving the way for safer xenotransplantation procedures.
New lab results show no recombination of porcine and human retroviruses, reducing the risk of PERV transmission to humans. This finding supports Immerge's progress toward clinical xenotransplantation research.
Immerge BioTherapeutics has identified the PERV receptor, a key factor in understanding the safety of xenotransplantation. This breakthrough allows for the development of safer porcine organs for human transplantation, addressing an unmet need in clinical transplantation.
Scientists have successfully cloned the world's first double knock-out miniature swine, eliminating a major hurdle in xenotransplantation research. The genetically modified pigs lack the gene GGTA1, which triggers an immune response against pig organs.
Researchers at Immerge BioTherapeutics have identified miniature swine that do not transmit the pig retrovirus (PERV) to humans. The study characterizes three sub-classes of PERV A, B and C found in the herd of inbred miniature swine, showing consistent non-transmitting phenotypes.
Researchers from the University of Missouri-Columbia and Immerge BioTherapeutics Inc. have successfully cloned a miniature swine with a gene knocked out of its DNA. This achievement moves closer to making animal-to-human organ transplantation a reality, offering hope to over 75,000 Americans waiting for organs.
A landmark study published in Science found no evidence of Porcine Endogenous Retrovirus (PERV) infection in 160 patients who received living pig tissue transplants. The study, which tested the safety of xenotransplantation, showed that pig tissue can survive in the human body for long periods with no ill effects.
The National Academies of Sciences, Engineering, and Medicine recommends federal guidelines to ensure the safe use of xenotransplantation. The guidelines address four major areas: source animal screening, patient surveillance, tissue banking, and national registries.