Articles tagged with Anemia
A new clinical trial has found luspatercept to be significantly more effective than epoetin alfa in treating MDS anaemia, reducing the need for blood transfusions. The results have implications for treatment algorithms and may establish luspatercept as a first-line treatment option.
A new study reveals that nearly 40% of teen girls and young women have low iron levels, with higher rates among Black, Latina, low-income, or low-BMI individuals. The study recommends considering routine screening for iron levels in adolescents and young women to prevent life-limiting symptoms associated with iron-deficiency anemia.
Among US females ages 12-21, iron deficiency affected nearly 40%, while iron deficiency anemia occurred in approximately 6%. Menstruation was a significant risk factor for both conditions, with over one-quarter of premenarchal girls experiencing iron deficiency.
A new study analyzing data from the ASPREE trial found that prolonged daily aspirin use increases the risk of anaemia by 20 per cent in people mostly aged 70 and over. Regular monitoring for anaemia should be considered for older adults taking low-dose aspirin.
A post-hoc analysis of the ASPREE trial found that low-dose aspirin was associated with a 20% increased incidence of anemia and decline in ferritin levels in healthy older adults. The study recommends periodic monitoring of hemoglobin for patients taking aspirin.
A large-scale registry study found that older autistic adults have a significantly higher risk of injury, especially self-inflicted, and physical conditions such as type 2 diabetes and anaemia. Autistic individuals had a seven-fold risk of self-harm compared to non-autistic people.
A landmark Malawian trial has found a single iron infusion can significantly reduce iron deficiency in pregnant women, compared to daily tablets. The treatment, Ferric carboxymaltose (FCM), reduced iron deficiency by around 60% and showed promise for addressing anaemia in resource-poor nations.
Researchers from China conducted a comprehensive review of dual therapy (DT) for H. pylori eradication, highlighting its high efficacy and patient compliance with minimal adverse events. High-dose DT administered over 14 days has emerged as the most effective treatment option.
Researchers have discovered that the enzyme COASY plays a critical role in regulating red blood cell production in the bone marrow. Vitamin B5 supplementation and another metabolite increased the maturation of red blood cells in patients with Myelodysplastic syndromes, offering new hope for alternative treatments.
Patients with myelofibrosis experience significant symptom improvements when treated with momelotinib, including reduced spleen size and decreased transfusion dependency. The Phase III MOMENTUM trial reports meaningful benefits over standard therapy danazol.
A new study suggests that chronic dysentery is unlikely to have been the cause of Edward the Black Prince's death. Instead, experts point to alternative causes such as malaria, inflammatory bowel disease, and brucellosis, which could have contributed to his fluctuating illness.
A study of 510 children with chronic kidney disease found that declining hemoglobin levels were associated with significant growth impairment even when above guideline-targeted levels. Lower hemoglobin values are linked to poorer growth, independent of kidney function and age.
Research on Fanconi anemia reveals its link to aggressive head-and-neck tumors due to gene-copy chaos, increasing the need for new treatments. The study also highlights a connection between smoking and drinking and elevated cancer risk.
Researchers at Kyoto University discovered METTL16's role in DNA repair and erythropoiesis, a process generating 200 billion new red blood cells daily. Tiny methyl groups on specific mRNAs play a pivotal role in this process, involving mechanisms mediated by RNA-binding proteins.
Two new studies found that dialysis facilities owned by nephrologists may provide better care, with patients receiving home dialysis more often. Additionally, a shorter interval between dialysis and surgery was associated with improved post-surgery survival rates.
A study found that impairing mitochondria in two different ways can cause severe anemia. Researchers used mouse models to investigate the role of mitochondria in blood cell differentiation and found that disrupting mitochondrial function and dynamics causes anemia through distinct mechanisms.
Anemia is common among adults with advanced kidney disease, associated with adverse outcomes and low eGFR levels. Effective iron supplementation is a low-risk intervention to address this issue, emphasizing the need for increased testing and treatment.
A randomized study of frequent blood donors found that iron deficiency in donors did not harm the quality of donated blood, nor did it negatively impact their health and quality of life. The study's results validate current donation practices, encouraging more people to become blood donors.
A combination of anemia and weak muscles in older people increases the risk of death by 64% for men and 117% for women. The two conditions together pose a significant risk, especially for elderly women, according to a study published in Archives of Gerontology and Geriatrics.
University of Cincinnati researchers are studying whether targeting an inflammation pathway can improve patient results for soldiers with burn injuries combined with traumatic brain injuries. The research focuses on a specific protein that causes inflammation, which can lead to complications such as anemia and death.
The NIH announced five cash prize winners and four honorable mentions in its Maternal Health Diagnostics Challenge. The winning technologies aim to reduce maternal morbidity and mortality, with a focus on detecting and differentiating common pregnancy-related conditions.
The American College of Physicians (ACP) says inadequate access to nutritious food negatively impacts the health of many Americans, exacerbating social factors and leading to various health issues. The ACP recommends strengthening the nation's food insecurity response and empowering physicians to address social drivers of health.
A phase 3 randomized study showed that momelotinib significantly improved outcomes for patients with myelofibrosis, a rare and fatal bone marrow cancer. The oral pill met all primary and secondary endpoints, showing a trend toward overall survival benefit within six months.
Researchers at Kyoto University identify a distinct subpopulation of fibroblasts responsible for producing the hormone erythropoietin (Epo), which stimulates red blood cell production. This discovery provides insight into renal anemia and may lead to novel treatment methods for patients with chronic kidney disease.
A study found that changes in anemia care policies led to lower rates of major adverse cardiovascular events, mortality, and stroke among patients with kidney failure receiving hemodialysis. The policy changes resulted from a shift towards more conservative ESA dosing, which reduced acute myocardial infarction risk.
A new study reveals that eating wild animals, known as bushmeat, is associated with reduced anaemia cases among children living in the Amazon rainforest. The researchers found that bushmeat consumption can partially protect the health of vulnerable rural children by increasing their iron levels.
A Rutgers analysis of Medicare database found that two IV iron formulations have a much higher chance of provoking severe allergic attacks. The risk was highest for iron dextran and ferumoxytol, with rates three to eight times higher than ferric gluconate.
A new study using pooled individual patient data from over 70,000 patients has found that artemisinin-based combination therapy can suppress the bone marrow response and contribute to anaemia. The analysis identified patients at greatest risk of severe anaemia and highlights potential advantages of alternative treatment regimens.
A world-first study found that space travel causes a 54% increase in red blood cell destruction, leading to severe anemia upon return to Earth. Astronauts experienced prolonged effects of anemia even after months of recovery.
Researchers developed a new compound based on Nobel Prize-winning discoveries that raised hemoglobin levels in patients with kidney disease undergoing dialysis and those not on dialysis. The oral medication was found to be as safe and efficacious as conventional treatment for anemia, offering a transformative approach to patient care.
Researchers have discovered that red blood cells bind to cell-free DNA during sepsis and COVID-19, leading to their removal from circulation and triggering inflammation. This finding opens the door to new treatments for inflammatory diseases and acute anemia.
A large-scale study shows that regular millet consumption can improve hemoglobin and serum ferritin levels, reducing iron deficiency anemia. The research found that millets increased hemoglobin levels by up to 13.2% and serum ferritin by an average of 54.7%.
A new mathematical model suggests that patients with anemia can be effectively treated with transfusions of blood substitutes, which are more readily available than real blood. This approach could reduce the negative effects of blood transfusion and lower costs.
A Brazilian study found that children exposed to malaria from birth are more likely to develop anemia by age two. The researchers, led by Dr. Marly Augusto Cardoso, followed 1,539 children and discovered that 12.6% were anemic, with a higher prevalence in rural areas not covered by the study.
A University of Alberta-led study found that anemia can generate different immune responses in males versus females, making females more prone to infections. The research highlights the importance of considering sex as a variable in prevention, diagnostic, and therapeutic strategies for immune-related conditions.
A small sachet of a fortified food-based supplement added to young children’s daily diets has shown remarkable results in preventing child mortality and malnutrition while promoting healthy development. The intervention resulted in lower prevalence of stunted growth, anemia, and adverse language and motor development outcomes.
Researchers have shown that physical exercise normalizes metabolic abnormalities caused by cancer, reducing anemia and associated fatigue. Exercise regenerates metabolism, blunting excessive blood cell formation and destruction, leading to improved tolerance of chemotherapy and radiotherapy.
A new study found that half of pregnant women had low iron levels and one in four had severe iron deficiency, despite the prevalence being common. Researchers urge revisiting clinical guidelines to include ferritin testing as a routine part of maternal care.
A new study published in PLOS ONE suggests that smartphone photos of the inner eyelid can be used to screen for anemia. The algorithm achieved accuracy rates of up to 94.4% in predicting anemia, making it a potential tool for early diagnosis and treatment in low-resource settings.
The new clinical practice guideline focuses on reducing blood loss and improving outcomes in heart surgery patients. It emphasizes patient-centered care by considering a patient's values and choices into treatment pathways.
Researchers found that fortified tea with folate and vitamin B12 can increase serum levels of these essential nutrients in Indian women. The study showed significant average increases in serum folate and vitamin B12 levels, as well as improved haemoglobin levels, after 2 months of daily consumption.
A new study identified genetic risk factors for pernicious anemia, a type of anemia caused by vitamin B12 deficiency due to autoimmune reactions. The study analyzed data from over 660,000 individuals and found associations between pernicious anemia and other autoimmune diseases.
Researchers have developed a remedy for renal anemia in cats using feline-derived erythropoietin, which shows minimal adverse reactions. The Pegylated fEPO was tested on 60 cases and proven effective in improving symptoms and quality of life for both cats and their owners.
A combination of inexpensive oral medications may treat fatigue-inducing anemias, a new discovery suggests. The therapy targets the root cause of anemia: disrupted cellular organelles, specifically the Golgi apparatus.
A recent cross-sectional analysis found a significant association between iron-deficiency anemia and the likelihood of developing insomnia in Chinese adults. Anemia was assessed using hemoglobin levels, while insomnia was evaluated using the Chinese version of the Athens Insomnia Scale.
A recent study developed an AI-based system to predict optimal medication dosages for patients with kidney disease undergoing hemodialysis. The system achieved high prediction accuracy rates, providing clinically appropriate classifications at even higher rates.
Iron deficiency affects two billion people, causing anaemia and serious health consequences. The new guidance outlines evidence-based approaches to diagnose and manage iron deficiency, leading to improved health outcomes.
A new study published in The Lancet Global Health found that iron infusion is highly effective in low-income settings compared to oral iron tablets. Women who received an iron infusion had normalized levels of haemoglobin after just six weeks, with continued benefits after one year.
New research led by UT Southwestern shows the effectiveness of a treatment for aplastic anemia and reveals the range of diagnosis and treatment options used by hospitals around the country. The studies highlight how collaborative research can improve outcomes for children with rare blood disorders, including myelodysplastic syndrome.
Researchers at University of Helsinki identified mechanism behind bone marrow failure in Fanconi anaemia by finding MYC gene overexpression. This led to stem cell detachment from the bone marrow and development of bone marrow failure.
A young man suffering from severe aplastic anemia has been given a life-saving blood transplant using the UM171 molecule, which increases stem cell production and reduces immunological complications. The procedure was performed by a medical team at the Institute of Hemato-oncology and Cellular Therapy.
Two large-scale genetic studies identified over 7,000 regions of the human genome influencing blood cell characteristics. These findings bring us closer to using genetic scoring in clinics to predict personal risk of developing blood disorders.
The REALITY trial found that restricting blood transfusion to those with very low haemoglobin levels has no negative impact on clinical outcomes, while also saving blood. The trial showed that the restrictive strategy was non-inferior to the liberal strategy in preventing 30-day major adverse cardiac events (MACE) and was more cost-eff...
The American Gastroenterological Association (AGA) recommends bidirectional endoscopy for asymptomatic patients with iron deficiency anemia to detect underlying causes such as gastrointestinal malignancy, peptic ulcer disease, and inflammatory bowel disease. Non-invasive testing, including Helicobacter pylori and celiac disease testing...
The RACE trial demonstrated that adding Eltrombopag to standard immunosuppressive treatment increases response rates in patients with Severe Aplastic Anaemia. The study found significant improvements in complete response rates, sustained at 6 months, and showed Eltrombopag was generally well-tolerated.
Researchers found a higher prevalence of anemia in pregnant women with malaria and HIV coinfections compared to those without infections. The study suggests that multipronged strategies to prevent and treat these infections are critical to ensure the survival of mothers and their unborn babies.
Advanced computer simulation techniques have determined which low-and-middle income countries would benefit from using iron-containing micronutrient powders to tackle childhood anaemia, with 54 out of 78 countries showing a net benefit. Policymakers can use individual reports for each country to balance benefits and risks.
A diet of high-iron beans improved the iron status and physical performance of women with anemia in Rwanda. The study shows that biofortified crops can be a sustainable alternative to address nutritional deficiencies in low-income countries.
Research team finds that high-altitude adaptations in the Himalayas may lower risk for hypertension and diabetes-associated anemia. The study, led by Katherine Wander of Binghamton University, found that a Tibetan-descended population living in Southwest China had lower rates of these conditions compared to low-altitude Han populations.
Screening for thyroid-stimulating hormone receptor antibodies (TSH-R-Abs) before pregnancy is crucial for patients with a history of autoimmune thyroid disease. This is because TSH-R-Abs can lead to irreversible impairment in fetal neurodevelopment. A case report highlights the importance of screening, especially in women with Graves' ...