Articles tagged with Anemia
The REALITY trial found that restricting blood transfusion to those with very low haemoglobin levels has no negative impact on clinical outcomes, while also saving blood. The trial showed that the restrictive strategy was non-inferior to the liberal strategy in preventing 30-day major adverse cardiac events (MACE) and was more cost-eff...
The American Gastroenterological Association (AGA) recommends bidirectional endoscopy for asymptomatic patients with iron deficiency anemia to detect underlying causes such as gastrointestinal malignancy, peptic ulcer disease, and inflammatory bowel disease. Non-invasive testing, including Helicobacter pylori and celiac disease testing...
The RACE trial demonstrated that adding Eltrombopag to standard immunosuppressive treatment increases response rates in patients with Severe Aplastic Anaemia. The study found significant improvements in complete response rates, sustained at 6 months, and showed Eltrombopag was generally well-tolerated.
Researchers found a higher prevalence of anemia in pregnant women with malaria and HIV coinfections compared to those without infections. The study suggests that multipronged strategies to prevent and treat these infections are critical to ensure the survival of mothers and their unborn babies.
Advanced computer simulation techniques have determined which low-and-middle income countries would benefit from using iron-containing micronutrient powders to tackle childhood anaemia, with 54 out of 78 countries showing a net benefit. Policymakers can use individual reports for each country to balance benefits and risks.
A diet of high-iron beans improved the iron status and physical performance of women with anemia in Rwanda. The study shows that biofortified crops can be a sustainable alternative to address nutritional deficiencies in low-income countries.
Research team finds that high-altitude adaptations in the Himalayas may lower risk for hypertension and diabetes-associated anemia. The study, led by Katherine Wander of Binghamton University, found that a Tibetan-descended population living in Southwest China had lower rates of these conditions compared to low-altitude Han populations.
Screening for thyroid-stimulating hormone receptor antibodies (TSH-R-Abs) before pregnancy is crucial for patients with a history of autoimmune thyroid disease. This is because TSH-R-Abs can lead to irreversible impairment in fetal neurodevelopment. A case report highlights the importance of screening, especially in women with Graves' ...
A new study by Swiss TPH and partners found that age, location, and anaemia status significantly impact childhood immune system development. The research suggests that considering these factors can improve the efficacy of childhood vaccinations, particularly in low- and middle-income countries where anaemia is prevalent.
A new study found that immune system composition changes significantly during early childhood, with anaemia potentially reducing vaccine responses in low-income countries. The research, published in Science Translational Medicine, analyzed blood samples from children in Mozambique and Tanzania.
Scientists have identified atypical immune B-cells that increase anti-PS antibody production associated with anaemia in malaria patients. These cells also develop and produce antibodies in uninfected individuals when exposed to broken red blood cell fragments.
A new study from Cincinnati Children's Hospital Medical Center reveals that many teenagers who undergo bariatric surgery experience low iron and B12 levels years later. Regular nutrition check-ups and supplementation can minimize these risks, emphasizing the importance of annual assessments.
Women with anemia are at high risk of postpartum hemorrhage and other complications after cesarean delivery. Early screening for iron deficiency can help prevent these issues by prescribing oral iron supplements or IV therapy as needed, potentially reducing blood transfusions.
Research at Karolinska Institutet found a correlation between early maternal anemia and increased risk of autism, ADHD, and intellectual disability in children. An estimated 15-20% of pregnant women worldwide suffer from iron deficiency anemia.
A Swedish study examining 500,000 children found a strong association between maternal anemia during pregnancy and the diagnosis of neurodevelopmental disorders. The study suggests that prenatal anemia may play a significant role in the development of these conditions.
Researchers at Johns Hopkins Medicine developed a new mouse model that mimics the effects of red blood cell transfusions on human infants with necrotizing enterocolitis (NEC). The study found that severe anemia increases the risk of NEC after transfusion, and that free hemoglobin can trigger an immune response in the intestine.
Researchers discovered that stem cells with Fanconi anemia tend to use aerobic energy production, leading to diverse symptoms. A specific signaling pathway may be crucial to treating the disease, and a drug inhibiting this pathway is being explored as a potential treatment option.
A daily dose of buprenorphine-naloxone is cost-effective compared to monthly injections of extended-release naltrexone, with similar effectiveness in quality of life and time abstaining from opioids. The researchers conclude that buprenorphine-naloxone should be preferred as the first-line treatment for opioid use disorder.
A new smartphone app uses fingernail photos to detect anemia with high accuracy, offering a non-invasive alternative to traditional blood tests. The app was developed by a biomedical engineer who lives with beta-thalassemia and aims to facilitate self-management for patients with chronic anemia.
Researchers have devised a novel method to block abnormal biological signals driving the rare and fatal disease Fanconi anemia. Inhibiting a regulatory protein called Sh2b3/Lnk restored bone marrow cell function and improved genome integrity in animal studies, providing hope for better treatments for children with the disease.
A recent study found that malnutrition and anemia prevalence among Rohingya children in a Bangladeshi refugee camp is alarming, exceeding emergency thresholds of 15% and 40%, respectively. The study highlights the urgent need for targeted nutrition support to address this critical public health issue.
Treating women subsistence farmers with a cheap deworming medication improved their physical stamina for agriculture work and potentially increased food production. The study found that even low levels of hookworms caused significant benefits in fitness and exercise capacity.
A major international study found that pregnant women with severe anaemia are twice as likely to die during or shortly after pregnancy compared to those without the condition. The research suggests that prevention and treatment of maternal anaemia must remain a global public health priority.
Researchers have discovered that reduced ribosome quantity impairs GATA1 production in blood stem cells, leading to Diamond-Blackfan anemia. This finding supports gene therapy as a potential treatment approach.
Researchers at UVA School of Medicine have discovered a 'complicated symphony' controlling the production of oxygen-carrying red blood cells, shedding light on iron-restricted anemias and potential new treatments. The study identified key proteins and mechanisms involved in the development of anemia.
A model plant study reveals a previously unknown pathway for genetic material exchange in germ cells, crucial for understanding Fanconi anemia disease. The study identifies the key protein FANCD2's important function in meiotic crossover formation.
A new electronic frailty index (eFI) tool helps GPs identify older people at risk of frailty and poor health outcomes. The eFI uses routine data from GP databases and has been shown to flag up patients who are living with mild, moderate, or severe frailty.
Researchers identified a new genetic syndrome caused by biallelic mutations in the FANCM gene, leading to early cancer formations and chemotherapy toxicity. Patients with this syndrome did not develop Fanconi anaemia, but had a higher risk of breast cancer and chromosomal fragility.
A study of 74 patients found that the rate of anemia increased from 20% pre-surgery to 47% 10 years after Roux-en-Y gastric bypass. Patients with regular bariatric specialist follow-up had lower rates of anemia compared to those without
Researchers recommend early blood testing for iron deficiency in young women, especially those who have been menstruating for over three years. The study found that iron deficiency without anemia is common among adolescent females and can be associated with lower standardized math scores and attention problems.
Researchers have discovered a new gene involved in Fanconi anaemia, a rare genetic disease affecting bone marrow and causing congenital defects. The RFWD3 gene was found to be related to DNA repair and mutations were detected in a child with the disorder.
A team of researchers has identified a new gene mutation associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure. The mutation in RFWD3 gene was found to disrupt DNA repair mechanisms, increasing cancer risk in individuals with the disease.
A new gene mutation, RFWD3, has been linked to defective DNA repair and Fanconi anemia, a rare genetic disorder. The mutation was found in a 12-year-old patient without known Fanconi anemia genes, and cells from the patient showed increased susceptibility to DNA damage.
A randomized study found that schools providing prevention education, insecticide-treated nets, and antimalarial treatment can dramatically cut malaria infection and reduce the risk of anemia among schoolchildren. The benefits lasted until the end of the school year.
A clinical trial comparing traditional ferrous sulfate with a new iron polysaccharide complex preparation found that traditional treatment is more effective in treating iron-deficiency anemia in young children. The study, published in JAMA, showed that a low-dose daily treatment can be effective in restoring normal hemoglobin levels wi...
A new study found that sanitation access is crucial for children's growth and health, with households having access to toilets or latrines seeing improved stunting, anemia, and diarrhea rates. Increasing community-level sanitation access can also have a significant impact on child health.
Researchers at Kyoto University identified a key gene that regulates iron uptake, revealing a functional defect in the duodenum and potentially leading to new treatment methods for anemia. The study found that Regnase-1 degrades iron-controlling genes, such as TfR1, which can help prevent debilitating disorders like hemochromatosis.
A new study found that hospital-acquired anemia affects nearly a third of hospitalized patients, increasing the risk of death or readmission. The severity of anemia was independently associated with a 39% increase in readmission or death within 30 days after discharge.
Researchers have discovered a small molecule called hinokitiol that can transport iron across cell membranes, potentially treating iron deficiency and overload. This breakthrough has significant therapeutic potential for addressing various iron-related disorders.
Researchers discovered Hinokitiol's ability to transport iron across cell membranes, correcting anemia caused by genetic deficiencies. The compound also promotes iron gut absorption and hemoglobin creation, suggesting its potential for treating human diseases.
A retrospective analysis of patients with babesiosis found six cases of warm-antibody autoimmune hemolytic anemia (WAHA) after treatment. Asplenic patients are at higher risk for this complication, which can be life-threatening and requires immunosuppressive treatment.
Researchers at Lund University successfully reprogrammed old blood stem cells to function like those of younger individuals, revealing a potential new approach to treating age-related diseases. This breakthrough suggests that epigenetic changes, rather than DNA mutations, underlie the decline in blood cell function with age.
Researchers found that a specific mutation in hemoglobin makes it selectively bind to carbon monoxide from cigarette smoke, preventing oxidation and anemia. The father's smoking habit prevents him from developing the disease, while his daughter requires treatment with antioxidants to manage her condition.
Researchers at Duke University developed iron-fortified nutrition bars that effectively combat anemia in Indian women, offering a practical and well-tolerated solution. The study involved 179 participants who received the supplement bar for 90 days, resulting in increased hemoglobin and hematocrit levels.
A randomized clinical trial found that delayed umbilical cord clamping reduced anemia prevalence in infants at 8 and 12 months of age. The intervention, which involved waiting three or more minutes after birth, increased iron stores and improved hemoglobin levels.
A new study from Uppsala University found that delaying umbilical cord clamping by more than three minutes can prevent iron deficiency and anemia in infants up to six months of age. This method resulted in a nine percent reduction in anaemia incidence at eight months and an eight percent decrease at twelve months.
A team of researchers has established a molecular link between Fanconi anemia and the PTEN gene, strongly associated with uterine, prostate, and brain cancer. The discovery improves understanding of Fanconi anemia and could lead to improved treatment outcomes for some cancer patients.
A study found that nearly one-fourth of ulcerative colitis patients with iron deficiency anemia were untreated, despite being diagnosed. Testing rates varied by region, with lower rates for the Midwest and South.
Researchers at Oregon Health & Science University have received a $9.9 million grant to investigate new treatments for Fanconi anemia, a devastating genetic disease affecting children. The five-year study aims to identify viable drug compounds and eventually lead to human clinical trials.
Researchers found that anemia was present in about a quarter of patients with stroke upon admission, associated with a higher risk of death for up to one year following either ischemic or hemorrhagic stroke. Elevated hemoglobin levels were also linked to poorer outcomes and a higher risk of death.
Researchers have found that anemia can negatively impact patients with traumatic brain injuries, leading to poorer outcomes. For each increase in hemoglobin levels, the likelihood of a good outcome increased by 33 percent.
A study published in JAMA found that severe anemia is associated with a significantly increased risk of necrotizing enterocolitis (NEC) in premature infants. The researchers discovered this link after analyzing data from over 600 VLBW infants enrolled in the study.
A recent study found that severe anemia is a significant risk factor for necrotizing enterocolitis in VLBW infants, while red blood cell transfusion was not significantly related to the development of NEC. This suggests that preventing severe anemia may be more important than minimizing RBC transfusion exposure as a strategy to decreas...
A study of US patients on dialysis from 2005 to 2012 found declining ESA use and hemoglobin concentrations, resulting in increased transfusions. However, rates of death and cardiovascular events decreased during this period, suggesting a possible beneficial effect of recent trends in anemia drug use.
Researchers at CNIO have developed a gene therapy to repair telomeres, delaying ageing and potentially treating aplastic anaemia. The treatment uses virus-delivered telomerase enzyme to extend telomeres, increasing blood cell production.
Researchers found that most cases of severe brain damage in newborns occur after birth, despite proper resuscitation. Infections and anemia before birth do not cause the damage, but rather trigger devastating outcomes that can be prevented with timely medical attention.
Researchers have identified a molecular target for DNA repair defects behind Fanconi anemia, a complex genetic disorder responsible for birth anomalies, organ damage, anemia, and cancer. The study reveals a potential therapeutic strategy and raises important questions about a compensatory DNA repair process.
An international team of researchers has established the cause of rare Fanconi Anemia: a de novo mutation in the RAD51 gene. The mutation leads to chromosome instability, bone marrow failure, leukemia, and solid tumors, resulting in a significantly reduced life expectancy.
A randomized clinical trial found that vitamin D2 supplements did not reduce the need for anemia drugs in dialysis patients. The study, published in the Journal of the American Society of Nephrology, suggests that nutritional vitamin D may have no role in treating anemia in patients with chronic kidney disease or kidney failure.
A new study reveals that hepcidin, a protein regulating iron absorption, can inhibit the body's ability to absorb iron supplements in quantities necessary and desirable. The researchers suggest waiting longer between doses may improve iron absorption efficiency and reduce side effects.