Articles tagged with Anemia
Women with anemia are at high risk of postpartum hemorrhage and other complications after cesarean delivery. Early screening for iron deficiency can help prevent these issues by prescribing oral iron supplements or IV therapy as needed, potentially reducing blood transfusions.
Research at Karolinska Institutet found a correlation between early maternal anemia and increased risk of autism, ADHD, and intellectual disability in children. An estimated 15-20% of pregnant women worldwide suffer from iron deficiency anemia.
A Swedish study examining 500,000 children found a strong association between maternal anemia during pregnancy and the diagnosis of neurodevelopmental disorders. The study suggests that prenatal anemia may play a significant role in the development of these conditions.
Researchers at Johns Hopkins Medicine developed a new mouse model that mimics the effects of red blood cell transfusions on human infants with necrotizing enterocolitis (NEC). The study found that severe anemia increases the risk of NEC after transfusion, and that free hemoglobin can trigger an immune response in the intestine.
Researchers discovered that stem cells with Fanconi anemia tend to use aerobic energy production, leading to diverse symptoms. A specific signaling pathway may be crucial to treating the disease, and a drug inhibiting this pathway is being explored as a potential treatment option.
A daily dose of buprenorphine-naloxone is cost-effective compared to monthly injections of extended-release naltrexone, with similar effectiveness in quality of life and time abstaining from opioids. The researchers conclude that buprenorphine-naloxone should be preferred as the first-line treatment for opioid use disorder.
A new smartphone app uses fingernail photos to detect anemia with high accuracy, offering a non-invasive alternative to traditional blood tests. The app was developed by a biomedical engineer who lives with beta-thalassemia and aims to facilitate self-management for patients with chronic anemia.
Researchers have devised a novel method to block abnormal biological signals driving the rare and fatal disease Fanconi anemia. Inhibiting a regulatory protein called Sh2b3/Lnk restored bone marrow cell function and improved genome integrity in animal studies, providing hope for better treatments for children with the disease.
A recent study found that malnutrition and anemia prevalence among Rohingya children in a Bangladeshi refugee camp is alarming, exceeding emergency thresholds of 15% and 40%, respectively. The study highlights the urgent need for targeted nutrition support to address this critical public health issue.
Treating women subsistence farmers with a cheap deworming medication improved their physical stamina for agriculture work and potentially increased food production. The study found that even low levels of hookworms caused significant benefits in fitness and exercise capacity.
A major international study found that pregnant women with severe anaemia are twice as likely to die during or shortly after pregnancy compared to those without the condition. The research suggests that prevention and treatment of maternal anaemia must remain a global public health priority.
Researchers have discovered that reduced ribosome quantity impairs GATA1 production in blood stem cells, leading to Diamond-Blackfan anemia. This finding supports gene therapy as a potential treatment approach.
Researchers at UVA School of Medicine have discovered a 'complicated symphony' controlling the production of oxygen-carrying red blood cells, shedding light on iron-restricted anemias and potential new treatments. The study identified key proteins and mechanisms involved in the development of anemia.
A model plant study reveals a previously unknown pathway for genetic material exchange in germ cells, crucial for understanding Fanconi anemia disease. The study identifies the key protein FANCD2's important function in meiotic crossover formation.
A new electronic frailty index (eFI) tool helps GPs identify older people at risk of frailty and poor health outcomes. The eFI uses routine data from GP databases and has been shown to flag up patients who are living with mild, moderate, or severe frailty.
Researchers identified a new genetic syndrome caused by biallelic mutations in the FANCM gene, leading to early cancer formations and chemotherapy toxicity. Patients with this syndrome did not develop Fanconi anaemia, but had a higher risk of breast cancer and chromosomal fragility.
A study of 74 patients found that the rate of anemia increased from 20% pre-surgery to 47% 10 years after Roux-en-Y gastric bypass. Patients with regular bariatric specialist follow-up had lower rates of anemia compared to those without
Researchers have discovered a new gene involved in Fanconi anaemia, a rare genetic disease affecting bone marrow and causing congenital defects. The RFWD3 gene was found to be related to DNA repair and mutations were detected in a child with the disorder.
Researchers recommend early blood testing for iron deficiency in young women, especially those who have been menstruating for over three years. The study found that iron deficiency without anemia is common among adolescent females and can be associated with lower standardized math scores and attention problems.
A team of researchers has identified a new gene mutation associated with Fanconi anemia, a rare genetic disorder characterized by bone marrow failure. The mutation in RFWD3 gene was found to disrupt DNA repair mechanisms, increasing cancer risk in individuals with the disease.
A new gene mutation, RFWD3, has been linked to defective DNA repair and Fanconi anemia, a rare genetic disorder. The mutation was found in a 12-year-old patient without known Fanconi anemia genes, and cells from the patient showed increased susceptibility to DNA damage.
A randomized study found that schools providing prevention education, insecticide-treated nets, and antimalarial treatment can dramatically cut malaria infection and reduce the risk of anemia among schoolchildren. The benefits lasted until the end of the school year.
A clinical trial comparing traditional ferrous sulfate with a new iron polysaccharide complex preparation found that traditional treatment is more effective in treating iron-deficiency anemia in young children. The study, published in JAMA, showed that a low-dose daily treatment can be effective in restoring normal hemoglobin levels wi...
A new study found that sanitation access is crucial for children's growth and health, with households having access to toilets or latrines seeing improved stunting, anemia, and diarrhea rates. Increasing community-level sanitation access can also have a significant impact on child health.
Researchers at Kyoto University identified a key gene that regulates iron uptake, revealing a functional defect in the duodenum and potentially leading to new treatment methods for anemia. The study found that Regnase-1 degrades iron-controlling genes, such as TfR1, which can help prevent debilitating disorders like hemochromatosis.
A new study found that hospital-acquired anemia affects nearly a third of hospitalized patients, increasing the risk of death or readmission. The severity of anemia was independently associated with a 39% increase in readmission or death within 30 days after discharge.
Researchers have discovered a small molecule called hinokitiol that can transport iron across cell membranes, potentially treating iron deficiency and overload. This breakthrough has significant therapeutic potential for addressing various iron-related disorders.
Researchers discovered Hinokitiol's ability to transport iron across cell membranes, correcting anemia caused by genetic deficiencies. The compound also promotes iron gut absorption and hemoglobin creation, suggesting its potential for treating human diseases.
A retrospective analysis of patients with babesiosis found six cases of warm-antibody autoimmune hemolytic anemia (WAHA) after treatment. Asplenic patients are at higher risk for this complication, which can be life-threatening and requires immunosuppressive treatment.
Researchers at Lund University successfully reprogrammed old blood stem cells to function like those of younger individuals, revealing a potential new approach to treating age-related diseases. This breakthrough suggests that epigenetic changes, rather than DNA mutations, underlie the decline in blood cell function with age.
Researchers found that a specific mutation in hemoglobin makes it selectively bind to carbon monoxide from cigarette smoke, preventing oxidation and anemia. The father's smoking habit prevents him from developing the disease, while his daughter requires treatment with antioxidants to manage her condition.
Researchers at Duke University developed iron-fortified nutrition bars that effectively combat anemia in Indian women, offering a practical and well-tolerated solution. The study involved 179 participants who received the supplement bar for 90 days, resulting in increased hemoglobin and hematocrit levels.
A new study from Uppsala University found that delaying umbilical cord clamping by more than three minutes can prevent iron deficiency and anemia in infants up to six months of age. This method resulted in a nine percent reduction in anaemia incidence at eight months and an eight percent decrease at twelve months.
A randomized clinical trial found that delayed umbilical cord clamping reduced anemia prevalence in infants at 8 and 12 months of age. The intervention, which involved waiting three or more minutes after birth, increased iron stores and improved hemoglobin levels.
A team of researchers has established a molecular link between Fanconi anemia and the PTEN gene, strongly associated with uterine, prostate, and brain cancer. The discovery improves understanding of Fanconi anemia and could lead to improved treatment outcomes for some cancer patients.
A study found that nearly one-fourth of ulcerative colitis patients with iron deficiency anemia were untreated, despite being diagnosed. Testing rates varied by region, with lower rates for the Midwest and South.
Researchers at Oregon Health & Science University have received a $9.9 million grant to investigate new treatments for Fanconi anemia, a devastating genetic disease affecting children. The five-year study aims to identify viable drug compounds and eventually lead to human clinical trials.
Researchers found that anemia was present in about a quarter of patients with stroke upon admission, associated with a higher risk of death for up to one year following either ischemic or hemorrhagic stroke. Elevated hemoglobin levels were also linked to poorer outcomes and a higher risk of death.
Researchers have found that anemia can negatively impact patients with traumatic brain injuries, leading to poorer outcomes. For each increase in hemoglobin levels, the likelihood of a good outcome increased by 33 percent.
A recent study found that severe anemia is a significant risk factor for necrotizing enterocolitis in VLBW infants, while red blood cell transfusion was not significantly related to the development of NEC. This suggests that preventing severe anemia may be more important than minimizing RBC transfusion exposure as a strategy to decreas...
A study published in JAMA found that severe anemia is associated with a significantly increased risk of necrotizing enterocolitis (NEC) in premature infants. The researchers discovered this link after analyzing data from over 600 VLBW infants enrolled in the study.
A study of US patients on dialysis from 2005 to 2012 found declining ESA use and hemoglobin concentrations, resulting in increased transfusions. However, rates of death and cardiovascular events decreased during this period, suggesting a possible beneficial effect of recent trends in anemia drug use.
Researchers at CNIO have developed a gene therapy to repair telomeres, delaying ageing and potentially treating aplastic anaemia. The treatment uses virus-delivered telomerase enzyme to extend telomeres, increasing blood cell production.
Researchers found that most cases of severe brain damage in newborns occur after birth, despite proper resuscitation. Infections and anemia before birth do not cause the damage, but rather trigger devastating outcomes that can be prevented with timely medical attention.
Researchers have identified a molecular target for DNA repair defects behind Fanconi anemia, a complex genetic disorder responsible for birth anomalies, organ damage, anemia, and cancer. The study reveals a potential therapeutic strategy and raises important questions about a compensatory DNA repair process.
An international team of researchers has established the cause of rare Fanconi Anemia: a de novo mutation in the RAD51 gene. The mutation leads to chromosome instability, bone marrow failure, leukemia, and solid tumors, resulting in a significantly reduced life expectancy.
A randomized clinical trial found that vitamin D2 supplements did not reduce the need for anemia drugs in dialysis patients. The study, published in the Journal of the American Society of Nephrology, suggests that nutritional vitamin D may have no role in treating anemia in patients with chronic kidney disease or kidney failure.
A new study reveals that hepcidin, a protein regulating iron absorption, can inhibit the body's ability to absorb iron supplements in quantities necessary and desirable. The researchers suggest waiting longer between doses may improve iron absorption efficiency and reduce side effects.
Scientists at UVA Health System find a way to prompt red blood cell production through dendritic cells, which could benefit people with diabetes, kidney disease, and cancer. The approach may one day allow doctors to produce red blood cells on demand, benefiting those who cannot receive blood transfusions due to religious beliefs.
A new class of oral medications, HIF-PHIs, stimulates red blood cell production by mimicking a low-oxygen state. Promising results were achieved in phase 2 clinical trials, showing improved hemoglobin levels and reduced anemia in kidney disease patients.
Researchers have discovered a link between Diamond-Blackfan anaemia and increased cancer susceptibility, using a new animal model that recapitulates key characteristics of the disease. The study found that patients with DBA are predisposed to lymphomas and solid tumours due to mutations in the RPL11 protein.
A study led by University of Texas M. D. Anderson Cancer Center researchers identified EphB4 as a trigger for tumor growth via STAT3 protein regulation, linking cancer anemia treatment to tumor progression.
A study by Juan Méndez at CNIO sheds light on molecular mechanisms of ageing in blood stem cells, opening a new avenue for reducing their decline with age and potentially treating aplastic anaemia. Researchers managed to prevent embryonic lethality by increasing the levels of gene CHK1, showing less pronounced anaemia in mice.
A new review presents a patient-specific plan to predict blood loss and address it, highlighting the commonality of anemia in surgical practice. The approach relies on detecting and treating anemia before surgery, reducing blood loss during surgery, and optimizing management after surgery.
Researchers identified two new genes, RAD51 and UBE2T, linked to Fanconi anemia, a rare genetic disorder. The study sheds light on the critical DNA repair pathway and its role in preventing cancer, maintaining tissues, and fertility.
Researchers have identified specific genetic mutations in patients with aplastic anemia that can help doctors optimize treatment. The study, which analyzed over 400 patient genomes, found that certain mutations are associated with poorer long-term outcomes and increased risk of blood cancers.
A systematic review highlights how anaemia can distort the regular method of diabetes diagnosis and lead to false diagnoses based on glycated haemoglobin (HbA1c). The study found that iron deficiency and anaemia can increase HbA1c values without corresponding rises in blood glucose, making diabetes diagnosis unreliable.
Researchers have identified a cell receptor that, when stimulated by a cholesterol-lowering drug, increases red blood cell production in patients with treatment-resistant anemias like DBA. The combination of low amounts of glucocorticoids and the repurposed anti-cholesterol drug shows promising results in clinical trials.
The US Preventive Services Task Force has updated its recommendations on iron supplementation and screening in pregnant women, finding that routine iron supplementation during pregnancy may reduce the incidence of iron deficiency and anemia. In contrast, new hepatitis C treatments show promise but may exceed insurers' willingness to pa...
Pazopanib, a cancer drug, shows promise in reducing bleeding and small AVMs in patients with hereditary hemorrhagic telangiectasia (HHT), a rare genetic disorder. The study aims to assess the efficacy of pazopanib in improving symptoms and quality of life for HHT patients.