Articles tagged with Anemia
Scientists at UVA Health System find a way to prompt red blood cell production through dendritic cells, which could benefit people with diabetes, kidney disease, and cancer. The approach may one day allow doctors to produce red blood cells on demand, benefiting those who cannot receive blood transfusions due to religious beliefs.
A new class of oral medications, HIF-PHIs, stimulates red blood cell production by mimicking a low-oxygen state. Promising results were achieved in phase 2 clinical trials, showing improved hemoglobin levels and reduced anemia in kidney disease patients.
Researchers have discovered a link between Diamond-Blackfan anaemia and increased cancer susceptibility, using a new animal model that recapitulates key characteristics of the disease. The study found that patients with DBA are predisposed to lymphomas and solid tumours due to mutations in the RPL11 protein.
A study led by University of Texas M. D. Anderson Cancer Center researchers identified EphB4 as a trigger for tumor growth via STAT3 protein regulation, linking cancer anemia treatment to tumor progression.
A study by Juan Méndez at CNIO sheds light on molecular mechanisms of ageing in blood stem cells, opening a new avenue for reducing their decline with age and potentially treating aplastic anaemia. Researchers managed to prevent embryonic lethality by increasing the levels of gene CHK1, showing less pronounced anaemia in mice.
A new review presents a patient-specific plan to predict blood loss and address it, highlighting the commonality of anemia in surgical practice. The approach relies on detecting and treating anemia before surgery, reducing blood loss during surgery, and optimizing management after surgery.
Researchers identified two new genes, RAD51 and UBE2T, linked to Fanconi anemia, a rare genetic disorder. The study sheds light on the critical DNA repair pathway and its role in preventing cancer, maintaining tissues, and fertility.
Researchers have identified specific genetic mutations in patients with aplastic anemia that can help doctors optimize treatment. The study, which analyzed over 400 patient genomes, found that certain mutations are associated with poorer long-term outcomes and increased risk of blood cancers.
A systematic review highlights how anaemia can distort the regular method of diabetes diagnosis and lead to false diagnoses based on glycated haemoglobin (HbA1c). The study found that iron deficiency and anaemia can increase HbA1c values without corresponding rises in blood glucose, making diabetes diagnosis unreliable.
Researchers have identified a cell receptor that, when stimulated by a cholesterol-lowering drug, increases red blood cell production in patients with treatment-resistant anemias like DBA. The combination of low amounts of glucocorticoids and the repurposed anti-cholesterol drug shows promising results in clinical trials.
The US Preventive Services Task Force has updated its recommendations on iron supplementation and screening in pregnant women, finding that routine iron supplementation during pregnancy may reduce the incidence of iron deficiency and anemia. In contrast, new hepatitis C treatments show promise but may exceed insurers' willingness to pa...
Pazopanib, a cancer drug, shows promise in reducing bleeding and small AVMs in patients with hereditary hemorrhagic telangiectasia (HHT), a rare genetic disorder. The study aims to assess the efficacy of pazopanib in improving symptoms and quality of life for HHT patients.
A study found that patients who received a stem cell transplant from donors with longer leukocyte telomere length had higher overall survival rates compared to those with shorter lengths. The researchers also discovered no association between donor or recipient telomere length and post-transplant complications.
Scientists at EMBL and Heidelberg University Clinic have discovered a new way to starve pathogens of iron, using the immune system's TLR2 and TLR6 molecules. This finding offers an alternative approach to treatments for anaemia of chronic disease, which affects chronically ill patients.
A study found that recent policy changes did not create racial disparities in the management of anemia and mineral metabolism among dialysis patients. The analysis of 7384 patients at 132 facilities showed similar trends in laboratory measures and management practices for different races.
Researchers at UT Southwestern Medical Center discovered that acetate supplements stimulate the formation of new red blood cells in mice with anemia. This could lead to alternative treatments for anemia, potentially reducing side effects associated with current therapies.
An experimental drug has demonstrated potential as a first treatment for anemia of inflammation, regulating blood's iron supply and maintaining its transport. The treatment, lexaptepid pegol, inactivates hepcidin hormone production, improving iron levels without interfering with the immune response.
A study of 158 pregnant teenagers found nearly half engaged in pica behaviors, such as consuming ice and starches, which are also associated with lower iron levels. This can lead to anemia, premature births, and low birth weights, posing a significant risk to infant mortality rates.
A new trial in Bangladesh aims to assess the effect of lactoferrin on treating iron deficiency anemia in pregnancy. If successful, it could lead to cost-efficient improvements in global newborn health and development.
Researchers used SWI to evaluate signal strength in different brain regions after acute hemorrhagic anemia. The study found lower SWI signals in the frontal cortex, temporal lobe, and thalamus after bloodletting procedures compared to pre-bleed values.
A 6200-year-old schistosomiasis parasite egg discovered in Syria's Tell Zeidan grave suggests ancient agricultural irrigation systems may have spread the disease. The find, dating back a thousand years earlier than previous discoveries, highlights how human technology can exacerbate disease burdens.
A study published in Acta Obstetricia et Gynecologica Scandinavica found that iron supplements improved energy, physical function, and social function in women with heavy menstrual bleeding. After one year of treatment, anemic women showed significant increases in these areas compared to non-anemic women.
A team of scientists reveals that a specific protein recognizes and repairs DNA crosslinks using the Fanconi anemia signal pathway. The study sheds light on the complex process of repairing damaged DNA, which can trigger cancer development. This new knowledge may lead to improved drugs for cancer treatment.
A new study found that the more red blood cells patients receive through transfusions, the higher their risk of developing infections. Elderly patients undergoing hip or knee surgeries were most susceptible, with a 30% lower risk of infection when fewer transfusions were used.
Researchers identify rare anemia syndrome Pearson Syndrome in patients with congenital anemia, emphasizing the importance of correct diagnosis and treatment. The condition has a different disease course and requires tailored treatment approach.
A new report illustrates a surprisingly large global burden of anemia, characterized by low hemoglobin levels and impaired oxygen delivery to the body. Despite decreasing prevalence between 1990 and 2010, anemia remains a significant health issue, particularly among young children and women in low- and middle-income regions.
The American College of Physicians recommends restricting red blood cell transfusions to severe anemia cases in patients with heart disease. ACP also advises against using erythropoiesis-stimulating agents in mild to moderate anemia with heart conditions due to increased risks of thromboembolic events and stroke rates.
Researchers debunk the notion that hepcidin spikes cause exercise-induced anemia, highlighting the need to understand what causes anemia to prevent it. The study provides insight into high hepcidin levels in non-exercisers with long-term anemia.
Researchers at Intermountain Medical Center Heart Institute discovered a link between high RDW levels and increased risk of depression in heart patients. Elevated RDW is associated with poor outcomes, including heart attacks and death, and may indicate anemia or other underlying conditions.
A Hopkins-led study finds that low vitamin D levels are associated with an increased risk of anemia in children. The research, which analyzed blood samples from over 10,400 kids, suggests that vitamin D's effects on red blood cell production and immune inflammation may play a role in the link between the two conditions.
Researchers found that a combination of anemia and high altitude increases the risk of poor outcomes, including persistent pneumonia and secondary infections, in children with pneumonia. The study analyzed data from 958 children and found that this combination causes a fourfold increase in treatment failure risk.
A study found that iron supplementation among children in a malaria-endemic area did not increase the incidence of malaria. However, hospital admission rates were higher in the iron group compared to the no-iron group.
A study published by the American Academy of Neurology found that anemia is associated with a nearly 41% higher risk of developing dementia. People with anemia at the start of the study were more likely to develop dementia over 11 years.
A study of over 90 studies found that daily iron intake during pregnancy increases average haemoglobin levels and reduces the risk of anaemia. Birth weight is also improved, but no reduction in preterm birth risk was observed.
A new protocol using single, high-dose erythropoietin administered two days prior to surgery reduces transfusion requirements by one-third and improves patient outcomes.
A team of researchers has identified a gene that can cause three distinct diseases: Fanconi anaemia, xeroderma pigmentosum, and progeria. The ERCC4 gene plays a crucial role in DNA repair mechanisms, highlighting the importance of understanding its function in preventing cancer.
A recent international study published in The New England Journal of Medicine found that darbepoetin alfa, a commonly used anemia drug for heart failure patients, does not reduce the risk of death or hospitalization. The treatment only increased hemoglobin levels but did not provide any significant clinical benefits.
A Phase 3 clinical trial by Cleveland Clinic and Sahlgrenska University Hospital found that darbepoetin alfa does not reduce the risk of death from any cause or hospitalization for worsening heart failure in anemic patients. Despite increasing hemoglobin levels, treatment did not provide improved health outcomes.
Researchers identified a genetic mutation that alters the kinetics of an ion channel in red blood cells, leading to anemia. The defect causes the channel to stay open too long, causing an ion leak and affecting the cell's volume regulation.
A global study found that children on dialysis with poor response to anemia medications are linked to inflammation, fluid retention, and hyperparathyroidism. High doses of anemia medications also increase the risk of premature death. The study provided valuable insights into anemia control in pediatric patients.
A study published in the Canadian Journal of Anesthesia found that hospitals treating patients with anemia before surgery had better outcomes, including reduced blood transfusions, infections, and shorter hospital stays. Early diagnosis and treatment of anemia are crucial to avoid unnecessary transfusions and improve patient care.
The study reveals that musculoskeletal and mental behavioral disorders are the leading causes of disability worldwide. Lower back pain, depression, iron-deficiency anaemia, and neck pain were found to be among the top sequelae responsible for the greatest overall health loss in both 1990 and 2010.
Scientists at the University of Georgia and Harvard Medical School have discovered a new gene that regulates heme synthesis in red blood cell formation. The study found that a deficiency in this gene leads to severe anemia, which promises to advance our understanding and treatment of human anemias and mitochondrial diseases.
A 1.5-million-year-old skull fragment from Tanzania shows signs of anemia caused by a nutritional deficiency, suggesting regular meat consumption in early hominids was common. The discovery supports the idea that early human ancestors were hunters and had a physiology adapted to regular meat consumption.
Researchers explored the effectiveness of resveratrol in preventing head and neck cancer in Fanconi anemia patients, a rare genetic disorder affecting DNA repair. The study found that resveratrol may eliminate cancer cells in these patients by making them sensitive to certain drugs.
A CNIO team has created a transgenic mouse model that simulates aplastic anaemia in humans. The model shows the link between telomere impairment and bone marrow failure.
Johns Hopkins undergraduates create HemoGlobe device to noninvasively detect and report anemia, using existing cell phones to estimate hemoglobin levels; the device aims to reduce anemia-related deaths in developing countries.
A new clinical study by the National Heart, Lung, and Blood Institute found that eltrombopag improved blood cell production in 11 out of 25 participants with severe aplastic anemia. The drug was well-tolerated, with few side effects, and six patients showed significant improvements in all three types of blood cells.
Researchers have identified FANCM's crucial role in recombination during genetic inheritance. The gene ensures ordered distribution and recombination of genetic material in germ cells of thale cress, a model organism.
Research reveals severe anemia in stroke patients can lead to a higher risk of death, with patients experiencing increased mortality rates after six to twelve months. Anemia is measured by hematocrit levels, and moderate to mild cases also show elevated mortality risks.
A study found that treating anemia in kidney transplant recipients slows the progression of kidney failure and improves survival of transplanted kidneys. Completely correcting anemia resulted in fewer patients developing kidney failure and more functional transplanted kidneys.
A University of Maryland study found that restricting blood transfusions after hip surgery did not harm patients and may even be unnecessary for some. The research included over 2,000 patients with anemia after hip fracture and showed no significant difference in recovery rates between those who received moderate transfusions and those...
A study by UC Berkeley researchers found that bushmeat consumption had a positive effect on children's nutrition, raising concerns about the impact of conservation efforts on local communities. The study estimated that a loss of access to wildlife as a food source would lead to a 29% increase in child anemia.
Researchers suggest that transfusion may not be the best treatment for hospitalized patients with anemia, as the age of stored blood may contribute to negative effects. Studies found that transfusions do not always restore levels of sphingosine 1-phosphate (S1P), a lipid mediator required for maintaining blood vessel integrity.
Researchers analyzed SEC23B gene mutations in CDA II patients and found that two variants, R14W and E109K, are more common in Italian population. The R14W variant is believed to have originated 3,000 years ago in Southern Italy, while E109K may have originated in the Middle East around 2,400 years ago.
Patients with anaemia undergoing non-cardiac surgery face a 42% increased risk of death and 35% higher risk of serious comorbidities compared to those without anaemia. Mild to severe anaemia also increases postoperative morbidity risks. Preoperative treatment of anaemia is recommended.
Researchers at St. Michael's Hospital have identified a new mechanism that may protect against organ injury and death from anemia. This discovery could lead to new treatments and approaches for patients with anemia.
A Cochrane Systematic Review found that micronutrient powders can reduce anaemia and iron deficiency in infants aged six to 23 months, particularly in Asia, Africa, and the Caribbean. The intervention resulted in a 31% reduction in anaemia risk and a 51% reduction in iron deficiency risk.
A recent NIH study found that ATGAM significantly improved blood cell counts and survival rates for patients with severe aplastic anemia compared to Thymoglobulin. The study enrolled 120 patients and showed improved outcomes after six months, with 96% of ATGAM patients surviving after three years.
Researchers mapped anemia risk in preschool-age children in Burkina Faso, Ghana, and Mali using national cross-sectional surveys. The maps indicate the geographical risk profile of anemia, allowing for targeted control measures such as nutrient supplements and fortified foods.