Articles tagged with Bacterial Infections
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Researchers found that mice with healthy gut microbiomes were less sick and less likely to spread infection. Introducing certain bacteria or chemical compounds improved immune responses and reduced virus levels.
The Vav3 protein creates bacterial docking stations on airways' surface, facilitating recurrent infections in cystic fibrosis. Inhibiting this protein may prevent respiratory complications by limiting bacterial adhesion.
A study by VIDO-InterVac researchers discovered that a Salmonella biofilm protein can cause autoimmune responses and arthritis in animals. Similar amyloid proteins have been associated with neurodegenerative diseases like Alzheimer's, Parkinson's, and ALS.
Researchers found that curli amyloid produced by Salmonella bacteria triggers autoimmune reactions in mice, leading to reactive arthritis. The study suggests that curli proteins may play a role in other autoimmune diseases and neurodegenerative processes.
Researchers have developed a novel approach to prevent and treat chronic and recurrent bacterial diseases caused by biofilms. The technology targets the DNABII family of DNA-binding proteins, which are common to all biofilms and disrupts them.
A new software program can identify drug-resistant genes in bacteria with up to 90% accuracy. The WSU research team developed a machine-learning algorithm that uses features of AMR proteins to identify AMR genes, providing a more efficient way to predict antimicrobial resistance.
Researchers discovered that uromodulin forms long filaments that envelop pathogens, neutralizing them and preventing infection. The findings offer pointers for developing new treatments and drugs to prevent urinary tract infections without antibiotics.
Researchers used cryo-electron tomography to reveal the molecular architecture of Uromodulin filaments, which form a fishbone-like structure that traps bacteria. The findings provide insights into Umod's role in protecting against urinary tract infections and its other physiological functions.
A new study from Tokyo Medical and Dental University identified CD86 as a novel cell surface marker that enables accurate analysis of hematopoietic responses to biological stress. The researchers found that CD86-based analysis can detect early activation phases of erythropoiesis in the bone marrow within hours after toxin injection.
Researchers from Massachusetts General Hospital found that hospitalized patients with a documented penicillin allergy were twice as likely to be prescribed alternative antibiotics. The study suggests that these substitutions may be unnecessary and could increase the risk of adverse side effects and antibiotic resistance.
Researchers at NYU Langone Health have developed a new vaccination strategy that targets the toxic molecules released by Staphylococcal bacteria, including MRSA, to prevent deadly infections. In a study published in the Journal of Experimental Medicine, mice vaccinated with this experimental vaccine demonstrated an immune response and ...
A new UK study found that faecal microbial transplantation (FMT) is more effective than antibiotics in treating Clostridium difficile infection, with higher cure rates and lower recurrence rates. FMT was also shown to be significantly more cost-effective, reducing hospitalization days and offering better quality of life for patients.
Researchers have found that CD47, a natural brake on the immune system, can be turned off to help fight infections. By blocking CD47-mediated signaling, scientists may develop a new immunotherapy to treat a wide range of infectious diseases.
A recent study found that certain genes are associated with the pathogens that infect chronic wounds and hinder the healing process. The research showed that patients with more diverse wound microbiomes healed faster.
The University of Queensland's antibiotic discoveries will be fast-tracked under a US$11 million international research deal. The funding supports the development of a new antibiotic, Octapeptin-X, targeting drug-resistant bacteria that evade current therapies.
Biosurfactant from yeast dissolves Pseudomonas aeruginosa biofilms, weakening interaction between biofilm and surface and breaking internal cohesiveness, leading to disruption. Combination with chemical surfactants demonstrates stronger antibiofilm effects at lower concentrations.
A recent study published in Global Change Biology found that infectious disease-induced mass mortality events occur in 14% of marine mammal species, with viruses causing 72% of these events. Habitat breadth was also a key factor, with pinnipeds being overrepresented among affected species.
Researchers analyzed bacterial RNA and protein expression patterns during plant-bacterial interactions, revealing the impact of plant immunity on bacterial mRNAs and proteins. The study identified previously unknown transcriptional regulators controlling bacterial gene expression and virulence.
Researchers from Radboud University Medical Center found that norepinephrine suppresses the function of white blood cells, impairing the body's ability to combat infections. The study suggests that alternative antihypotensive agents like vasopressin may be more effective in sepsis patients.
Research suggests serotonin can reduce the ability of certain intestinal pathogens to cause deadly infections by reducing gene expression and preventing bacterial colonization. The study found that mice overproducing serotonin were less likely to become infected with a deadly mouse gut bacterium.
The American Gastroenterological Association recommends against using probiotics to treat most digestive diseases due to a lack of strong evidence supporting their efficacy. However, certain probiotic formulations may benefit patients in specific situations, such as preventing Clostridioides difficile infection or managing pouchitis.
Scientists investigated how immune cells respond to Salmonella infection and found that cathepsins move to the nucleus of infected cells, leading to inflammatory programmed cell death. This discovery shows the benefit of monitoring protein dynamics during infection and unraveling new pathways to defend against pathogens.
Scientists at Kazan Federal University identify a unique post-translational modification in Staphylococcus aureus elongation factor P protein. This discovery provides a promising target for developing new antibiotics to combat nosocomial infections.
Researchers have developed a nanometric-scale theoretical model to create structures that kill bacteria by using elastic forces. The flexibility of these pillars is closely connected to their appearance, and varying the height of the pillars can determine their bactericidal efficacy.
A multicentre study involving over 500 patients found that a shorter treatment duration, reduced to half the standard 14-day course, was equally effective in treating bacteraemia. The researchers also identified certain risk factors, including older age and pathogen type, which can influence the effectiveness of antibiotic treatment.
Researchers at the University of Bern have discovered how Clostridium perfringens causes fatal intestinal bleeding in piglets. The toxin attaches to CD31, a key molecule on endothelial cells, leading to cell death and damage to blood vessels.
Researchers at Penn State created a brief animated video to educate people about the risks of antibiotics, finding it effective in convincing participants that antibiotic use can be risky. The study suggests that a video intervention could help increase public awareness and promote antibiotic stewardship.
Researchers created a new method to map metabolic pathways in microbes, unlocking routes for new vaccines and antimicrobials. The study reveals new insights into the metabolic function of M. agalactiae and M. pneumoniae, two common bacteria that infect livestock and humans respectively.
Researchers at University of Queensland are studying bacteria and fungi in sheep faeces and pastures to discover new natural antiparasitics. The goal is to prevent multi-drug resistance and safeguard livestock, with potential benefits for the environment and farming industry.
Researchers at Ohio State University found that e-cigarette users' mouths contain potent infection-causing organisms, similar to those found in people with periodontitis. The study suggests that vaping can lead to gum disease and cancer, even in healthy individuals who have not smoked. The findings challenge the claim that e-cigarettes...
Researchers have developed a novel nanoscale topography that imparts durable antiviral and antibacterial properties to an aluminum alloy, reducing the spread of infections in hospitals. The surface was found to be effective against bacteria and viruses, with most being inactivated within 2-3 hours.
The study found that a specific strain, Sm6, is widely distributed worldwide and carries key virulence genes and resistance genes. This suggests a possible mechanism for the spread of different S. maltophilia subtypes in hospital settings.
A natural product called dephostatin has been found to be an effective partner for the antibiotic colistin in treating infections caused by the bacteria Salmonella. The combination significantly prolonged animal survival and used a lower concentration of colistin, reducing its toxic effect.
Researchers found that LACTIN-V, a product containing healthy vaginal bacteria, significantly reduced the recurrence of bacterial vaginosis (BV) in women. The study also suggests that LACTIN-V may have the potential to prevent HIV infection and preterm birth.
The Department of Defense has awarded $10M to Sanford Burnham Prebys to develop broad-spectrum antivirals that can combat multiple respiratory viruses. The research aims to provide safe and effective therapies for U.S. military forces and the nation, reducing secondary infections and spread.
Researchers at Monash University have made a significant breakthrough in the development of new glycopeptide antibiotics, which could provide a vital advantage in the fight against resistant bacteria. By combining natural enzymes with synthetic chemistry, scientists can now explore new antibiotics that have never been made before.
UT Southwestern researchers discovered a novel mechanism by which Campylobacter jejuni bacteria sense and respond to butyrate, a beneficial fatty acid produced in the large intestine. This finding provides potential therapeutic targets for preventing C. jejuni-induced diarrhea.
Researchers developed a low-toxicity antimicrobial peptide that effectively fought drug-resistant bacteria in laboratory cell cultures and mice, offering hope for treating respiratory infections. The new peptide, D8, showed remarkable stability and activity against superbugs, posing less risk to human cells.
Researchers found fecal microbial transplantation reduced bloodstream infections and improved patient quality of life in chronically ill patients. FMT decolonized multi-drug resistant bacteria, allowing patients to undergo stem-cell transplants and return to work.
A new investigation at Flinders University seeks to understand why bacterial infections predispose individuals to severe COVID-19. The research aims to connect respiratory tract bacterial colonization with COVID-19 outcomes in the community.
A large population study found a significant association between blood infections with anaerobic bacteria and an increased risk of developing colorectal cancer. The study revealed that infections with specific bacteria, such as Clostridium septicum and Bacteroides ovatus, were linked to a substantial increased risk of CRC.
A study found the dangerous mcr-1 gene in two healthy humans and a pet dog in Portugal, providing resistance to colistin, an antibiotic of last resort. The presence of this gene in humans and animals raises concerns about potential transmission and the emergence of untreatable infections.
Researchers aim to understand COVID-19 infection rates and identify individuals with different immune responses. They plan to collect blood samples from residents and healthcare workers to analyze the impact of SARS-CoV-2 on the human body.
Researchers designed a new microfluidic device that uses magnetic nano-beads to isolate minute bacterial particles. The device improves the detection of drug-resistant strains and difficult-to-detect micro-particles such as Ebola and coronaviruses.
Rates of E. coli-related sepsis vary greatly between UK NHS regions and are linked to the presence of pathogenic E. coli types in sewage. The study found higher prevalence of E. coli B2 types in South Wales, which correlates with higher sepsis rates.
A recent study by European Society of Clinical Microbiology and Infectious Diseases found that paper towels significantly reduce virus contamination compared to hand dryers. The study simulated contaminated hands using paper towels and jet air dryers, finding that paper towels reduced viral dispersal to environmental surfaces by 5 times.
Researchers have developed an antibody treatment that improves survival in rodent models of sepsis by targeting a protein called tetranectin. The therapy boosts survival even when started late after sepsis onset, suggesting its potential for treating severe bacterial infections and secondary sepsis in COVID-19 patients.
Researchers identified bacterial exchange of genes allowing resistance to antibiotics, highlighting the complex process and potential for frequent sharing in hospital settings. The study's findings have implications for designing new strategies to prevent and control multidrug-resistant bacterial infections.
Cells in vulnerable entry routes to bacterial infection buffer themselves when immune system detects danger by reorganizing surface cholesterol. This defense mechanism, identified by UTSW researchers, could offer new strategies for fighting infections without antibiotics.
A study by Kevin Schneider and colleagues found that the bacterial strain Xylella fastidiosa subsp. pauca could have significant economic impacts on olive tree cultivation in Greece, Italy, and Spain. Replanting with resistant varieties or removing infected plants can mitigate these losses.
A recent study led by the Murdoch Children's Research Institute found that Fijians carrying a pneumonia-causing bacteria are more likely to be of iTaukei ethnicity, young, living in urban areas, or with low family income. The study also linked toddlers and children under six years old to a higher burden of pneumococcal bacteria.
The NHS could save up to £89 million annually by implementing widely available diagnostic tests, reducing unnecessary antibiotic prescriptions. The study found that 80-90% accurate point-of-care tests can help distinguish between bacterial and viral infections.
Researchers have developed a platelet-rich plasma lysate that, when teamed with antibiotics, can eradicate bacterial biofilms common in joint infections. The therapy has shown great results in horses and may also be applied to humans and dogs.
Researchers from University of Jyväskylä uncovered historical data on phage therapy's successful use against dysentery and staphylococcal infections in Brazil. The study sheds light on the revived interest in phage therapy as an alternative to antibiotics in the fight against antimicrobial resistance.
Researchers found that the abundance of Lactobacillus iners was associated with clearance of high-risk HPV infections, while Gardnerella bacteria were linked to progression to precancer. Monitoring Gardnerella and microbial diversity could help identify women at risk for pre-cancer.
Infections are responsible for one in five childhood deaths in England and Wales, with respiratory infections leading the way. The proportion of deaths caused by infections has declined, but not among infants and young children, who saw a significant increase in cases.
A new study published in Scientific Reports found that cannabidiol (CBD) enhances the effect of antibiotics against Staphylococcus aureus bacteria, a major human pathogen. The combination of CBD and antibiotics showed a more powerful effect than using antibiotics alone, reducing the need for antibiotics to achieve the same outcome.
Researchers at Chalmers University of Technology developed antibacterial surfaces using graphite nanoplatelets, reducing bacterial infections by 99.99% and preventing antibiotic resistance. The surfaces are designed to kill bacteria without damaging healthy human cells.
Engineers created a tiny device to rapidly detect harmful bacteria in blood, allowing for prompt diagnosis and treatment of potentially deadly infections. The device can capture up to 86% of target bacteria, including E. coli, making it ideal for laboratory and healthcare settings.
Researchers at the University of Bonn have deciphered daptomycin's mode of action, blocking cell wall construction and leading to bacterial death. The study sheds light on the antibiotic's mechanism, paving the way for optimization and combination therapies against antibiotic-resistant bacteria.