Research on infections caused by bacteria and how to fight them. Covers antibiotic resistance, biofilms, congenital syphilis, Lyme disease, and precise treatments.
Wildfire smoke aerosolizes bacteria and fungi from burning materials, potentially infecting people who breathe in the plumes. Researchers argue that public health sciences must expand their focus to include the impact of microbial cargo on human populations
A preclinical study by researchers from the Institute of Biomedicine of Seville found that a combination of imipenem and meropenem may be effective in treating infections caused by carbapenemase-producing A. baumannii. The study showed promise for treating severe infections, including pneumonia and bacteremias.
This atlas of S. pneumoniae and host gene expression provides a comprehensive understanding of the pathogen's adaptation to different body locations and the host's response. Certain bacterial genes are highly expressed across all anatomical sites, making them ideal targets for new treatments.
Researchers have created a comprehensive gene expression database to study pneumococcal infections. The database reveals that the bacteria behaves differently depending on the site of infection and the organs respond accordingly. This could lead to new treatments, such as anti-inflammatory therapies.
Researchers have developed an efficient method to study phage-microbe interactions, which can reveal bacterial receptors exploited by phages and cellular mechanisms used to respond to infection. The approach has implications for understanding microbiomes, developing new medicines and addressing antibiotic-resistant infections.
Researchers analyzed gut composition and DNA to identify key factors for successful fecal microbiota transplants, including the donor's microbiome and recipient's pre-transplant gut community structures. The study suggests that preparing donors' and patients' gut ecosystems prior to transplant may increase the likelihood of success.
The Society for Healthcare Epidemiology of America has updated clinical recommendations on evaluating symptoms to diagnose infections in nursing home residents. The guidance emphasizes that subtle non-specific signs and symptoms should not automatically prompt a work-up for infection.
A study published in eLife journal reveals that a specific strain of lung bacteria, Lactobacillus murinus, can inhibit the growth of pneumococcal pathogens and prevent colonization. The findings suggest that probiotics could be a potential treatment alternative to antibiotics for respiratory illnesses.
Researchers found that infection with Porphyromonas gingivalis causes skeletal muscle metabolic dysfunction, leading to insulin resistance and metabolic syndrome. The study also discovered a link between periodontal bacteria and altered gut microbiome, which contributes to the development of metabolic syndrome.
A study by Anglia Ruskin University found that COVID-19 can cause various eye symptoms, with 16% of respondents reporting sore eyes as a symptom. The researchers argue that sore eyes should replace conjunctivitis as a possible COVID-19 symptom due to its differentiation from other types of infections.
A recent study published by North Carolina State University researchers has identified a significant association between Bartonella infection and the development of neuropsychiatric symptoms, including depression, anxiety, and sleep disorders. The study also found that many patients with Bartonella infections exhibited skin lesions, wh...
A new technology uses light to manipulate various liquids, reducing the risk of infection and contamination in medical testing. The device has great potential in fields like DNA analysis, proteomics, and clinical diagnosis, with applications in COVID-19 research.
Researchers identified coral GSDME as a pyroptosis-inducing protein in reef-building corals, revealing its role in pathogen-induced coral death. Activation of coral GSDME triggers rapid cell swelling and cytoplasmic content release, leading to necrotic tissue damage.
Scientists have created a method to expand lipids in cell membranes, enabling the imaging of proteins and organelles with unprecedented resolution. This breakthrough allows for detailed insights into bacterial infection mechanisms and potential therapeutic targets.
Researchers have developed new compounds that kill bacteria responsible for diseases in rice, kiwi and citrus. The plant-inspired alkaloids work by increasing levels of reactive oxygen species in the bacteria, causing cell death.
A new study published in Scientific Reports confirms that common house spiders carry harmful bacteria and can transmit them through their fangs when biting. The study found that some of these bacteria are multi-drug resistant, making infections difficult to treat with regular medicine.
Researchers at Singapore-MIT Alliance for Research and Technology (SMART) have developed a method to produce customisable engineered lysins that can selectively kill specific bacteria while leaving others unharmed. This discovery presents a promising alternative to antibiotics for treating existing drug-resistant bacteria.
A new method for detecting bacteria and infections has been developed using fluorescent nanosensors. These sensors can track down pathogens faster and more easily than traditional methods, allowing for improved patient care and rapid diagnosis of sepsis.
Research reveals slow-moving bacteria can outcompete fast-moving counterparts due to efficient invasion strategies. The study uses genetics, experiments, and physics to understand the behavior of bacteria on an individual and collective level.
A Canadian team has developed an inexpensive molecule to fight antibiotic-resistant strains of Neisseria gonorrhoeae and N. meningitidis, two bacteria responsible for gonorrhea and meningococcal meningitis. The molecule's specificity allows it to target pathogenic Neisseria while leaving other types unaffected.
A new lung-on-chip model has provided insight into the body's response to early tuberculosis infection. The study revealed that alveolar epithelial cells play a crucial role in controlling bacterial growth by producing surfactant, which reduces surface tension and prevents uncontrolled bacterial growth.
Researchers found that slower-moving bacteria outcompete faster-moving cells in densely packed groups, allowing them to spread across surfaces. This discovery sheds light on how bacteria spread within the body during infections.
A team of researchers has unpacked the bacterium Francisella tularensis' toolbox, revealing the shapes and interactions of its infectious machinery. The insights point to a way in which the bacteria's unique infectious machinery might be blocked, potentially preventing it from infecting over 200 animal species.
Scientists have discovered how a common virus infects and takes over bacterial cells, enabling targeted manipulation of the gut microbiome. The crAssphage virus uses its own enzyme to produce RNA copies of its genes, similar to human enzymes involved in RNA interference.
Researchers found that PBT2 disrupts metals in polymyxin-resistant bacteria, resensitizing them to treatment and boosting survival rates in mice with sepsis. The compound may offer a solution to the growing threat of antibiotic resistance, which poses a grave danger to patients with bacterial infections.
Researchers have discovered that coinfection with cytomegalovirus and Aspergillus fumigatus triggers synergistic interactions between the two pathogens and human cells, leading to increased risk of complications.
Researchers have discovered that an experimental Alzheimer's disease treatment, PBT2, is effective at disrupting and killing antibiotic-resistant bacteria. The study shows that combining PBT2 with the antibiotic polymyxin successfully tackles superbugs like Klebsiella pneumoniae and Pseudomonas aeruginosa.
Researchers find that Staphylococcus aureus thrives in glucose-rich diabetic conditions, triggering virulent features and unchecked infection. Understanding this mechanism could lead to treatments targeting the bacteria's glucose hunger.
A single clinical laboratory test has been developed to detect any infection from any body fluid, without special handling or processing. The test employs powerful DNA-sequencing technology and relies on specially developed analytical software to compare DNA sequences in the sample to massive genomic databases.
Researchers repurpose an antirheumatic gold drug, auranofin (AUR), to revive the potency of 'last-resort' antibiotics against multi-drug resistant superbugs. The combination therapy shows promising results in eradicating multidrug-resistant bacteria in animal models.
Researchers at Temple University Health System found that bacterial biofilms in the urinary tract can trigger autoimmune reactions in lupus patients. The study identified a link between chronic bacterial infections and increased frequency of lupus flares, suggesting a potential new approach to controlling flare-ups.
Researchers at the Weizmann Institute of Science reveal retrons, hybrid structures found in many bacterial species, are 'guards' that prevent viruses from spreading. These retrons activate a programmed cell death mechanism to protect the bacterial colony.
A new study has uncovered DNA evidence of Bartonella quintana, the bacteria responsible for trench fever, in civilian remains dating back thousands of years. The discovery sheds light on the complex history of trench fever and provides insight into the lives of Christian citizens in Roman Syracuse.
Researchers are exploring three approaches using the Wolbachia bacterium to control the buffalo fly population and prevent its spread southwards. The methods include artificially infecting adult flies or pupae, releasing sterile males into overwintering areas, and blocking transmission of nematodes closely related to Stephanofilaria.
Researchers at Texas A&M AgriLife Communications have discovered that some phages can stop bacteria from sharing genes for antibiotic resistance by attaching to and disarming pili on bacterial surface. This discovery may lead to new treatments for infections, reducing the need for antibiotics or gentler alternatives.
A study found that hospital floors are quickly and frequently contaminated with antibiotic-resistant bacteria within hours of patient admission. The researchers observed a significant transfer of pathogens from the floor to patients' socks, bedding, and nearby surfaces, highlighting the need for improved infection control measures.
Scientists used CRISPR interference to study virulence genes in a mouse model of pneumonia, observing surprising variability in disease progression. The results point to several genes as having important roles in pneumococcal infections, including the bacterial capsule genes and the gene for pneumolysin.
Researchers examined Pseudomonas aeruginosa strains in cystic fibrosis patients, revealing unique mucus properties that contribute to antibiotic resistance and immune evasion. The study's findings could lead to the development of more effective mucolytic drugs.
Researchers created a glycan grammar system using natural language processing algorithms, enabling the prediction of immune responses to specific glycans. The tools allow for systematic study of glycans and their role in host-microbe interactions, expanding understanding of pathogenicity and molecular mimicry.
Scientists found that lipid droplets are not only used as an energy source but also act as a weapon against bacterial invaders. These fatty droplets can be used to target and kill bacteria, providing a new way to fight infection.
Researchers have identified a novel immune defence mechanism orchestrated by lipid droplets that attracts and eliminates invading pathogens, providing a broad-spectrum response. This strategy could be used to develop new therapeutic approaches in the era of antibiotic resistance.
Researchers found that hypochlorous acid can chemically modify malodorous compounds and rapidly inactivate infectious particles, promoting greater latrine use. The study also shows potential for HOCl to improve latrine odor and reduce transmission of diseases such as dengue fever.
A five-year study aims to explain the microbial, clinical, and antimicrobial resistance factors of three major multidrug-resistant pathogens. The research will utilize state-of-the-art analysis of genomes and microbiome analyses using stool samples and blood samples.
A study by the University of Jena found that a toxic substance from Staphylococcus aureus stimulates immune cells to produce anti-inflammatory messenger substances, reducing inflammation and promoting tissue healing. The researchers also demonstrated that these substances promote tissue regeneration in an animal model.
A new silk-based wound dressing infused with nanodiamonds can detect early signs of infection, promote healing and reduce infection from certain bacteria. The technology offers a non-invasive solution to traditional wound management challenges.
Scientists at Penn Medicine have engineered bacteria-killing molecules from toxic proteins found in wasp venom, which could help combat antibiotic-resistant infections. The new antimicrobial molecules work by disrupting bacterial membranes and summoning immune cells, showing promise as potential treatments for sepsis and tuberculosis.
Researchers repurposed wasp venom peptides to develop anti-infectives with dual antimicrobial and immunomodulatory properties. Mice treated with these peptides exhibited reduced bacterial counts and improved survival rates.
The University of Guam is surveying and monitoring invasive pests of solanaceous crops, including Tuta absoluta, a moth that can destroy entire crops, and Ralstonia solanacearum race 3 biovar 2, a bacterial wilt that infects through the roots. The work aims to prepare the island for management if these pests arrive.
Research led by UTSW scientists finds that endocannabinoids can shut down genes needed for pathogenic intestinal bacteria to colonize and cause disease. The study suggests that these native chemicals similar to those found in cannabis may eventually lead to new ways to fight gastrointestinal infections.
Researchers discovered a significant rise in scarlet fever cases globally, attributed to superantigen-toxin 'supercharged clones' of Streptococcus pyogenes bacteria. The toxin genes were acquired through viral infections, enabling the bacteria to better colonize and outcompete other strains.
A $779,000 grant from the USDA will support a four-year project to develop a comprehensive fire blight management strategy for American fruit growers. The research aims to improve application timing and efficacy of defense inducers and identify new genetic sources of fire blight resistance.
The AGA Fecal Microbiota Transplantation National Registry reported that FMT led to a cure of C. difficile infection in 90% of patients across 20 North American FMT practice sites, with few serious side effects. The study included 259 patients enrolled between December 2017 and September 2019.
Researchers have identified a new virus, BV01, that infects a significant portion of the human gut microbiome, leading to changes in bacterial gene expression. The study reveals how the virus disrupts normal gut function and affects human health and disease.
Researchers developed a single-use treatment for ear infections that don't require refrigeration, addressing logistical challenges for some patients. The new treatment uses hydrogels to release an antibiotic, killing bacteria at a lower dose than traditional drops.
Researchers identified Paenibacillus species as the causative agent of post-infectious hydrocephalus (PIH), which affects millions of children worldwide. The discovery has the potential to reduce morbidity and mortality by shifting treatment from surgery to antibiotics and vaccines.
Researchers in Uganda have identified a new species of bacteria that may contribute to postinfectious hydrocephalus, a common cause of neurosurgery in children worldwide. The study found Paenibacillus frequently co-occurred with cytomegalovirus infections in affected infants.
Researchers identified a previously unknown strain of Paenibacillus thiaminolyticus bacteria as the primary cause of post-infectious hydrocephalus in Ugandan infants. The bacteria is linked to cytomegalovirus (CMV) infection, which causes neurological damage and can lead to severe cognitive and physical disabilities.
Researchers found that dietary fiber-derived fatty acids activate macrophage activity against Salmonella infection by binding to apoptosis-associated speck-like protein (ASC), triggering inflammasome activation. This new mechanism provides insights into the effects of dietary fiber on the immune system.
A study by Karolinska Institutet researchers found that MAIT cell activation is strongly linked to severe COVID-19 disease. The number of MAIT cells in the blood declines sharply in patients with moderate or severe COVID-19, while pro-inflammatory MAIT cells accumulate in the airways.
Researchers at UNSW Science discovered a new molecular pathway that controls Shiga toxin production in E. coli, which could lead to the development of drugs suppressing toxin production during infections. The study's findings provide a potential breakthrough for treating severe E. coli infections.