Articles tagged with Bacterial Infections
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A new consensus statement offers UTI treatment recommendations to reduce overdiagnosis and overtreatment, while protecting against antimicrobial resistance. The statement aims to help healthcare providers diagnose, treat, and prevent UTIs in PALTC residents, who face increased risks of bacterial colonization and infection.
Researchers suggest that infectious agents may play a role in Alzheimer's disease, challenging the current amyloid hypothesis. Recent studies have linked certain viruses and bacteria to AD pathology, sparking fresh interest in this unorthodox approach.
A bacterial superbug can prevent stem cells in the gut from regenerating the inner lining of the intestine, causing potentially severe disease. This damage impairs tissue repair and recovery from disease, particularly in older adults.
Fecal Microbiota Transplants (FMT) have shown high success rates in treating C.diff infection, with 78% of patients experiencing no recurrence of diarrhoea within 90 days. This treatment is particularly effective compared to antibiotics, which have lower success rates for relapsing infections.
A new study reveals unprecedented details of the bacterium Francisella tularensis' key membrane protein Flpp3, responsible for its virulence. The researchers used X-ray free electron laser technology to gather detailed structural information, which will help develop targeted drugs and effective vaccines against tularemia.
Researchers developed a novel treatment that compacts and stabilizes neutrophil extracellular traps (NETs) to enhance bacterial capture, resist degradation, and improve sepsis outcomes. The treatment improved survival in mice with sepsis by reducing severity of illness and decreasing bacteria levels.
Perturbation of gut microbiota by influenza virus promotes secondary bacterial superinfection in mice. Treatment with acetate corrects this sensitivity.
Researchers discover potential superbug-killing compound AB569 that targets priority pathogens and additional bacteria causing foodborne illness. The compound has shown promising results in treating a wide range of infections, including those caused by Pseudomonas aeruginosa.
Researchers identified how Staphylococcus aureus and Staphylococcus epidermidis promote skin inflammation and barrier damage in Netherton syndrome. The study provides a detailed genomic description of the skin microbiome and offers a potential new treatment target by targeting the microbiome.
Researchers have identified a rare immune cell type that expresses both alpha-beta and gamma-delta T-cell receptors, which can both protect against infection and trigger autoimmune responses.
Researchers at Temple University Health System have developed a new monoclonal antibody that can break apart communities of harmful bacteria, allowing for more effective treatment of infections. The therapy has shown promise in eradicating biofilms on medical devices and reducing the risk of sepsis.
A new study led by NYU College of Dentistry researchers found that vaping alters the oral microbiome, making users more prone to inflammation and infection. E-cigarette users were found to have different bacteria in their mouths compared to smokers and non-smokers.
A new paper-based device has been developed to enable quick diagnosis of bacterial infections at the point of care. The test uses lasers to identify the presence of bacteria and determine which antibiotic is most effective in treating it.
A team of researchers used a statistical technique to identify ecological risk factors affecting coral diseases, including growth anomalies and white syndromes. They found larger corals had higher disease risk, with certain conditions such as high fertilizer and pesticide runoff associated with growth anomalies.
Researchers developed AB569, a combination of acidified nitrite and disodium ethylenediaminetetraacetic acid, which killed Gram-negative and Gram-positive bacterial pathogens, including Pseudomonas aeruginosa. The agent was found to be nontoxic to human cells at bactericidal concentrations, suggesting a potential therapeutic agent for ...
Researchers discovered that immune cells count their neighbors before activating to avoid overreactions. This new understanding could lead to improved cancer immunotherapies and treatments for autoimmune diseases.
A new clinical trial has found that using more than one antibiotic to treat MRSA infection provides no health benefits and increases the risk of side effects. The three-year study involved over 350 patients and tested whether adding a second antibiotic improved health outcomes.
A new study found that the same bacteria are present in the dermis layer of skin across all ages and genders, contradicting the long-held assumption that each person's microbiome is unique. This discovery has significant implications for understanding skin disorders like eczema and psoriasis.
A new group of antibiotics, corbomycin and complestatin, have been discovered with a unique approach to killing bacteria by blocking the function of the bacterial cell wall. The researchers demonstrated its effectiveness in mice against drug-resistant Staphylococcus aureus infections.
A new UNLV study found that a high-carbohydrate diet nearly eliminated symptoms of Clostridioides difficile (C. diff) infections in mice, whereas high-fat/high-protein diets exacerbated the infection. The research suggests that diet may promote microbial groups that can be protective against C. diff even after antibiotics.
Research suggests that bacteriophages found in children's intestinal tracts may play a role in childhood stunting. The viruses affect bacterial communities in the gut, and altering these communities could help improve health. This discovery offers hope for developing new cost-efficient therapies.
A new study published in mSystems found that mice fed a high-protein, high-fat diet developed severe C. difficile infections, while those on a high-carbohydrate diet recovered. The researchers suggest that diet may promote protective microbial groups after antibiotics.
Researchers conducted a large trial of MRSA blood infections and found that combining two antibiotics was not more effective than using one alone, but led to more kidney injuries. The study's findings aim to guide best management for patients worldwide.
Researchers found that immune cells perceive each other's density to regulate their proliferation, leading to more efficient immune reactions. This mechanism could improve cancer immunotherapies by reducing the risk of excessive immune responses.
Researchers suggest new vaccines targeting all pneumococcal strains colonizing the nose and throat, irrespective of capsular type, will be needed to prevent meningitis. Emerging non-PCV type strains cause meningitis at least as severely as targeted types, highlighting the need for updated vaccination strategies.
Researchers found that 50% of lupus skin rashes contained high levels of Staphylococcus aureus bacteria. A protein called interferon increases the stickiness of staph to the skin. This discovery highlights the increased risk of infection and spreading in lupus patients.
A teenage girl's symptoms improved with treatment, but further testing revealed no evidence of infection, highlighting the potential health risks of vaping. The case report suggests that e-cigarettes may be a plausible cause of subacute epiglottitis, a life-threatening condition.
A Tufts University-led team discovered that embryonic brain signals direct the migration of immune cells to infection sites, significantly improving embryo survival rates. Without a brain, embryos are more susceptible to bacterial infections and succumb quickly.
Scientists aim to eliminate persister cells, causing chronic health issues like airway infections and tuberculosis, by targeting their formation mechanisms through self-digestion. By mapping the self-digestion-related mechanisms in E. coli, researchers hope to develop effective anti-persister therapeutics.
Researchers propose using genomic data and mathematical modelling to design vaccines for the specific geographic location where they will be used. This approach aims to minimize rates of pneumococcal disease, a serious infection that can cause pneumonia, sepsis, and bacterial meningitis.
A Northwestern University study found that 45% of antibiotic prescriptions for Medicaid patients lacked a clear reason, highlighting concerns about antibiotic overuse. The research used Medicaid claims data to determine the context in which antibiotics were prescribed, revealing gaps in current ambulatory stewardship policies.
A vegetarian diet may be associated with a lower risk of urinary tract infections (UTIs), according to a study published in Scientific Reports. The study found that the overall risk of UTIs was 16% lower in vegetarians than in non-vegetarians, with a greater reduction in men than women.
A new study maps TB immune responses in diverse models including genetically diverse mice and blood samples from adolescents with TB. The study reveals similarities and differences between human, mouse, and macaque responses, providing valuable insights for developing effective therapies.
Researchers have developed color-changing bandages that can sense drug-resistant and drug-sensitive bacteria in wounds and treat them accordingly. The bandages change color to indicate the type of bacteria present, allowing for targeted treatment with antibiotics.
A team of international scientists has created a global map of dengue transmission intensity and predicted that releasing infected mosquitoes with Wolbachia could reduce cases by up to 90%. The study also suggests that the Sanofi Pasteur dengue vaccine could reduce cases by up to 30%.
Commonly used TB vaccines differ significantly in live bacteria content and cytokine responses, sparking concerns about their equivalence. The study highlights the need for a large-scale clinical trial to standardize BCG vaccine formulations.
A study of 11,784 children found that 25% received suboptimal antibiotic treatments. The most common cases included 'bug-drug mismatch' and prolonged use after surgery. Healthcare providers often overlooked these cases due to limited review by antimicrobial stewardship programs.
Researchers have developed a new treatment that completely kills the bacterial infection causing severe decline in lung function and death in cystic fibrosis patients. The treatment combines three antibiotics with no side effects, improving quality of life and survival chances for infected CF patients.
Researchers have discovered a rare African-specific variant of the TP53 gene that causes iron accumulation in macrophages, leading to poorer responses to bacterial infections. However, this variant also improves response to malaria toxin, potentially offering protection against severe inflammation and disease severity.
Researchers identified a highly competitive bacterium in the gut microbiota that protects against enteric pathogens. This discovery offers new avenues for developing antibiotic-free treatments.
Researchers discovered how an antibiotic, vancomycin, forms a mucoadhesive complex with gut mucins, trapping it and prolonging its exposure to the infectious microbe. This finding could lead to delayed transit of the antibiotic, improving its effectiveness in treating debilitating gut infections like PE.
Scientists discovered that Mycobacterium bovis can survive and grow in small amoebae organisms found in soil and dung. The bacterium adapts to ambient temperatures and remains metabolically active, potentially explaining high transmission rates between animals.
Scientists at University of Gothenburg discovered a new species of antibiotic-resistant bacteria, Scandinavium goeteborgense, isolated from an infected wound. The bacteria exhibit novel genetic variants of resistance, highlighting the need for precise treatment choices.
A blood test using eight gene signatures can predict the onset of tuberculosis three to six months before symptoms appear. This finding could help target antibiotics and save lives, particularly by identifying individuals at risk of developing TB disease after being infected with the bacteria.
A new point-of-care diagnostic test has been developed using a biomarker called RC0497, which can differentiate infected individuals from healthy controls. The test shows promise in enabling early detection and timely treatment of this potentially deadly tick-borne disease.
UNSW researchers found that whooping cough bacteria are adapting to evade vaccine-generated immunity by producing more nutrient-binding proteins and fewer immunogenic proteins. A new vaccine is needed to protect vulnerable populations, particularly newborns and those with weakened immune systems.
University of Tartu scientists have discovered that sleeping bacteria can learn about the growth of other bacteria by spying on them. This discovery offers hope for creating a solution for chronic infections that do not respond to antibiotic treatment.
A team of Israeli researchers has identified a short window of opportunity for treating antibiotic-resistant infections, where aggressive bacteria can be controlled with currently-available therapies. This breakthrough offers new hope for patients fighting life-threatening infections with weakened immune systems.
New research found that after recovery from a respiratory infection, particular cells in the innate immune system in the lung are more effective, offering extra protection against new infections. This heightened immunity is due to the production of cytokines by lung macrophages, which cause inflammation and help fight pathogens.
Researchers at UC San Diego have discovered a bacterial immune system that works by abortive infection, where the infected cell self-destructs. This new system could be employed to improve treatment of multidrug-resistant bacterial infections through phage therapy.
Researchers study how gut infections damage the nervous system, leading to chronic inflammation and conditions like IBS. They find that specific genes contribute to cell death and propose potential treatments by boosting polyamine production or restoring gut microbial communities.
Scientists found that nerve cells release infection-fighting cytokines to combat bacterial invaders, rather than immune cells. This discovery provides new insights into the body's response to food poisoning and other illnesses.
Researchers at Lund University developed a hydrogel based on the body's natural peptide defense, preventing and treating wound infections while reducing inflammation. The gel kills multi-resistant bacteria and has an immunosuppressive effect.
A study by the Universitat Autonoma de Barcelona has identified the regulation and metal uptake systems of Mycoplasma genitalium, a sexually transmitted pathogen responsible for genitourinary diseases. The discovery reveals strategies that bacteria use to acquire essential metals for survival, making them a promising therapeutic target.
A new study has found that metal particles from brake pads can cause inflammation and reduce the ability of immune cells to kill bacteria, similarly to diesel exhaust. Brake dust is estimated to contribute up to 20% of total PM2.5 traffic pollution.
A team of researchers used atomic force microscopy to study the dynamic assembly of antibodies against the self-molecule GM1. The autoantibodies form a hexameric ring structure on the membrane, serving as a landing place for complement proteins. This process is crucial in Guillain-Barr’ syndrome, an autoimmune disorder.
Researchers have found that deleting the BMAL1 clock gene makes immune cells more effective at fighting off pneumonia-causing bacteria. The study reveals that strengthening the actin skeleton of these cells is key to their increased effectiveness.
A recent study found that oral infections are not linked to increased risk of death or serious infection after stem cell transplantation. The researchers suggest that conservative dental treatment may be sufficient for patients with asymptomatic dental infections, and radical treatment is only necessary in specific cases.
Researchers have identified the structure of a lethal toxin produced by C. difficile bacteria, paving the way for new drugs to neutralize it. The finding uses cryo electron microscopy and X-ray crystallography to map out delivery and binding components of the toxin.
Researchers found that intravenous BCG vaccination significantly increased protection against TB in rhesus macaques. The study showed that IV BCG elicited strong, sustained T cell responses in the lungs, leading to a high degree of protection against infection and disease.