Research on infections caused by bacteria and how to fight them. Covers antibiotic resistance, biofilms, congenital syphilis, Lyme disease, and precise treatments.
Infectious disease experts call for novel approaches to end the growing scourge of 'superbugs,' citing 2 million annual infections and 100,000 deaths. The authors recommend new strategies to prevent infections, encourage economic investment in anti-infective treatments, and alter host-microbe interactions.
Researchers identify normalizing p62 levels in immune system cells as a strategy to clear an infection that is deadly to patients with cystic fibrosis. This approach enables the natural cellular process of autophagy, which helps digest pathogens and clear them away, thereby controlling inflammation and saving patients from death.
A meta-analysis found that current smokers with HIV were at double the risk of bacterial pneumonia than non-smokers, but stopping smoking decreased this risk by about a third. Stopping smoking reduced the risk of bacterial pneumonia by approximately 30-70% compared to non-smoking counterparts.
The study highlights links between NTDs and socio-economic prosperity, finding that integrated treatment efforts are cost-effective public health interventions. The report recommends prioritizing NTD programs worldwide to improve health and prosperity for over 1 billion people.
Researchers found that probiotic supplementation improved gastrointestinal immune function and decreased inflammation in SIV-infected macaques treated with ARV. These findings suggest that probiotics could benefit ARV-treated HIV patients, potentially leading to better treatment outcomes.
A Kansas State University-led study reveals a new protein that affects how cells in the innate immune system function and protect humans against invading bacteria. The researchers characterized a glycosyltransferase activity protein that targets GAPDH function to inhibit NF-kappaB activation, leading to enhanced disease susceptibility.
Researchers have identified specific volatile organic compounds (VOCs) produced by certain bacteria, which can be used to diagnose lung infections. The findings suggest a potential breath test to detect bacterial infections, such as tuberculosis, in just minutes.
Researchers have observed the detailed changes in a virus's structure as it infects an E. coli bacterium, providing new insights into the viral infection process. The study reveals that the virus extends its ultra-thin fibers to find an optimal site for infection and ejects its genetic material through the host cell membrane.
A new study found that unnecessary antibiotics increase the risk of recurrence of deadly Clostridium difficile infections. Researchers reviewed patient cases and found that 77% of patients received at least one dose of unnecessary antibiotic, leading to a substantial increased risk of recurrence.
Researchers at Duke University developed a genomic signature to diagnose flu and staph infections, distinguishing between infected and uninfected individuals with high accuracy. This approach could lead to earlier diagnoses, reduced antibiotic misuse, and improved treatment decisions.
Researchers have created a synthetic stool called RePOOPulate to cure C. difficile infections, offering a safer alternative to existing treatments. The artificial poop was tested on two patients with chronic infections and showed promising results in eliminating the infection.
Researchers have discovered a new compound that restores health to mice infected with methicillin-resistant Staphylococcus aureus (MRSA). The compound targets an enzyme essential for bacterial survival and has been shown to be highly active against MRSA in mice.
Researchers identified the mechanism by which Staphylococcus aureus colonizes nasal passages, finding that Clumping factor B (ClfB) binds to skin protein loricrin with high affinity. This interaction is crucial for successful colonization and opens new avenues for developing therapeutic strategies.
A recent study published in Genome Biology analyzed Clostridium difficile genomes from 486 patients to investigate transmission. The results indicate that transmission between patients occurs at relatively low frequency, with most cases attributed to specific strains.
Researchers discovered that neutrophil membrane tethers act like slings to anchor the cell and maintain control during high-speed blood flow. This unique structure enables neutrophils to navigate through narrow venules without being swept away, allowing them to effectively present their antigen-sensing ligands at the infection site.
A recent study published in The Journal of Experimental Medicine found that patients with sepsis had abnormally low levels of the inflammatory protein LECT2. Injecting LECT2 into septic mice promoted bacterial clearance by immune cells and increased their production of survival-promoting factors.
Researchers at Lund University discovered that antibodies in the immune system can be turned around by certain bacteria, affecting their recognition and neutralization. The study shows that this phenomenon varies depending on the severity of the infection, with more serious diseases having the correct antibody orientation.
Researchers have found that Salmonella bacteria change key cells in the intestine to cross the gut wall and infect vital organs. This allows Salmonella to thrive and cause severe symptoms like diarrhoea, fever, and even death in young children.
A study found that contact precautions for patients with drug-resistant infections reduced visits by healthcare workers, but increased hand hygiene compliance upon exiting patients' rooms. However, this intervention had negative effects on patient care and mental wellbeing.
A study found that antibodies attached to bacteria via their Fc regions in saliva, while in blood they bound primarily via their Fab regions. This difference in orientation was linked to the local antibody concentration, with low levels favoring Fc-mediated binding and high levels favoring Fab-mediated binding.
A study of over 33,000 outpatient male veterans found that a longer duration of antimicrobial treatment did not reduce the risk of early or late recurrence of urinary tract infections (UTIs). The optimal treatment duration for UTI in men is currently unknown.
A recent study published in PLOS One reveals that a common diarrhea-causing bacterium triggers an overactive immune response, worsening illness in hospital-acquired infections. Researchers found that activating a protective mechanism involving the PPARgamma pathway can reduce disease severity and be activated by existing diabetes drugs.
Undergraduate researchers at Worcester Polytechnic Institute created engineered surfaces that kill 34% of E.coli bacteria when peptides are lying flat, but 82% when attached vertically. The team developed a technique to monitor AMP attachment and plans to test other materials for optimal antimicrobial activity
A team of immunologists found that the flu virus alters host immune systems, compromising its capacity to effectively fight off bacterial infections. The molecule TLR7 recognizes viral genomes and signals scavenger cells to ingest fewer bacteria, leading to increased risk of superinfections.
UCI researchers found that histone proteins stored in lipid droplets can target and kill bacterial infections, providing a novel approach to fighting bacterial growth. This discovery could lead to new treatments for patients with bad bacterial infections.
Using DNA sequencing, researchers confirmed an ongoing MRSA outbreak in a hospital, identifying the source and extent of the infection. The team linked the outbreak to an unsuspecting carrier and treated them to eradicate the bacteria, preventing further spread.
Researchers found that antibiotic resistance for urinary tract infections increased by over 30% between 1999 and 2010, making treatment more challenging. The Southeast region had the highest burden of antibiotic resistance, while states in New England and Pacific regions showed lower levels of resistance.
Researchers have discovered how a particular type of carbapenemase enzyme reorients bound antibiotics to destroy their antimicrobial activity. This understanding could lead to the design of new drugs that can resist being broken down by such enzymes, helping combat increasing antibiotic resistance.
A recent study published in the Journal of Leukocyte Biology found that T-cells responsible for controlling herpes viruses are reduced significantly during new infections, allowing latent viruses to reactivate. This understanding could lead to prevention strategies and improved treatment options for people with herpes.
Scientists have confirmed the existence of a new tick-borne disease in Switzerland, neoehrlichiosis, which has infected eight patients with severe symptoms. A DNA test has been developed to detect the infection quickly, allowing for timely treatment.
Researchers found that eliminating bacteria's DNA and boosting human beta-defensin-3 can kill NTHI bacteria, a major cause of middle ear infections. The study suggests a new treatment approach to target biofilms formed by the bacteria.
A combination of six naturally occurring bacteria eradicates a highly contagious form of Clostridium difficile, a cause of bloating, diarrhea, and over 2,000 UK deaths in 2011. Faecal transplantation resolves symptoms and contagiousness, but the new approach aims to reduce antibiotic use.
A recent study suggests that fecal microbiota therapy may help pediatric patients with recurrent C. diff. diarrhea, while another study highlights the increased risk of health complications in hospitalized children with CDI, including longer hospital stays and higher mortality rates.
Researchers used UV-C to eliminate Acinetobacter and Clostridium difficile bacteria from patient room surfaces, reducing CFUs by 98.1% and 97.9%, respectively. The study suggests UV light could be a promising addition to hospital infection control strategies.
A study of nearly 75,000 ICU patients in 43 hospitals shows that daily antimicrobial soap and ointment use significantly decreases bloodstream infection rates. The approach, known as universal decolonization, resulted in a 44% reduction in MRSA-related infections.
Researchers at the University of Washington examined the pathogen Pseudomonas aeruginosa, which colonizes in cystic fibrosis patients. They found that certain cells called cheater cells share public goods without releasing them, leading to destabilization of cooperation and potential new strategies for infection control.
A new study found that living near livestock may increase the risk of acquiring MRSA, with regional density of livestock being an important risk factor for nasal carriage. The study suggests that community members in animal-dense regions who are otherwise unaffiliated with livestock farming are at higher risk.
Researchers discovered that immune cells use vitamin B products to recognize bacterial infections, triggering an immune response. This finding opens up potential targets for improving treatments or developing a vaccine for tuberculosis.
A computer simulation study found that hospitals working together and coordinating their infection control procedures can significantly reduce the prevalence of MRSA infections. By implementing contact isolation protocols, hospitals can not only improve their own infection control but also benefit neighboring hospitals.
A new class of treatment has been identified against methicillin-resistant Staphylococcus aureus (MRSA), a 'superbug' responsible for difficult-to-treat illnesses. The compound, developed from an anti-cancer agent, shows promise in treating MRSA-infected mice and has the potential to combat drug-resistant tuberculosis.
Researchers found that T2R38 is expressed in upper respiratory tract cells and activated by bacteria, correlating with increased susceptibility to sinus infections. Genetic variation in the T2R38 gene contributes to individual differences in respiratory infection risk.
Researchers have made progress in tackling C. difficile infections using mouse models and human patients, with potential treatments including an oral medication and genetic mutation detection. The studies found that administering an oral supplement can prevent CDI, while detecting a specific gene mutation may predict recurrent infections.
Researchers have developed a new class of antibiotics that disarm pathogens instead of killing them, effectively treating antibiotic-resistant infections. By blocking the synthesis of endotoxin, a toxic product shed by bacteria, these antibiotics prevent inflammation and protect against potentially lethal infections.
The study found significant variation in adoption of screening and infection control interventions aimed at MDROs and C. difficile, with some hospitals screening for all admissions and others infrequently.
Researchers describe experiments exploring multi-drug tolerance, a phenomenon that allows bacteria to outwit antibiotics. By analyzing HipA protein's structure and biochemical components, they gained insight into how this mechanism enables bacterial dormancy.
Scientists have isolated and studied 11 viruses that can infect and kill the acne-causing bacterium P. acnes, potentially paving the way for topical therapies. The study found that these phages share a high degree of similarity in their DNA, making it less likely to develop resistance to phage-based antimicrobial therapy.
Researchers at UC Berkeley discovered that corneal epithelial cells express small antimicrobial peptides to defend against bacterial infection. These peptides prevent bacteria from binding to epithelial cells and are crucial in protecting the eye against infections, as evidenced by mice lacking cytokeratin 6A being more susceptible.
Researchers at MU developed a technique using bacteriophages to selectively kill harmful bacteria in water treatment facilities. This method could save taxpayers money by reducing cleaning costs and has potential applications against deadly antibiotic-resistant bacteria.
A new X-ray study reveals that persister cells are regulated by toxins produced by the bacteria themselves, allowing them to enter a dormant state. This understanding can lead to the development of treatments that block toxin function and production, potentially improving outcomes in life-threatening diseases.
Scientists have identified a substance that primes the body's immune system to fight infections, including flu, in a nasal spray. The synthetic form of Pam2Cys has shown promise in activating the innate immune system without replacing a normal response.
A new model developed by Weizmann Institute mathematicians and physicians proposes a more individualized approach to chemotherapy by considering not only the quantity but also the quality of blood cells. This could lead to better precautions for high-risk patients and spare unnecessary preventive treatments for those at low risk.
Researchers at Case Western Reserve University have developed novel antivirulence drugs that block toxin production in bacteria, rendering them harmless. The discovery has the potential to combat antibiotic-resistant infections like MRSA and strep.
New guidelines from Infectious Diseases Society of America recommend penicillin or amoxicillin for confirmed strep throat infections. The guidelines also advise against tonsillectomy for children with recurrent strep throat unless in specific cases.
Researchers at Boston Children's Hospital have created a model to study sepsis in newborns, identifying diagnostic markers and potential treatments. The model has shown that even at the earliest hours of life, newborns can mount a robust inflammatory response to bacterial challenge.
A recent study in Rochester, NY, documents 19 cases of infected tattoos caused by a type of bacteria often found in tap water. Premixed gray ink is the suspected source of the infection, which was treated with antibiotics and resolved in most patients.
Researchers at the University of Nottingham have developed a novel antimicrobial catheter that can kill most urinary bacteria, including Proteus bacteria, for up to twelve weeks. This innovation has significant advantages over existing solutions, offering a solution to recurrent infections in long-term catheter users.
Researchers at Tel Aviv University have developed a treatment for coral infected with White Plague disease, a deadly bacterium that causes 9% of Favia favus corals to die. The treatment uses viruses that infect bacteria, providing a breakthrough in developing regionalized treatments.
New research from the Trudeau Institute reveals a negative feedback loop regulating immune response to bacteria, preventing tissue damage while controlling bacterial growth. The study's findings have potential applications in improving prevention and treatment strategies for bacterial infections.
Researchers at the University of Iowa have developed a mouse model of Fukuyama's muscular dystrophy, providing insight into disease development. Vitamin B3 has also been shown to aid in fighting staph infections by increasing C/EBPε expression in mice. Meanwhile, a new class of cerebrospinal fluid-based biomarkers for neurodegenerative...
Researchers at the University of Delaware found that beneficial bacteria in soil can signal plants' stomata to close, preventing disease infection. This discovery highlights the potential for probiotics to bolster plant immunity naturally.