Articles tagged with Bacterial Infections
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A novel treatment using resolvins has restored appropriate neutrophil motion in burn-injured rats, significantly improving survival rates. The treatment may help determine risk of septic complications in patients and prevent associated deaths.
Anand Srinivasan receives fellowship support from the American Heart Association to create a new chip-based platform for testing antibacterial and antifungal treatments for infective endocarditis. The technology can quickly test thousands of microbial biofilm samples, potentially saving lives.
Researchers have developed HIV-derived antibacterial compounds that target and disrupt bacterial membranes, showing powerful activity against clinically resistant bacteria. These engineered cationic antimicrobial peptides (eCAPs) may also be applicable to treatment of other respiratory infections and biodefense applications.
Researchers at the University of Calgary found that platelets actively search for specific bacteria and seal them off from the body, reducing the risk of infection. This mechanism is crucial in combating harmful bacteria like MRSA, which can lead to serious conditions.
Researchers have identified a new virus, CyCV-VN, in patients with severe brain infections in Vietnam. The virus was found in 28 out of 644 patients, but not in those with non-infectious brain disorders. Further research is needed to determine its role in causing the symptoms.
Researchers found that an antibiotic can trigger its own production, increasing levels by dramatically. This breakthrough could enable faster and more cost-effective production of antibiotics.
A multidisciplinary approach combining preventive measures and regular monitoring significantly reduced ventilator-associated tracheobronchitis (VAT) infections in pediatric intensive care patients. The initiative, implemented at Nationwide Children's Hospital, resulted in a 53% drop in VAT cases compared to pre-intervention rates.
The researchers discovered that altering the expression of the glgS gene affects the production of structures involved in bacterial pathogenicity, which indirectly impacts glycogen production. This finding may provide clues for future strategies to combat bacterial infections by modulating glycogen production.
A University of Iowa-led team recommends a three-step protocol to reduce post-surgical staph infections, which can cause significant pain and financial burden. The guideline involves nasal swabs and application of an anti-bacterial nose ointment before surgery to target MRSA bacteria.
Researchers from the University of Toronto have created an electronic chip that can analyze samples for panels of infectious bacteria in a matter of minutes. The technology can identify multiple pathogens and determine antibiotic resistance, addressing the urgent need for rapid diagnosis.
A study found that an intervention improving clinician education and personalized audit and feedback reduced broad-spectrum antibiotic prescribing for common pediatric bacterial ARTIs by nearly half. Antibiotic prescribing for viral infections remained low, with no significant change after the intervention.
A new study found that the bacterium NI1060 causes gum disease by triggering a normally protective protein called Nod1 to destroy more bone, not just fight infection. This discovery could lead to personalized therapy for dental patients.
The Duke Clinical Research Institute is part of a $62 million NIH-funded initiative to combat antibiotic resistance. Researchers will focus on developing new treatments for MRSA and E. coli, improving diagnostics, and stewardship practices. The goal is to reduce the reliance on antibiotics and improve patient care.
Scientists discover protein c-FLIP-R that confers protection on immune cells against apoptosis, a type of cellular suicide. The discovery reveals mice with elevated c-FLIP levels are less susceptible to Listeria infections, sparking hope for potential therapeutic approaches.
Researchers have shown that interleukin-22 reduces lung inflammation during influenza A virus infection and protects against secondary bacterial infection. The study suggests that interleukin-22 may play an important role in maintaining epithelial integrity, providing a potential benefit for patients with flu.
Research suggests that 70% of women with uncomplicated urinary tract infections improve within a week without antibiotic treatment. The study's findings indicate that women may be more willing to delay antibiotic use than expected, highlighting the potential benefits of alternative treatments.
Researchers found that using germ-killing soap and ointment on all ICU patients was more effective than other strategies, reducing bloodstream infections and MRSA presence by up to 44%. The study also showed the approach could prevent infections caused by germs other than MRSA.
Researchers found a protective molecular switch in Salmonella Typhimurium that helps the bacteria adapt to hostile environments during infection. This switch, using S-thiolation, may provide insight into fighting systemic illness and could be exploited to develop new treatments.
Researchers have synthesized potent new compounds that effectively interfere with Staphylococcus aureus quorum sensing, a key behavior in the development of disease. The peptides work by blocking chemical receptors and can target all four subtypes of staph, making them a promising new antibiotic strategy.
A study of nearly 8,000 septic shock patients found that the anatomic source of infection significantly impacts hospital mortality, with certain sites associated with higher or lower chances of survival. Infections related to hydronephrosis were linked to the highest chance of survival, while those in ischemic bowel had the lowest.
Research reveals that non-pathogenic bacteria naturally occurring in the human intestine can eliminate Stx from the intestinal contents and completely prevent HUS in a mouse model.
Researchers have discovered that thioridazine, a drug previously used to treat schizophrenia, works against antibiotic-resistant bacteria by removing glycine from the cell wall. This interaction enables antibiotics to attack and kill the weakened bacteria, paving the way for new treatments.
A study published in PLOS Medicine reveals that Mycoplasma pneumoniae is carried at high rates in the upper respiratory tracts of healthy children. The researchers found no significant difference in prevalence between asymptomatic and symptomatic groups, highlighting limitations in current diagnostic tests.
Researchers at the University of Southern Denmark have made a groundbreaking discovery about bacterial biofilm formation, a major contributor to complicated infections. The study found that small RNA molecules play a crucial role in determining whether bacteria form biofilms or swim, offering new avenues for treating such infections.
Researchers have successfully infected mosquitoes with the Wolbachia bacterium, rendering them immune to malaria parasites. The scientists maintained a stable infection in Anopheles stephensi mosquitoes for 34 generations, and all infected female mosquitoes became infected within eight generations when mated with uninfected males.
A study found that antibiotics are frequently prescribed for acute rhinosinusitis in the US, especially among younger adults and primary care patients. The study highlights the need to promote clinical practice guidelines to reduce unnecessary antibiotic use.
Researchers used bacteriophages to attach to and kill bacteria that form biofilms on implanted devices, reducing antibiotic-resistant infections. The technology shows promise for combating antibiotic-resistant infections and developing bacterial sensing devices.
A new biosensor can detect antibiotic resistance in bacteria in just 10-12 minutes, significantly faster than existing methods. This technology targets antibiotic-resistant Staphylococcus and has the potential to revolutionize the treatment of superbugs.
A new study found that adults with depression and certain antidepressant medications are more likely to develop Clostridium difficile infections, a serious and costly hospital-associated infection. Individuals with major depression were 36% more likely to develop the infection than those without depression.
Research identifies a key gene that regulates both protection against bacterial infection and excessive blood clotting, leading to potential new treatments for deep-vein thrombosis. The study found that inhibiting the enzyme could offer hope to patients prone to clots.
Researchers at the University of Pittsburgh have discovered a potential treatment for deadly, drug-resistant bacterial infections that uses the same approach as HIV to infect cells. The new antibiotic, called engineered cationic antimicrobial peptides (eCAPs), has shown rapid destruction of bacteria resistant to standard antibiotics.
A recent study has found a significant link between certain antidepressants and an increased risk of Clostridium difficile infection. People with major depression were 36% more likely to develop CDI, while the use of mirtazapine and fluoxetine doubled the risk. Researchers stress that the exact cause of this association is unknown.
A handheld diagnostic device uses microfluidic technology with nuclear magnetic resonance to diagnose TB and other bacterial infections in under 3 hours, improving on standard culturing practice. The device also detects antibiotic-resistant strains and has potential applications in resource-limited settings.
Researchers at University at Buffalo have found a breast milk protein complex, HAMLET, that can help restore sensitivity to antibiotics in drug-resistant bacteria. The study showed that HAMLET can lower the dose of antibiotics needed by a factor of eight or more, making it a promising treatment option for superbugs like MRSA.
Researchers found that testing patients with three risk factors upon hospital admission can identify nearly three-fourths of asymptomatic C. difficile carriers, who are the primary source of transmission in hospitals. The study suggests a targeted screening approach to control C. difficile infection.
Research by scientists from the Max F. Perutz Laboratories suggests that treating flu-related tissue damage can aid in combating co-infections with bacteria like Legionella pneumophila, which cause pneumonia and potentially fatal outcomes.
Research at Washington University School of Medicine suggests that Gardnerella vaginalis bacteria is likely the cause of bacterial vaginosis, a condition linked to preterm birth and increased risk of sexually transmitted diseases. The condition affects one in every three women and often does not cause significant symptoms.
A high-salt diet significantly increases the risk of gastric cancer in animals infected with Helicobacter pylori. The study found that CagA, a bacterial oncoprotein produced by H. pylori, plays a key role in cancer development.
A new study found significant variability in sepsis incidence rates depending on the method used, with a 3.5-fold difference between methods. This discrepancy limits efforts to improve treatment for sepsis, highlighting the need for uniform definitions and universal measurement of outcomes.
Scientists discovered that certain bacteria require parts of the CRISPR system to stay infectious, using it to shut off a gene that triggers detection by the immune system. This finding could accelerate vaccine development, but also highlights the dangers of defensive tools being co-opted for stealth.
A study published in Infection Control and Hospital Epidemiology found that a dedicated daily cleaning crew can effectively reduce C. difficile contamination in hospital rooms. The intervention included a standardized disinfection process, which significantly improved disinfection rates compared to traditional cleaning practices.
A recent study found that Antimicrobial Copper surfaces can continuously kill 83% of bacteria causing HAIs within two hours, reducing the risk of infection. The use of copper alloy surfaces has been shown to significantly lower the proportion of patients developing HAIs in Intensive Care Units.
A scissor-like enzyme discovered by UT Southwestern researchers can cut off fatty acids from proteins, disabling the immune system's communication infrastructure and allowing bacteria to grow and survive. This discovery provides insight into severe bacterial infectious diseases and cancer, and may lead to the development of new treatme...
A new vaccine candidate for post-operative staph infections failed to demonstrate efficacy in reducing serious infections and was associated with increased mortality among patients who developed the infection. The study found no significant difference in efficacy between the vaccine and placebo groups, and reported a higher rate of mul...
Researchers at LSU Health Sciences Center discovered that a common sexually transmitted infection-causing parasite cultivates bacteria beneficial to it, changing the thinking about which comes first–infection or bacteria. The study found two unique bacterial communities strongly associated with trichomonas infection.
Scientists at the University of Pittsburgh School of Medicine identified a biological pathway that triggers excessive inflammation in pneumonia and sepsis, leading to improved lung function and survival in animal models. The team developed small molecules to inhibit this protein, offering hope for new treatments for these conditions.
A recent study published in The Lancet reveals evidence for transmission of Mycobacterium abscessus between Cystic Fibrosis patients through DNA sequencing, highlighting the global spread of antibiotic-resistant bacterial species. The research team developed new measures to protect Cystic Fibrosis patients from this emerging threat.
Researchers found that a strain of probiotic bacteria can alter its coat to outcompete harmful bacteria. This ability may prevent the growth of Clostridium perfringens in poultry, reducing the risk of necrotic enteritis and food poisoning.
A study by Mayo Clinic researchers found that histamine 2 receptor antagonists increase the risk of Clostridium difficile infection in hospitalized patients, particularly those receiving antibiotics. The study highlights the need for judicious use of these drugs to reduce C. diff infection rates.
A new portable device can count all five subtypes of white blood cells within minutes, providing an accurate differential and enabling the detection of rare basophils. This technology could improve outpatient monitoring of patients with chronic conditions and bring medical care to remote areas.
Researchers found that certain bacteria in the stomach microbiota can prevent pathology from H. pylori infection, while others exacerbate it. The study suggests that targeting specific microbes may lead to a cure for ulcers and gastric cancer.
A new study found that people with higher levels of infection in their blood, including cold sores, were more likely to have cognitive problems than those with lower levels. The research suggested a link between infection and increased risk of low scores on cognition tests.
A study found that pubic hair removal, particularly shaving, can increase the risk of spreading Molluscum contagiosum. Researchers believe micro trauma from hair removal facilitates transmission of the pox virus through self-infection or scratching.
Researchers at Harvard Medical School identified a novel lipopolysaccharide modification that contributes to F. tularensis lethality and developed a live attenuated vaccine strain. Additionally, scientists studied the dynamics of plague in an urban environment, finding that while port cities are susceptible to outbreaks, they may not b...
Researchers found that certain bacteria in the stomach microflora can change the response to Helicobacter pylori infection, potentially allowing for prediction of disease development and identification of potential probiotics. The study, published in Infection and Immunity, has implications for treating human infections.
A recent study reveals that antibiotic-resistant E. coli strain ST131 is increasingly found in hospitals and long-term care facilities, particularly among older adults and nursing home residents. The study found that LTCF residence was the strongest predictor of ST131 infection, with LTCF residents having 8 times the risk of contractin...
Researchers at Oregon State University have developed an improved purification method for oysters that effectively removes Vibrio parahaemolyticus bacteria, reducing the risk of gastroenteritis. The new process uses temperature-controlled depuration with ultraviolet light, eliminating 99.9% of bacteria after four to five days.
Research reveals that certain brain cells are better equipped to fight off viral infections due to their unique immune defense mechanisms. The study found that granule cell neurons, which rarely become infected, have different gene profiles compared to cortical neurons, making them more resistant to infection.
New research reveals that antibiotic-resistant Staph bacteria exhibit a seasonal pattern, with community-associated strains more likely to infect children during the summer months. In contrast, healthcare-associated strains are more prevalent among seniors during the winter months.
Healthcare workers who wear special fitted face masks are less likely to get clinical respiratory and bacterial infections. The study, published in the American Journal of Critical Care Medicine, found that continuous use of N95 masks provides significant protection against both types of infections.