Articles tagged with Bacterial Infections
Researchers discovered that mice without NLRP6 receptor protein are better protected against bacterial infections and can more easily remove bacteria. This finding opens up a new therapeutic track for treating bacterial infections beyond antibiotics.
A new study led by St. Jude Children's Research Hospital identified an innate immune system component that suppresses inflammation, which in turn dampens the immune response to infections. The findings suggest that targeting this protein could block bacterial infection and offer a completely new approach to fighting infections.
Biochemist Alejandro Heuck maps molecular structure of needle-like tool used by bacteria to drill holes in mammalian cell walls. Researchers aim to identify new targets for developing drugs and treatments against diseases caused by bubonic plague, dysentery, food poisoning, and sepsis.
Researchers at Caltech have developed a method to measure the rate of DNA transfer from viruses to bacteria. They found that the amount of genetic material within the bacterial cells determines how quickly the bacteriophage's DNA is transferred, not the pressure in the virus itself.
Researchers found that inhibiting a key immune response early on can shorten TB treatment time and prevent relapse. In a study, mice treated with standard TB medication plus a TNF-alpha inhibitor had a significantly lower bacterial burden than those receiving only the standard treatment.
A study by UCSF found that bacterial vaginosis increases female-to-male HIV transmission risk threefold. Women with the condition are more likely to transmit HIV to their male partners, highlighting the need for better understanding and treatment of the disorder.
A novel diagnostic test has been developed to accurately detect Group B Streptococcal infection in babies, allowing for quicker treatment and potentially reducing mortality rates. The test detects the presence of a specific gene in the bacteria, which is an important disease-causing factor.
A survey of 3,800 home healthcare providers found that many agencies lack written policies on handling infection control for antibiotic-resistant infections. The study highlights the need for simple and quick actions like hand washing, vaccinations, and patient isolation to decrease infections in home care settings.
Researchers developed a new swab technique that can spot tuberculosis in non-human primates with no outward signs of disease. The method has been successfully tested on Asian monkey populations, revealing a significant prevalence rate and potential for primate-to-primate transmission.
Researchers discovered how bacteria release proteins to spread infections, providing a new target for antibiotic development. The discovery sheds light on the mechanism by which normal, non-pathogenic bacteria can release proteins through their membrane pores.
Researchers have developed a new class of antimicrobials that target bacteria virulence factors, reducing the risk of antibiotic resistance. The most potent substance prevented UTIs from developing in mice for over eight hours and reduced bacterial growth by nearly 10,000 times.
Researchers found that bacteria take advantage of autophagy, a cellular waste disposal system, to cause recurring UTIs. Disabling this system in mice led to quicker and more thorough clearance of the infection.
Researchers at the University of Nevada, Las Vegas have identified three viruses that target the bacteria causing American Foulbrood Disease in honeybees. The discovery offers hope for a new treatment to replace current methods that involve burning infected hives and could help save millions of bees.
Researchers used whole-genome sequencing to distinguish between related MRSA strains, potentially shortening outbreak duration. The study identified genetic differences between strains that current methods couldn't detect.
A study found that hospitalization rates for community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) in NYC tripled between 1997 and 2006. The highest rates were seen among men, children, and homeless populations.
A new MIT study examines how chronic inflammation can lead to cancer. The researchers found that the liver and colon respond differently to infection, with neutrophils secreting hypochlorous acid damaging proteins and DNA in the colon. The study could help predict the risk of chronic inflammation and develop ways to halt it.
Research found no increase in infective endocarditis among dental patients following updated guidelines, which restrict antibiotic use to those at greatest risk of complications. The study's results are reassuring but suggest further research is needed to support the findings.
Researchers found a new genetic mechanism that bacteria use to cause shigellosis, increasing its virulence. This discovery could lead to the development of targeted treatments for this deadly disease.
The Trudeau Institute has received a National Institutes of Health grant to study new treatments for bacterial infections. The institute's lab will investigate the effectiveness of Aronora's therapeutic approach on various types of bacterial infections, building on earlier studies that showed promise in mice.
Researchers at Ohio State University discovered that caspase-11 enables immune cells to fuse and degrade bacteria causing Legionnaires' disease. The enzyme's activation helps kill the bacteria by triggering a fusion event between phagosomes and lysosomes, preventing bacterial replication.
The study found that daily bathing of patients with disposable cloths containing chlorhexidine gluconate reduced MRSA transmission rates from 4.99 cases per 1,000 patient days to 0.88 cases per 1,000 patient days, a significant 82% decrease. This intervention was effective in preventing MRSA infections in a geriatric setting.
A bacterial sepsis outbreak at a Los Angeles County dialysis center was caused by improper disinfection of reusable medical devices, including a dialyzer. The investigation found genetic links between the bacteria infecting three patients, leading to changes in facility procedures and improved infection prevention training.
New research from Johns Hopkins Medicine reveals that patients with a past history of skin infection are three times more likely to develop painful and costly surgical site infections during operations. Despite following proper procedures to prevent SSIs, some patients appear to be more susceptible to contracting an infection due to un...
A team of researchers at UCSC has developed a photoactive compound that releases nitric oxide when exposed to light, eradicating highly resistant 'Iraqibacter' bacteria. The treatment was tested in laboratory models and showed promising results.
A new medical imaging device has been developed to diagnose and treat chronic ear infections by detecting biofilms behind the eardrum. The device uses optical coherence tomography and can identify biofilms in patients with chronic infections, but not those with normal ears.
A Scripps-led study reveals that the nuisance seaweed Leptolyngbya crossbyana produces honaucins with potent anti-inflammation and bacteria-controlling properties. These compounds could one day treat chronic inflammatory conditions, bacterial infections, acne, and other skin conditions.
Researchers found that P. aeruginosa infection is associated with worse clinical outcomes, including more hospitalizations, ICU admissions, and exacerbations in COPD patients. The study suggests that addressing P. aeruginosa infections may be crucial in managing COPD.
Scientists have determined the genetic sequences of all 12 available strains of vancomycin-resistant Staphylococcus aureus bacteria, which acquired resistance independently after acquiring a specific transposon. The findings may lead to new ways to prevent and treat infection by MRSA, VRSA, and VRE.
A microfluidic chip test has been developed to detect latent tuberculosis, promising to be cheaper and faster than current methods. The test uses a novel approach to detect interferon-gamma in blood samples, triggering an electrical signal for diagnosis.
Scientists traced the origin and development of vancomycin-resistant S. aureus by analyzing genome sequences of 12 strains. The study found that each strain acquired resistance independently and identified shared features among the strains that may have helped them evade human immune defenses.
Proper treatment of diabetic foot infections can prevent lower extremity amputations, and about half of these amputations can be prevented. A multidisciplinary team, including infectious diseases specialists, podiatrists, surgeons, and orthopedists, is recommended for best care.
Researchers found that MRSA strain CC5 is adept at acquiring resistance genes, including the one making it resistant to vancomycin, by co-existing with other bacteria. The strain's unique traits, such as lacking bacteriocin production and producing enterotoxins, enable it to thrive in mixed infections.
A Mayo Clinic study found a significant increase in C. diff infections in children between 2004 and 2009, with 75% of cases acquired in the community. The study also highlights the importance of prevention measures to reduce the spread of this environmental infection.
Researchers found that surface layer proteins of C. difficile produce a different cytokine response in patients with recurrent infection compared to those with initial onset. This suggests a more chronic inflammatory process, potentially leading to continuous or re-infection.
Researchers found that T cell imbalance increases risk for gastrointestinal infection recurrence, particularly in C. difficile cases. Patients with recurrent infections had higher levels of regulatory and TH17 cells, which could lead to targeted molecular therapies.
A new study reveals that MRSA nasal colonization is associated with longer hospital stays and an increased risk of surgical site infections (SSIs) in patients undergoing major gastrointestinal surgery. The researchers found that 70% of wound infections in MRSA-positive patients stemmed from the bacterium.
Scientists at the University of Nottingham have proven a long-held theory about bacterial communication by showing that quorum sensing's effectiveness depends on bacterial population density. This discovery can inform research into disrupting QS and stopping toxin production in pathogenic organisms like Pseudomonas aeruginosa.
Researchers developed a simple and inexpensive method to detect more cases of tuberculosis using vacuum filtering a sputum sample through a small filter. The new technique detected 89% of cases in Brazil, compared to 60% detection with the traditional method.
A study published in PLOS ONE found that the use of polymyxins and tigecycline, considered 'drugs of last resort', increased at US Veterans Affairs medical centers between 2005 and 2010. The findings suggest a growing epidemic of multidrug-resistant bacteria.
A recent study by the University of Edinburgh found that large city hospitals act as breeding grounds for the superbug MRSA prior to its spread to smaller hospitals. Researchers analyzed over 80 variants of a major clone of MRSA and identified mutations leading to new strains, tracing their spread nationwide.
A recent study published in PLOS ONE found that male adolescents have bacteria in their urinary tracts, which are similar to those found in young women. The researchers discovered that the types of bacteria on the penis differ from those in the urethra and that circumcision status affects bacterial composition.
Native gut bacteria help fend off invaders, suggesting ways to prevent or treat deadly forms of E. coli by selectively removing nutrients and boosting others. The study also identifies potential targets for prevention and treatment using antibiotics.
Researchers at Nanyang Technological University have developed a superbug killer coating that is 99% effective against bacteria and fungi. The coating uses a magnetic-like feature to attract and kill microorganisms, offering an alternative solution to combat antibiotic-resistant superbugs.
A Michigan State University researcher has developed a synthetic biosensor that glows green in response to conditions mimicking human tuberculosis infection. The goal is to find new treatments for chronic TB and multidrug-resistant TB.
Researchers at the University of Manchester have identified a protein called calpain that allows Listeria bacteria to spread infection within human cells. By blocking this protein, new anti-infective drugs may be developed to combat antibiotic resistance.
A research group from Ben-Gurion University of the Negev has identified genetic mutations in the GUCY2C gene that cause intestinal blockages in newborns from two Bedouin tribes in Israel. The mutations may have evolved to protect against diarrheal diseases in the harsh desert climate.
A study found that children with juvenile idiopathic arthritis have a higher risk of hospitalized bacterial infections than children without the condition. High-dose steroids significantly increased this risk, while methotrexate and tumor necrosis factor inhibitors did not.
Researchers found that Listeria uses nitric oxide to evade the immune system and facilitate cell-to-cell spread, allowing it to multiply in its host. This strategy allows pathogens like Rickettsia and HIV to spread throughout the host in a similar manner.
Researchers at Brigham and Women's Hospital have identified pathways of naturally occurring molecules in the human body that can boost the effectiveness of antibiotics. The study found that certain molecules called resolvins and protectins were key in resolving infections and reducing tissue damage.
Researchers used video microscopy and mathematical modelling to challenge common assumptions about Salmonella infection. They found that macrophage infection rates are lower than previously thought, but infected cells can still be reinfected by other bacteria.
Cardiac device infective endocarditis (CDIE) is a serious complication with high in-hospital and 1-year mortality rates, especially if valve involvement occurs. Coexisting valve infection and heart failure were also common complications.
Scientists found that Burkholderia cenocepacia bacteria interfere with cells' ability to fight infection, exacerbating the disease in cystic fibrosis patients. Rapamycin, an existing drug, helped control the infection in mice, suggesting autophagy as a potential target for new treatments.
Researchers found that the sasX gene is more prevalent in MRSA strains from China than previously thought, with its frequency increasing significantly over the past decade. The gene plays a pivotal role in establishing MRSA epidemics and may be involved in molecular processes that help bacteria spread and cause disease.
Activated CD14+Trem-1+iNOS+ intestinal macrophages increase NO production, leading to enhanced intestinal permeability and bacterial product translocation. This upregulation contributes to the development of decompensated liver cirrhosis.
Scientists at the University of York discovered that bacteria release long protein chains to form biofilms on implanted devices, making infections difficult to treat. This understanding could lead to new treatments and prevention methods for cardiac device infections.
Researchers discovered that macrophages produce hydrogen peroxide, which activates the temperature sensor TRPM2 at normal body temperature. This mechanism enhances phagocytic activity and may lead to new treatment strategies for infection.
A study discovered Bacillus cereus bacteria in a pharmacy robot's washing station, contaminating intravenous drugs. The contamination highlights the need for strengthened cleaning and maintenance procedures to prevent life-threatening infections.
A large multicenter study found that patients with community-onset Clostridium difficile infection have a four times higher risk of colectomy compared to those who developed symptoms in the hospital. Older adults and individuals with severe cases are also at higher risk for CDI-related colectomies.
Scientists have developed a simple test to identify MRSA in wounds that can detect the superbug quickly, enabling more effective treatment. The test uses tiny electrical sensors to analyze swab samples, potentially reducing laboratory processing time.
A study published in the American Journal of Infection Control found that approximately six percent of Chicago-area ambulance sites sampled positive for Staphylococcus aureus, a bacterium causing serious infections. The research also revealed that 77% of isolates detected showed resistance to at least one commonly used antibiotic