Articles tagged with Bacterial Infections
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Researchers discovered that Escherichia coli bacteria contain genes that inhibit the growth of other E. coli cells upon contact. This 'stop on contact' phenomenon may contribute to chronic urinary tract infections and has potential implications for new antibiotics.
Researchers evaluated the relationship between routine childhood vaccines and hospitalization for infectious diseases not targeted by vaccination. The study found no adverse associations between multiple vaccinations and increased risk of nontargeted infectious disease hospitalizations.
A team of scientists has identified a key protein, LcrV, that allows Yersinia pestis to evade the host's immune response. By developing an altered version of this protein, rV10, they have created a potential plague vaccine that triggers only small amounts of IL-10 and protects against infection.
Researchers propose a mechanism by which mifepristone increases the risk of fatal C. sordellii infections, including septic shock and death. The antiprogesterone effects of mifepristone may disrupt immune function, allowing bacteria to thrive in the cervical canal.
Researchers found that bacterial infections can activate self-reactive B cells with significant affinity, driving them to mature into harmful memory B cells. This activation is facilitated by the cooperation of autoantigens, innate immunity, and T cells.
A growing appetite for public reporting of hospital infection rates could lead to improved patient safety and quality of care. UT Southwestern professor Dr. Jane Siegel advocates for standardized reporting systems to track key metrics, but notes that challenges exist due to differences in patient populations and data collection methods.
Researchers explore bacterial cooperation as a therapeutic target to combat antibiotic-resistant infections. By understanding how bacteria collaborate, scientists hope to develop novel treatments that can effectively target these complex interactions.
Researchers discovered that hawkmoth caterpillars infected with non-pathogenic bacteria produce antibacterial peptides that confer resistance against lethal insect pathogens. This finding suggests that field-immunized insects may exhibit different immune responses than laboratory models, challenging the validity of current studies.
Researchers found that a yellow-orange pigment produced by Staphylococcus aureus helps the bacteria resist neutrophil killing and produce disease. The discovery provides an novel target for treatment of serious Staph infections, including those caused by antibiotic-resistant MRSA.
Scientists at UCSD found that white blood cells increase production of protein HIF-1 in response to bacteria, stimulating antimicrobial compounds to kill invading organisms. Treating white blood cells with chemicals can enhance their bacterial killing ability.
Researchers show that HIF-1 alpha regulates bactericidal agents and enhances expression of bacteria-killing cells. Increasing HIF-1 activity increases the killing capacity of phagocytes, providing a novel approach to treating bacterial infections.
A study of 1,779 patients with infective endocarditis found that healthcare-associated S aureus IE was common worldwide, with distinct features compared to community-acquired forms. MRSA is now a relatively common cause of IE globally, associated with persistent bacteremia and requiring better treatment strategies.
Researchers found that bacterial infections trigger the production of antibodies against 'self' glycosphingolipids, leading to autoreactive T cell activation. This mechanism may contribute to the pathogenesis of autoimmune diseases such as multiple sclerosis and Guillain-Barré syndrome.
A study found that smoking parents had a higher rate of disease-producing bacteria in their children compared to non-smoking parents. Bacterial interference against these pathogens was also less common in smoking parents' children.
A promising new TB drug, PA-824, has entered human clinical trials, showing activity against both actively dividing and slow-growing M. tb stages. The drug may significantly reduce the time needed to cure TB, offering hope for shorter treatment regimens.
Researchers found that MRSA bacteria can survive on hospital surfaces like bed linen, keyboard covers, and acrylic fingernails for extended periods. The study emphasizes the importance of regular hand washing and environmental disinfection in healthcare settings.
Researchers found that Pseudomonas aeruginosa biofilms develop faster in the presence of neutrophils, which are sent to fight infections. The biofilms become resistant to antibiotics and the immune system, leading to chronic lung damage and death.
Researchers have captured a detailed picture of the large doughnut-shaped base of the syringe barrel embedded in bacterial membranes. This discovery may lead to the development of new antibacterial drugs that can selectively target disease-causing bacteria, rendering them harmless while sparing beneficial ones.
Research finds bacteria in subgingival plaques of periodontally diseased individuals are also present in their heart arteries, potentially causing inflammation and increasing heart attack risk. Maintaining good periodontal health is advised to prevent this potential effect.
Alcohol consumption and cigarette smoke both impair lung defenses against Streptococcus pneumoniae, a bacterium that causes pneumonia and other infections. Researchers exposed rats to smoke and varying levels of alcohol, then infected them with S. pneumoniae, finding that the combination increased bacterial penetration into the lungs.
Two studies document a significant rise in superbugs, including methicillin-resistant Staphylococcus aureus (MRSA), affecting people worldwide. The prevalence of MRSA has more than doubled, with 76% of community-acquired isolates being resistant to antibiotics.
A new study reveals that E.coli bacteremia affects up to 53,000 non-institutionalized seniors each year, with a significant risk of septic shock and death. Researchers suggest developing a vaccine could save many lives, but currently, there is no similar vaccine available.
A Columbia University/University of Iowa study reveals that inherited variations in the Factor H gene may trigger age-related macular degeneration through inflammation and immune responses. Researchers found that targeting molecules involved in immune system response could lead to powerful new therapies for treating and preventing AMD.
Researchers at Yale University have identified a molecule that detects parasitic infections in humans, shedding light on how the body recognizes parasites. The discovery of Toxoplasma profilin and TLR11 provides crucial information for developing novel strategies to combat parasitic infections.
Researchers identified two strains of lactobacillus that can trap and block HIV, potentially providing a safe and cost-efficient method for preventing its spread. The technology could be used to protect infants and women in poor countries via fermented foods or feminine products.
Three marine phages, sequenced from cyanobacteria in low-nutrient oceans, exhibit genes adapted for infecting photosynthetic bacteria. These genes may help the host maintain photosynthesis during infection, and could influence phage ecology and range.
Scientists have found that Pseudomonas bacteria can switch between two phases, improving their competitive advantage. The switches are caused by spontaneous gene mutations, enabling the bacteria to respond more quickly to changes.
Researchers found a strong association between high levels of C. pneumoniae antibodies and the occurrence of heart attacks in young men. The study suggests that C. pneumoniae may play a role in the pathogenesis of heart disease, but further research is needed to confirm the link.
Researchers found that hormonal contraceptives and bacterial infections like BV and GBS increase the risk of shedding type-2 herpes. Treatment for these infections may help reduce HSV-2 shedding frequency, controlling its transmission.
A novel genetic vaccine against Pseudomonas aeruginosa has been developed using a modified adenovirus vector expressing a region of the outer membrane called OprF. Immunization with this vaccine induces antibody production and protects mice from deadly doses of the bacteria, even after repeated exposure.
Researchers have found that a key clone of community-acquired MRSA has evolved from the 1950s pandemic-causing strain, developing resistance to meticillin antibiotics. The highly-virulent toxin Panton-Valentine leucocidin is shared by both strains, posing a serious public health challenge.
A novel vaccine against Pseudomonas aeruginosa has been successfully tested in mice, inducing antibody production and protection against the deadly bacteria. The vaccine uses a modified adenovirus vector expressing a region of the bacteria's outer membrane, which was previously recognized as a promising vaccine candidate.
A study suggests that community acquired MRSA has evolved from a 1950s pandemic-causing strain, developing resistance to treatment by powerful antibiotics. The new strain shares the same highly-virulent toxin and poses a serious public health challenge.
A study of 127 young women found that those who developed physically later were more likely to contract HPV, chlamydia, and bacterial vaginosis. Younger, more sexually mature teens had lower infection rates due to higher estrogen levels.
Purpura fulminans is a newly emerging deadly disease characterized by skin lesions and tissue damage. Researchers at the University of Minnesota have identified three recommended treatments for purpura fulminans, including antibiotic therapy against Neisseria meningitidis and methicillin-resistant S. aureus.
The first UK cases of Lymphogranuloma venereum (LGV) have been reported in gay men, mostly from London. The disease is caused by a particularly invasive strain of Chlamydia trachomatis and can lead to chronic infection with fistulas and problems with the lymphatic system.
A new study suggests that child care attendance can lead to higher rates of pneumococcal carriage in both children and non-children. The research model predicts that communities with more children in child care have higher carriage rates among all age groups. Vaccination, good hygiene, and regular toy cleaning are key preventive steps.
Bacteria such as Klebsiella pneumoniae and Staphylococcus aureus are major causes of neonatal infections and deaths in hospital settings. Infections can be spread through unhygienic conditions, contaminated hands of healthcare providers, and antimicrobial resistance.
A new type of T lymphocyte called the Tn cell has been discovered by researchers at U.Va. that regulates neutrophil production. The process is known as the neutrophil turnstile, which uses negative feedback to adjust neutrophil numbers in response to bacterial presence.
Researchers discovered that bacteria's pili induce changes in host gene expression, keeping host cells alive longer. The study found that artificial mechanical pull on the host cell membrane triggers a signaling cascade to affect host gene expression.
A recent study by VUMC researchers confirms a dramatic spread of MRSA in the noses of healthy children, with 9.2% positivity rate, up from 1% three years ago.
Researchers aim to control biofilm formation by manipulating quorum sensing in bacteria. They are designing new compounds that mimic natural molecules to disrupt bacterial signaling, potentially preventing hospital infections.
Researchers at the University of Pennsylvania School of Medicine identified a biochemical target that could lead to a new class of antibiotics to fight TB. They found that inhibiting an enzyme in a common biochemical pathway can stop the bacteria from multiplying and eventually kill them.
Phage nucleic acid transport poses a fascinating biophysical problem. Researchers used fluorescently labeled phage DNA to investigate the dynamics of DNA ejection from single phages, demonstrating that release is not an all-or-none process but rather a complex and stepwise process.
University of Florida researchers have developed a patent-pending method to improve antibiotic development, combining testing of various drug concentrations at the site of infection with laboratory analyses and mathematical models. This approach aims to reduce the lengthy and expensive trial-and-error process that can take years.
Shigella bacteria uses a Type III secretion system to inject proteins into human cells, causing inflammation and symptoms of dysentery. The bacteria's lipopolysaccharide (LPS) shield protects it from being destroyed by the immune system.
A randomized trial found that 3-day regimens of amoxicillin-clavulanate were less effective than ciprofloxacin in treating acute uncomplicated cystitis in women. Amoxicillin-clavulanate was also less effective among susceptible bacterial strains, highlighting the need for alternative treatments.
Researchers found that UTI-causing E.coli strains matched genetically with bacteria from cows and are resistant to antibiotics. The discovery has major public health implications due to the practice of administering subtherapeutic antibiotic doses in animals.
A study found that induction at 32 weeks pregnancy can significantly lower infections in both mom and baby, as well as shorten hospital stay for newborns. This approach may be a viable option for women with prolonged premature membrane rupture to minimize potential infection risks.
Researchers at VIB have discovered a way to prevent E. coli bacteria from adhering to the wall of the urinary tract, potentially leading to a new treatment for chronic urinary tract infections. By targeting the protein Adhesine FimH on the bacteria's pili, a new medication could be developed to combat this widespread problem.
A study found that rats infected with E. coli as newborns had impaired memory in adult life when exposed to an immune challenge. The researchers suggested that this may be due to altered cytokine production and changes in brain architecture, potentially linking early-life infections to later disease susceptibility.
Research from Imperial College London finds that bacterial communities mirror human social life, with close contacts more likely to share infections. Despite potential advantages like antibiotic resistance, the variation in pathogen strains' ability to spread is largely explained by chance.
Researchers will investigate the spread of 'superbugs' and develop more effective antimicrobial agents and vaccine strategies to treat lung infections. The goal is to determine when segregation of CF patients is necessary, reducing social strain on families and individuals.
Researchers found that diabetic patients are more likely to develop bacteremia caused by urinary tract infections, leading to a higher risk of death. The study suggests that diabetics should seek medical care promptly if they experience signs and symptoms of urinary tract infection or bacteremia/sepsis.
A case report reveals a traveller from a tsunami-affected region developed mucormycosis, highlighting the need for early diagnosis and treatment. The study suggests that travellers repatriated from affected areas can serve as predictors of infections in survivors.
A recent study explores the issue of antibiotic misuse, finding that more than half of patients in the US are taking unnecessary antibiotics for colds and flu. The study aims to educate providers and patients on proper use of antibiotics, highlighting the risks of antibiotic-resistant bacteria.
Enterococcus faecalis uses a Sonar-like system to detect human blood cells and produce a toxin in response, providing a potential mechanism for developing new antibiotic treatments. This discovery could also be adapted to help the aging population cope with vision loss.
A study by Johns Hopkins Medicine found that pulsatile lavage equipment was the cause of an Acinetobacter baumannii outbreak, infecting 11 patients. The investigation led to changes in hospital procedures, including wearing masks and gloves during procedures and using private treatment rooms.
Yale researchers, Jorge Galán, Ruslan Medzhitov, and John Carlson, have been awarded $3 million to investigate Campylobacter jejuni and its impact on the immune system. The funding will support their work in understanding infectious disease mechanisms and developing new treatments.
Researchers analyzed 829 S. aureus strains from Rotterdam and found three major and two minor genetic clusters, mirroring UK study results. However, the new study identified hypervirulent clones associated with serious infections in healthy carriers.