Articles tagged with Bleeding
Researchers compared long-term survival, stroke, reoperation, and bleeding events after bioprosthetic vs mechanical prosthetic mitral valve replacement among 3,433 patients. They found no significant difference in survival at 15 years, but significant differences in risk of reoperation, bleeding, and stroke between the two groups.
Researchers analyzed genomic data from 16,000 individuals to understand the impact of mutations in two genes associated with a blood disorder. They found that about 1.3% carry a mutation in at least one gene, and algorithms predicted varying levels of harm from these mutations.
Researchers at TSRI have identified a molecule, lysophosphatidic acid (LPA), that triggers schizophrenia-like symptoms in animal models, including hyperactivity, anxiety, and altered brain structure. The study provides new tools for preventing or treating psychiatric disorders such as schizophrenia, bipolar disorder, and autism.
A meta-analysis published in The Lancet found that longer dual antiplatelet therapy (DAPT) after drug-eluting stent (DES) implantation was associated with increased mortality. Shorter DAPT, on the other hand, was linked to lower rates of all-cause and non-cardiac mortality, as well as reduced risk of major bleeding.
A study of 11,648 patients found that extended dual antiplatelet therapy after bare metal stent placement did not significantly increase rates of stent thrombosis or major adverse cardiac and cerebrovascular events. However, the sample size limitations may have impacted the results, suggesting further trials are needed.
Pazopanib, a cancer drug, shows promise in reducing bleeding and small AVMs in patients with hereditary hemorrhagic telangiectasia (HHT), a rare genetic disorder. The study aims to assess the efficacy of pazopanib in improving symptoms and quality of life for HHT patients.
The study found bivalirudin to be associated with significantly lower rates of bleeding complications and death, but failed to meet its co-primary composite endpoints. The high prevalence of heart attacks in patients may have diluted the benefits reflected in the rates of death and bleeding.
A novel anti-clotting therapy was compared to established anticoagulants in a Phase III trial, but showed similar efficacy and higher moderate to severe bleeding rates, leading to its early termination due to allergic reactions.
The study found that adding ticagrelor to aspirin therapy after a heart attack significantly reduced the rate of subsequent death from cardiovascular causes, with benefits appearing for nearly three years. The trial recruited 21,162 patients and showed a 15% reduction in cardiovascular death with both ticagrelor doses.
Researchers developed PolySTAT, an injectable polymer that strengthens blood clots, reducing bleeding in battlefield injuries and traumatic accidents. The synthetic polymer outperforms natural clotting factors and has the potential to treat hemophilia and improve hemorrhaging treatments.
Researchers found a conclusive link between genetic variants and increased bleeding risk with warfarin treatment. Patients with specific genetic differences benefit from alternative anticoagulants like edoxaban, offering improved safety and efficacy.
The NHS savings plan resulted in reduced use of procedures considered low-value. However, the application of these reductions was inconsistent across commissioning groups, with some trusts increasing their rates.
A new study in JAMA found that patients taking nonsteroidal anti-inflammatory drugs (NSAIDs) along with anticoagulant medications after a heart attack are at higher risk for bleeding and cardiovascular events. The research suggests that there is no safe window for concomitant NSAID use, even short-term treatment.
Reversing international normalized ratio (INR) below 1.3 within 4 hours and maintaining systolic blood pressure less than 160 mm Hg at 4 hours were associated with lower rates of hematoma enlargement. Resuming anticoagulant therapy was linked to a lower risk of ischemic events without increased bleeding complications.
A nationwide study found that a new transfusion technique significantly improved survival rates among trauma patients with major bleeding. The equal-ratio blood transfusion reduced mortality within the first 24 hours and stopped bleeding in 86% of patients, compared to 78% in the unequal-ratio group.
Patients receiving fondaparinux had a lower risk of major bleeding events and death following a heart attack compared to those receiving low-molecular-weight heparin. This association was observed in both hospital settings and six months post-incident.
Researchers at St. Michael's Hospital found that stroke survivors are more likely to commit driving errors, particularly during complex tasks, and made a greater number of hazardous errors in simulated driving conditions compared to healthy drivers.
Delayed consent to administer tissue plasminogen activator (tPA), a clot-busting drug, occurred in over 50% of cases among ischemic stroke patients. Women and weekends were more likely to experience these delays. Training tools could reduce tPA delay time by improving the consent process. Additionally, insertable cardiac monitoring det...
A study comparing two transfusion strategies for patients with severe trauma found that a balanced ratio of plasma, platelets, and red blood cells resulted in fewer deaths from exsanguination and improved hemostasis within 24 hours. No significant differences were observed in overall mortality at 24 hours or 30 days.
A study of nearly 350 hospitals found that hospital readmissions after surgery are often related to complications from the surgery itself, rather than a worsening of pre-existing medical conditions. The most common reasons for readmission included surgical site infections and intestinal blockages.
A new LA BioMed study found that platelet transfusions and DDAVP are not effective in preventing further bleeding or death in patients with traumatic brain injuries. The researchers analyzed data from 408 patients and found no significant differences in mortality or hemorrhage progression between those who received the treatments and t...
A new interventional radiology procedure has been shown to preserve the uterus in patients with placenta accreta, reducing the risk of massive obstetric hemorrhage and potential hysterectomy. The study found that placement of balloons in the main artery of the pelvis prior to a Caesarean section is safe for both mother and baby.
A new emergency treatment protocol for subarachnoid hemorrhage from ruptured aneurysms significantly reduces in-hospital rebleeding and improves clinical outcomes. Patients treated under the protocol show a lower incidence of repeated hemorrhage within 24 hours, compared to those treated earlier.
The DAPT Study found that continuing dual antiplatelet therapy for at least 30 months significantly reduced the risk of stent thrombosis and major adverse cardiovascular events. This benefit was observed across all stent types and patient characteristics, with a notable reduction in heart attack risk.
A study of 4,524 patients found that intravascular VCDs were more effective than manual compression in achieving hemostasis, with fewer device failures and shorter time to hemostasis. The results suggest that VCDs may be a safer alternative for closing artery access sites following coronary angiography.
Bio-inspired bleeding control is achieved through the synthesis of platelet-like nanoparticles that mimic the human body's own coagulation processes. These tiny particles can be added to blood flow to supply or augment the patient's natural platelet supply, stemming bleeding and initiating healing.
A new screening tool, based on nine clinical variables, helps identify high-risk patients before heart procedures, allowing for strategies to avoid bleeding complications. This led to a significant reduction in post-procedure complications, including the need for blood transfusions, across Allina Health hospitals.
Researchers have developed artificial platelet-like nanoparticles that combine morphological, mechanical, and surface chemical properties of natural platelets. These artificial platelets can simulate natural platelets' ability to collide with red blood cells, enabling selective clot formation at vascular injury sites.
Patients with atrial fibrillation taking dabigatran are at a higher risk of major and gastrointestinal bleeding compared to warfarin users. The study found that African-Americans and patients with chronic kidney disease were more likely to experience major bleeds.
A Medicare beneficiary study suggests dabigatran may be associated with a higher incidence of major bleeding compared to warfarin. Dabigatran was also found to have a higher risk of gastrointestinal bleeding but lower risk of intracranial hemorrhage than warfarin.
A pilot study found that S-equol supplements improved vaginal epithelium and reduced vaginal atrophy in postmenopausal Japanese women. The supplement showed a positive trend to superiority compared to the placebo group without significant abnormalities in vaginal cells or hormone levels.
Combining common painkillers like ibuprofen and aspirin with other medications significantly increases the risk of upper gastrointestinal bleeding. Researchers analyzed data from over 114,000 patients to identify risk factors and recommend strategies to minimize this risk.
A study comparing bioprosthetic and mechanical aortic valve replacements found no significant difference in 15-year survival or stroke rates between the two groups. Bioprosthetic valves were associated with a higher likelihood of reoperation, but lower major bleeding rates.
The Canadian Medical Association Journal refutes criticisms of the BART trial that showed a substantially increased risk of death associated with aprotinin. The authors argue that regulatory bodies should have mandated a second large trial to confirm or refute the results.
A study of 3,481 patients with intracerebral hemorrhage found that inpatient statin use was associated with lower mortality rates and higher discharge rates to home or rehabilitation. The study suggests that continuing statin therapy after brain hemorrhage may be beneficial for improved outcomes.
A GW researcher is investigating the phenomenon of global brain injury in patients with intracerebral hemorrhage (ICH). The study aims to understand the impact of ICH on clinical outcomes and develop more effective treatment strategies. With a grant of $154K, Dr. Shahram Majidi will analyze CT scans and clinical data from 354 patients.
A network meta-analysis of nearly 50 randomized trials compared the efficacy and safety outcomes of eight anticoagulation options for venous thromboembolism. Rivaroxaban and apixaban were associated with the lowest bleeding risk, while UFH-vitamin K antagonist combination was linked to higher recurrent venous thromboembolism rates.
Researchers developed synthetic platelet-like particles that can augment natural blood clotting, potentially reducing trauma-related bleeding deaths. The particles were tested in animal models and human blood, showing effectiveness in slowing bleeding without causing adverse effects.
Researchers found that fibronectin can switch its function from stopping bleeding to preventing overactive blood clots, which could improve results from transfusions.
A study published in Neural Regeneration Research reports on a patient with subarachnoid hemorrhage who showed an unusual neural connection between the injured cingulum and brainstem cholinergic nuclei. The authors used diffusion tensor tractography to investigate this phenomenon.
A study analyzed all trials to date, finding that bivalirudin-based regimens increase the risk of heart attacks and stent thrombosis, while heparin-based regimens decrease bleeding risk. The magnitude of benefit was attenuated when glycoprotein IIb/IIIa inhibitor use was similar in both arms.
A patient with intraventricular hemorrhage (IVH) showed selective verbal memory impairment due to left fornical crus injury, as reported by Dr. Sung Ho Jang and colleagues. The patient's visual memory improved over time, while verbal memory remained impaired.
Anticoagulant-associated intracerebral hemorrhage (AAICH) poses a significant challenge, with a mortality rate as high as 42.3% to 67%. The latest supplement from the Journal of Neurosurgery provides evidence-based guidelines and strategies for managing patients with AAICH.
A study of 90,618 patients with DVT found CDT increased adverse events and hospital charges without significant impact on mortality rates. Patients treated with CDT had more blood transfusions, pulmonary embolism, and vena cava filter placement.
A recent Temple University Health System study compared the safety of two treatments for deep vein thrombosis (DVT): catheter-based clot removal and blood-thinning medication. The study found similar in-hospital mortality rates for both groups, but higher bleeding risks with the catheter procedure.
Researchers have developed nanoparticles that increase survival rates and show no signs of interference in healing after blast trauma. The artificial platelets, called hemostatic nanoparticles, were found to be effective in stopping bleeding and increasing survival rates.
A national team of researchers found that adding clot-busting medications to conventional approaches significantly reduces deaths from sudden-onset pulmonary embolism. The meta-analysis of 16 trials assessed over 2,115 patients and showed a 47% lower mortality rate with thrombolysis.
A meta-analysis of 16 trials found thrombolytic therapy to be associated with a 47% lower odds of death, but also increased risk of major bleeding and intracranial hemorrhage. The study also showed lower rates of recurrent pulmonary embolism in patients treated with thrombolysis.
Researchers at Chalmers University of Technology have developed a new technology that uses microwaves to quickly and accurately diagnose stroke patients. The system, called Strokefinder, has been shown to differentiate between bleeding strokes and clot-induced strokes with great certainty in clinical studies.
A new method developed by Johns Hopkins researchers uses MRI scans to measure damage to the blood-brain barrier, allowing for more precise administration of intravenous tPA. The technique shows promise in predicting which stroke patients will benefit from treatment and which may suffer bleeding complications.
Researchers are exploring a new therapy to eliminate the major risk of minor bleeding after stroke, focusing on diabetic patients who are at higher risk. The treatment involves an iron chelating agent that can remove excess iron from the brain, reducing damage and promoting recovery.
A study published in Neural Regeneration Research found an unusual neural connection between the injured cingulum and brainstem cholinergic nuclei in a patient with subarachnoid hemorrhage. This phenomenon was detected using diffusion tensor tractography, revealing a novel pathway for neural communication.
Researchers found that Hybrid SPECT-CT was 100% accurate in localizing gastrointestinal bleeding in patients with prior surgeries. The technology has the potential to improve clinical care by resolving ambiguities in planar scintigraphy.
A study found that intermittent PPI therapy is non-inferior to continuous infusion, reducing costs and improving patient comfort. Researchers suggest adopting the new approach could lower healthcare costs while maintaining quality care.
Researchers develop software to identify patients at risk of bleeding from stroke treatment, which could help doctors make more accurate assessments and treat more patients. The program uses pattern recognition software similar to airport security to analyze brain scans and predict the likelihood of bleeding with high accuracy.
A quality improvement initiative improved treatment times and reduced complications for over 71,000 stroke patients treated with tissue plasminogen activator (tPA), resulting in lower in-hospital deaths and intracranial hemorrhages.
A specialized ambulance equipped with a CT scanner, laboratory, and telemedicine connection was shown to reduce treatment time for ischemic stroke patients. The study found that the average alarm-to-treatment time decreased by 25 minutes, and the rate of thrombolysis increased from 21% to 33%.
A long-term study of bleeding patterns in women of multiple race/ethnicities during the menopausal transition found that prolonged and heavy bleeding is common, affecting up to 91% of participants. The research provides quantitative data on normal bleeding patterns, which can help alleviate concern and inform diagnostic approaches.
A University of Manchester study reveals that infection after a stroke significantly worsens outcomes, with the immune system's response to the infection causing more damage. Researchers identified specific blood cells and molecules involved in this process, paving the way for potential anti-inflammatory therapies.
Patients given aspirin after non-heart-related surgery had a higher risk of serious bleeding than those who did not receive aspirin. Aspirin did not reduce incidence of post-operative heart attacks and death, according to data from POISE-2.