Articles tagged with Bleeding
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A study of over 4,000 patients found that discontinuing warfarin therapy within 3 months after surgery increases the risk of stroke, thromboembolic complications, and cardiovascular death. Continuing warfarin treatment for an additional 3-6 months may reduce cardiovascular mortality.
Rates of hemorrhage for older warfarin patients are significantly higher than reported in clinical trials. Hemorrhage rates were found to be 11.8% in the first 30 days and 3.8% over a 13-year period.
Researchers discovered that thrombin activity propagates through blood in steady waves, crucial for sealing large wounds but potentially leading to complications. This finding sheds light on the mechanisms behind severe bleeding in hemophilia patients and has implications for other cardiovascular disorders.
A large registry study found that patients with low levels of platelet inhibition after receiving a drug-eluting stent are at higher risk for blood clots and heart attacks. However, this responsiveness to clopidogrel was also linked to reduced bleeding complications.
The study found a significant decrease in mortality rate for upper gastrointestinal bleeding, from 4.69% in 1989 to 2.13% in 2009. The proportion of patients undergoing in-hospital endoscopic therapy increased from 2% to 27%, and hospital stays decreased from 4.5 days to 2.8 days.
Patients with atrial fibrillation experienced more major and non-major clinically relevant GI bleeding when taking rivaroxaban than warfarin. Major and non-major, clinically relevant bleeding occurred more frequently with rivaroxaban use.
Research found that antidepressant use, particularly SSRIs, increases the risk of intracranial and intracerebral hemorrhages by 50% and 40%, respectively. However, the actual increased risk for most people is extremely low, occurring at a rate of one additional stroke per 10,000 people per year.
A study of 38 premature babies from low-income families found a higher risk of brain bleeds, fewer follow-up appointments, and more ER visits compared to those from higher-income families. The findings highlight the critical need for better identification of high-risk pregnancies and reduction of premature births.
A study found that vigorous physical activity increases the risk of bleeding in children with moderate or severe hemophilia A or B. Most bleeds associated with physical activity occur within an hour of activity, and the absolute increase in risk may be small.
A new study published in The Lancet found that apixaban is more effective and safer than warfarin for patients with atrial fibrillation and at least one additional risk factor for stroke. This suggests that current risk scoring systems may be less relevant when using apixaban, potentially simplifying treatment decisions.
A new study found no significant association between corticosteroid use and increased bleeding events after tonsillectomy. The research suggests that the commonly used corticosteroid dexamethasone does not significantly increase the risk of serious bleeding in children undergoing the procedure.
A recent study published in JAMA found that administering dexamethasone to children before tonsillectomy did not significantly increase post-operative bleeding. The researchers tested the hypothesis that dexamethasone would result in a 5% higher rate of bleeding events compared to placebo, but the results showed no significant difference.
A study of patients treated with warfarin suggests that resuming therapy after gastrointestinal tract bleeding is associated with a lower risk of blood clots and death. The analysis found that resuming warfarin was linked to a significantly increased risk of thrombosis and death from any cause if therapy was not resumed.
Researchers at London School of Hygiene & Tropical Medicine create comic to highlight life-saving benefits of tranexamic acid (TXA) for trauma patients. The comic aims to appeal to doctors, nurses, and paramedics on the front-line of medicine, promoting awareness about the latest research findings.
A new study published in Neurology finds that people who drink heavily (3+ drinks/day) are at higher risk for stroke almost a decade and a half earlier than those who don't. Heavy drinking is linked to a more severe form of stroke, leading to poorer long-term outcomes.
The WOEST study reveals that omitting aspirin in patients treated with oral anticoagulants and having a coronary stent is safe. Results show less bleeding and lower mortality rates compared to traditional triple therapy. This finding has significant implications for future treatment guidelines.
The study found that vorapaxar is beneficial for long-term secondary prevention of heart attacks in patients under 75 years old with no history of stroke and a body weight over 60kg. The drug's cardiovascular advantages are likely to outweigh the bleeding risks associated with it.
A new study found no significant difference between prasugrel and clopidogrel in preventing death, heart attack, or stroke in ACS patients who do not undergo coronary stenting or bypass surgery. However, prasugrel showed a lower risk of recurrent adverse events after 12 months of treatment.
Researchers at Case Western Reserve University developed synthetic platelets that double the survival rate of internal injury victims in the first hour after injection. The nanoparticles work by creating healthy clots and binding to natural platelets to form larger clots, reducing bleeding time.
Researchers have made progress toward a portable emergency treatment for stopping life-threatening internal bleeding. Synthetic platelets, artificial versions of blood's natural clotting particles, are being developed to quickly and efficiently form clots at internal wounds, increasing survival rates in laboratory tests.
A review of 172 studies found insufficient evidence to support the use of misoprostol in preventing postpartum hemorrhage in low-income countries. Researchers argue that resources should be focused on improving primary care facilities rather than relying on a pill to prevent every illness.
A study found that rheumatoid arthritis patients are four times more likely to develop gum disease, with severe cases associated with increased inflammatory markers and antibodies. Gum disease in these patients may contribute to the development and maintenance of systemic inflammation.
Researchers have discovered a promising compound that inhibits clotting in the bloodstream without triggering excessive bleeding. PAMAM G-3, an experimental compound, prevents activation of the process leading to blood clot formation while maintaining normal blood clotting factors.
Researchers have discovered that tPA can protect brain cells from oxygen and glucose loss after a stroke, even when its clot-dissolving powers are removed. A modified version of tPA could provide benefits to patients without increasing the risk of bleeding.
Researchers have developed a new experimental drug that reduces brain damage and improves motor skills in stroke-afflicted rodents. The drug, 3K3A-APC, extends the therapeutic window of tPA, allowing for more effective treatment beyond the three-hour time frame.
A Saint Louis University scientist is working to harness the anti-inflammatory activity of antithrombin to reduce the incidence and severity of heart disease. He has also been studying the control of blood clotting factors for 23 years, with a focus on improving the effectiveness of activated protein C.
A new study from the University of Manchester confirms safety indicators for people taking anticoagulant drugs to regulate atrial fibrillation, a condition that increases stroke risk. The study found that patients with high INR levels were more likely to experience bleeding episodes.
Researchers at Tufts Medical Center have developed a novel drug approach to prevent deadly blood clots in heart disease patients without increasing the risk of serious bleeding. The new pepducin, PZ-128, inhibits platelet function and appears to be safe for human testing.
Researchers from Duke University Medical Center found that tPA is safe to use in acute stroke patients on warfarin, contradicting previous concerns about high intracranial bleeding risk. The study included over 23,000 patients and found similar intracranial hemorrhage risks for those on warfarin and non-warfarin users.
The CHA2DS2-VASc score has been validated in different populations, identifying very low risk patients who do not need antithrombotic therapy. New oral anticoagulants have a greater net clinical benefit compared to warfarin when both bleeding and stroke risks are high.
A study of nearly 200,000 individuals found daily low-dose aspirin use associated with increased risk of major gastrointestinal or cerebral bleeding. Patients with diabetes had high rates of major bleeding, irrespective of aspirin use.
A 34-year study found that Japanese-American men who did not eat foods rich in vitamin D had a higher risk of stroke later in life. Men with the lowest dietary vitamin D intake had a 22% increased risk of stroke, while those with the highest intake had a 27% lower risk.
Specialized care from experienced teams reduces the chance of immediate death and disability by 30% for patients with bleeding brain aneurysms. Patients who receive this treatment have better long-term survival and quality of life.
A simple, low-cost checklist significantly improved adherence to essential childbirth care practices at a hospital in south India. The program increased the number of practices performed by healthcare workers from an average of 10 to 25 out of 29.
Researchers found tPA is safe for warfarin-treated stroke patients, with similar bleeding risks regardless of medication use. The study suggests tPA should not be withheld from these patients, as it minimizes brain damage and disability.
A study found the diagnostic yield of colonoscopy for melena after a nondiagnostic upper endoscopy to be 4.8 percent, significantly lower than previously reported. The rate of therapeutic intervention was also very low at 1.7 percent, suggesting that most procedures are diagnostic-only and can be performed on an elective basis.
A Mayo Clinic study reveals that people with rheumatoid arthritis are at a higher risk of developing lower gastrointestinal issues, which can be life-threatening. Smoking, steroid use, and prior abdominal surgery increase the risk, emphasizing the need for new prevention and treatment strategies.
A pre-procedure bleeding risk score can predict greater risk and higher costs for patients undergoing percutaneous coronary intervention (PCI) procedures. The study identified that high-risk patients experience increased rates of complications, longer hospital stays, and higher total costs.
A new study found that the novel oral anti-coagulant rivaroxaban is as effective as traditional treatment for blocked lung blood vessels, with lower rates of major bleeding. The EINSTEIN-PE trial compared rivaroxaban to standard therapy and demonstrated its non-inferiority in treating pulmonary embolism.
A new class of platelet blockers has been shown to reduce the risk of recurrent cardiovascular events in patients with known atherosclerosis. Adding vorapaxar, an investigational platelet blocker, to standard antiplatelet therapy cuts the likelihood of another cardiac event by 13% compared to placebo.
A new study published in International Forum of Allergy and Rhinology found that ketorolac is a safe and effective pain medication for patients after sinus surgery, without the side effects of narcotics. The study compared ketorolac to fentanyl and found no significant differences in nasal bleeding or pain relief.
Researchers found dapagliflozin effective as an add-on for type 2 diabetes treatment, despite long-term safety data limitations and increased hypoglycemia risk. Peer mentoring improved glucose control among African American veterans through behavioral interventions. However, the use of antiplatelet therapy in patients with chronic kidn...
Researchers have developed a new method to predict which patients are at risk of continued brain bleeding after a stroke. Using CT scans, doctors can now identify
A case report reveals the devastating consequences of dabigatran-induced brain hemorrhage, emphasizing the importance of rapid assessment and intervention after minor head trauma in patients taking anticoagulant medications. The study's findings underscore the need for medical providers to be aware of this high-risk complication.
A simplified approach to preventing post-birth bleeding appears safe and effective, reducing the risk of severe bleeding by almost half. The study's findings suggest that a uterotonic agent like oxytocin can be used to prevent PPH, making it accessible to more women in areas with limited medical staff.
Researchers say anti-clotting effect of heparin is well established but its impact on cancer patients remains unclear. The SAVE-ONCO study found semuloparin reduced thromboembolism incidence but had no significant effect on major bleeding and death.
A new study by the American Heart Association found that combining clopidogrel with aspirin for stroke prevention in patients with subcortical strokes may increase the risk of bleeding and death. The trial involved over 3,000 patients and showed that there was no difference in stroke recurrence between treatment arms.
Researchers developed a minimally invasive treatment to dissolve brain blood clots, increasing patients' independence by 10-15% six months post-procedure. The technique reduces the need for craniotomy surgery and is as safe as supportive therapy.
In a large head-to-head study, warfarin and aspirin showed similar efficacy in reducing mortality and stroke risk in patients with heart failure and normal heart rhythms. Warfarin was found to be more effective in preventing strokes after four years of treatment.
Researchers discovered that rivaroxaban, a new anti-clotting drug, is less likely to cause brain bleeding in patients with atrial fibrillation (AF) who are at high risk of stroke. The study found five risk factors that increase the likelihood of AF patients experiencing intracranial bleeding.
Upper GI bleeding is common and serious in dialysis patients, with rates 10 times higher than in the general population. The condition can lead to early deaths and substantial negative effects on kidney function.
Researchers found that a new drug called cangrelor helped patients maintain platelet inhibition at higher rates than placebo before undergoing cardiac surgery. This was significant because premature discontinuation of antiplatelet therapy prior to surgery can lead to increased ischemic complications.
A new treatment for hemophilia A has shown significant reductions in bleeding events and infusion frequency, particularly in children and adolescents. The study suggests that prophylaxis is the optimal treatment for patients with severe hemophilia, improving quality of life.
The FDA approved the first handheld device to detect life-threatening brain bleeding, which could be a lifesaver for Sailors and Marines. The portable Infrascanner reveals intracranial hematomas after an injury, allowing for early diagnosis and treatment.
Researchers have discovered that administering aspirin after standard therapy for venous thromboembolism (VTE) may prevent the recurrence of potentially deadly blood clots. The WARFASA study found that low-dose aspirin reduced VTE recurrence by 6.6% compared to placebo, with a similar incidence of major and non-major bleeding.
A study by researchers at Thomas Jefferson University and UC Davis Medical Center found that preoperative aspirin therapy significantly decreases the risk of major postoperative complications in cardiac surgery patients. The therapy is associated with a lower risk of 30-day mortality, major adverse cardiocerebral events, postoperative ...
A meta-analysis found that self-monitoring of oral anticoagulation therapy with vitamin K antagonists reduced the risk of thromboembolic events, such as deep vein thrombosis and stroke, by 49% compared to conventional care. Self-monitoring was particularly beneficial for younger patients and those with mechanical heart valves.
The South West Ambulance Service will introduce TXA for civilian trauma patients, which has shown a 30% reduction in death from bleeding when used within three hours of trauma. The cost of the drug is estimated to be £2,560 in year one, with potential savings of many lives and reduced trauma-related disability.
A cartoon character is being used to promote the use of tranexamic acid, a life-saving drug that is not being used enough. The animation, designed by Hywel Roberts, aims to increase awareness and uptake of the generic drug among healthcare professionals.
Research found that higher CHADS2 scores are associated with increased risks of stroke, systemic embolism, and major bleeding in A-Fib patients taking oral anticoagulants. Additionally, a study on warfarin patients suggests a 12-week monitoring interval is non-inferior to the current four-week schedule.