Articles tagged with Bleeding
Upper GI bleeding is common and serious in dialysis patients, with rates 10 times higher than in the general population. The condition can lead to early deaths and substantial negative effects on kidney function.
Researchers found that a new drug called cangrelor helped patients maintain platelet inhibition at higher rates than placebo before undergoing cardiac surgery. This was significant because premature discontinuation of antiplatelet therapy prior to surgery can lead to increased ischemic complications.
A new treatment for hemophilia A has shown significant reductions in bleeding events and infusion frequency, particularly in children and adolescents. The study suggests that prophylaxis is the optimal treatment for patients with severe hemophilia, improving quality of life.
The FDA approved the first handheld device to detect life-threatening brain bleeding, which could be a lifesaver for Sailors and Marines. The portable Infrascanner reveals intracranial hematomas after an injury, allowing for early diagnosis and treatment.
Researchers have discovered that administering aspirin after standard therapy for venous thromboembolism (VTE) may prevent the recurrence of potentially deadly blood clots. The WARFASA study found that low-dose aspirin reduced VTE recurrence by 6.6% compared to placebo, with a similar incidence of major and non-major bleeding.
A study by researchers at Thomas Jefferson University and UC Davis Medical Center found that preoperative aspirin therapy significantly decreases the risk of major postoperative complications in cardiac surgery patients. The therapy is associated with a lower risk of 30-day mortality, major adverse cardiocerebral events, postoperative ...
A meta-analysis found that self-monitoring of oral anticoagulation therapy with vitamin K antagonists reduced the risk of thromboembolic events, such as deep vein thrombosis and stroke, by 49% compared to conventional care. Self-monitoring was particularly beneficial for younger patients and those with mechanical heart valves.
The South West Ambulance Service will introduce TXA for civilian trauma patients, which has shown a 30% reduction in death from bleeding when used within three hours of trauma. The cost of the drug is estimated to be £2,560 in year one, with potential savings of many lives and reduced trauma-related disability.
A cartoon character is being used to promote the use of tranexamic acid, a life-saving drug that is not being used enough. The animation, designed by Hywel Roberts, aims to increase awareness and uptake of the generic drug among healthcare professionals.
Research found that higher CHADS2 scores are associated with increased risks of stroke, systemic embolism, and major bleeding in A-Fib patients taking oral anticoagulants. Additionally, a study on warfarin patients suggests a 12-week monitoring interval is non-inferior to the current four-week schedule.
A new study found that spinal bleeding is common in young children with traumatic brain injury, suggesting abusive trauma. Complete spine imaging can help distinguish between abusive and accidental injury in these cases. The study's findings support the importance of imaging the whole spine for accurate diagnosis.
A pilot study found Angiomax to significantly reduce major bleeding events in patients with severe aortic stenosis, compared to heparin treatment. The anticoagulant showed a 60% reduction in major bleeding events.
A new treatment for severe hemophilia A patients with inhibitors has been shown to be highly effective in preventing bleeding events. The study, published in the New England Journal of Medicine, found that FEIBA infused three times a week resulted in a 62% reduction in all bleeding events and a 72% reduction in target joint bleeding.
Researchers suggest that the placenta's invasiveness into the uterine wall may lead to increased blood loss at delivery. Biomarkers produced by trophoblasts could potentially predict risk, allowing women to make informed decisions about their birthing site and medical care.
A Mayo Clinic study of 1,382 procedures found no increased risk of bleeding in patients taking anti-clotting drugs during removal of precancerous lesions. Bleeding was more common when procedures were performed on the esophagus and stomach, but not linked to medication use.
The American College of Physicians recommends that doctors assess the risk of venous thromboembolism and bleeding in patients hospitalized for medical illnesses, such as stroke, before initiating therapy to prevent VTE. Heparin or related blood thinners are prescribed unless the assessed risk of bleeding outweighs likely benefits.
A new drug called apixaban has shown to be effective in treating atrial fibrillation, reducing the risk of stroke by 21% and major bleeding by 31%. The study found that apixaban is better than warfarin in preventing strokes and was associated with less bleeding.
A team of researchers has identified a non-classical form of Fetal and Neonatal Immune Thrombocytopenia (FNIT) that causes excessive platelet activation and blood clot formation in the placenta, leading to miscarriage. The condition can be prevented with intravenous IgG and anti-FcRn therapies.
Researchers have developed a genetically engineered clotting factor that controls bleeding in animal models of hemophilia. The variant protein is safer and more effective than existing treatments, with potential to treat a range of bleeding disorders.
A study of 107,018 Medicare patients found that same-day discharge after elective PCI did not increase the risk of death or rehospitalization. Patients who underwent shorter procedures with lower predicted risk were more likely to be discharged the same day.
Patients taking SSRIs with antiplatelet therapy have a higher risk of bleeding compared to those taking ASA alone. The study found that combining an SSRI with ASA increased the risk by 42%, while dual antiplatelet therapy increased the risk by 57%. Women and patients who underwent angioplasty had lower bleeding risks.
A large-scale review of DBE found a pooled detection rate of 68.1% for all small intestinal diseases, with inflammatory lesions and vascular lesions being the most common findings in suspected mid-gastrointestinal bleeding patients. The study concluded that DBE is a valuable modality with acceptable detection and complication rates.
A study published in Clinical Gastroenterology and Hepatology found that low-dose aspirin increases the risk of gastrointestinal bleeding, particularly when combined with other medications. However, proton pump inhibitor use can reduce this risk.
A retrospective study of 17,872 patients found no association between statin use and increased risk of intracerebral hemorrhage after ischemic stroke. The study's results contradict previous findings and suggest that current treatment guidelines recommending statin therapy for most patients with a history of ischemic stroke may be safe.
Researchers found that high levels of lysophosphatidic acid (LPA) can lead to congenital hydrocephalus in mice by disrupting brain development and causing excess cerebrospinal fluid buildup. Blocking LPA's action prevents the effect, offering a potential new treatment for the condition.
A randomized multicentre open-label study found that 24-month duration of dual therapy is no better than six months in preventing adverse cardiac events, but significantly increases the risk of bleeding and transfusion. The study challenges current guideline recommendations.
A phase II dose-finding study found that darexaban, a Factor Xa inhibitor, increased bleeding risks by two to four-fold in patients with acute coronary syndrome. The trial explored the safety and optimal dosing regimen of darexaban in secondary prevention of ischaemic vascular events.
A new study shows that patients with coronary artery disease are more likely to experience thrombotic and bleeding complications after orthopedic surgery. The study found that increasing age, kidney disease, and female sex were strong predictors of these events.
A large study on very old patients with atrial fibrillation found that adequate management of anticoagulation therapy can reduce bleeding risks. The study suggests that age should not be a contraindication to treatment for these patients.
A large-scale trial reveals apixaban's superiority over warfarin in preventing stroke and systemic embolism, while also reducing major bleeding and mortality. Apixaban results in a significant relative reduction in stroke and bleeding events, making it a more effective treatment option.
The ARISTOTLE trial shows apixaban reduces stroke by 21% and major bleeding by 31% compared to warfarin, without significant increases in bleeding risk. The study's benefits are consistent across various patient subgroups and settings, offering a promising alternative for treating patients with atrial fibrillation.
A global study led by University of Edinburgh found that rivaroxaban is as effective as warfarin in reducing stroke risk for patients with irregular heartbeats. The new treatment has a lower risk of fatal bleeding and requires less monitoring than the current standard treatment.
A large double-blind study has shown that rivaroxaban is noninferior to warfarin for preventing stroke and blood clots in patients with atrial fibrillation. The study found that rivaroxaban use led to less intra-cranial and fatal bleeding, making it an attractive alternative to the current standard treatment.
A researcher is investigating the factor that initiates the immune system's overreaction after a traumatic event. The goal is to interrupt this chain of events and prevent unnecessary cell death in the intestines.
Dr. Robert Garfield, a researcher at St. Joseph's Hospital and Medical Center, has received a $100,000 phase 1 grant from the Bill and Melinda Gates Foundation to develop a device that can prevent post-partum hemorrhage, a major cause of mortality in pregnant women worldwide.
Scientists at Washington University School of Medicine used evolutionary clues to reveal how a key clotting protein assembles. They found that two histidines play a crucial role in sensing pH changes and guiding the assembly of von Willebrand Factor, leading to new insights into common bleeding disorders.
Emerging evidence suggests a strong association between bleeding and adverse outcomes in patients with acute coronary syndromes undergoing percutaneous coronary interventions (PCI). Strategies to minimize bleeding include radial access and adjusting anticoagulant doses based on body weight, age, and renal function.
A meta-analysis of studies found that new tonsillectomy techniques, including vessel sealing systems and Harmonic Scalpel, show promise in reducing pain, bleeding, and recovery time compared to traditional methods. However, the optimal technique with lowest morbidity rates remains unclear.
A new study reveals that patients implanted with the HeartMate II left ventricular assist device (LVAD) are at a higher risk of internal bleeding than those who received an earlier model. The research found nearly 22% of patients experienced gastrointestinal bleeding, while eight percent suffered from major adverse neurological events.
A new Johns Hopkins research suggests that nighttime surgery has no effect on patient survival for heart and lung transplants. Despite concerns about surgeon fatigue, the study found no significant difference in outcomes between day and night surgeries.
A study comparing transarterial embolization to surgery in patients with uncontrolled peptic ulcer bleeding after endoscopy found TAE is a safe procedure with high technical success rate. It reduces the need for surgery and overall complications without increasing mortality.
The FIGO PALM-COEIN classification system provides a universally accepted method for classifying abnormal uterine bleeding, facilitating communication among clinicians and researchers. The system categorizes causes of AUB into nine categories, enabling consistent and practical application of medical and surgical therapy.
Research at DDW 2011 shows that patients taking clopidogrel after polyp removal have a relatively low risk of bleeding. Teduglutide increases intestinal absorption, decreasing dependence on intravenous fluid in those with short bowel syndrome. Rifaximin reduces death rates in advanced liver cirrhosis and ascites patients.
Researchers found that a year of healthy life could be saved for around the price of filling up an average family car in the UK. Administering tranexamic acid within three hours of injury saves estimated 755,000 life years per 1,000 bleeding trauma patients in the UK, Tanzania, and India.
Women who are obese during early pregnancy have a significantly increased risk of their baby dying before, during or up to one year after birth. Obesity also increases the risk of complications such as bleeding and infections during and after a hysterectomy operation.
Researchers investigated the association between bleeding and mortality in patients on dual antiplatelet therapy (DAPT) versus aspirin alone. The study shows patients with moderate or severe bleeding had a higher incidence of all-cause, cardiovascular and cancer mortality.
A large multicentre trial found that radial access for coronary angioplasty in patients with acute coronary syndromes does not reduce death, heart attack, stroke, or major bleeding compared to femoral access. However, it significantly reduces complications at the access site and improves patient comfort.
A minimally invasive procedure, pelvic arterial embolization is a safe and effective treatment for postpartum hemorrhage, preserving the uterus and allowing resumption of menstruation. The study showed an initial clinical success rate of 86 percent, with repeat procedures increasing the overall bleeding control to 97.8 percent.
Researchers found that early treatment within an hour of injury reduced mortality by over 30% compared to placebo, while delayed treatment beyond 3 hours showed no benefit and possible harm. Tranexamic acid's benefits were also observed in patients who received treatment between one and three hours post-injury.
A large-scale study of 34,670 women found that moderate coffee consumption was associated with a lower risk of stroke. The study suggests that coffee may have beneficial effects on the cardiovascular system, including reducing inflammation and improving insulin sensitivity.
A recent study found that gastrointestinal bleeding in non-ICU patients is rare, regardless of medication use. The authors conclude that the risks of acid suppressive agents may outweigh the benefits for average hospital inpatients.
A University of Cincinnati researcher won a prestigious award for his study on familial intracranial aneurysms and their genetic connection. The research found that concordance in the location of aneurysms within families was higher than between families, suggesting a heritable component to anatomic vulnerability.
Research finds late-stage age-related macular degeneration associated with a 56% increased risk of any type of stroke. Specifically, late AMD was strongly linked to over six times the risk of brain hemorrhage but not with brain infarction, according to a study presented at the American Stroke Association's International Stroke Conference.
A Scripps Research scientist has identified a natural molecule that inhibits the activation of thrombin-activatable fibrinolysis inhibitor (TAFI), preventing stable clot formation. This discovery could lead to novel and cost-effective treatments for blood clotting diseases like Hemophilia A.
Joslin Diabetes Center researchers discovered that plasma kallikrein interferes with brain clotting, leading to increased bleeding during strokes. Normalizing blood glucose levels may block this effect and reduce brain hemorrhage.
The drug tranexamic acid (TXA) has been shown to reduce the risk of death in trauma patients with severe bleeding by 10%, potentially saving over 70,000 lives each year. TXA reduces clot breakdown and has few side effects, making it a promising treatment option for civilian and military settings.
Warfarin users are more likely to die from traumatic injuries compared to non-users, especially among younger patients with severe head injuries. The study found a 50% increase in mortality from severe head injuries in patients under 65 on warfarin.
A computer decision model suggests that statin therapy may increase the risk of recurrent intracerebral hemorrhage in patients with a history of brain hemorrhage. Statins may not provide sufficient benefits to outweigh these risks for this patient group, particularly those with lobar intracerebral hemorrhage.
A recent study found that patients undergoing carotid endarterectomy (CEA) can safely continue taking clopidogrel, but bleeding complications are associated with using a Dacron patch. The study analyzed 260 consecutive patients and found no significant difference in operative blood loss between those on clopidogrel and aspirin alone.
Researchers found that apixaban was more effective than enoxaparin in preventing major venous thromboembolism without increasing bleeding risk. This innovative treatment has improved methods for patients undergoing hip or knee replacement surgery, and may also be beneficial for cancer patients with VTE.