Articles tagged with Bleeding
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The study found that oral rivaroxaban reduced the risk of death, heart attack, or stroke by 21% compared to placebo, with a lower risk of clinically significant bleeding. The medication inhibits factor Xa and has been shown effective in preventing venous thromboembolism.
Researchers at Harvard University have uncovered a fundamental feedback mechanism that regulates blood clotting, leading to new insights into bleeding disorders and potential treatments.
Women with heavy menstrual cycles may be at risk for undiagnosed bleeding disorders. The new guidelines emphasize recognizing symptoms beyond just heavy bleeding, such as family history and laboratory tests. Early diagnosis can prevent complications like bleeding to death during menstruation, childbirth, or surgical procedures.
Women with excessive menstrual bleeding may have underlying bleeding disorders. The consensus conference recommends hematologic evaluations to diagnose conditions like Von Willebrand Disease, which affects 74-92% of women with menorrhagia.
A study published in World Journal of Gastroenterology found that small colon polyps can be removed without interrupting anticoagulation therapy, resulting in an acceptable bleeding rate. The procedure was performed on 123 patients with lesions up to 1 cm in size.
Researchers analyzed primary care records of 5,477 colorectal cancer patients and 38,314 controls to quantify the exact risks posed by eight clinical features. The study found that rectal bleeding carries a high risk warranting investigation regardless of other symptoms.
The World Federation of Hemophilia launches a video podcast on comprehensive care, emphasizing the need for multidisciplinary teams to provide accurate diagnosis, prompt treatment, and support for families. Comprehensive care is crucial in both developing and developed countries to improve patient outcomes and prevent complications.
A large and solitary congenital arterioportal fistula (APF) was diagnosed in a 73-year-old woman. Transcatheter closure using multiple coils was initially successful but resulted in two subsequent episodes of alimentary tract hemorrhage, suggesting that APFs with significant collateral circulation may be challenging to treat.
Researchers created a new method to estimate bleeding risk for heart attack patients using eight basic medical facts. The CRUSADE bleeding score assigns points to each factor, ranging from very low to high risk of bleeding.
Cerebral microbleeds, small deposits of hemosiderin in the brain, are more common among older adults taking anti-clotting medications like aspirin. The study found an association between these medications and brain microbleeds, particularly among those taking higher doses.
Researchers at Uppsala University have identified the three genes that determine warfarin dosage: VKORC1, CYP2C9, and CYP4F2. This discovery will enable more precise treatment and reduce the risk of bleeding or blood clots.
A new study finds that X-ray-guided spinal tap procedures fail in about 60% of young infant cases and cause bleeding in 25% of infant cases. For patients over 80, the risk of bleeding doubles, but can be reduced by inserting the needle in the middle of the lower back.
Researchers found a new drug derived from magnolia trees to be effective in preventing blood clots without causing excessive bleeding. The Phase II study showed that the compound was generally well-tolerated and did not increase bleeding risk, even when taken with standard anti-clotting medications.
Minimally invasive treatments using embolization effectively control life-threatening bleeding in women after C-sections, reducing the need for blood transfusions and hospital stays. Interventional radiology also helps women with invasive placenta by stopping excessive bleeding and potentially eliminating the need for a hysterectomy.
A new study shows sonohysterography as an effective diagnostic tool for women with adenomyosis, improving detection rates and reducing errors in interpretation. The technique helps identify specific signs of the condition, such as 'myometrial cracks,' which were previously difficult to characterize on standard ultrasound.
Research published in Clinical Gastroenterology and Hepatology found that patients with upper GI bleeding admitted on weekends had a 22% higher mortality rate and were less likely to undergo early endoscopy. Patients with peptic ulcer-related UGIB also faced increased mortality, hospital charges, and length of stay.
A multicenter study led by Johns Hopkins shows that an experimental clot-busting treatment can increase survival rates and improve function in patients with intracranial hemorrhage, a lethal form of stroke. After six months, about 10% had no lingering disability and 40% were independently caring for themselves.
Patients with mild to severe kidney dysfunction require lower warfarin doses and closer monitoring due to increased bleeding risk. Warfarin dose is significantly affected by kidney function, even after accounting for genetics.
Researchers have reconstructed the chronology of Oetzi's injuries, finding evidence of a short-lived arrow wound and a blow to the back before his death. The study suggests that Oetzi endured at least two injuring events, which could indicate two separate attacks.
Researchers capture images of bleeding inside heart muscle after heart attack using MRI scans, finding correlation between bleeding and extent of heart damage. Patients with larger heart attacks show more significant bleeding and poorer recovery chances.
New analysis by University of Cincinnati researchers found that genetic testing to guide initial dosing of warfarin may not be worth the costs for typical patients. However, it could be beneficial for those at high risk of major bleeding. The study suggests that testing should be done in-house and at lower cost without delays.
Mayo Clinic researchers studied 816 women who underwent global endometrial ablation (GEA) to assess its effectiveness in reducing menstrual bleeding. They found that only 16% of patients required hysterectomy five years after the procedure, which is nearly half of what was previously reported.
A new study reveals that smokers with a family history of brain aneurysm are significantly more likely to suffer a stroke. The research found that current smokers were six times more likely to experience a stroke, and quitting smoking could reduce this risk by over half.
A study found that dexamethasone effectively reduces postoperative nausea and vomiting after tonsillectomies, but also increases the risk of bleeding in children. The largest dose was associated with a nearly 7 times higher risk of bleeding.
Researchers have found that preventive use of antithrombotic medication can reduce incidence of thromboembolic events in cancer patients. The PROTECHT Study shows a 47.2% reduction in risk, while also demonstrating safety with minimal major bleeding episodes.
The study presents a new combination therapy for previously untreated ITP, an investigational oral treatment for chronic ITP, and a low-dose platelet transfusion strategy. These approaches aim to minimize bleeding episodes in patients with platelet disorders.
A study published in the Academy of General Dentistry reveals that stopping antiplatelet medications before dental procedures increases the risk of permanent disability or death. Dentists can help patients by discussing treatment risks and benefits with their physicians.
Double-balloon enteroscopy is a cost-effective approach for patients with obscure gastrointestinal bleeding, offering reduced costs and complications compared to other diagnostic methods. The study suggests that an initial capsule-directed double-balloon enteroscopy may be preferred over other options due to its potential for fewer com...
A study published by researchers in Japan found that Double Balloon Endoscopy (DBE) was effective in diagnosing small intestinal lesions in patients with obscure GI bleeding, with a sensitivity of 92.7%. DBE also showed therapeutic benefits for most patients, and the technique was more sensitive than capsule endoscopy in certain cases.
Research suggests a shared metabolic pathway between vitamins E and K may cause interaction, diminishing vitamin K levels as vitamin E increases. The Women's Health Study found 24% fewer deaths from heart disease in women taking 600 IU vitamin E supplements.
Patients who receive written and verbal instructions on proper warfarin use are less likely to experience gastrointestinal and brain bleeding problems. Improved doctor-patient communication may also prevent a substantial number of injuries and resulting hospitalizations.
A multicenter study led by Johns Hopkins Children's Center found that hydrocortisone treatment in preemies has little to no benefit and may increase the risk of brain bleeding. Low cortisol levels in premature babies do not appear to be harmful, contrary to common belief.
A study published in Neurology found that African-Americans are more likely to have cerebral microbleeds, which can increase the risk of having a stroke. Researchers discovered that African-Americans had 32% more microbleeds than Caucasians and were more likely to have them in certain areas of the brain.
A study of 87 stroke patients found that blacks had a 32% higher microbleed prevalence than whites, with more frequent and varied locations in the brain. Hypertension was also associated with microbleed frequency.
A new study found that warfarin, commonly used to prevent blood clotting, increases the risk of brain hemorrhage and death if a hemorrhagic stroke occurs. The study showed that people taking warfarin with an INR above three had twice as much initial bleeding as those not on the drug.
Primary aortoenteric fistula (PAEF) is a rare but life-threatening condition that can cause massive gastrointestinal bleeding. PAEFs often present with a herald bleed prior to exsanguination, making early diagnosis challenging. The incidence of PAEF is likely higher than estimated, and prompt surgical intervention is crucial for survival.
Researchers successfully treated bleeding gastric varices using a novel sclerotherapy combining alpha-cyanoacrylate alkyl with aethoxysklerol, with no complications or re-bleeding observed in six months. The treatment was found to be an effective alternative for obliteration and eradication of gastric fundal varices.
A study published in World Journal of Gastroenterology found that severe comorbidity is the main factor affecting clinical outcome in very old patients with acute gastrointestinal bleeding. Older patients (over 80 years) experience similar severity and rebleeding rates as younger populations, but higher mortality rates.
Researchers used 3-D MRI to accurately detect bleeding in diseased carotid arteries, a condition that may lead to stroke. The technique identifies complicated plaques with surface ulcerations and blood clots, which are major causes of vascular events.
Researchers developed a simplified clinical score to predict active bleeding in UGIB patients. The study showed that early or delayed urgent endoscopy can be differentiated according to the score, allowing effective treatment of high-risk patients.
The APPRAISE-I trial found a non-statistically significant trend that patients taking apixaban with aspirin or clopidogrel had lower incidence of heart attack, stroke, and cardiovascular death, compared to those taking a placebo. However, bleeding complications were a concern, especially at higher doses.
The European Society of Cardiology recommends pre-hospital treatment with antiplatelet agents, such as aspirin and clopidogrel, to improve clinical outcomes in STEMI patients. Unfractionated heparin is also used during primary PCI in STEMI, while bivalirudin has been shown to reduce major bleeding and ischemic events.
The use of anticoagulants, antiplatelet agents, and thrombolytics in acute coronary syndromes (ACS) increases the risk of bleeding, which has emerged as a major contributor to poor outcomes. Careful selection of drugs and measures to prevent gastrointestinal bleeding can help mitigate this risk.
A Phase II study found trends suggesting apixaban reduces heart attack, stroke risk but increases bleeding among higher doses, warranting further study.
Drug-eluting stents should be avoided in patients with diabetes, short lesions, or large vessel sizes due to high restenosis risk. Extended dual antiplatelet therapy also poses bleeding complications, making bare metal stents a safer option for some patients
A large prospective study found that consuming nuts, corn, or popcorn does not increase the risk of diverticulosis or diverticular complications in men. Conversely, higher intake was associated with lower risks of new diverticulitis cases.
A study found that smoking is associated with a higher rate of bleeding in patients undergoing uvulopalatopharyngoplasty and tonsillectomy. Smokers experienced a 10.9% post-operative hemorrhage rate, compared to 3.3% for non-smokers.
A U-M study finds that proton pump inhibitors (PPIs) are a cost-effective way to prevent upper GI bleeding in patients taking aspirin for cardiac events. Starting PPI therapy at age 50 or older is estimated to be highly cost-effective, while starting at younger ages may only be marginally so.
A study found that people with gastrointestinal bleeding after a stroke are more likely to die or become severely disabled than those without GI bleeding. Gastrointestinal bleeding was associated with a higher risk of mortality and severe dependency, even after adjusting for other factors.
Maternal death rates in the US remain constant, but a study suggests reducing cesarean-related deaths by implementing thromboprophylaxis can lower mortality. The risk of death attributable to cesarean delivery is approximately 2/100,000 procedures, which can be significantly reduced with universal thromboembolism prophylaxis.
A study examining anti-clotting therapy following cardioembolic stroke found that warfarin treatment appears to be safe and can begin at any point during hospital stay. In contrast, bridging with full doses of heparin or enoxaparin may carry high risk of intracranial and systemic bleeding.
A study found that selective serotonin reuptake inhibitors (SSRIs) are associated with increased gastrointestinal bleeding risk, especially when combined with other stomach-harming medications. Acid-suppressing agents may reduce this risk.
Researchers have developed a treatment using hydrogen sulfide to induce reversible metabolic hibernation, significantly improving survival rates for rats after extreme blood loss. The study found that 75% of treated rats survived at least two weeks compared to 23-14% in control groups.
A new study by researchers at the Medical College of Wisconsin found that the severity of retinal hemorrhaging in young children is closely correlated with the severity of motor vehicle crashes. The study examined ten cases and found extensive retinal hemorrhages in eight patients, similar to those seen in shaken baby syndrome.
A new study published in Nature Medicine reveals why tPA, the most effective emergency stroke treatment, carries risks of brain bleeding. Researchers found that the leukemia drug Gleevec inhibits a protein receptor involved in this effect, suggesting it could prevent problems and improve treatment outcomes.
A new study found that bowel preparation with oral sodium phosphate does not improve cleanliness and visibility in small bowel capsule endoscopy for patients with obscure GI bleeding. The standard method of an eight-hour fast before the procedure was shown to be equally effective.
A new study from the University of Michigan Stroke Program reveals that women and Mexican-Americans are at a higher risk of suffering a type of stroke related to a ruptured brain aneurysm. Women had a 74% greater chance, while Mexican-Americans had a 67% greater chance, compared to non-Hispanic white men.
A new study published in the New England Journal of Medicine found that coagulation factor VIIa can reduce cerebral hemorrhage size, but does not prevent long-term mortality or severe impairment. The study showed that patients with smaller hemorrhages and certain age restrictions may benefit from treatment.
A study found Mexican Americans and women are more likely to experience subarachnoid hemorrhage due to differences in tobacco use and hypertension treatment. Researchers identified 107 cases over seven years among 29,907 people in southeast Texas.
The HORIZONS AMI trial found bivalirudin significantly reduces major bleeding and cardiovascular events in STEMI patients undergoing angioplasty. The study showed a 24% reduction in net adverse clinical events and a 33% decrease in overall mortality at 30 days.