Articles tagged with Bleeding
A study examining anti-clotting therapy following cardioembolic stroke found that warfarin treatment appears to be safe and can begin at any point during hospital stay. In contrast, bridging with full doses of heparin or enoxaparin may carry high risk of intracranial and systemic bleeding.
A study found that selective serotonin reuptake inhibitors (SSRIs) are associated with increased gastrointestinal bleeding risk, especially when combined with other stomach-harming medications. Acid-suppressing agents may reduce this risk.
Researchers have developed a treatment using hydrogen sulfide to induce reversible metabolic hibernation, significantly improving survival rates for rats after extreme blood loss. The study found that 75% of treated rats survived at least two weeks compared to 23-14% in control groups.
A new study by researchers at the Medical College of Wisconsin found that the severity of retinal hemorrhaging in young children is closely correlated with the severity of motor vehicle crashes. The study examined ten cases and found extensive retinal hemorrhages in eight patients, similar to those seen in shaken baby syndrome.
A new study published in Nature Medicine reveals why tPA, the most effective emergency stroke treatment, carries risks of brain bleeding. Researchers found that the leukemia drug Gleevec inhibits a protein receptor involved in this effect, suggesting it could prevent problems and improve treatment outcomes.
A new study found that bowel preparation with oral sodium phosphate does not improve cleanliness and visibility in small bowel capsule endoscopy for patients with obscure GI bleeding. The standard method of an eight-hour fast before the procedure was shown to be equally effective.
A new study from the University of Michigan Stroke Program reveals that women and Mexican-Americans are at a higher risk of suffering a type of stroke related to a ruptured brain aneurysm. Women had a 74% greater chance, while Mexican-Americans had a 67% greater chance, compared to non-Hispanic white men.
A new study published in the New England Journal of Medicine found that coagulation factor VIIa can reduce cerebral hemorrhage size, but does not prevent long-term mortality or severe impairment. The study showed that patients with smaller hemorrhages and certain age restrictions may benefit from treatment.
A study found Mexican Americans and women are more likely to experience subarachnoid hemorrhage due to differences in tobacco use and hypertension treatment. Researchers identified 107 cases over seven years among 29,907 people in southeast Texas.
The HORIZONS AMI trial found bivalirudin significantly reduces major bleeding and cardiovascular events in STEMI patients undergoing angioplasty. The study showed a 24% reduction in net adverse clinical events and a 33% decrease in overall mortality at 30 days.
Hermansky-Pudlak syndrome (HPS) is a bleeding disorder caused by platelet function defects. A rare case of HPS presents with gastroduodenal ulcers, which may be confused with bleeding due to the underlying platelet issue.
A new treatment using tissue plasminogen activator (tPA) has dramatically decreased death and disability in patients with intracerebral hemorrhage (ICH), a condition where blood clots inside the brain. The treatment, which clears trapped blood from the brain, showed an 80% survival rate for patients.
Hemosuccus pancreaticus is a rare cause of intermittent upper GI bleeding, often associated with chronic pancreatitis. Early diagnosis and treatment are crucial, with interventional radiology and surgical options available.
An intensive educational program reduced the rate of postpartum hemorrhage by 45% and decreased episiotomies by 10.6%. The program also promoted the use of oxytocin to contract the uterus after birth.
Researchers found that continuous oral contraceptives significantly improved pain and behavioral changes in women compared to standard 28-day birth control pills. The study also showed a significant decrease in moderate to heavy bleeding days among women who received the continuous birth control regimen.
A Phase III study found that high-dose tirofiban was non-inferior to abciximab in reducing ST-segment elevation in STEMI patients. Tirofiban also showed improved safety profiles with lower thrombocytopenia rates compared to abciximab.
This meta-analysis found that aprotinin decreases intraoperative blood product needs and has no significant impact on postoperative bleeding, thromboembolic events, or mortality. More research is needed to confirm these results.
A large cohort study found that male smokers who consumed more magnesium had a 15% lower risk of cerebral infarction, a type of stroke. The association was strongest in men younger than 60 years.
Patients receiving antiplatelet medications like aspirin after stroke show improved outcomes with clot-busting therapy. However, the study found a higher risk of brain hemorrhage in these patients, challenging existing guidelines.
The NHLBI has published its first US clinical practice guidelines for von Willebrand Disease, a condition that affects 1 in 100 to 1,000 people. The guidelines provide recommendations for screening, diagnosis, and treatment of the three major types of VWD, emphasizing proper diagnosis and treatment to prevent complications.
A study examining long-term outcomes following blood clots found that patients with pulmonary embolism are at higher risk of experiencing recurrent clotting, major bleeding episodes, or death. The research also highlights the need for better anticoagulation strategies to reduce complications in the community setting.
A rare case of ADF was reported, where the prosthesis was detached from the duodenal wall and a pediculated fragment of the greater omentum was placed to relieve mechanical bowel obstruction. The clinical suspicion for ADF is essential, with esophago-gastro-duodenoscopy and CT scans being the most commonly used diagnostic techniques.
A novel treatment for DVT uses a fiber-binding agent to clear clots rapidly and safely, with 90% of patients experiencing complete resolution of symptoms after six months. The therapy reduces the risk of bleeding and post-thrombotic syndrome, enabling patients to resume normal activity within a week.
A trial found idraparinux causes significantly more bleeding than vitamin K antagonists in patients with atrial fibrillation at risk of stroke. The treatment requires regular monitoring and dose adjustment, but an unmonitored regimen would be preferable for improved safety.
Cholesterol-lowering drugs like atorvastatin may increase the risk of hemorrhagic stroke, a bleeding in the brain. The study found that people taking these medications after a stroke were more likely to experience a second stroke involving blood clots.
Catheters equipped with balloons, lasers, and miniature drills can treat tears in arteries, improving safety for emergency repairs. The technology has reduced the risk of life-threatening bleeding from vessel punctures during angioplasty procedures.
A study of over 13,000 patients found that bivalirudin alone and other regimens have comparable mortality and ischemic outcomes at 1 year. Bivalirudin monotherapy reduces bleeding complications and hospital costs, making it a favored treatment option
A Phase 2 study found that eltrombopag elevated platelet counts to a safe level in over 75% of chronic ITP patients within two weeks, reducing bleeding symptoms. The therapy also showed similar incidence and severity of adverse effects compared to the placebo group.
A 30-year study found that hysterectomy more than doubles the risk of requiring stress-urinary-incontinence surgery. The highest risk was within five years after surgery, with multiparous women particularly affected. Researchers suggest surgical trauma and changes to pelvic-floor supportive tissues may contribute to this association.
Researchers will investigate barriers to treating ischemic strokes and explore the effectiveness of patient navigators and imaging studies to address disparities in DC hospitals. The projects aim to improve stroke prevention, diagnosis, and treatment for medically underserved communities.
The HORIZONS AMI trial demonstrated the superiority of bivalirudin over standard drug therapy in reducing net adverse clinical events by 24% and major bleeding by 40% in heart attack patients at 30 days. The study showed significant reductions in cardiac deaths, with a 27% decrease compared to standard therapy.
The MacArthur Foundation is funding Pathfinder International to implement a range of interventions, including the non-pneumatic anti-shock garment, to treat postpartum hemorrhaging in developing countries. The program aims to reduce maternal mortality by addressing the leading cause of maternal death, postpartum hemorrhage.
Researchers used capsule endoscopy to evaluate unexplained gastrointestinal bleeding and found six previously undiagnosed cases of Crohn's disease. The study highlights the tool's ability to detect inflammation in the small intestine, which can be missed by colonoscopies.
Research highlights underreporting of NSAID use, leading to significant GI complications and healthcare costs. Administering proton pump inhibitors with NSAIDs can help mitigate these risks and reduce hospitalization costs.
Scientists at the University of Illinois Chicago have identified calpain-1 as a key enzyme in blood clot formation, which could lead to safer anti-clotting treatments. The study also found elevated protein tyrosine phosphatase-1B levels in mice lacking calpain-1, potentially providing insights into diabetes and obesity research.
A recent study suggests that CT angiography can accurately diagnose aortic injuries in blunt trauma patients without the need for catheter angiography. In challenging cases, CTA offers a rapid and non-invasive diagnosis, potentially sparing patients from serious complications.
A study found that a specific tonsil removal technique associated with reduced postoperative heavy bleeding and pain. The intracapsular technique, which removes at least 90% of tonsil tissue while sparing the capsule, resulted in fewer complications compared to traditional tonsil removal surgery.
Researchers found beta blockers to be more effective and safer than banding in reducing the risk of variceal bleeding in cirrhotic patients. The study, published in Liver Transplantation, compared the two treatments and found that beta blockers lowered the risk of bleeding by over 90%, while banding reduced the risk by less than 70%.
Researchers at the University of Washington have developed a new emergency treatment using high-intensity focused ultrasound to seal punctured lungs. The technique, inspired by Star Trek technology, shows promise in replacing painful and invasive procedures for lung injuries.
A study of 40,171 patients found a 4-6 fold increase in gastrointestinal bleeding when warfarin was used with antiplatelet agents. Physicians should be aware of these risks to better assess their patients' therapeutic risk-benefit profiles.
A new study published in the Journal of the American College of Surgeons shows that recombinant human thrombin reduces surgical complications and stops bleeding in 95 percent of patients within 10 minutes. The treatment also has a lower risk of antibody development compared to current standard blood-clotting treatments.
Clemson University receives funding for developing an implantable biochip that can relay vital health information in emergencies. The device has potential applications in trauma care, space exploration and monitoring of diseases such as diabetes.
Researchers have discovered that consuming popcorn may lower the risk of diverticulitis by 28% in individuals with diverticular disease. A randomized clinical trial also found rosiglitazone to be an effective treatment for mild-to-moderately active ulcerative colitis.
New research explores liver biomarkers, disease complications, and novel treatments to improve outcomes in patients with liver disease. A study found that an elevated ALT/AST ratio can predict coronary atherosclerosis in women, independent of metabolic syndrome.
A new study from the University of Michigan Stroke Program finds that ICH patients who had a do-not-resuscitate order issued in the first 24 hours or had care withdrawn were twice as likely to die. Early limitations on care may be an overlooked factor in calculating ICH survival odds, according to researchers.
A three-year study found that patients with bleeding strokes received significantly less cholesterol-lowering medications, diabetes medication, and weight-loss management compared to those with ischemic strokes. Smoking cessation therapy also showed significant disparity between the two groups.
A University of Kentucky study finds that doses higher than a baby aspirin may not prevent cardiovascular events and increase bleeding risk. The research suggests that using the minimum effective dose of 75-81 mg may be optimal for most patients.
Research shows that elderly patients (90+ years) who receive recommended treatments for acute coronary syndromes have better survival rates, but at a higher risk of bleeding complications. Guidelines must be balanced to balance survival benefits with increased bleeding risk.
A new UCSF study predicts a woman's chance of undergoing a hysterectomy based on symptoms and medical history. The study found that women with a combination of symptoms, lack of symptom resolution, and previous GNRH agonist use are more likely to undergo the procedure.
Endoscopic ligation is cost-effective for cirrhotic patients if quality-adjusted life years are considered. Ligation prevents more deaths and episodes, but is not as cost-effective when only life-years are considered.
A new thrombin-receptor antagonist (TRA) has shown significant reduction in serious cardiovascular events, mainly heart attacks, with no increase in bleeding risks in a high-risk patient population. The study found a 46% lowering in serious cardiovascular events, an early and strong efficacy signal for this novel antiplatelet compound.
Researchers found that older mothers with normal, full-term pregnancies were more likely to undergo Caesarean delivery than younger women with similarly low-risk pregnancies. Women giving birth for the first time were six times more likely to deliver by Caesarean.
A study found that routine upstream administration of platelet glycoprotein IIb/IIIa inhibitors reduced composite ischemia events, while deferred selective use resulted in fewer major bleeding complications. However, the criterion for noninferiority was not met.
A recent study using MRI found that 26% of vaginally delivered babies had small bleeds in and around the brain. The bleeds were likely caused by pressure on the skull during delivery. Most bleeds resolve over time without issues, but larger ones may cause problems later in childhood.
A study found that brain hemorrhages associated with warfarin increased by over tenfold in people over age 80, while the rate for all other populations quadrupled between 1988 and 1999. The increase was largely due to greater use of the drug, which is prescribed to prevent blood clots.
Researchers demonstrated the safety and effectiveness of continuous-use oral contraceptives eliminating menstrual cycles in a study published in Contraception. Healthy women between 18-49 years old showed significant relief from menstrual cycle symptoms without breaks or placebos.
A University of Rochester study published in Obstetrics and Gynecology journal found that low doses of mifepristone shrink uterine fibroid tumors and greatly improve the quality of life in women who suffer from pain and heavy bleeding. The treatment resulted in a 135% improvement in quality of life for women taking mifepristone compare...
A more restrictive drug coverage policy in British Columbia resulted in lower upper gastrointestinal bleeding rates compared to Ontario. The study suggests that limiting access to NSAIDs like coxibs can protect the population from adverse effects.
A new study found bivalirudin, an anti-clotting agent, is equally effective as a combination of injectable blood thinners in treating acute coronary syndromes, resulting in fewer cases of major bleeding. The medication reduced the risk of mortality by reducing bleeding complications.
The MEDAL trial found that etoricoxib and diclofenac have similar heart attack and stroke rates, but different side-effect profiles. Etoricoxib reduces gastrointestinal bleeding risk but may increase cardiovascular events.