Articles tagged with Bleeding
A study found that brain hemorrhages associated with warfarin increased by over tenfold in people over age 80, while the rate for all other populations quadrupled between 1988 and 1999. The increase was largely due to greater use of the drug, which is prescribed to prevent blood clots.
Researchers demonstrated the safety and effectiveness of continuous-use oral contraceptives eliminating menstrual cycles in a study published in Contraception. Healthy women between 18-49 years old showed significant relief from menstrual cycle symptoms without breaks or placebos.
A University of Rochester study published in Obstetrics and Gynecology journal found that low doses of mifepristone shrink uterine fibroid tumors and greatly improve the quality of life in women who suffer from pain and heavy bleeding. The treatment resulted in a 135% improvement in quality of life for women taking mifepristone compare...
A more restrictive drug coverage policy in British Columbia resulted in lower upper gastrointestinal bleeding rates compared to Ontario. The study suggests that limiting access to NSAIDs like coxibs can protect the population from adverse effects.
A new study found bivalirudin, an anti-clotting agent, is equally effective as a combination of injectable blood thinners in treating acute coronary syndromes, resulting in fewer cases of major bleeding. The medication reduced the risk of mortality by reducing bleeding complications.
The MEDAL trial found that etoricoxib and diclofenac have similar heart attack and stroke rates, but different side-effect profiles. Etoricoxib reduces gastrointestinal bleeding risk but may increase cardiovascular events.
A study found that only 14 of 15 hospitals provided inadequate discharge information, with most instruction sheets written at a high reading level. The researchers propose an evidence-based emergency department discharge form to improve patient safety and reduce the risk of brain hemorrhage or swelling.
Researchers at MIT and Hong Kong University have developed a biodegradable liquid that can stop bleeding in wounded rodents within seconds by forming a protective barrier gel. This breakthrough could significantly impact medicine, particularly in emergency surgery situations.
A study found that misoprostol is an effective way to prevent postpartum hemorrhage in countries with limited hospital services. The drug significantly reduced the risk of acute postpartum hemorrhage and average blood loss, offering a cost-effective solution for resource-poor settings.
A new study published in the New England Journal of Medicine found that a specific drug, enoxaparin, significantly reduces major bleeding risks during stent and angioplasty procedures. The researchers also showed that patients receiving this drug were more likely to achieve optimal blood thinning levels.
A new study found that older age is an independent risk factor for developing bleeding in the body, particularly intracranial hemorrhage in the brain. Carefully monitored warfarin therapy can be used with reasonable safety in older patients.
A new study published in the Journal of Periodontology found that combining tongue and tooth brushing with dental flossing significantly decreased gingival bleeding by 38 percent after a two-week oral hygiene program. Halitosis was also reduced, with gingival bleeding sites increasing by almost four percent in those who didn't floss.
A novel gene therapy could provide a permanent genetic cure for hemophilia A patients, including those with expensive and ineffective treatments. The treatment involves cloaking Factor VIII in platelets to avoid antibody attacks, making it effective even in patients with inhibitory antibodies.
A recent study found that women who have undergone Female Genital Mutilation (FGM) are more likely to experience difficulties during childbirth and their babies are at a higher risk of death. The study also estimated that in the African context, an additional one to two babies die per 100 deliveries due to FGM.
A Canadian Blood Services scientist has developed a potential alternative to costly IVIg treatment, which could lead to more effective and safer therapies for patients with life-threatening illnesses. The synthetic product could also reduce production costs and increase availability.
Researchers explore new GI technologies, including endoscopic ultrasound and fine needle intervention, to visualize the heart and coronary arteries with improved accuracy. The studies show promising results, suggesting that these techniques may be safe alternatives to traditional methods.
Researchers developed a simple clinical rule to predict patients at high risk for subarachnoid hemorrhage (SAH), reducing investigation rate to 66%. The rule uses 4 simple observations, including vomiting, diastolic blood pressure, and age, to identify patients who require further investigation via CT and/or LP.
A study analyzed MRIs of 24 patients with ischemic stroke to identify signs at increased risk for skull hemorrhaging. The researchers found that patients with parenchymal enhancement or hyperintense MCA sign may be at higher risk for developing hemorrhagic complications after tPA treatment.
A patient on warfarin developed life-threatening internal bleeding after consuming chamomile tea and lotion. Chamomile's synergistic effect with warfarin highlights the potential dangers of mixing herbal remedies with prescribed medications.
Researchers at Tulane University discovered that blocking the effects of carbon monoxide can limit bleeding in cases of soft tissue trauma. The study found that inhibiting CO helped control blood pressure and prevent massive bleeding by constricting damaged blood vessels, while maintaining circulation to other parts of the body.
A neoprene suit, called NASG, can save lives of women suffering from obstetrical hemorrhaging due to childbirth by reversing shock and decreasing bleeding. The study found a 69% decrease in death and severe illness among patients treated with the NASG.
A study of 700 autopsy cases found that retinal hemorrhages occur more frequently than initially thought and are not always indicative of child abuse. The research suggests that doctors should consider other possibilities when evaluating children with retinal hemorrhages, rather than automatically diagnosing abuse.
A new study suggests that lower doses of the clot-busting drug tPA can effectively treat intracerebral hemorrhage without increasing bleeding risks, with mortality rates dropping to 13 percent in some cases. The findings are promising for patients who suffer from this type of stroke, which affects over 100,000 Americans annually.
Researchers followed 207 patients who survived intracerebral hemorrhage and found no increased risk of second hemorrhage among those taking antiplatelet therapy. The location of the original hemorrhage was associated with a higher risk of recurrence, particularly in the cerebral cortex.
Researchers found no association between aspirin use and increased risk of recurrent intracerebral hemorrhage. However, the benefits of aspirin for certain patients with intracerebral hemorrhage are uncertain due to limited data.
A study of nearly 30,000 patients found that 42 percent received doses outside the recommended range, with excess doses linked to increased risks of bleeding and mortality. The researchers suggest improving dosing accuracy could save lives and reduce healthcare costs.
A long-term study showed that AMG 531 increased platelet counts in patients with immune thrombocytopenic purpura (ITP), with 47% of patients experiencing a durable response. The treatment was generally well-tolerated, but some serious adverse events were reported.
Researchers studied 18 cystic fibrosis patients who experienced variceal bleeding and found that most could manage without liver replacement. The study's findings challenge the common assumption that CF patients with bleeding complications are poor candidates for liver transplants.
A recent study found that even healthy people taking high doses of ibuprofen are at risk of internal bleeding, with blood loss ranging from 40mL to 299mL. The research highlights the need for caution when using ibuprofen, particularly in older adults and those with debilitating conditions.
Researchers found that patients taking non-steroidal anti-inflammatory drugs (NSAIDs) and aspirin were more likely to experience serious gastrointestinal problems such as ulcers, perforations, or bleeding. The risk of GI problems was significantly increased when combining NSAIDs with aspirin.
A Canadian study found that severe maternal morbidity rates declined between 1991 and 2001, with lower rates of postpartum hemorrhage requiring transfusion. However, a significant increase in uterine rupture cases was observed during this period, with women who experienced these complications being 158 times more likely to die.
The STEEPLE study examines the safety and efficacy of enoxaparin in percutaneous coronary intervention patients, comparing it to UFH regimens. The results confirm earlier findings that enoxaparin is simple and effective, with minimal bleeding risk, and suggest its use as a standard treatment option.
The OASIS-5/MICHELANGELO study found fondaparinux to be as effective as enoxaparin in preventing heart attacks and death at nine days after an event, but demonstrated a dramatic reduction in major bleeding. Patients also had a lower mortality rate at six months.
A study of 372 community-dwelling older patients found that those receiving high-quality care had better survival rates than those without it. The research created a quality-of-care score based on 236 process-of-care measures, with survival improving steadily as the score increased.
Researchers found that participants with moderate leisure-time physical activity had a 14% lower risk of any type of stroke, while those with high activity levels had a 26% lower risk. Daily commuting activities also showed a significant association with reduced stroke risk.
A study by Bernhard Nieswandt and colleagues reveals that mice lacking factor XII cleared blocked arteries after injury, unlike humans who develop coronary artery disease with elevated factor XII levels. The findings suggest drugs inhibiting this protein may be useful for treating certain heart diseases without increasing bleeding risk.
A research team has identified a genetic defect that weakens blood vessels in the brain, making infants vulnerable to cerebral hemorrhage. The discovery may lead to new strategies for disease prevention, such as reducing stress during birth.
A retrospective study found that patients taking SSRIs were at a similar risk of GI bleeding as those taking NSAIDs. The study suggests that physicians should closely monitor for this serious adverse event, especially in patients taking both SSRIs and NSAIDs.
A study published in the Canadian Medical Association Journal found that thrombolysis for acute ischemic stroke is a safe and effective therapy. The results indicate excellent outcomes for over one-third of patients and low rates of symptomatic intracranial hemorrhage and orolingual angiodema.
A survey of 1,105 emergency physicians found that many are hesitant to use tissue plasminogen activator (tPA) due to bleeding risks, despite its potential to restore blood flow in the brain. Team-based approaches and risk-reducing measures may help increase tPA adoption.
A study at Duke University Medical Center found that genetic variations in platelet surface receptors and coagulation proteins are associated with increased post-operative bleeding. This discovery may lead to genetic screening as a tool for pre-operative evaluation of heart surgery patients.
A new study found that erythropoietin reduced inflammation and cell death, improving functional recovery after hemorrhagic stroke in rats. The treatment also showed decreases in brain water content and increases in behavioral recovery.
A new study found that aspirin is as effective as warfarin in treating blocked brain arteries but has a significantly lower risk of major hemorrhage and death. The study, which involved over 500 patients, suggests that aspirin could be a safer alternative to warfarin for those with intracranial stenosis.
In a randomized clinical trial, researchers found that combining three anti-platelet drugs did not increase the risk of bleeding, and treatment adherence was high. The combination of cilostazol, clopidogrel, and aspirin was tested in patients who had undergone successful angioplasty and stent implantation.
A new study published in the New England Journal of Medicine found that treatment with recombinant activated factor VII (rFVIIa) significantly reduces bleeding in brain, decreases mortality by nearly 40%, and reduces long-term disability for patients with intracerebral hemorrhage (ICH). The study showed a significant improvement in cli...
Researchers found that ximelagatran was as effective as warfarin in preventing venous thromboembolism, but had a lower risk of bleeding. In another study, ximelagatran also showed promise for stroke prevention in patients with atrial fibrillation, with a lower rate of major and minor bleeding
A new stroke-prevention drug, Exanta, has been shown to reduce the risk of major hemorrhage by 26% and is equivalent to warfarin in preventing strokes. However, its high price makes it cost-ineffective for most patients at low risk of bleeding, except those with a high risk of both stroke and bleeding.
Current cardiology guidelines suggest clopidogrel as an alternative to low-dose aspirin, but recent research indicates it may impair ulcer healing and increase bleeding rates. Patients at high-risk for gastrointestinal complications should consider a combination of aspirin and stomach ulcer medications.
The McMaster researchers developed a detailed bleeding history questionnaire to discriminate between patients with QPD and those without. The tool helps identify higher likelihoods of bleeding that leads to lifestyle changes, bruises or bleeding in joints, providing valuable clues for doctors diagnosing the condition.
A recent study published in the New England Journal of Medicine found that vaginal birth after a prior cesarean delivery poses relatively low risks. However, the study also revealed that women attempting vaginal birth after a cesarean delivery may face increased complications such as uterine rupture and infant brain oxygenation issues.
A study published in Archives of Internal Medicine found a significant association between antidepressant use and risk of abnormal bleeding. The risk increased with the degree of serotonin reuptake inhibition, particularly for drugs with high levels of inhibition, which were associated with a 2.6-fold increased risk of bleeding events.
Researchers clarify that achieving an INR range of 2.0 to 3.0 is key to reducing stroke risk without increasing hemorrhage risk in atrial fibrillation patients. The study suggests that older patients with atrial fibrillation can still benefit from warfarin therapy, despite higher risks of intracranial hemorrhage.
A study by Chelsea S. Kidwell and colleagues found that MRI detected acute bleeding not seen on CT scans, improving detection rates for chronic hemorrhage and microbleeds. The results suggest that MRI may be superior to CT as the sole imaging technique for acute stroke diagnosis.
A review of herbal and nutritional supplements found eight products associated with clinically significant ocular side effects, including ginkgo biloba, Echinacea purpurea, chamomile, licorice, canthaxanthine, Datura, niacin, and vitamin A. The side effects range from dry eye to retinal hemorrhages and transient visual loss.
A randomized trial found that coronary angioplasty within 24 hours of medical therapy for heart-attack patients can significantly improve outcomes. The study, GRACIA-1, showed a halved rate of death, reinfarction, or revascularisation at 12 months compared to conservative treatment.
A recent audit found that using diathermy in tonsillectomies increases the risk of postoperative haemorrhage, particularly in adults and procedures performed by junior surgeons. The study suggests that hot techniques should be used with caution and emphasizes the importance of training junior surgeons to control bleeding.
A study conducted at the Mayo Clinic found that gastrointestinal endoscopy assistants, trained under supervision, can perform large-volume paracenteses safely and efficiently, with a median procedure time of two hours. The practice has been shown to save physician time without increasing patient risk.
A study of 546 stroke patients found that higher NIHSS scores were associated with increased risk of being discharged to rehabilitation or nursing facilities. The NIHSS score was also found to be a predictor of discharge destination, even after accounting for other factors.
The meta-analysis of 22,000 patients found that enoxaparin was more effective than unfractionated heparin in preventing combined rates of death or heart attack. However, the difference was not significant for major bleeding or transfusion rates.
Studies show that enoxaparin is non-inferior to unfractionated heparin in preventing death or non-fatal myocardial infarction in patients with non-ST elevation acute coronary syndromes. Enoxaparin also shows a lower rate of non-fatal MI with a modest excess of bleeding.