Simultaneous inhibition of two signaling pathways, mTOR and MAPK, resulted in enhanced antitumor effects in mouse models of prostate and breast cancer. This combination therapy may improve the treatment of human cancers, particularly for patients with advanced, hormone-refractory prostate cancer.
Greg Ganger, a Carnegie Mellon professor, will collaborate with HP Labs on a research initiative focused on data storage infrastructure issues. The award includes on-campus support for one graduate student researcher and aims to strengthen the collaboration between HP's scalable storage researchers and Carnegie Mellon's Parallel Data Lab.
Research found obesity in older people increases mobility problems and everyday task difficulties, but doesn't significantly impact mortality rates. The study highlights the need for healthcare professionals to advise older adults on weight management and encourage physical activity to reduce disability burden.
A new biopesticide has been developed for use on organic crops, offering a natural alternative to synthetic pesticides. The product is safe for humans, animals, and the environment, and will be available this October for conventional growers.
A team of US engineers has successfully developed software that enables deaf and hard-of-hearing Americans to communicate using American Sign Language (ASL) over mobile phones. The breakthrough allows for real-time video communication, making it a significant improvement over text messaging, which can convey emotion but is slower.
Two face transplants have shown promising results, with one patient recovering fully from a bear attack two years ago and another successfully treating a large facial tumor. The procedures involved allograft tissue transplantation and immunomodulatory drugs to prevent rejection.
A consortium of researchers is undertaking a five-year initiative to improve diagnosis and treatment of mild traumatic brain injury (MTBI). The Department of Defense has awarded $35 million to support the project, which aims to develop innovative methods for diagnosing and treating MTBI. The research will focus on basic and clinical st...
Researchers found two distinct species of grouper in the Pacific and Atlantic Oceans, despite their identical physical appearance. The study reveals that the Pacific grouper is a separate species from the Atlantic goliath grouper.
Research led by Beth Israel Deaconess Medical Center identifies a previously unrecognized problem faced by mTORC1 inhibitors: activating the MAPK pathway, which encourages cancer cell survival. Scientists found that combining mTORC1 and MAPK inhibitors may offer a new treatment option for cancer patients.
Ohio State University researchers have developed coatings that encourage neurons in the body to grow and connect with electrodes, boosting implant effectiveness. The coatings, which release neurotrophins over time, show promise for treating conditions such as Parkinson's disease and macular degeneration.
A study by Sheffield University and the University of St. Andrews found that relearning can trigger forgotten information when forgetting is induced by directional decay in synaptic connectivity. This suggests that evolution may have selected physiological mechanisms involving forgetting using a form of synaptic drift.
Dinoflagellates have evolved a unique way to pack their genetic material into compact chromosomes without using histones. This discovery raises questions about the evolution of chromosomes and whether dinoflagellates once had histones but lost them. The study provides new insights into the biochemical basis of chromosome formation.
Research by Jürgen Scheffran suggests climate change could trigger wars and conflicts due to resource scarcity and environmental degradation. The expert recommends addressing climate change through international cooperation and national policy.
A recent study found that individuals appearing underage and intoxicated can purchase alcohol at professional sports stadiums, with sales rates of 18% for pseudo-underage buyers and 74% for pseudo-intoxicated buyers. Location was a key factor, with sales in the stands being 2.9 times more likely than at concession booths.
An international team of engineers is developing mission-critical control software for future European robotic space missions. The project aims to improve the reliability of control systems required for autonomous rendezvous of satellites.
Researchers at University College London have combined silicon, iron, and manganese to create a new material with unique properties. The discovery demonstrates a simple recipe for reaching this 'quantum halfway house' and suggests new mechanisms for controlling electrical currents and magnetism in semiconductor devices.
Researchers at Princeton University will study 'intractability' with a $10 million NSF grant, aiming to understand the limits of computer power. The center will address problems in cryptography and quantum computing, potentially leading to breakthroughs in computer security.
Researchers have developed biodegradable polymers called polyketals that can deliver drugs, proteins, and snippets of ribonucleic acid to specific areas in the body. The microparticles degrade quickly into biocompatible compounds, reducing inflammation.
A five-year randomized trial found that patients participating in health tests and consultations demonstrated lower risk of heart and cardiovascular diseases. The impact of testing was also cost-effective, with no increase in healthcare system contacts and improved life expectancy.
Researchers at Duke University have synthesized largazole, a marine algae extract with potential as an anti-cancer agent. The team's efficient synthetic route enables the production of gram-sized quantities, paving the way for further study and potential treatment of various cancers.
Researchers developed ferroelectric polymer-based capacitors that deliver power more rapidly and are much lighter than conventional batteries. By tuning the dielectric property and energy density, they created materials with high performance and flexibility.
The University of Kentucky will investigate how particle size and shape affect brain entry, focusing on nano-sized cerium oxide. The EPA has awarded a $2M grant for four years to examine potential health impacts.
Researchers have identified two receptors on the tongue that detect the taste of calcium, which is crucial for building strong bones. This discovery could lead to the development of foods and drinks that are more palatable and easier to consume.
The National Human Genome Research Institute has awarded over $20 million in grants to develop innovative DNA sequencing technologies that can sequence a person's genome for $1,000 or less. The goal is to enable routine sequencing of genomes to advance scientific knowledge and healthcare.
A new study published in BMC Infectious Diseases reveals a significant increase in human rabies cases in China since the new millennium. The researchers found that the number of cases jumped dramatically from 159 to 3,279 between 1990 and 2006, with most patients contracting the disease after being bitten by dogs.
A Phase 2 trial of PTC124 demonstrated statistically significant improvements in CFTR-mediated chloride transport and lung function in patients with nonsense-mutation CF. The study showed that PTC124 induced chloride transport responses across various patient genotypes, offering a potential new treatment paradigm for this genetic disease.
Researchers have engineered the first drug-delivery particles capable of passing through human mucus, which could treat a range of diseases. The new system uses a polymer coating to allow drugs to penetrate mucus layers in minutes.
Researchers at Beth Israel Deaconess Medical Center discovered that PTEN tumor suppression is maintained through a nuclear localization pathway. The study found that the loss of PML and HAUSP can force PTEN out of the nucleus, preventing its ability to act as a tumor suppressor.
Researchers monitoring daily satellite images of Greenland's glaciers have discovered break-ups at two of the largest glaciers, including Petermann and Jakobshavn. The expected disintegration of the Northern hemisphere's longest floating glacier will continue within the next year.
A new study suggests that processing red tomatoes with heat and fat can increase the absorption of lycopene, a naturally occurring pigment linked to cancer prevention. The researchers found that the bent molecular form of lycopene is more easily absorbed into the bloodstream than its linear form.
Researchers used proteomics to compare the nuclear proteome of immature and mature gonadotrophic cells, revealing novel proteins that regulate gonadotropin gene transcription and RNA splicing. Urban air pollution was found to affect placental development, leading to reduced fetal growth and pregnancy complications.
Dr. Edward Duckworth is using less-invasive techniques to remove tumors, repair life-threatening aneurysms, and reduce seizures in epilepsy patients. The procedure involves reaching the brain through smaller openings, resulting in decreased pain and shorter hospital stays.
A new study found that exposing fetal mice to high saturated fats can cause them and their offspring to develop type 2 diabetes. This unusual form of inheritance, known as metabolic programming, has implications for human health, particularly for children born to malnourished mothers.
Researchers at Joslin Diabetes Center identified a protein called BMP-7 that induces the formation and function of brown fat cells. This discovery may lead to new treatments or prevention strategies for obesity and its associated diseases.
A new medical imaging technology could provide a long-awaited test for early diagnosis of osteoarthritis, allowing doctors to prevent or reduce permanent damage. The method uses modified MRI to determine the concentration of glycosaminoglycan, a biomarker for OA and cartilage disorders.
The Centre for Addiction and Mental Health (CAMH) has received a $15 million investment from the Canada Foundation for Innovation to propel its research on mental illness and addiction forward. The funding will support six research themes, including optimizing treatment across mental illness and substance use disorders.
Researchers at Purdue University developed a new monolithic comb drive device that can precisely move or sense movement at an atomic scale. The device has twice the dexterity of similar devices and could improve probe-based sensors for detecting viruses and biological molecules.
Researchers at Ohio State University have created a catalyst that converts ethanol into hydrogen with a 90% yield, using inexpensive ingredients. The new catalyst is less expensive than others being developed worldwide, making it more practical for widespread use in hydrogen-powered cars.
Researchers discovered compounds that interact with tau protein in three specific ways, which could lead to early diagnosis and treatment of Alzheimer's disease. These compounds may bind to tau filaments, inhibit filament formation, or drive tau protein to form filaments.
Researchers at Brookhaven National Laboratory found that vigabatrin induced satiety in obese animals, leading to significant weight loss and reduced food consumption. The study suggests that vigabatrin could potentially treat severe obesity, including binge eating patterns similar to those seen in cocaine dependency.
A study found that alcohol dependence in women is associated with delayed reproduction, including menstrual disorders and unplanned pregnancies. Women who drink may want to consider the long-term consequences of drinking on later childbearing.
A new study analyzing Oetzi's hair samples reveals his clothes were made from sheep and cattle fur, supporting the idea that he was a herdsman. The technique used could be faster and more reliable for checking animal hair products and aiding manufacturers in adhering to EU laws.
A study published in BMC Psychiatry found that pregnant women experiencing severe stress during the second month of pregnancy are more likely to have children who develop schizophrenia. Women born in Jerusalem during the Arab-Israeli war had a higher risk of schizophrenia, particularly females.
Researchers at UNC are developing a unique way to deliver a nucleic acid derived from bacteria to tumors, allowing the body's immune system to recognize and attack cancerous cells. The goal is to create a reliable delivery method for immunotherapy, which has shown promise but faces challenges in consistency.
Researchers found that sales rates to pseudo-underage buyers were 18% and to pseudo-intoxicated buyers were 74%. The study suggests sports stadiums serve alcohol to minors and intoxicated fans, highlighting the need for responsible service and law enforcement monitoring. Sales were more likely in stadium stands than concession booths.
Researchers at the University of Texas Health Science Center have successfully manipulated flavor enzymes in plants, opening up possibilities for fine-tuning fruit flavors. The breakthrough could also lead to novel pest control methods using green leaf volatiles and jasmonates.
Researchers have identified Smurf1 as a signaling partner that damages bone in rheumatoid arthritis, guiding the development of new drugs to reverse bone loss. The study also suggests potential applications against osteoporosis by targeting Smurf1 with specific drugs.
A study on Trichoplax genome findings aids researchers in learning how groups of genes function in humans and other species. The genetic code of this simple saltwater creature reveals common genes among many species, helping scientists figure out their lineage and divergence.
A possible link has been discovered between childhood middle ear infections and a tendency to be overweight later in life. Research suggests that prompt diagnosis and treatment of ear infections may help fight obesity in some people.
A group of experts has developed a roadmap for improving our understanding of how mercury moves through the marine ecosystem and into the fish we eat. The report prioritizes integrated monitoring across habitats, considering links between marine sources, biotransfer processes, and bioaccumulation mechanisms.
Numerical simulations of nutrient transport changes in Honghu Lake Basin revealed that human activities increased rapidly and became a dominant factor in changes of the nutrient transportation. The study found variations in nutrient production and concentration, with increasing rates of eutrophication over time.
Scientists at University of Michigan and U.S. Naval Research Laboratory demonstrate a solid-state qubit that can be both 0 and 1 at the same time, enabling faster quantum computing and improved computer security. The breakthrough enables the creation of a code that would be impossible to crack with conventional computers.
Research suggests that codeine may be unsuitable for all breastfed infants due to rapid metabolism into morphine, which can cause central nervous system depression. Fortunately, removal of exposure leads to dramatic improvement and no long-term adverse effects.
Scientists have discovered a diatom that can reduce the toxicity of red tide algae to both animals and other algae, potentially mitigating economic damage to the seafood and tourism industries. The research suggests that the diatom may degrade or neutralize the toxins produced by the red tide, offering new hope for reducing its impact.
Research found pregnant women experiencing high psychological stress are more likely to give birth to a child with schizophrenia. The study, which analyzed data from 88,829 people born in Jerusalem between 1964 and 1976, discovered a significantly higher incidence of schizophrenia among females.
Researchers at LSUHSC have identified a naturally occurring fatty acid, 2-AG, that functions as an endogenous COX-2 inhibitor, protecting brain cells from neurodegenerative diseases. The study provides new therapeutic approaches to prevent devastating disorders like stroke and Alzheimer's.
A new guideline developed by the American Academy of Neurology recommends surgery as a treatment option for people with extreme face pain due to trigeminal neuralgia. The guideline suggests that patients who don't respond well to drugs should consider surgical interventions to target the root of the trigeminal nerve.
Planting trees around poultry farms can reduce emissions of dust, ammonia, and odors by up to 56% and 53%. Trees also conserve energy, improve air quality, and filter pollutants from soil and groundwater.
The study suggests that universal vaccine coverage in young adolescent girls, initial catch-up efforts for women under 21, and revised screening policies can significantly reduce cervical cancer rates. Vaccination is predicted to be economically attractive if achieved in 12-year-old girls with long-lasting protection.
Researchers have identified a unique 'odor profile' for skin cancer using advanced chromatography techniques. The discovery could lead to a rapid, non-invasive diagnostic test that detects skin cancer before symptoms appear.