Articles tagged with Bleeding
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A new NIH-funded study will investigate a deadly bleeding disorder called coagulopathy that occurs without warning in trauma patients. Researchers hope to develop effective therapeutic approaches with the goal of saving lives.
The OPTIMIZE trial found that shortening dual antiplatelet therapy after drug-eluting stent implantation may reduce bleeding risks and treatment costs. Patients who received shorter-term therapy had similar rates of NACCE as those on longer-term therapy.
The EUROMAX trial reveals that administering bivalirudin to STEMI patients in pre-hospital settings significantly reduces death and major bleeding complications compared to heparin. Bivalirudin also showed a lower rate of reinfarction and death, however with increased risk of acute stent thrombosis.
The SAFE-PCI for Women trial found that radial access reduced bleeding and complication rates compared to femoral access, with a significant benefit seen in the overall cohort. The study's findings suggest that radial access is a reasonable strategy for women undergoing cardiac catheterization.
Researchers at the University of Illinois Chicago have discovered a molecular switch that causes small, beneficial clots to enlarge further during wound healing. By blocking this switch, potent anti-clotting drugs can be developed to prevent large clots from forming while preserving the body's ability to form primary clots.
A new study finds that an experimental drug called 3K3A-APC reduces brain damage and eliminates brain hemorrhaging in stroke-afflicted mice and rats. The drug extends the therapeutic window of FDA-approved clot-busting therapy tPA, counteracting its tendency to induce bleeding.
A University of Michigan Health System study found that high-skilled surgeons had significantly fewer post-surgery complications and shorter operations. The study used video ratings data of 20 bariatric surgeons' operating skills to predict patient outcomes, with low skill surgeons experiencing higher complication rates.
Researchers at The Feinstein Institute for Medical Research identified the cold-inducible RNA-binding protein (CIRP) as a key player in triggering inflammation during hemorrhagic shock and sepsis. Blocking CIRP activity may improve patient survival rates, according to preclinical studies.
A study found that oxytocin injections given by health workers without midwifery skills can reduce postpartum bleeding and mortality rates. The trial showed a significant reduction in postpartum hemorrhage among women who received the injection, highlighting a potential solution for preventing this deadly condition in rural communities.
A new study found that Americans in higher socio-economic groups have a 13% greater chance of surviving subarachnoid hemorrhage than those in lower-income groups. However, this status did not influence mortality rates in Canada, where universal health insurance may play a role in improving outcomes.
A clinical decision rule, known as the Ottawa SAH Rule, has been developed to identify neurologically intact patients with headache in the emergency department who have subarachnoid hemorrhage. The rule uses five variables from a patient's history and examination to predict diagnosis, showing 100% sensitivity but only 15.3% specificity.
Researchers developed a therapeutic principle using Poxue Huayu and Tianjing Busui Decoction to break blood stasis and replenish essence. The treatment demonstrated significant reductions in brain water content, intracerebral hematoma volume, and neurologic impairment in cerebral hemorrhage rat models.
A new study published in the Journal of Neurosurgery found significant racial and ethnic differences in outcomes following a type of stroke called subarachnoid hemorrhage. Hispanic patients were more likely to survive, while Asian/Pacific Islanders were more likely to die from the condition.
A randomized study found that prasugrel pre-treatment in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) significantly increases the risk of life-threatening bleeding without reducing major ischemic events. This shift away from pre-treatment may lead to changes in treatment strategies.
The PRAGUE 14 trial found no correlation between pre-surgical interruption of antithrombotic therapy and perioperative cardiovascular or bleeding complications. Instead, factors like high platelet count, prosthetic valve presence, age, and acute surgery were identified as independent risk factors.
The study found that edoxaban was non-inferior to warfarin in treating VTE, but efficacy was superior in patients with pulmonary embolism and right ventricular dysfunction. Edoxaban also showed reduced bleeding rates in high-risk sub-groups.
A study published in the Journal of the American Medical Association found that otamixaban, a novel anticoagulant, did not reduce ischemic events but increased bleeding among patients with non–ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention (PCI). The trial compared otamixaban with unfraction...
Researchers from UTHealth and Lund University have discovered a genetic variant in the Factor V gene causing an abnormal form of the protein FV-Short, leading to excessive TFPI formation and uncontrolled bleeding. The study provides insight into the clotting process and offers potential treatment possibilities for the rare condition.
A genetic mutation in coagulation factor 5 is identified as the cause of a severe hereditary bleeding disorder in East Texas. The mutation leads to the production of a truncated form of FV, which forms a complex with tissue factor pathway inhibitor-α that inhibits coagulation pathways.
A randomized clinical trial found a significant increase in cerebral vasospasm and EVD-related complications when CSF was drained continuously in patients with subarachnoid hemorrhage. The study, halted early due to high complication rates, suggests continuous drainage may not be the best method for intracranial pressure management.
A new image-guided surgical system uses steerable needles to penetrate the brain and remove blood clots with minimal damage. The system has shown promising results in removing up to 92% of simulated blood clots, offering a new treatment option for patients with life-threatening hemorrhages.
Prothrombin complex concentrates (PCCs) are recommended as the first line of defense for reversing warfarin-associated hemorrhage in emergency departments. PCCs can reverse anticoagulation three to five times faster than fresh frozen plasma, making them a life-saving treatment option.
High platelet reactivity after drug-eluting stent implantation was associated with increased risk of stent thrombosis and heart attack, while also reducing major bleeding. However, the association between high platelet reactivity and mortality was not independent.
Researchers discovered that significant others' excessive fears about SAH recurrence negatively impact patients' psychosocial recovery. Patients whose significant others were the most fearful experienced compromised recovery, with worse general health and limitations in everyday activities.
A new study suggests that Chinese people are at a higher risk of stroke than Caucasians. The research found a slightly higher overall risk of stroke in Chinese people, with a range of 205 to 584 strokes per 100,000 Chinese people age 45 to 74 compared to 170 to 335 strokes per 100,000 Caucasian people in the same age group.
A study published in Plastic and Reconstructive Surgery reveals that nearly half of cosmetic plastic surgery patients take herbal supplements, which can increase complication risk. The study advises patients to stop taking supplements at least two weeks before surgery to minimize risks.
A US study found a decline in ischemic stroke mortality among Black children over the past decade. The relative risk decrease was attributed to improvements in long-term blood transfusion therapy for sickle cell disease prevention.
A study of nearly 60,000 patients with acute ischemic stroke found that faster thrombolytic treatment was associated with lower mortality and improved walking ability at discharge. The study suggests accelerating patient presentation and streamlining healthcare systems to reduce treatment times can improve outcomes.
Researchers found a 13-fold increase in wrist procedures for percutaneous coronary intervention (PCI) between 2004-07 and 2012. This shift may improve PCI safety, particularly in high-risk patients, by reducing bleeding complications.
Researchers developed a new method to measure cerebral blood flow in children on ECMO, finding that those who experienced strokes or brain bleeds had significantly higher blood flow rates than normal, two to six days prior. This technique could help physicians predict and prevent complications, with potential lead time for intervention.
The guideline advises that taking aspirin or warfarin before dental procedures, cataract surgery, and dermatologic procedures is likely safe. However, patients undergoing procedures like retinal surgery or orthopaedic hip procedures may experience increased bleeding risk.
The new guideline from the American Academy of Neurology helps people with stroke and atrial fibrillation decide whether to take blood thinners during surgery. For minor procedures, the risk of bleeding is small, but for certain hip and colon procedures, it's higher.
A new study identifies larger arachnoid cysts and recent head trauma as key risk factors for rupture or bleeding in children. The study found that the risk of rupture was significantly higher for children with larger cysts, with an estimated 16 times greater risk for cysts measuring five centimeters or larger.
A University of Oregon study found that 17% of female students alter their menstrual cycle for convenience or personal preference. Women who prefer a monthly cycle are less likely to modify their bleeding schedule, suggesting healthcare providers can educate them on suitable options.
Researchers have found that combining a new-generation mechanical heart valve with low-dose anticoagulation therapy significantly lowers the risk of bleeding events while maintaining stroke and neurological event rates. This study uses a new bileaflet design, and its findings may lead to reduced anticoagulation therapy for patients
Two new papers highlight the risks of dabigatran etexilate (Pradaxa) in cases of closed head injuries, showing a higher mortality rate and increased risk of hemorrhage progression. The studies emphasize the need for effective anticoagulation reversal protocols to improve patient outcomes.
Patients receiving SSRIs before surgery had higher odds of in-hospital mortality and bleeding events. The study, which included over 530,000 patients, suggests that patient factors or SSRIs themselves may be responsible for the increased risks.
A large study found that selective serotonin reuptake inhibitors (SSRIs) are associated with a 10% increased risk of adverse outcomes after surgery, including bleeding and transfusions. The study suggests that patients on SSRIs should discuss their medication with their surgeon or primary care physician before undergoing surgery.
A study reviewed 12,101 patients to assess the accuracy of patient history, clinical examination, and sonography in diagnosing ectopic pregnancy. Transvaginal sonography is identified as the single best diagnostic method for evaluating suspected ectopic pregnancy.
Researchers found that combining fluoroscopy and CT scans reduces major complications during gastric tube insertion by nearly eliminating misplacement errors.
Researchers recommend radiosurgery for treating unruptured AVMs due to its reasonable benefit-to-risk profile. The procedure resulted in AVM obliteration in 62% of patients, with a reduced annual hemorrhage rate compared to left untreated AVMs.
The GIE special issue discusses the management of serrated colon polyps, including risk factors and management recommendations. Prophylactic clip closure is shown to reduce delayed postpolypectomy hemorrhage in large sessile or flat lesions.
Scientists at the University of Nottingham are leading a four-year study to investigate the effectiveness of tranexamic acid in treating intracerebral haemorrhage, a devastating type of stroke. The trial aims to recruit 2,000 people worldwide and assess whether the drug can reduce permanent brain damage and improve survival rates.
A recent study found that preterm infants with low-grade brain bleeding have similar neurodevelopmental outcomes as those with no bleeding. The study analyzed 1472 extremely preterm infants and found that those with grade 1 or 2 PIVH did not have an increased incidence of poor outcomes compared to infants without PIVH.
A study of over 3.3 million PCI procedures found that major bleeding was associated with significantly increased in-hospital mortality, with an estimated 12% of deaths related to bleeding complications. The researchers suggest that bleeding-related mortality may be modifiable through established strategies.
A University of Michigan Stroke Program study suggests that the combination of blood thinners and tPA treatment for stroke does not increase the risk of brain bleeding. The research, based on data from 830 patients, found no significant difference in brain bleeding rates even among those taking aspirin or clopidogrel.
A clinical decision support tool helped identify high-risk patients before coronary interventions, leading to reduced bleeding complications and shorter hospital stays. The use of bivalirudin as a bleeding avoidance strategy improved patient outcomes, including lower complication rates and death.
Researchers are developing artificial blood platelets laced with regulatory chemicals that can be injected into the bloodstream to control bleeding and promote healing. The synthetic platelets have shown promise in animal models, reducing clotting time by approximately 30 percent.
A new progestogen-only treatment has been found to halt acute abnormal uterine bleeding in women, with 44 of 48 participants experiencing complete cessation of bleeding within five days. The therapy, which involves a low-dose injection and oral pills, shows promise as a temporary bridge to longer-term targeted therapies.
Researchers found that implementing a standardized comprehensive maternal hemorrhage protocol significantly reduced blood product utilization, resulting in a 45% reduction in puerperal hysterectomy. The study also showed a significant decrease in morbidity, with reductions in red blood cells, platelets, and cryoprecipitate usage.
Prompt identification and treatment of perioperative strokes can significantly improve neurologic outcomes. The article reviews management options for perioperative stroke, including blood thinners, clot-busting drugs, mechanical devices, ultrasound, and hemicraniectomy.
A minimally invasive surgical procedure to remove blood clots in brain tissue after hemorrhagic stroke appears safe and effective in improving long-term disability and reducing hospital time. The study found that patients treated with the surgery had less disability, spent less time in the hospital, and were less likely to be in a long...
Researchers tracked 73 subjects with intracerebral hemorrhage (ICH) to find that about 60% of newborns had visible seizures at the time of stroke, while 43% of older children did. Within two years, 13% of study subjects developed epilepsy, and patients with elevated brain pressure were more likely to experience later seizures.
Researchers found that minimally invasive delivery of tPA directly into brain clots improved functional recovery in patients with intracerebral hemorrhage, reducing hospital stays and costs. Patients who received the active tPA treatment recovered more quickly and independently after a year.
A new study found that up to 34% of stroke patients who had their life support withdrawn might have achieved an acceptable level of functioning if support had been continued. The study compared the outcomes of 78 patients whose life support was withdrawn with those of similar patients who remained on life support.
Research found Native Hawaiians and Pacific Islanders have a higher risk of intracerebral hemorrhage before age 45 compared to non-Hispanic whites. The study revealed that Native Hawaiians were 54 years old when they had a hemorrhagic stroke, whereas non-Hispanic whites were 68 years old, highlighting the disparity in vascular health.
The radial approach for percutaneous coronary interventions (PCI) is associated with reduced bleeding complications and improved survival rates, particularly in STEMI patients. The European Society of Cardiology recommends radial access as the default strategy for PCI in high-risk acute coronary syndromes.
A study published in Neurology found that smoking and poor blood pressure and cholesterol levels significantly increase the risk of death for patients who have survived subarachnoid hemorrhage. The research, which followed over 64,000 Finns, revealed that lifestyle changes can help prevent early deaths among SAH survivors.
Researchers have identified a specific section of chromosome 2 that regulates von Willebrand factor levels, a key substance in blood clotting. The findings may lead to improved diagnosis and treatment for bleeding disorders.
The Pipeline embolization device shows encouraging results in patients with certain types of difficult-to-treat brain aneurysms, including a 68% complete blockage rate. However, the data also show substantial risks, including major complications and fatal bleeding, particularly for aneurysms in specific locations.