Articles tagged with Bleeding
The AleCardio trial was ended early after patients treated with aleglitazar showed higher rates of heart failure, kidney events, and gastrointestinal bleeding. The study found no cardiovascular benefits despite dual-action on PPAR receptors, leading researchers to consider the class of drug being tested clinically.
A study published in GIE: Gastrointestinal Endoscopy found that cold snare polypectomy significantly reduces the risk of delayed bleeding in patients taking anticoagulants. The procedure outperformed conventional polypectomy in removing small colorectal polyps without causing significant harm to submucosal vessels.
A recent study found that warfarin treatment is associated with a lower risk of death, heart attack, or stroke without an increased risk of bleeding for patients with established cardiovascular disease and atrial fibrillation. The study included over 24,000 patients with kidney function measured through serum creatinine levels.
Researchers aim to create artificial platelets that can stick to injury sites and signal natural platelets to home in on them, offering a potential solution to bleeding disorders. The technology has broad applications in stanching bleeding and detecting diseases.
The Hartford Consensus aims to educate law enforcement on the importance of controlling hemorrhage in active shooter incidents. The initiative, led by the American College of Surgeons, provides training and equipment for police officers to respond to mass casualty events.
Researchers created a synthetic version of low-molecular-weight heparin that can be counteracted by an existing drug and cleared by the liver, not the kidneys. This new form of heparin is safer for patients with poor kidney function, reducing the risk of uncontrolled bleeding.
Researchers found that collecting and bleeding horseshoe crabs for biomedical purposes causes short-term changes in their behavior and physiology. The study suggests delaying the blood harvest or improving transportation conditions could help the animals recover and breed again, potentially mitigating population declines.
Researchers developed an antibody blocking coagulation factor XII, which prevents thrombosis without increasing bleeding risk in clinical settings. This innovation reduces the clotting risk in emergency situations like ECMO treatment and cardiovascular surgery.
A new gene therapy has led to a dramatic decline in bleeding events in dogs with naturally occurring hemophilia A. The treatment involves packaging specialized blood platelets with genes that express clotting factor, resulting in significantly fewer serious bleeding events over three years.
Researchers discover embolic material, polyvinylpyrrolidone (PVP), at site of fatal brain hemorrhages occurring days after aneurysm treatment. PVP is suspected to have traveled through vasculature from PED delivery site to location where hemorrhage occurred.
Scientists will attempt to identify a molecular signal indicating severity of brain-injury in patients at risk for vasospasm after hemorrhagic stroke. The goal is to establish individualized care and respond rapidly to changing health conditions, allowing earlier intervention and preventing secondary injuries.
Synaptosomal-associated protein-25 expression is significantly lower after subarachnoid hemorrhage, which may relate to cognitive disorders that follow. The study found lower expression levels in the temporal lobe, hippocampus, and cerebellum at days 1 and 3.
A study published in the Journal of Clinical Investigation reveals that type 2B von Willebrand disease is associated with platelet dysfunction. Researchers found that a mutation in the von Willebrand factor protein can inhibit platelet activation and promote thrombocytopathy.
The ENGAGE AF-TIMI 48 trial found edoxaban to be at least as effective as warfarin in preventing stroke or systemic embolism, while significantly reducing bleeding and cardiovascular death. High-dose edoxaban showed a 21% reduction in stroke risk and a 20% decrease in major bleeding compared to warfarin.
Researchers at MU School of Medicine found a new protocol using preventive blood thinners reduces life-threatening blood clots in brain-injured patients. The study compared outcomes between 107 and 129 patients treated with or without the medication, showing zero instances of deep-venous clotting among those who received it.
A study of 60 people aged 45 years or older found that accelerated surgery within six hours reduced major complications by 30% compared to standard care. Faster surgery may be better for hip fractures, say researchers at McMaster University.
A new NIH-funded study will investigate a deadly bleeding disorder called coagulopathy that occurs without warning in trauma patients. Researchers hope to develop effective therapeutic approaches with the goal of saving lives.
The OPTIMIZE trial found that shortening dual antiplatelet therapy after drug-eluting stent implantation may reduce bleeding risks and treatment costs. Patients who received shorter-term therapy had similar rates of NACCE as those on longer-term therapy.
The EUROMAX trial reveals that administering bivalirudin to STEMI patients in pre-hospital settings significantly reduces death and major bleeding complications compared to heparin. Bivalirudin also showed a lower rate of reinfarction and death, however with increased risk of acute stent thrombosis.
The SAFE-PCI for Women trial found that radial access reduced bleeding and complication rates compared to femoral access, with a significant benefit seen in the overall cohort. The study's findings suggest that radial access is a reasonable strategy for women undergoing cardiac catheterization.
Researchers at the University of Illinois Chicago have discovered a molecular switch that causes small, beneficial clots to enlarge further during wound healing. By blocking this switch, potent anti-clotting drugs can be developed to prevent large clots from forming while preserving the body's ability to form primary clots.
A new study finds that an experimental drug called 3K3A-APC reduces brain damage and eliminates brain hemorrhaging in stroke-afflicted mice and rats. The drug extends the therapeutic window of FDA-approved clot-busting therapy tPA, counteracting its tendency to induce bleeding.
A University of Michigan Health System study found that high-skilled surgeons had significantly fewer post-surgery complications and shorter operations. The study used video ratings data of 20 bariatric surgeons' operating skills to predict patient outcomes, with low skill surgeons experiencing higher complication rates.
Researchers at The Feinstein Institute for Medical Research identified the cold-inducible RNA-binding protein (CIRP) as a key player in triggering inflammation during hemorrhagic shock and sepsis. Blocking CIRP activity may improve patient survival rates, according to preclinical studies.
A study found that oxytocin injections given by health workers without midwifery skills can reduce postpartum bleeding and mortality rates. The trial showed a significant reduction in postpartum hemorrhage among women who received the injection, highlighting a potential solution for preventing this deadly condition in rural communities.
A new study found that Americans in higher socio-economic groups have a 13% greater chance of surviving subarachnoid hemorrhage than those in lower-income groups. However, this status did not influence mortality rates in Canada, where universal health insurance may play a role in improving outcomes.
A clinical decision rule, known as the Ottawa SAH Rule, has been developed to identify neurologically intact patients with headache in the emergency department who have subarachnoid hemorrhage. The rule uses five variables from a patient's history and examination to predict diagnosis, showing 100% sensitivity but only 15.3% specificity.
Researchers developed a therapeutic principle using Poxue Huayu and Tianjing Busui Decoction to break blood stasis and replenish essence. The treatment demonstrated significant reductions in brain water content, intracerebral hematoma volume, and neurologic impairment in cerebral hemorrhage rat models.
A new study published in the Journal of Neurosurgery found significant racial and ethnic differences in outcomes following a type of stroke called subarachnoid hemorrhage. Hispanic patients were more likely to survive, while Asian/Pacific Islanders were more likely to die from the condition.
A randomized study found that prasugrel pre-treatment in patients with non-ST-elevation acute coronary syndrome (NSTE-ACS) significantly increases the risk of life-threatening bleeding without reducing major ischemic events. This shift away from pre-treatment may lead to changes in treatment strategies.
The PRAGUE 14 trial found no correlation between pre-surgical interruption of antithrombotic therapy and perioperative cardiovascular or bleeding complications. Instead, factors like high platelet count, prosthetic valve presence, age, and acute surgery were identified as independent risk factors.
The study found that edoxaban was non-inferior to warfarin in treating VTE, but efficacy was superior in patients with pulmonary embolism and right ventricular dysfunction. Edoxaban also showed reduced bleeding rates in high-risk sub-groups.
A study published in the Journal of the American Medical Association found that otamixaban, a novel anticoagulant, did not reduce ischemic events but increased bleeding among patients with non–ST-segment elevation acute coronary syndromes undergoing percutaneous coronary intervention (PCI). The trial compared otamixaban with unfraction...
Researchers from UTHealth and Lund University have discovered a genetic variant in the Factor V gene causing an abnormal form of the protein FV-Short, leading to excessive TFPI formation and uncontrolled bleeding. The study provides insight into the clotting process and offers potential treatment possibilities for the rare condition.
A genetic mutation in coagulation factor 5 is identified as the cause of a severe hereditary bleeding disorder in East Texas. The mutation leads to the production of a truncated form of FV, which forms a complex with tissue factor pathway inhibitor-α that inhibits coagulation pathways.
A randomized clinical trial found a significant increase in cerebral vasospasm and EVD-related complications when CSF was drained continuously in patients with subarachnoid hemorrhage. The study, halted early due to high complication rates, suggests continuous drainage may not be the best method for intracranial pressure management.
A new image-guided surgical system uses steerable needles to penetrate the brain and remove blood clots with minimal damage. The system has shown promising results in removing up to 92% of simulated blood clots, offering a new treatment option for patients with life-threatening hemorrhages.
Prothrombin complex concentrates (PCCs) are recommended as the first line of defense for reversing warfarin-associated hemorrhage in emergency departments. PCCs can reverse anticoagulation three to five times faster than fresh frozen plasma, making them a life-saving treatment option.
High platelet reactivity after drug-eluting stent implantation was associated with increased risk of stent thrombosis and heart attack, while also reducing major bleeding. However, the association between high platelet reactivity and mortality was not independent.
Researchers discovered that significant others' excessive fears about SAH recurrence negatively impact patients' psychosocial recovery. Patients whose significant others were the most fearful experienced compromised recovery, with worse general health and limitations in everyday activities.
A new study suggests that Chinese people are at a higher risk of stroke than Caucasians. The research found a slightly higher overall risk of stroke in Chinese people, with a range of 205 to 584 strokes per 100,000 Chinese people age 45 to 74 compared to 170 to 335 strokes per 100,000 Caucasian people in the same age group.
A study published in Plastic and Reconstructive Surgery reveals that nearly half of cosmetic plastic surgery patients take herbal supplements, which can increase complication risk. The study advises patients to stop taking supplements at least two weeks before surgery to minimize risks.
A US study found a decline in ischemic stroke mortality among Black children over the past decade. The relative risk decrease was attributed to improvements in long-term blood transfusion therapy for sickle cell disease prevention.
A study of nearly 60,000 patients with acute ischemic stroke found that faster thrombolytic treatment was associated with lower mortality and improved walking ability at discharge. The study suggests accelerating patient presentation and streamlining healthcare systems to reduce treatment times can improve outcomes.
Researchers found a 13-fold increase in wrist procedures for percutaneous coronary intervention (PCI) between 2004-07 and 2012. This shift may improve PCI safety, particularly in high-risk patients, by reducing bleeding complications.
Researchers developed a new method to measure cerebral blood flow in children on ECMO, finding that those who experienced strokes or brain bleeds had significantly higher blood flow rates than normal, two to six days prior. This technique could help physicians predict and prevent complications, with potential lead time for intervention.
The guideline advises that taking aspirin or warfarin before dental procedures, cataract surgery, and dermatologic procedures is likely safe. However, patients undergoing procedures like retinal surgery or orthopaedic hip procedures may experience increased bleeding risk.
The new guideline from the American Academy of Neurology helps people with stroke and atrial fibrillation decide whether to take blood thinners during surgery. For minor procedures, the risk of bleeding is small, but for certain hip and colon procedures, it's higher.
A new study identifies larger arachnoid cysts and recent head trauma as key risk factors for rupture or bleeding in children. The study found that the risk of rupture was significantly higher for children with larger cysts, with an estimated 16 times greater risk for cysts measuring five centimeters or larger.
A University of Oregon study found that 17% of female students alter their menstrual cycle for convenience or personal preference. Women who prefer a monthly cycle are less likely to modify their bleeding schedule, suggesting healthcare providers can educate them on suitable options.
Researchers have found that combining a new-generation mechanical heart valve with low-dose anticoagulation therapy significantly lowers the risk of bleeding events while maintaining stroke and neurological event rates. This study uses a new bileaflet design, and its findings may lead to reduced anticoagulation therapy for patients
Two new papers highlight the risks of dabigatran etexilate (Pradaxa) in cases of closed head injuries, showing a higher mortality rate and increased risk of hemorrhage progression. The studies emphasize the need for effective anticoagulation reversal protocols to improve patient outcomes.
Patients receiving SSRIs before surgery had higher odds of in-hospital mortality and bleeding events. The study, which included over 530,000 patients, suggests that patient factors or SSRIs themselves may be responsible for the increased risks.
A large study found that selective serotonin reuptake inhibitors (SSRIs) are associated with a 10% increased risk of adverse outcomes after surgery, including bleeding and transfusions. The study suggests that patients on SSRIs should discuss their medication with their surgeon or primary care physician before undergoing surgery.
A study reviewed 12,101 patients to assess the accuracy of patient history, clinical examination, and sonography in diagnosing ectopic pregnancy. Transvaginal sonography is identified as the single best diagnostic method for evaluating suspected ectopic pregnancy.
Researchers found that combining fluoroscopy and CT scans reduces major complications during gastric tube insertion by nearly eliminating misplacement errors.
Researchers recommend radiosurgery for treating unruptured AVMs due to its reasonable benefit-to-risk profile. The procedure resulted in AVM obliteration in 62% of patients, with a reduced annual hemorrhage rate compared to left untreated AVMs.
The GIE special issue discusses the management of serrated colon polyps, including risk factors and management recommendations. Prophylactic clip closure is shown to reduce delayed postpolypectomy hemorrhage in large sessile or flat lesions.
Scientists at the University of Nottingham are leading a four-year study to investigate the effectiveness of tranexamic acid in treating intracerebral haemorrhage, a devastating type of stroke. The trial aims to recruit 2,000 people worldwide and assess whether the drug can reduce permanent brain damage and improve survival rates.
A recent study found that preterm infants with low-grade brain bleeding have similar neurodevelopmental outcomes as those with no bleeding. The study analyzed 1472 extremely preterm infants and found that those with grade 1 or 2 PIVH did not have an increased incidence of poor outcomes compared to infants without PIVH.