Articles tagged with Blood Cancer
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Researchers have developed unique virus-derived particles that can kill human blood cancer cells in the laboratory and eradicate the disease in mice. These non-replicating particles, derived from rhabdovirus, work by direct cytolysis and induction of antitumor immunity, showing promise as a new therapy for leukemia.
A study by Karoline Kollmann and colleagues reveals CDK6's role in regulating tumour growth while also promoting blood vessel formation. The researchers found that a mutant form of CDK6 retains its ability to regulate expression despite losing kinase function.
Researchers discovered a new molecular pathway causing heart failure and showed that JQ1 blocks this pathway to protect the heart. The compound works within the cell's nucleus, preventing damaging stress responses.
Researchers have identified glycolysis as a key mechanism for endothelial cell energy production and blood vessel formation. Blocking glycolysis could prevent excessive angiogenesis in diseases like cancer, offering new therapeutic options.
A new study found that regions near petroleum refineries and manufacturing plants releasing benzene have significantly higher non-Hodgkin lymphoma incidence rates. The risk of the disease decreases with increasing distance to these facilities.
Researchers have discovered that cancer cells can fuse with blood cells, enabling them to travel through the body and seed new tumors. This breakthrough has major implications for treating metastatic cancers.
A new study found that DNA abnormalities, specifically clonal mosaic events, are more common in people with type 2 diabetes than the general population. This increase in CMEs may partly explain why individuals with type 2 diabetes have a higher risk of blood cancers like lymphoma and leukaemia.
A new analysis found that African Americans with chronic lymphocytic leukemia present with advanced disease and have shorter survival times than Caucasians. The study suggests that biological factors may account for racial disparities in cancer survival.
Researchers will study pediatric sarcomas, a rare and aggressive form of cancer affecting 11% of all childhood cancers, with the goal of developing new therapies. The project aims to improve outcomes for children with advanced or metastatic disease, who have limited success with current treatments.
Researchers have found antibodies against the human papillomavirus (HPV) that may help predict individuals at risk of HPV-related oropharyngeal cancer. The study found that these antibodies were detectable in nearly 35% of patients with cancer, compared to less than 1% of those without cancer.
A study by Dana-Farber Cancer Institute researchers found that active surveillance and watchful waiting are safe alternatives to initial treatment for men with low-risk prostate cancers. These strategies can lead to better quality of life and reduced healthcare costs, with some patients experiencing up to 13 months additional quality-a...
The Leukemia & Lymphoma Society (LLS) and Dana-Farber Cancer Institute are partnering to establish a network of sites for clinical trial testing in community oncology settings. This partnership aims to increase trial enrollment and advance innovative blood cancer therapies, ultimately saving lives.
A recent study revealed a new mutation in atypical chronic neutrophilic leukemia (CNL) patients, allowing doctors to prescribe targeted treatment ruxolitinib. The treatment brought significant improvements to the patient's health, including reduced white blood cell counts and normalized other blood counts.
Researchers used advanced amplification technology to detect abnormal DNA in blood samples from patients with gastrointestinal stromal tumors (GIST). The new blood test found secondary resistance mutations in the KIT gene, which were missed by traditional tissue analysis.
Researchers at UCLA refine their 'NanoVelcro' device to capture and analyze single cancer cells from patient blood, enabling 'liquid biopsies' for metastatic melanoma. The improved device allows doctors to tailor personalized treatment to specific patients.
Researchers found that women with ovarian cancer had higher blood calcium levels than those without the disease. The study suggests that high calcium levels may be a biomarker for early detection of ovarian cancer.
A recent study published in Mayo Clinic Proceedings found that microscopic hematuria is an unreliable indicator of urinary tract malignant tumors. The study developed a Hematuria Risk Index to predict cancer risk, identifying low-risk patients who may not need further evaluation and reducing unnecessary evaluations.
Dr. James Watson suggests that antioxidants in late-stage cancer cells can promote cancer progression, and that reducing antioxidant levels may be key to developing new anti-metastatic drugs. He calls for a faster timetable for researching this proposition.
Researchers found that people with Type 2 diabetes who received diabetes education after a cancer diagnosis had fewer visits to the emergency room and hospital admissions. They also tested their blood sugar levels more often, resulting in lower healthcare costs.
Researchers at Johns Hopkins Kimmel Cancer Center have created a test that combines blood DNA analysis with genome sequencing to detect cancers. The new approach was successful in identifying cancer-specific chromosome changes in the blood of patients, but may require larger clinical trials to determine its effectiveness.
A new study uses blood testing to predict cathepsin activity, enzymes accelerating diseases like atherosclerosis and cancer. The technique achieved high predictability, ranging from 90 to 95 percent, and may help develop personalized treatments for tissue-destructive diseases.
A study found that survivors of cervical, blood, and colorectal cancers experience poorer physical and mental health-related quality of life compared to those with other types of cancer. The analysis estimated that 3.3 million and 1.4 million US cancer survivors face below-average physical and mental health, respectively.
Researchers found a direct relationship between telomere length and pancreatic cancer risk: shorter telomeres increase the likelihood of developing the disease. The study used data from over 1,500 individuals, including those with pancreatic cancer and healthy controls, to demonstrate this link.
A new study found that men with high blood pressure, high blood sugar, and a high body mass index are more likely to die from prostate cancer. Researchers also discovered that combining these metabolic factors increases the risk of death, suggesting that lifestyle changes may help prevent this.
UK scientists have developed a new drug that primes the immune system to fight cancer, with promising early laboratory results showing it can lead to long-term survival in lymphoma patients. The treatment uses a chemical called R848, which signals to certain immune cells to attack cancer.
Dartmouth College researchers have found that variations in white blood cell patterns can help predict the onset of certain cancers and diagnose them. By analyzing methylation signatures in leukocytes, they discovered correlations between specific cancers and unique patterns of immune cell subsets.
Researchers discovered that MYC protein boosts existing gene expression, rather than turning genes on or off, leading to a universal amplifier effect. This understanding could lead to new therapeutic strategies for cancers, such as targeting MYC activity instead of eliminating it.
The Legacy Bead program at St. Jude Children's Research Hospital uses glass beads to mark treatment milestones, such as losing hair or completing chemotherapy. Patients and family members can use the beads to express their feelings and create a tangible way to share their experiences.
Researchers identified a specific HIF2α mutation in tumor cells of patients with rare cancers, offering clues about cancer cell metabolism. The finding may lead to new targets for cancer treatment development and improve understanding of the mechanisms behind the Warburg effect.
Drs. Blazar and June will present their lecture on adoptive T-cell therapy, which has potential to establish tolerance to hematopoietic or solid organs allografts, treat autoimmunity, and promote immunity to cancer and chronic infection. The researchers have made significant contributions to advancing the field of BMT.
Researchers create super-sensor using nanoscale gold spheres to detect single samples of the smallest known viruses. The sensor uses 'whispering gallery mode' to measure precise frequency changes, allowing for accurate detection and sizing of viruses.
A team of scientists from the University of Southampton will explore ways to prevent graft-vs-host disease (GVHD) and improve bone marrow transplants by stimulating donor T-cells to target cancerous cells while reducing immune system reactions.
A new approach using an HIV drug has significantly reduced the incidence of graft-versus-host disease (GvHD) in bone marrow transplant patients. The treatment redirects immune cells away from vital organs, reducing the risk of GvHD without compromising the patient's ability to fight cancer.
Physiologists and neuropathologists from the University of Zurich have identified the origin of metastasis formation in intestinal cancer cells. Cancer cells manipulate specific doorman receptors on blood vessel endothelium to enter other organs via bloodstream.
Research established RNA Polymerase I (Pol I) activity as essential for cancer cell survival, and its inhibition with CX-5461 selectively activates p53 to kill tumors. The drug was shown to be 300 times more potent than non-genotoxic p53 activators.
Researchers at Moffitt Cancer Center tested a 2-drug combination of sirolimus and tacrolimus to prevent acute grades of graft vs. host disease after blood cell transplantation, finding it more effective than another combination in preventing grades II-IV acute GVHD and moderate-severe chronic GVHD.
Researchers at UC San Diego have identified a new signal transduction pathway in alternative RNA splicing, which could lead to novel cancer drugs. The SRPK kinase plays a central role in regulating VEGF and controlling tumor growth.
A new analysis found that many adolescent and young adult cancer survivors experience chronic medical conditions, poor quality of life, and barriers to healthcare access. The study suggests that these negative behaviors are potentially modifiable through proper follow-up care and promotion of healthy habits.
Researchers at The Miriam Hospital found a 20 percent increased risk of developing blood cancers such as non-Hodgkin lymphoma, leukemia, and myeloma in patients with type 2 diabetes. Analyzing over 17,000 cases worldwide, they concluded that preventing diabetes may also lower the incidence of these malignancies.
A Phase III clinical trial found lenalidomide treatment decreased the risk of progressive myeloma or death in stem cell transplant patients, with a 63 percent reduction in disease progression risk. The study's results support the use of lenalidomide maintenance therapy after stem cell transplantation to improve patient outcomes.
Researchers at Vetmeduni Vienna have shown that chronic myeloid leukaemia (CML) and B-cell acute lymphoid leukaemia (B-ALL) arise from the same long-term haematopoietic stem cells. Understanding this finding is crucial for developing targeted therapies, as current treatments may not effectively target cancer stem cells.
Researchers present new methods for early lung cancer detection, including digital chest tomography and a blood test for BARD1 antibodies. These techniques have shown promising results in detecting lung cancer with high sensitivity and specificity.
A McGill University team has developed a new microarray technology that can accurately measure multiple proteins in a droplet of blood to detect breast cancer. The test, which uses a 'fingerprint' approach, showed promise in classifying patients with estrogen receptor-positive breast cancer.
Scientists at Fox Chase Cancer Center found that defects in ribosomal proteins can lead to blood and other cancers. Inactivating L22, a key protein, triggered changes in cell signaling pathways associated with inflammation, which may be targeted for cancer treatment.
Scientists will investigate the role of Myc oncoproteins and a specific mRNA-binding protein, TTP, in controlling tumor growth. The study aims to define mechanisms that could lead to the development of new anti-cancer drugs.
Researchers at Emory University identified a new function for p14 ARF, a gene that normally prevents cancer. The protein regulates tumor-induced angiogenesis, attracting new blood vessels to growing tumors. Restoring p14 ARF interferes with this process, suggesting a potential therapeutic target.
Blood cancers in pregnancy can lead to increased risk of blood clots and health complications for the mother. Termination is recommended at early stages, while cancer therapy is possible later. Progesterone-only contraceptives are considered safe for patients in long-term remission.
A new approach using an HIV drug has significantly reduced the incidence of graft-versus-host disease (GvHD) in blood cancer patients after allogeneic stem cell transplantation. Maraviroc dramatically reduced GvHD in organs such as the gut and liver without compromising the immune system.
A University of Rochester Medical Center study found that nearly 78% of cancer-related blood clots occur in outpatients during chemotherapy treatment. The study's findings suggest a shift towards outpatient care and the need for education and compliance to prevent blood clots.
Researchers at Dana-Farber Cancer Institute have created a peptide cocktail that sparks a stronger diverse immune response in laboratory culture than individual peptides. The combination of four antigenic peptides is believed to provide an effective therapeutic application for patients with multiple myeloma and related diseases.
A NYU Steinhardt professor has received a $720,000 grant to investigate the link between insulin and obesity-related cancers. Her research aims to understand how insulin affects cancer cell growth and development, particularly in relation to carbohydrate diets.
A new regimen of conditioning therapy before stem cell transplant has improved survival outcomes for older patients with hematologic malignancies. The study found that 5-year overall survival rates were around 35%, and progression-free survival rates were around 32%.
Patients aged 60-75 who received the mini-transplant experienced comparable survival rates across three age groups, with increased comorbidities and cancer aggressiveness affecting outcomes. The five-year survival rate was 35% for overall and 32% for disease-progression free
A recent study found that mutations in the SF3B1 gene are associated with a milder form of myelodysplastic syndromes (MDS) and better overall survival rates. The researchers also discovered a close relationship between the mutated gene and the presence of ring sideroblasts, abnormal precursors to red blood cells, which can cause anaemia.
A large study found that high blood pressure is associated with a higher risk of developing cancer and dying from the disease, particularly in men. The study analyzed data on blood pressure and cancer incidence and death in over 289,000 participants.
A genomic study identified the SF3B1 gene as frequently mutated in myelodysplasia, a precursor to leukaemia. The mutation is associated with ring sideroblasts and anaemia, leading to more straightforward diagnosis through a single blood test.
A study found that rescue workers and civilians exposed to World Trade Center dust had lower mortality rates compared to the NYC general population. Higher exposure levels were associated with increased mortality, particularly among those with high levels of WTC-related exposure.
A team co-led by Fred Hutchinson Cancer Research Center has been selected to participate in a National Cancer Institute-funded research consortium. The researchers will analyze proteins in blood associated with genetic alterations leading to cancer, with the goal of developing reliable blood tests for early detection and treatment.
23andMe's Myeloproliferative Neoplasms (MPN) research initiative aims to recruit 1,000 individuals with these rare blood cancers to participate in genetic analysis and online discussions. The program will advance research and create a community for those affected by MPNs.
Using a 'systems biology' approach, researchers identified proteins in the blood that change in abundance long before aggressive breast cancer is clinically detectable. The study found that host tissues respond to and amplify signals from tumor cells, leading to changes in blood-protein levels.