Articles tagged with Blood Cancer
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Research published in Occupational and Environmental Medicine suggests that growing up on a livestock farm is associated with an increased risk of developing blood cancers. The study found that those who grew up on poultry farms were three times more likely to develop a blood cancer.
Scientists have developed a tiny fiber-optic biosensor to detect elevated PSA levels in cases of breast cancer. The biosensor's sensitivity and specificity are comparable to those found in current screening methods for breast cancer.
A Duke University Medical Center research team has discovered new proteins in blood cells of patients with advanced prostate cancer and metastatic breast cancer. These proteins are associated with embryonic development and may help doctors gauge the progression or response to treatment more accurately.
A new molecular imaging agent has been developed to detect tumor angiogenesis, a process of rapid blood vessel growth associated with malignant cancers. The agent, which targets the CD105 protein biomarker, shows promising results in early studies, including high uptake by tumors in mice.
The National Institutes of Health has signed a research and development agreement with two non-profit organizations to develop potential clinical therapies for rare blood cancers. The collaboration aims to bridge the gap between basic research and human testing, with the goal of accelerating the delivery of improved therapies to patients.
A new study by the NYU Cancer Institute reveals that novel mutations in the Notch signaling pathway lead to the development of chronic myelomonocytic leukemia, a type of blood cancer. The study suggests potential targets for future therapies.
The TET1 enzyme controls gene activity during fetal development, preventing genes from being turned off at critical stages. By modifying methyl groups, TET1 acts as a safeguard to ensure normal cell growth and development.
A new microfluidic device, developed by MIT researchers, can detect single cancer cells in a blood sample and also identify viruses like HIV. This device has the potential to revolutionize cancer diagnosis and make it more accessible in developing countries.
A study of nearly 40 tumor genomes has yielded new and unexpected insights into the events that lead to multiple myeloma, a form of blood cancer. The researchers discovered genes never before associated with cancer, as well as genetic mutations disrupting common pathways that trigger cell change.
Research suggests that high levels of 'good' cholesterol (HDL) are associated with a reduced risk of bowel cancer. The association remains intact even after accounting for other factors such as inflammation, insulin resistance, and oxygen free radicals. HDL may alter the inflammatory process in some way, according to the study's authors.
A blood test can accurately detect biomolecular markers of bladder cancer risk linked to environmental exposures like cigarette smoke and industrial pollutants. The test measures methylation patterns in immune system cells, which are associated with an increased likelihood of disease.
A nine-year study found that high fiber intake was associated with a significantly reduced risk of total death, cardiovascular, infectious, and respiratory diseases in both men and women. Dietary fiber from whole plant foods, such as grains, was particularly beneficial.
Scientists discovered how stressed cells boost thrombin production, a key blood-clotting factor, which may be taken advantage by cancer cells. This process could explain why cancer patients are more likely to suffer from blood clots and septicaemia.
Researchers at the University of Wisconsin-Madison have successfully reprogrammed diseased blood cells into pluripotent stem cells, allowing for the observation of leukemia's onset in a laboratory dish. This breakthrough enables scientists to pinpoint the earliest stages of cancer development.
Researchers have developed PiggyBac, a genetic tool that can speed the discovery of novel genes involved in cancer. The system has identified new candidate cancer-causing genes and will complement advances in genomics and genetics of cancer.
A new study by UC Berkeley researchers found that children with acute lymphoid leukemia (ALL) had almost twice the chance of having been exposed to three or more X-rays compared to those without leukemia. The results differ slightly by region, with a modest increase associated with chest X-rays.
Researchers describe an indirect approach to reducing JAK2 activity by pharmacologically targeting HSP90. Inhibiting HSP90 normalized blood counts and improved survival in two mouse models of MPN, promoting JAK2 degradation in samples from patients with the disease.
A new risk prediction model for venous thromboembolism (VTE) in cancer patients has been developed, incorporating two new biomarkers. The model improves the classification of patients into different risk categories, with a significant increase in accurate predictions of VTE development.
Researchers at VCU Massey Cancer Center have discovered a new link between chronic inflammation and cancer, highlighting the importance of sphingosine-1-phosphate (S1P) in regulating inflammation. S1P is found to be a missing cofactor required for TRAF2's activity, which controls inflammation and cancer.
The study found a significantly higher incidence of MDS among seniors, with alarming rates of complications such as heart attacks, diabetes, and sepsis. The disease also proved to be costly to treat, with median Medicare bills exceeding $16,000
A new study found a link between chronic HBV and progression to cancers other than hepatocellular carcinoma, specifically Non-Hodgkin Lymphoma (NHL) and Cholangiocarcinoma. Higher levels of viral replication were associated with increased risk, indicating a potential causal effect.
Researchers at Fred Hutchinson Cancer Center have developed a method to expand stem/progenitor cells from cord blood units, resulting in successful treatment of high-risk leukemia. The expanded cells can rapidly give rise to white blood cells and other components of the blood system.
Scientists at Yale University have successfully used nanosensors to detect cancer biomarkers in whole blood for the first time. The new device can accurately measure concentrations of specific biomarkers with unprecedented precision, enabling faster and more reliable diagnoses.
A Yale University team developed a method to rapidly manipulate and sort cells in blood using magnetizable liquids. This technique could dramatically improve the speed and sensitivity of tests for cancer biomarkers, blood disorders, viruses, and other diseases.
A new study demonstrates advances in optimizing treatments and quality of life for patients with multiple myeloma. The research explores optimal induction therapies, advance care planning, and a potential new first-line therapy for non-Hodgkin lymphoma.
A study published in the Journal of the National Cancer Institute found that erythropoiesis-stimulating agents increase the risk of venous thromboembolism in cancer patients. The use of these agents, approved to reduce blood transfusions during chemotherapy, may outweigh benefits due to associated risks.
Researchers are developing innovative treatments to starve cancer cells of glucose, a strategy that has shown promising results in breast and colon cancer cases. RNA interference is also being explored as a gene therapy approach to block genes involved in cancer growth, with significant progress made in administering these medicines.
Researchers at Fox Chase Cancer Center discovered the Id3 protein plays a crucial role in directing blood cell progenitors to become gamma-delta T cells. These unique cells possess attributes of both the adaptive and innate arms of the immune system, providing enhanced protection against infections and diseases.
Researchers have found that tumor cells release microvesicles that stimulate the growth of blood vessels, allowing tumors to grow. A new molecule called Diannexin has been identified as a potential therapeutic agent that can block this process and starve tumors.
Researchers at Tel Aviv University discovered that transfusions of 'young' blood –– blood stored for less than 9 days –– increased the odds of survival in animals with leukemia and breast cancer. Fresh blood may be a game-changer in cancer treatment, potentially improving survival rates.
Novel treatments, including fostamatinib disodium, have shown significant clinical activity in treating leukemia and lymphoma. The study found improved response rates and prolonged stable disease in patients with relapsed or refractory B-cell non-Hodgkin lymphoma.
A team of Stanford researchers has created a prototype blood scanner that can detect cancer biomarkers in the bloodstream at an early stage of the disease. The system uses magnetic nanotechnology to spot cancer proteins, which is tens to hundreds of times more sensitive than existing commercial devices. This technology holds promise fo...
Researchers found blood transfusions in hospitalized cancer patients increased venous thromboembolism (VTE) and arterial thromboembolism (ATE) rates, comparable to erythropoiesis-stimulating agents (ESAs). This study highlights the need for cautious use of transfusions and exploration of ways to reduce clot risk in cancer patients.
Researchers found that the use of predictive biomarkers and targeted therapies significantly delayed the need for conventional chemotherapy in patients with early-stage but high-risk chronic lymphoid leukemia (CLL). The study resulted in a four-year delay in treatment compared to two years, showing promising results for personalized care.
A landmark clinical trial is underway to test whether a low-molecule-weight heparin can prevent pulmonary embolism in patients receiving chemotherapy on an outpatient basis. The trial aims to identify high-risk cancer patients and demonstrate that blood clots can be prevented with anti-coagulant therapy.
Researchers at Columbia University's Mailman School of Public Health found a strong association between neutropenia, or low white blood count, and women of African descent. This association may affect disparities in disease treatment and outcomes for cancer therapy, particularly among those with breast and colon cancer.
Advances in treatment have led to increased long-term survival for US children diagnosed with acute lymphoblastic leukemia, acute non-lymphoblastic leukemia, or non-Hodgkin lymphoma. Period analysis reveals improved survival rates between 1990 and 2004, with projections suggesting continued progress through molecularly targeted therapies.
The VCU Massey Cancer Center is spearheading a phase II clinical study for certain sub-types of non-Hodgkin's lymphoma, combining the novel drugs bortezomib and vorinostat. The study aims to assess the effectiveness and side effects of this drug regimen in patients whose disease has progressed following treatment with other regimens.
Individuals with low vitamin D levels have a higher risk of death from all causes, according to a study analyzing data from the Third National Health and Nutritional Examination Survey. The analysis found that those with vitamin D deficiency had a 26% increased rate of death compared to those with adequate levels.
The USPSTF recommends against routine prostate cancer screening for men over 75 due to insufficient scientific evidence showing improved health outcomes. Men under 75 may benefit from screening with more evidence needed, according to the updated recommendations.
Researchers have identified microRNAs in blood plasma and serum that can signal the presence of various solid-tumor cancers at an early stage. The discovery has potential to become a new class of biomarkers for early cancer detection, offering advantages over protein-based systems.
University of Manchester researchers have received £1.6 million in funding to study a group of genes identified as playing a key role in leukaemia. The grant will help analyze the common mechanisms of action for patient benefit, potentially leading to the development of targeted therapies.
Scientists are testing a new cancer treatment that uses transfused white blood cells to combat advanced forms of cancer. The treatment, called Leukocyte InFusion Therapy (LIFT), has shown promising results in lab mice and aims to replicate those findings in human patients.
Research found that individuals with gum disease have an increased risk of various cancers, including lung, kidney, and pancreatic cancers. Gum disease was associated with a 14% higher overall cancer risk compared to those without gum disease.
Researchers at the OU Cancer Institute have identified a new gene called RBM3 that causes cancer. The gene is vital for cell division in normal cells but leads to increased tumor formation when overexpressed in cancerous cells.
Recent studies suggest that preoperative chemotherapy can be effective in early breast cancer treatment, but individual responses may vary. Additionally, a case-control study found no increased risk of cancer among frequent blood donors. Furthermore, researchers have identified a novel mechanism to overcome resistance to targeted thera...
Researchers at Fox Chase Cancer Center have discovered that a genetic misalignment can turn a normally quiet developmental gene into a potent driver of T-cell lymphoma in adult mice. The study found that the Dlx5 protein, which is not typically active in healthy adult cells, can be targeted for inhibition to slow cancer growth.
Researchers found a single PSA test can predict advanced prostate cancer with high accuracy, allowing for targeted screening and potentially reducing overdiagnosis. The study revealed that men with higher PSA levels are at increased risk of developing advanced cancer, highlighting the potential for early detection to improve outcomes.
A new study found significant racial and ethnic differences in the treatment and survival of patients with extremity soft-tissue sarcomas. Blacks had lower rates of surgeries that would have saved their arm or leg, higher death rates, and were least likely to receive additional treatments for improved survival.
A recent study found that postmenopausal women taking anastrozole after tamoxifen treatment had a 38% reduced risk of breast cancer recurrence. Additionally, research indicates that blood transfusions may slightly increase cancer risk in the months following the procedure, likely due to underlying undiagnosed cancer.
A recent survey reveals a significant gap in knowledge among primary care physicians regarding rare blood cancers like leukemia and lymphoma. The findings emphasize the importance of education and referrals to specialists in improving patient survival rates. As long-term cancer survivors, patients are at risk of developing second cance...
Researchers found that a specific hormone, TNF-alpha, drives the JAK2 enzyme to cause an often deadly red blood cell cancer called polycythemia vera. The study showed mice with normal TNF-alpha production developed severe bone marrow fibrosis within weeks.
Researchers found that blocking blood vessel growth with an antiangiogenic agent can reduce inflammation and improve antitumor efficacy of oncolytic virus therapy. This approach may increase survival rates for patients with aggressive brain tumors.
Researchers develop compound that targets leukemia at stem-cell level, where malignancy is born, potentially leading to more effective treatments. DMAPT appears to be unique in its ability to kill both dormant and dividing cancer cells without harming healthy blood cells.
A long-term study found that stem cell transplant patients experience decreased sexual function and activity, particularly in females. While males recover partially over time, females remain compromised. The study suggests systemic therapies and chronic graft-versus-host disease contribute to sexual dysfunction.
Researchers at Purdue University have developed a new technology that detects cancer cells in the bloodstream by scanning surface veins. This non-invasive method allows for earlier diagnosis and more accurate monitoring of disease progression, enabling personalized treatment.
Dana-Farber Cancer Institute scientists have identified a protein that prevents the body's immune system from recognizing and attacking Hodgkin lymphoma cells. They are now investigating targeted therapies to disable this molecular 'bodyguard' and boost a patient's ability to fight the blood cancer.
A retrospective study published in The Lancet found no excess risk of cancer among individuals who received blood products from donors with previously diagnosed cancers. The study included over 12,000 exposed individuals and 342,082 unexposed individuals, concluding that long-term cancer survivors might be a safe donor group.
Researchers found bone marrow-derived endothelial progenitor cells (EPCs) play a critical role in early stages of tumor progression. Eliminating EPCs stops cancer growth by preventing blood vessel formation.
A blood test detecting tumor-related proteins may help monitor treatment effectiveness and predict cancer recurrence. Patients with low protein levels were more likely to remain in remission, while those with high increases were at higher risk of cancer return.