Patients with cancer who live in rural Pennsylvania counties are more likely to receive complex surgeries at high-volume hospitals due to their perceived better outcomes. However, for less complex surgeries, rural patients are less likely to opt for high-volume hospitals despite potential benefits from centralization.
Researchers find immunotherapy treatment anti-CTLA-4 leads to greater survival in mice with glioblastoma and discover new way cells kill cancer by triggering microglia, specialized immune cells in the brain. This breakthrough could lead to more effective treatments for human brain cancer.
Researchers investigated H3K27me3 expression patterns in pediatric brain tumors, finding a global loss of this epigenetic mark in diffused midline glioma (DMG). This loss was associated with high relapse rates and poor survival, highlighting the potential for targeting H3K27me3 as an epigenetically guided cancer therapy.
A study by Dana-Farber Cancer Institute researchers found that gliomas can arise from epigenetic changes, which affect gene activity without altering DNA sequence. The findings pinpoint two genes, an oncogene and a tumor suppressor, whose activities are epigenetically altered in human gliomas.
Researchers at Mass General Cancer Center treated 16 patients with a BRAF/MEK inhibitor, resulting in a 91% reduction in tumor size and complete response in all patients who received one or more cycles of therapy. The treatment showed unprecedented success in targeting brain tumors using precision medicine approaches.
Researchers have developed a technology to capture and release cell-free DNA from urine using nanowire surfaces, successfully detecting IDH1 mutation in glioma patients. This method opens possibilities for the detection of other tumor mutations and could revolutionize cancer diagnosis.
Researchers have developed a new technique to generically treat several kinds of cancer, showing tumors grew almost three times less and survival rates reached 100% after just one injection. The method targets cancer cells with alpha radiation, sparing healthy tissue.
A new evidence-based framework proposes integrating palliative care into neurology teams to address the total pain of neurologic illness, including psychological, social, and spiritual distress. This approach aims to screen for and prevent suffering by incorporating a palliative care model from day one.
Researchers have made a significant finding in detecting brain tumors by exploiting folate receptors. Folate receptor expression is significantly higher in glioma tissue compared to adjacent healthy brain tissue, presenting a promising target for future treatments.
Researchers have developed a biodegradable ultrasound device that can open the blood-brain barrier, allowing chemotherapy to penetrate and kill brain cancer cells. The device is as powerful as traditional ceramic-based devices and has shown promising results in animal trials.
A new study found that obesity is associated with an increased risk of certain cancers, with stronger links in female patients for gallbladder and endometrial cancer. The study also revealed differential effects between sexes on colorectal, esophageal, and liver cancer.
Researchers found that rare brain tumor patients struggle to access therapy and experience devastating psychological impact after diagnosis. The study calls for improved mental health services and specialized support for these patients.
A new targeted therapy drug vorasidenib has been shown to extend treatment time without worsening glioma in people with IDH1 and IDH2 mutations. The study suggests a possible new treatment option for slow-growing but deadly brain tumors, delaying chemotherapy and radiation.
A phase 2 trial found that immune checkpoint inhibitor pembrolizumab had a durable antitumor effect in 24 of 57 patients with metastatic brain cancer. The study achieved its primary endpoint, with median overall survival of 8 months and seven patients surviving longer than two years.
Researchers presented findings on pembrolizumab for brain metastases, virtual mind-body interventions for post-treatment survival, and dynamic HER2-low status in triple negative breast cancer. The studies aim to improve treatments and outcomes for patients with cancer.
Researchers have created an open-source, reproducible analysis platform for pediatric brain tumors, providing a cloud-based resource for comprehensive data on the disease. The platform contains genomic and clinical data from over 1,000 pediatric brain tumors and 22 patient-derived cell lines.
A recent meta-analysis shows that amino acid PET can accurately differentiate between recurrent brain metastases and treatment-related changes. This technology has the potential to reduce unnecessary invasive procedures and overtreatment in patients with cancer.
Glioblastoma steals cognitive faculties as it spreads, but its insidious ability to infiltrate neighboring networks may be its undoing. Researchers found neural activity can restructure connections in surrounding tissue, causing decline. The drug gabapentin blocks this growth-causing activity in mice with glioblastoma.
The gene LRRC4 regulates synapse formation, stability and excitatory transmission, playing a crucial role in learning, memory formation and storage. It also has key implications in neuronal disorders and aggressive brain and spinal cord cancer.
Researchers have found an advanced immunotherapy treatment, called CAR T therapy, to be effective in targeting Diffuse Intrinsic Pontine Glioma (DIPG) tumours. The treatment involves isolating a patient's immune cells and re-infusing them into the patient to fight their cancer.
Researchers at Sanford Burnham Prebys have discovered that a 3D view of the genome can reveal genes in tumors that may be future targets for therapy. By visualizing how the genome is organized and arranged within tumor cells, they were able to identify new candidate targets for treatments.
A study of 7807 children found no increased risk of brain tumours, leukemia, or lymphoma after a single CT scan. However, exposure to 4 or more scans before adulthood significantly increases the risk of intracranial tumours, leukemia, and non-Hodgkin lymphoma
Researchers at Cold Spring Harbor Laboratory have developed a potential therapeutic for diffuse intrinsic pontine glioma (DIPG) using antisense oligonucleotide technology. The treatment has slowed tumor growth, reversed changes in cancer cells, and increased survival rates in mice with DIPG.
Researchers develop mechanical nanosurgery to destroy tumour cells from within, reducing GBM tumour size universally, including in TMZ-resistant cases. The treatment uses magnetically controlled carbon nanotubes to provide mechanical stimulation, damaging cellular structures and causing tumour cell death.
Researchers at Trinity College Dublin have discovered a new process that explains why cells have unique identities. By studying Polycomb protein complexes, the team found that different forms of these proteins recruit distinct complexes to DNA, shedding light on cellular identity and its potential impact on cancer treatments.
Researchers at the University of Texas M. D. Anderson Cancer Center have developed a novel approach to administer intrathecal and intravenous immunotherapy to treat leptomeningeal disease (LMD) in melanoma patients, showing promising results in improving survival rates and quality of life for some patients.
Researchers used long-read sequencing to identify novel mutational patterns and complex genomic rearrangements in cancer genomes, including those associated with liposarcoma. This approach offers a more comprehensive understanding of DNA mutations and their impact on cell function.
Scientists have identified a new molecule that could help distinguish and treat patients with a specific subgroup of medulloblastoma, the most common malignant brain tumor in children. The discovery points to potential targeted therapies using a drug or drugs to block the molecule's activity.
Researchers developed an AI-based diagnostic screening system called DeepGlioma to analyze tumor specimens and detect genetic mutations rapidly. The system identified molecular subgroups with high accuracy and has the potential to improve access and speed of diagnosis for patients with deadly brain tumors.
Researchers have identified a key cause of metastasis from aggressive brain cancer in children and found a potential new therapy. Medulloblastoma cells hijack neurodevelopmental signaling pathways to promote tumor cell spreading. Targeting these pathways with a drug called dasatinib has shown promise in killing metastatic tumors.
The American Roentgen Ray Society (ARRS) has awarded four radiologists with the 2023 Resident/Fellow in Radiology Awards for their exceptional research, education, and administrative work. Drs. Elliot T. Varney, Vincius Alves, Luca Pasquini, and Pallavi Srivastava will present their research findings at the upcoming ARRS Annual Meeting...
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
Researchers from UCL Cancer Institute found that head injuries may contribute to the development of gliomas, a type of aggressive brain tumour. Studies in mice and human populations suggest that genetic mutations acting with inflammation can change cell behavior, increasing cancer risk.
A study by the American Academy of Neurology found that people with primary central nervous system tumors who are unemployed experience more severe symptoms of pain, discomfort, anxiety, and depression compared to those employed. The research also highlights disparities in unemployment rates among different demographics, such as Hispan...
Researchers developed a new device to identify key membrane proteins in urine indicative of brain tumors. This could lead to early detection and increased survival rates for patients.
A new study suggests that higher consumption of ultra-processed foods may be linked to an increased risk of developing and dying from cancer. The study found that each 10% increase in ultra-processed food consumption was associated with a 2% increase in cancer incidence, as well as a 6% increase in mortality from cancer.
Researchers developed a method to measure individual biological response to therapy using functional near-infrared spectroscopy, enabling real-time evaluation of radiotherapy's impact on patients. This technique allows for tailored radiation doses to optimize treatment and improve outcomes.
Researchers at Michigan Medicine discovered a gene, ZMYND8, that contributes to the survival of mutant IDH1 glioma cells in response to radiation. Knocking out ZMYND8 renders the cells radiosensitive, offering a new therapeutic avenue for patients.
A study of 184 grade I and II meningiomas found associations between specific tumor mutations and increased or decreased recurrence rates. Mutations in ATM and CREBBP were linked to accelerated recurrence, while POLE mutations showed protective effects, highlighting potential targets for intervention.
Researchers at Rice University have developed a new fluorescent dye that can cross the blood-brain barrier, allowing for noninvasive brain imaging and differentiation between healthy tissue and tumor cells. The dye's long-lasting fluorescence enables stable imaging over extended periods.
Researchers discovered a drug combination that targets immune evasion pathways in MYC amplified Medulloblastoma, a fatal childhood brain cancer. The treatment uses epigenetic drugs to unblock 'don't eat me' pathways and make tumors more appealing to macrophages.
Researchers found that white matter hyperintensities are independently associated with premature brain aging, leading to progressive age-like brain atrophy. The study used machine-learning algorithms to estimate brain age and analyzed the relationship between WMH load and BrainGAP scores.
A new AI-based predictive method has been created to detect radiotherapy failure in brain metastasis, showing an 83% accuracy rate compared to the human eye's 65%. The technique uses deep learning and attention mechanisms to analyze MRI images and provide more informed treatment decisions.
SourceYork University·JournalIEEE Journal of Translational Engineering in Health and Medicine·TypeComputational simulation/modeling·DateDec 19, 2022
Researchers analyzed COX-2 levels and segmental chromosome aberrations in pediatric neuroblastoma tumor samples. Positive correlations between pre-CT Ch 7q gain and COX-2 expression were found, as well as negative correlations between Ch 7q gain and Ch 11q deletion.
Tricia King's project aims to create personalized treatment plans for brain cancer survivors by identifying environmental, clinical, and genetic risk factors. The research has the potential to improve treatment outcomes for patients with various types of cancer.
Researchers have identified three new subtypes of glioblastoma, a type of brain cancer, based on the presence of specific non-cancer cells. These subtypes may help identify targeted therapies, such as immunotherapies, for improved patient outcomes.
A massive collaborative study using federated learning developed a model that enhances identification and prediction of boundaries in three tumor sub-compartments without compromising patient privacy. The dataset, comprising 6,314 glioblastoma patients from 71 sites globally, is the largest and most diverse ever considered.
Researchers developed a mouse model of pediatric glioma with a histone mutation called H3.3-G34, revealing a promising outlook for long-term survival through radiation therapy combined with small-molecule inhibitors. The treatment approach also showed immune memory, allowing mice to eliminate new tumor growth without additional treatment.
Researchers found that blocking DHODH enzyme halts cancer growth in mouse models, sparing healthy brain cells. This potential treatment pathway shows promise for future clinical trials, offering a non-toxic alternative to current treatments.
Scientists have uncovered the mechanics of the blood-tumour barrier in medulloblastoma, a malignant paediatric brain tumour. By silencing a specific ion channel, researchers found that chemotherapy medication etoposide was better able to cross the barrier and treat the tumour cells.
A study by Uppsala University has identified a stem cell protein, SOX9, that makes tumor cells resistant to radiation treatment, leading to recurrence and increased mortality. The research found that SOX9 protects resting cancer cells against radiation, promoting their survival and resistance.
Research reveals that individuals with inflammatory breast cancer are at a higher risk of brain metastases, which can lead to improved survival rates and quality of life. The study suggests that patients with triple-negative breast cancer face an even higher risk, emphasizing the need for earlier detection and more aggressive treatment.
Researchers discovered that animal models with germline alteration rs55705857 developed gliomas significantly faster than those without the alteration. The study offers new insights into tumor formation and may lead to novel therapies targeting this specific change.
Researchers developed a biosensor that can detect brain cancer from minute blood samples using surface-enhanced Raman spectroscopy. The test distinguishes primary brain tumors from secondary tumors and predicts tumor location within the brain with high accuracy.
Researchers have discovered that a type of pediatric brain tumour, medulloblastoma, develops in a pre-malignant form during human fetal brain development. This finding suggests that medulloblastomas could be preventable by identifying the genetic variations that cause them and acting before they develop.
The grant aims to disrupt systemic barriers hindering underrepresented groups' participation in the life sciences. Northwestern will hire 15 new tenure-track faculty and deploy innovative strategies to ensure their success.
Scientists discover that methotrexate causes oxidative damage to the cerebrospinal fluid and choroid plexus, leading to cognitive impairment. Adding antioxidants to the CSF may protect against this damage, offering a potential treatment for 'chemo brain'. Researchers are exploring other chemotherapy drugs and testing antioxidant treatm...
Researchers from the University of Queensland are conducting a three-year project to combat melanoma, focusing on stopping its progression to the brain and investigating its seeding in a neural environment. The team aims to develop new therapies to improve treatment outcomes for affected US troops and Australians.
A new study found that high-grade gliomas remodel the surrounding brain environment to protect tumour cells and hide them from the body's defences. Lower grade tumours often develop a new mutation allowing rapid cell division, potentially progressing to higher grade forms.
A study found that prolonged mental labor leads to glutamate accumulation in the prefrontal cortex, causing cognitive fatigue and altering control over decisions. Researchers suggest taking rest and sleep as a solution to overcome this limitation.