Articles tagged with Brain Cancer
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The study estimates 17.5 million cancer cases and 8.7 million cancer-related deaths worldwide in 2015, with prostate cancer being the most common in men and breast cancer in women. The report also highlights an increase in cancer incidence due to aging and demographic changes.
A national cohort study found that young cancer survivors (diagnosed before age 25) have a more than two-fold increased risk of suicide compared to their non-cancer peers. The study, led by Maria Winther Gunnes, analyzed data from over 1.2 million people born in Norway between 1965 and 1985.
Researchers identified altered proteins affecting gene expression as the driving force behind childhood ependymomas. This discovery provides a critical marker for predicting prognosis and offers a potential new therapy target.
Researchers at Huntsman Cancer Institute have identified a group of existing drugs that reduce or eliminate childhood brain tumors while sparing normal brain tissue. The zebrafish animal model system developed by the researchers closely resembles an aggressive subtype of pediatric brain tumors.
A collaborative clinical trial will test the safety and efficacy of combination checkpoint inhibitors in treating children with brain tumors. The trial aims to reduce toxicities associated with standard treatments and improve long-term survival rates.
Researchers have identified neurotrophin signaling proteins as promising therapeutic targets and biomarkers for childhood cancers. These proteins, including BDNF and NGF, can inhibit tumor growth and make cancer cells more susceptible to chemotherapy, offering new hope for improved treatment outcomes.
Castro aims to develop novel immunotherapies for brain cancer using cutting-edge technology, including genetically engineered mouse models and gene transfer technologies. Her research focuses on understanding the tumor immune-microenvironment and its response to therapeutics.
Researchers at KU Leuven have developed a novel cell-based immunotherapy that combines chemotherapy, inducing specific type of cell death in brain cancer cells. This approach stimulates the immune system to attack and activate dendritic cells, resulting in a drastically increased survival rate of mice with brain tumors.
Researchers at Sidney Kimmel Cancer Center found that Gamma Knife and RapidArc radiation therapy for brain metastases produce similar results, with the latter being faster. This study offers patients a choice of treatments and highlights the importance of advanced radiosurgery technology in treating increasing cases of brain metastases.
A powerful three-way mechanism driving childhood brain cancer growth has been discovered by scientists. The MYB-QKI gene fusion is found in rare pediatric glioma subtype angiocentric glioma and drives tumor formation through abnormal expression, disruption of tumor suppression, and activation via a positive feedback loop.
Researchers have identified an abnormal fused gene that drives pediatric brain tumors through three distinct biological mechanisms. This finding may advance diagnosis and treatment by identifying the MYB-QKI fusion gene as a defining event in angiocentric glioma, allowing for targeted therapies.
The UPMC-developed GlioSeq test provides rapid and accurate profiling of genetic abnormalities in brain tumors, guiding treatment planning. This next-generation sequencing test identifies previously known alterations as well as new molecular markers, enabling personalized management of patients.
Researchers reveal brain cancer's highly organized structure, with glioma cells forming streams, swirls, and spheres to protect and spread tumor growth. These structures are not related to specific cancer mutations and can be targeted for treatment.
Two studies examined long-term outcomes in childhood and young adult cancer survivors, finding increased hospitalization rates for certain types of cancer. Long-term survivors also faced a higher risk of neurocognitive impairment, particularly those with osteosarcoma.
Researchers have invented a device that provides real-time augmented images under the microscope, allowing surgeons to clearly distinguish cancerous from healthy tissue. This technology can improve surgical accuracy and efficiency in brain cancer and aneurysm patients.
The new center aims to develop and translate new cancer care applications based on nanotechnology, focusing on melanoma and malignant brain cancers. Researchers will use Cornell dots, silica-organic hybrid nanoparticles, to improve cancer diagnostics, surgery, and targeted drug delivery.
Researchers found that brain metastases share some genetic similarities with the primary tumor but also have key differences, including potential drug targets in over half of patients. Genetic analysis of brain metastases could reveal new treatment options, especially when compared to primary tumors.
Scientists have found possible cancer markers in neural crest cells, a discovery that may lead to better diagnosis and treatment of brain and skin cancers. The research uses repetitive DNA sequences to identify potential genomic changes associated with cancer development.
Researchers at University of Hawai'i Cancer Center discover two compounds that effectively stop the growth of brain cancer cells and breast tumors. These targeted treatments are less toxic and could improve quality of life for patients with no effective treatment options besides surgery.
Researchers have developed an imaging technology that can provide surgeons with a color-coded map of a patient's brain, distinguishing between cancerous and healthy tissue. This could potentially make brain tumor removal safer and more effective by allowing surgeons to visualize the area being operated on.
A new way of classifying brain cancers has been found, with striking molecular differences between various forms of gliomas. This discovery could lead to more precise diagnosis and patient management.
Researchers at The University of Texas MD Anderson Cancer Center found that blocking FGL2 protein could potentially treat brain cancer. By modulating the immune system's checkpoints, FGL2 promotes tumor growth and suppresses the immune response.
Researchers at Johns Hopkins Medicine have discovered a genetic pathway that regulates thousands of genes and may fuel cancer cell growth. Blocking this pathway with the experimental drug selumetinib led to reduced tumor growth and increased cell death, offering new hope for aggressive pediatric brain cancer treatment.
Researchers at Johns Hopkins Medicine have developed a new nanoparticle-based gene therapy that effectively kills brain cancer cells in rats and lengthens their survival. The treatment uses biodegradable nanoparticles filled with genes for an enzyme that turns a compound into a potent killer of cancer cells.
Researchers at Virginia Commonwealth University have discovered a novel microRNA-gene interaction that could lead to new therapies for malignant glioma, the most common and deadly form of brain tumor. Increasing miR-184 expression slows glioma cell growth by regulating SND1, a cancer-promoting gene.
Researchers at Northwestern University have discovered a potential drug therapy for a rare, incurable pediatric brain tumor by targeting a genetic mutation. The experimental drug GSKJ4 delayed tumor growth and prolonged survival in mice with diffuse intrinsic pontine glioma (DIPG).
A chemotherapy regimen of procarbazine, CCNU, and vincristine (PCV) following radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas. This trial found patients with oligodendroglioma had better outcomes than those with astrocytoma or oligoastrocytoma.
A new drug-based treatment may offer effective options for teenagers with neurofibromatosis type 2 (NF2), a devastating condition that affects 1 in 25,000 people worldwide. Researchers will investigate the mechanism of NF2 and explore how existing drugs can be repurposed to treat the condition.
Two patients with cardiac lymphoma presented with brain metastasis, highlighting the need for identifying prognostic factors that predict brain relapse. Cardiac lymphoma is a rare condition often overlooked due to its potential for central nervous system metastasis.
The new program uses a statistical model to accurately predict IDH1 mutation likelihood and requires only four questions from healthcare providers. The app aims to conserve research dollars by helping researchers narrow down which tumors should be tested as data.
A new study has identified a previously unknown mechanism used by neurons to survive, which is also hijacked by brain cancer cells. The discovery may lead to new investigations of brain cancer treatments and provide insight into Parkinson's disease.
Brain cancer specialists argue that current science is guiding compromising care, emphasizing the need for individualized treatment approaches. They identify five misconceptions that lead to poorer care, including assuming all tumor cell types act similarly and neglecting important biological differences.
Researchers discovered that cancer-causing genes are transcribed in childhood brain tumor cells due to 'hijacked' gene enhancers. The study also found that epigenetic regulation plays a crucial role in the activation of these genes, providing new targets for treatment development.
Researchers at Duke University Medical Center have identified a genetic mutation in PPM1D that contributes to the growth and death of tumor cells in brainstem glioma. This mutation may render radiation therapy ineffective, providing immediate clinical benefits and paving the way for new drug development.
A chemotherapy regimen after radiation therapy improved progression-free survival and overall survival in adults with low-grade gliomas by an average of 5.5 years compared to radiation alone. The study, RTOG 9802, also found better outcomes for patients with oligodendroglioma and females.
Researchers at the University of Toronto have defined potential treatment targets for Diffuse Intrinsic Pontine Glioma (DIPG), a previously incurable form of pediatric brain cancer. The team identified three subgroups of DIPG with distinct molecular features, providing hope for future patients.
Researchers at Cedars-Sinai will investigate the potential links between air pollution and brain cancer, with a focus on three pollutants: naphthalene, butadiene, and isoprene. The study aims to determine if prolonged exposure to these toxins can cause molecular changes in the brain that lead to brain tumor development.
A study published in Molecular Neurobiology found that sodium butyrate reduces survival of cultured medulloblastoma cells and enhances expression of markers for a mature neuronal phenotype. This suggests the compound may promote cell death and favor maturation towards less malignant-prone phenotypes.
A recent study found that in K9 osteosarcoma samples, NOTCH signaling was elevated overall but aspects of Notch signaling were noticeably deactivated in the worst cancers. The researchers also discovered that HES1 protein expression was lower in aggressive tumors, contradicting previous expectations.
A Stanford-led study found that men diagnosed with azoospermia have a significantly higher risk of developing cancer than the general population. The study, which analyzed data from over 2,200 infertile men, found that azoospermic men were nearly three times more likely to receive a cancer diagnosis than non-azoospermic men.
A US study found that reducing unnecessary and high-dose pediatric CT scans could lower the overall lifetime risk of future imaging-related cancers by 62 percent. The research suggests that eliminating unnecessary imaging and lowering doses for the highest-dose scans could prevent thousands of future cancers.
A new molecular imaging technique, F-18 FET, has been shown to be highly effective in detecting and differentiating brain lesions in children, with an accuracy rate of 94%. This study improves the clinical management of pediatric brain cancer patients by providing more accurate information about tumor progression and treatment.
A large population-based study confirms a small increased cancer risk following CT scans in childhood and adolescence. The researchers found a significant increase in cancer incidence among exposed individuals, with the highest risk seen in children under five years old.
A virtual reality simulator called NeuroTouch provides neurosurgery trainees with valuable opportunities to practice essential skills and techniques for brain cancer surgery. The system uses 3-D graphics and haptic technology to simulate common tasks and tools, allowing surgeons to practice basic surgical skills.
A new probe developed at Norris Cotton Cancer Center and Dartmouth College helps surgeons differentiate between cancerous tissue and normal tissue in low-grade tumors. The probe reads how light travels through tissue, producing a straightforward answer as to whether the tissue is cancerous.
The Center for Cancer Support and Education in Arlington, Mass., will receive a $10,000 grant from ASTRO's Survivor Circle program to fund breast cancer, advanced cancer, and brain cancer support groups. The Center offers emotional support during treatment and recovery for patients and their family members.
A new PET imaging technique using an amino acid probe can predict the effectiveness of brain cancer treatment as early as two weeks after initiation, without requiring invasive biopsies. This method provides vital information about the body's response to therapy and has shown promising results in patients with aggressive glioma tumors.
Radiation exposure from CT scans in childhood may increase the risk of developing leukemia and brain cancer. A study published in The Lancet found that cumulative doses of around 50-60 mGy from 5-10 scans tripled the risk of these cancers.
A new study from Lawson Health Research Institute found that doctors treating brain cancer patients are unclear about reporting requirements. Only 41% of patients were advised not to drive, and only 30% were reported to the Ministry of Transportation, despite brain tumors compromising a patient's ability to safely operate a motor vehicle.
A study published in Cancer found that frequent dental x-rays are linked to an increased risk of developing meningioma, the most commonly diagnosed primary brain tumor in the US. Patients who received bitewing exams or panorex exams on a yearly or more frequent basis were at higher risk of developing meningioma.
A study published by Johns Hopkins scientists found no substantial evidence that brain cancer blood vessels are composed mainly of cancer cells. The research contradicts previous claims about the composition and potential impact on treatment strategies for these types of tumors.
Researchers used Sendai virus to transport Quantum Dots into brain cancer cells, specifically binding them to epidermal growth factor receptor (EGFR), a marker often over-expressed in tumors. This technology could aid diagnosis and potentially lead to individualized treatment plans.
A UCSF team has developed methods to reveal a molecular marker in tissue samples from brain tumors that has been linked to better survival odds. Monitoring this marker could provide doctors with a better way to follow their patients after surgery and assess how they respond to recommended treatments.
Researchers found that shortening telomeres in cancer cells makes them more sensitive to radiation treatment, leading to faster cell death. The study's results may lead to safer and more effective combination therapies for pediatric brain cancers.
Researchers found over half of diffuse intrinsic pontine glioma (DIPG) tumors carried extra copies of specific cancer-linked genes, offering potential new treatments. The study, led by St. Jude Children's Research Hospital scientists, analyzed 43 DIPG samples and identified two key regulatory mechanisms disrupted in the tumor.
Researchers at Johns Hopkins Kimmel Cancer Center have created a comprehensive map of genetic mutations in oligodendroglioma, the second-most common form of brain cancer. The study reveals that CIC and FUBP1 genes are critical in tumor development and may hold the key to attacking this cancer.
A novel combined therapy has been developed to treat brain cancer patients with neoplastic meningitis, a devastating neurological complication. The treatment involves delivering chemotherapy directly to the brain's surfaces while draining excess spinal fluid to alleviate pressure and improve quality of life.
Research published in BMJ Open found a strong association between contact allergies and reduced rates of breast, non-melanoma skin, and brain cancers. However, higher rates of bladder cancer were detected among those with contact allergies.
Brain cancer patients who exercise regularly live significantly longer than sedentary patients, with a median survival of 21.84 months compared to 13.03 months. The study provides evidence that exercise interventions may impact progression and survival beyond symptom relief.
A new study published in Bioelectromagnetics suggests that radio frequency exposure from cell phones does not increase the risk of developing brain cancers. The researchers found no statistically significant change in brain cancer incidence rates between 1998 and 2007, contradicting some previous studies.