Articles tagged with Brain Cancer
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Researchers discovered that IDH mutation leads to a metabolic battle between molecules ?-KG and 2-HG, contributing to cancer development. Bolstering ?-KG production could offer a new treatment option for patients with the mutation, which affects 75% of people with low-grade brain tumors and 20% of those with acute myeloid leukemia.
A study comparing photon-based and proton-beam radiation therapies found that photon-based therapy resulted in better long-term survival rates, particularly among younger patients and those with ependymomas. The research suggests a potential shift in treatment guidelines for spinal cord glioma patients.
Researchers at Georgetown University Medical Center have found an arsenic-based agent already FDA-approved for a type of leukemia may be helpful in treating Ewing's Sarcoma and medulloblastoma. The drug inhibits the hedgehog/GLI1 pathway, which is also common in other cancers.
The study found that children with medulloblastoma have fewer genetic alterations than adult counterparts, which may lead to easier therapy development. Genetic changes in pediatric cancers are distinct from adult tumors, and understanding these differences is crucial for improving treatment outcomes.
Researchers found that narciclasine, a natural compound in daffodil bulbs, markedly reduces cancer cell proliferation and migration. The study suggests that narciclasine selectively inhibits the growth of very aggressive cancer cells while avoiding adverse effects on normal cells.
Scientists have developed a new form of methotrexate as nose drops to treat brain cancer, showing promise in bypassing the blood-brain barrier. In initial testing on laboratory rats with brain cancer, the nose drop drug reduced tumor weight by almost one-third compared to injectable treatment.
Scientists have developed a new approach to deliver therapeutic genes into brain cancer cells, using chlorotoxin from deathstalker scorpion venom and nanoparticles of iron oxide. This method has shown promise in inducing nearly twice the amount of gene expression in brain cancer cells compared to traditional approaches.
Researchers at Georgia Institute of Technology develop a system to excavate brain tumor cells by directing them away from their location in the brain to a gel-based 'sink' where they can be removed or killed. The goal is to improve survival rates and reduce toxic effects of treatment for pediatric medulloblastomas.
Researchers at UMass Medical School have identified a crucial pathway in malignant glioma cells that can be targeted with existing cancer drugs, offering new possibilities for therapy. The discovery was made using genome-wide RNA interference screening and has implications for the treatment of this deadly brain cancer.
The Interphone International Study Group found no increase in brain cancer among users, but heavy users appeared at a higher risk. The study's inconclusive results were attributed to restricted access to participants and flawed ethics reviews.
A recent study found that childhood cancer survivors who had brain or central nervous system cancers, or leukemia, achieved lower-than-expected educational success. The study, which analyzed data from over 10,000 survivors, revealed significant differences in educational attainment between these groups and the general population.
Researchers have discovered genetic differences in pediatric brain tumors that can help explain tumor development and potentially lead to targeted treatments. The study identified a subset of malignant astrocytomas with specific genetic alterations, which may enable more individualized care for children with brain cancer.
A recent study published in the Journal of the National Cancer Institute found no significant link between increased cell phone usage and brain tumor incidence. The research analyzed data from Denmark, Finland, Norway, and Sweden over a 30-year period, concluding that induction periods may be longer than previously thought.
A new study has found that long-duration exposure to formaldehyde used in embalming practices is associated with an increased risk of death from myeloid leukemia. The study, published in the Journal of the National Cancer Institute, also found no associations with other lymphohematopoietic malignancies.
Researchers found that physical activity in adolescence was associated with a 36% lower risk of glioma, the most common type of brain cancer. Participants who were obese during adolescence had an increased risk of glioma, while height was linked to twice the risk.
Researchers found that whole-brain radiotherapy did not extend lives or improve independence in patients with limited brain metastases and stable cancer. However, it slowed cancer progression by five weeks and reduced the risk of brain-related deaths.
A new study has found that nearly three percent of healthy people have an abnormality on a brain MRI scan, raising concerns about the benefits of commercial brain screening. The researchers argue that there is limited medical evidence to support treatment for incidental abnormalities, potentially creating anxiety among patients.
Researchers have developed a targeted cancer treatment using nanomaterials that selectively kills brain cancer cells while leaving healthy cells unaffected. The therapy uses titanium dioxide nanoparticles bonded to biological material and targets specific cell surface receptors on cancer cells.
A protein called Huwe1 normally functions to eliminate unnecessary proteins, acting as a tumor suppressor in brain cancer. Deregulation of Huwe1 function is involved in tumor development and may be an important factor in the development of brain cancer.
A multidisciplinary study using NASA's electronic nose found that it can detect odour differences between normal and cancerous brain cells, opening up possibilities for new diagnosis and treatment methods. The device has shown promise in detecting cellular trafficking, brain cancer metastasis, and stem cell migration.
Researchers at the University of Michigan developed a method to analyze changes in a tumor's blood flow and volume, allowing for early prediction of patient survival. The 'parametric response map' approach showed promising results in predicting treatment response earlier than traditional methods.
University of Washington researchers found a combination of nanoparticles and chlorotoxin, a scorpion venom compound, cuts brain cancer cell spread by 98% compared to 45% with chlorotoxin alone. The additive treatment disables machinery that allows tumor cells to change shape, preventing further invasion.
A new study of 20,000 MS patients and 204,000 controls found a 10% lower overall cancer risk for people with MS compared to those without the disease. However, this came at the cost of higher risks for brain tumors and urinary organ cancers, increasing by up to 44%
Researchers have discovered eight gene mutations linked to medulloblastoma, the most common childhood brain cancer. The study, funded by the Canadian Cancer Society, may lead to better drug treatments and improved survival rates for children with this disease.
Researchers have designed intelligent molecules that can recognize diseased cells, such as cancer cells, and trigger cell death only in their presence. This approach aims to reduce nonspecific side effects and improve therapeutic accuracy.
Recent studies suggest a possible link between long-term cell phone use and increased risk of brain tumors, prompting a call for collaborative research initiatives. Scientists emphasize the need for definitive evidence to determine the risks associated with electromagnetic field exposure from cell phones.
Debra DeMella, a brain tumor survivor, received the 2008 Survivor Circle Award from the American Society for Radiation Oncology (ASTRO) for her dedication to helping others living with cancer. She founded Brainstormers, a brain tumor support group, and served on various boards to improve quality of life for patients.
Researchers at Duke University Medical Center have identified two types of cells in the brain that can give rise to medulloblastoma, a type of brain tumor. The study provides critical insight into how cancers develop and may help develop more rational and effective approaches to treatment.
A veterinary neurologist is studying gliomas in dogs and people to develop more precisely targeted treatments. Researchers are using canine models to identify molecular similarities between human and animal gliomas.
Researchers discovered that astatine-211 can kill residual cancer cells without harming sensitive brain tissue, leading to longer survival rates among patients. The isotope's potency and short lifespan make it a promising treatment option for brain tumors.
The Seneca Valley Virus shows promise as a treatment for some metastatic cancers. Cervical cancer survivors are at greater risk of second cancers due to radiation exposure. A novel trial design identifies promising treatments in clinical trials.
UT Southwestern researchers Dr. Luis Parada and Dr. Thomas Südhof have been elected to the Institute of Medicine for their international distinction in developmental biology and neuroscience. They join a prestigious group of medical scientists shaping public health policies and advising federal governments.
A new report found that children with brain tumors have lower grades in each subject, particularly in foreign language, with over 58% of female patients receiving below an eight. Despite this, most survivors completed the ninth grade at the usual age, suggesting a glimmer of hope for these students.
A review of published literature found that delays in childhood cancer diagnosis are short but the impact on prognosis remains unclear. The study suggests that delays can be attributed to gatekeeper-type healthcare systems, clinical presentation, stage of disease, and parent/patient factors.
Researchers at M. D. Anderson Cancer Center have identified a new oncogene, insulin-like growth factor binding protein 2 (IGFBP2), that contributes to the formation of two types of brain malignancies, astrocytoma and oligodendroglioma.
A large study of 28,000 Danish utility workers found no evidence of increased cancer risk from low-frequency electromagnetic fields. However, women exposed to medium frequency fields were more likely to develop brain cancer than those with lower exposure levels.
Boston College biologists identify KetoCal as an effective alternative therapy for malignant brain cancer, slowing tumor growth and enhancing health in mice. The study found that KetoCal decreased tumor growth by 35-65% and improved survival rates compared to standard diets.
Researchers found that dual therapy with Avastin and chemotherapy agent irinotecan halted tumor growth up to twice as long as comparative therapies, offering a significant advance in treatment for aggressive gliomas. The study's findings may lead to new options for patients with the poorest possible prognosis.
A new study found that the loss of PTEN function in glioma cells leads to high levels of B7-H1 expression, making it harder for T-cells to kill cancer cells. This discovery may have implications beyond brain tumors and could affect the effectiveness of emerging therapies.
A large cohort study of over 420,000 cell phone users found no link between long-term or short-term cell phone use and an increased risk of brain tumors, salivary gland tumors, eye tumors, or leukemias. The study suggests that cell phone use is not associated with cancer risk.
Researchers are evaluating the use of Aricept to prevent cognitive decline and memory problems in pediatric brain cancer survivors who have received cranial radiation. The study, which will enroll 35 patients ages 8-17, aims to assess whether the drug can help maintain baseline cognitive abilities and social relationships.
Research from the University of Minnesota found that children who received radiation for cancer are at higher risk for developing secondary brain tumors. Prolonged follow-up is crucial for early detection, and long-term screening recommendations are needed for all childhood cancer survivors.
Childhood cancer survivors are at higher risk for developing second cancers, including CNS tumors, which can have devastating consequences. Radiation exposure is associated with a higher risk of malignant brain tumors like glioma and benign tumors like meningiomas, particularly in children under age 5.
Researchers have found that a cancer-fighting virus called VSV kills the most malignant form of brain cancer in mice, targeting invasive tumour cells. The study also discovered that delivering VSV intravenously can effectively treat malignant glioma with minimal side effects.
A recent study by the University of Rochester Medical Center found that lead exposure is associated with an increased risk of brain cancer in adults. The research, which analyzed data from over 318,000 people, revealed a 50% higher death rate among those exposed to lead compared to unexposed individuals.
A six-month walking exercise program may help alleviate cognitive impairment in cancer survivors. Researchers aim to identify new tactics to improve quality of life for those affected by chemotherapy-induced memory problems.
Researchers found space-time clustering of glioma tumour cases in different geographical locations, consistent with patterns caused by infections. The study suggests a possible link between infection and brain tumours, potentially leading to future preventative measures.
A study analyzing cancer cases in young children over 45 years found space-time clustering of leukaemia and brain tumour cases, suggesting a potential link between infectious viruses and childhood cancer. The research suggests that minor illnesses during early childhood may trigger cancer in genetically susceptible individuals.
A University of Minnesota study reveals that nearly 20% of childhood cancer survivors experience physical limitations and trouble performing daily activities. Survivors of brain and bone cancers are most affected, with many reporting difficulties attending work or school.
Researchers introduce molecularly engineered DNA strands into cell cultures to detect biomarkers in complex samples. The technique could help identify cancers at earlier stages and monitor residual cancer after treatment.
A study of 11,481 childhood cancer survivors found that 20% had physical performance limitations compared to 12% of their siblings. Rehabilitation programs improved survival rates after heart attacks by reducing subsequent heart attacks by 17%.
Researchers developed a new radiation technique that targets cancer while sparing hair follicles, resulting in minimal hair loss. The study used intensity modulated radiation therapy (IMRT) on 10 patients with stage IV brain cancer, showing promising results and improved overall survival rates.
A team of researchers from the University of Illinois at Urbana-Champaign has developed an alternative therapy to surgery for brain cancers. By engineering T-cell receptors with enhanced binding capacity, the approach aims to eradicate tumors with minimal side effects.
Childhood cancer survivors are more likely to experience academic problems, social isolation, and difficulties with friendships. Researchers found that these issues affect up to 46% of survivors, particularly those with brain cancers, leukemia, or neuroblastoma.
Neural stem cells in the subventricular zone of the forebrain give rise to malignant astrocytoma in genetically engineered mice. The study challenges current dogma that tumors arise from glial cells throughout the brain.
A recent study suggests that Gulf War veterans may be at a greater risk of developing brain cancer, potentially linked to exposure to nerve agents during the conflict. The National Academies of Sciences, Engineering, and Medicine report highlights the need for further research into this potential health consequence.
Tom Curran, a prominent cancer researcher, has been elected Fellow of the Royal Society. His work on molecular oncology and neurobiology has made significant impacts on our understanding of brain cancers and gene regulation.
Scientists at Johns Hopkins Medicine have identified Notch2 as a key gene target in childhood brain tumors, medulloblastoma. High levels of the Notch2 gene are associated with poorer outcomes and cancer cell growth promotion.
A new RNAi delivery system has been developed to target brain cancer cells, using antibodies to cross the blood-brain barrier. The treatment has shown promising results in mice with brain tumors, increasing survival time by almost twice as much as a control group.
A recent study by the American Academy of Neurology found that people with low incomes are at a higher risk of developing brain tumors. The study analyzed data from Michigan and found a significant difference in brain cancer rates between those with low incomes and those without, particularly among younger adults.