Articles tagged with Breast Cancer
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In a Phase II clinical trial, eribulin mesylate demonstrated significant anti-tumor activity in heavily pretreated patients with locally advanced or metastatic breast cancer. The study showed an Overall Response Rate of 9.3% and a manageable tolerability profile with low incidence of Grade 3 and 4 neuropathy.
A study by Dana-Farber Cancer Institute found that chemotherapy can diminish ovarian reserve, making it harder for premenopausal breast cancer survivors to get pregnant. The research suggests that tracking breast cancer survivors' fertility after treatment is crucial.
A study found that Black and Hispanic women are less likely than white women to receive follow-up radiation for early breast cancer, suggesting thousands may be undertreated. The disparity is attributed to various barriers, including logistical problems, insurance status, and patient preferences.
Studies found that mutations in the p14ARF gene can promote melanoma development, even with normal p16 levels. Researchers also discovered an estrogen signaling pathway in aggressive prostate cancer, driving its growth. Additionally, adding paclitaxel to standard chemotherapy improves outcomes in early breast cancer patients.
A recent study published in the journal Cancer found that pre-operative assessments by physical therapists can detect and treat lymphedema, a chronic condition caused by excess lymph fluid. The study showed that early detection and management can prevent the condition from progressing to a chronic stage.
Researchers have identified a unique genetic signature that can alert physicians to high-risk breast tumors masquerading as low-risk tumors. The genetic signature is associated with a higher chance of cancer recurrence and standard anti-estrogen therapy being ineffective.
Global menopause experts conclude that HRT is safe and beneficial for healthy women in the early postmenopausal period. The Zürich Summit reviews evidence on the safety, risks, and benefits of HRT, finding no increased risk of chronic heart disease or breast cancer in this group. HRT also maintains bone health and may delay cognitive d...
Early nursing intervention and effective strategies can decrease lymphedema incidence, manage chronic lymphedema, and improve quality of life in breast cancer patients. Nurses play a crucial role in educating patients about triggers and symptoms, conducting regular assessments, and pursuing research to address this issue.
Researchers develop a biomarker to detect pleural mesothelioma through plasma osteopontin levels. NYU Cancer Institute also explores using microRNAs to discover novel biomarkers and presents a new strategy for restoring androgen sensitivity in prostate cancer, as well as a potential melanoma vaccine
A Phase II clinical trial led by researchers at The University of Texas M. D. Anderson Cancer Center found that Iressa enhanced the effectiveness of hormonal therapy in treating specific types of metastatic breast cancer. The combination resulted in a 45% reduction in risk and improved clinical benefits for patients.
Researchers at WashU Medicine found that a bone-strengthening drug called zoledronic acid reduced the growth of breast tumor cells in bones by 23% after three months. Women treated with the drug were also less likely to develop large metastatic tumors, suggesting it may help prevent cancer spread.
Excess IGF-1R protein indicates reduced responsiveness to Gleevec in gastrointestinal stromal tumors. Alternative treatments may be effective for patients with high IGF-1R levels.
Researchers at Georgetown University Medical Center have developed a blood test that can predict treatment efficacy in metastatic breast cancer patients. The test measures circulating tumor cells and has been shown to be a reliable predictor of disease progression.
The American Urological Association is calling for legislative action to cover erectile dysfunction therapy after radical prostatectomy. Researchers found that the costs of ED treatment are significantly less than breast reconstruction, but current insurance policies do not provide coverage for men with ED following prostate surgery.
Researchers at Mayo Clinic found a correlation between women who underwent pre-surgical breast MRI and an increased rate of mastectomy. The study suggests that MRI may lead to greater anxiety, prompting patients and physicians to choose mastectomy over lumpectomy.
A new study shows that an anesthetic injection into nerves in the neck can significantly reduce the frequency and severity of hot flashes and night awakenings in breast cancer survivors. The treatment, called a stellate ganglion block, was shown to provide lasting relief for most patients.
Researchers at UT Southwestern Medical Center found that methylation acts as a biological clock indicating cell division history and cancer risk. Having children or approaching menopause can turn the clock back, reducing breast cancer risk.
A pilot study found that stellate-ganglion block reduced hot flushes in breast cancer survivors by up to 90% and improved sleep quality. The procedure provided long-term relief with minimal side effects, increasing overall quality of life and compliance with treatment.
Ning Wong, a physician at Fox Chase Cancer Center, has received the ASCO Career Development Award for her exceptional work in genitourinary malignancies and health services research. The $200,000 grant will support her independent clinical cancer research program.
A clinical trial found that adding ultrasound screening to mammography increases the detection of breast cancer, but also raises the risk of false positive findings and unnecessary biopsies. The study suggests that women at high risk of breast cancer may benefit from supplemental ultrasound screening.
A study of nearly 65,000 women found that physical activity significantly reduces the risk of premenopausal breast cancer. Women who exercised regularly had a 23% lower risk of developing breast cancer before menopause.
The Breast Cancer Campaign emphasizes the need for improved quality of life and treatment options for survivors, citing advances in diagnosis and care. Despite increased survival rates, many survivors experience debilitating side effects such as fatigue and body image issues, affecting their psychological well-being.
Women with a sister diagnosed with breast cancer face an increased risk of developing the disease throughout their lives. Regular exercise during adolescence and young adulthood is associated with a lower risk of premenopausal breast cancer. Meanwhile, disparities in rectal cancer outcomes persist despite access to oncologists, highlig...
A study found that adding ultrasound to mammography for high-risk women increased cancer detection by 4.2 cancers per 1,000 women, while also increasing false-positive results by 10.4%. The diagnostic accuracy of combined screening was higher than mammography alone
A multicenter trial found that breast ultrasound combined with mammography detected more cancers than mammography alone in high-risk women. The study used over 2,800 participants, including 40 diagnosed with breast cancer, and showed that breast ultrasound is a cost-effective and non-invasive screening option.
A review of 62 studies found that physical activity significantly reduces breast cancer risk in lean women, particularly those who engage in moderate and vigorous exercise after menopause. Obesity and family history of breast cancer counteract these benefits.
A new study emphasizes that six-month short-interval follow-up examinations can accurately detect cancers in patients with 'probably benign' breast lesions, resulting in high sensitivity. This approach avoids unnecessary biopsies and ensures timely cancer detection.
Scientists at Emory University's Winship Cancer Institute discovered a new regulation mechanism in breast cancer cells responding to estrogen. The study found that methylation on estrogen receptors prolongs their life and effectiveness in driving tumor growth.
Researchers found that tumour growth rates vary considerably among patients, with generally slower growth rates with increasing age at diagnosis. The new model estimated the mean time for a tumour to double in size from 10 to 20 mm in diameter is 1.7 years.
A research team led by M. D. Anderson Cancer Center scientists created a whole-organ genomic survey to chart the molecular journey from normal cell to invasive cancer in bladder tissue. They identified a crucial new category of genes, known as 'forerunner genes,' that launch the process of cancer development.
Breast cancer patients with a history of mood and anxiety disorders are more likely to develop posttraumatic stress disorder (PTSD) after diagnosis. The study found that 16% of breast cancer patients developed PTSD within 18 months of diagnosis, with women having previous mood disorders being over twice as likely to develop the condition.
The University of Pittsburgh Cancer Institute has established a groundbreaking BRCA cancer research program focusing on genetic mutations that significantly increase breast, prostate, ovarian, and pancreatic cancer risks. The program aims to identify innovative ways to reduce the risk for high-risk patients.
A new study identifies a specific genetic variation in the FGFR2 gene that alters its binding to regulatory proteins, leading to increased expression and an elevated risk of breast cancer. The mutation occurs in non-coding regions of the gene, affecting its regulation rather than protein production.
Preliminary research suggests that high-risk women with breast cancer who don't have a BRCA1/2 mutation may be at a higher risk of developing a second breast cancer. The study supports the use of prophylactic mastectomy as an option for these women, but raises questions about the role of sentinel node biopsy.
A recent study led by Northwestern Memorial physician Virginia Kaklamani suggests that variations of the adiponectin gene may increase a woman's risk of developing breast cancer. This discovery could lead to the development of a genetic testing model to predict breast cancer risk more accurately.
Researchers found that daily aspirin use was associated with a small reduction in the risk of ER+ breast cancer, but not total breast cancer risk. Aspirin's irreversible effects on cyclooxygenase enzymes may disrupt breast cancer development by reducing estrogen production.
Researchers measured breast cancer patients' upper limb volume before and after surgery to establish a baseline and monitor for lymphedema. The study found that early detection using compression garments effectively treated subclinical lymphedema.
A mathematical model suggests that women with wild-type CYP2D6 genotype may derive as much benefit from tamoxifen as from aromatase inhibitors, potentially leading to personalized therapy approaches. Additionally, a study finds that cancer stem cells resistant to standard chemotherapy are responsive to targeted therapy.
A study by researchers at Baylor College of Medicine found that conventional chemotherapy often fails to eliminate breast cancer stem cells, leading to potential relapse. Treatment with lapatinib and other drugs appears to kill both tumor cells and stem cells, reducing the risk of recurrence in patients with HER2-positive tumors.
Indigenous Polynesian populations face higher cancer mortality rates due to factors like smoking, obesity, and limited access to screenings. Screening programs for breast cancer cover less than half of Pacific women compared to European New Zealanders.
Research published in PLOS Genetics found that hormone-dependent and independent breast cancers originate from distinct genetic variants, suggesting separate biological pathways. This discovery could guide future research into prevention and treatments for the different cancer types.
A team of researchers at UNC Chapel Hill has discovered new targets for cancer treatment by identifying proteins that promote blood vessel formation in tumors. The study found 55 genes overexpressed in breast cancer vessels, offering potential new targets for therapy.
Advances in breast reconstruction techniques, such as nipple-sparing mastectomy, DIEP flaps, and acellular dermis graft slings, are addressing the cosmetic issues left by lumpectomy. These innovative methods aim to create more natural-looking breasts with improved symmetry and aesthetics for breast cancer patients.
Regular mammograms significantly decrease the risk of late-stage breast cancer in women 80 and older, with only about one-fifth receiving them. The study found that each mammogram performed was associated with a further reduction in late-stage disease risk.
Researchers found that regular mammograms significantly reduce the risk of being diagnosed with advanced stage breast cancer in women over 80. Women who received mammograms were more likely to be diagnosed with early-stage disease and had a higher five-year survival rate compared to non-users.
A new study reveals that cancer survivors in Canada have low levels of physical activity and high prevalence of obesity. The findings suggest that lifestyle interventions to promote physical activity and healthy weight management are necessary among cancer survivors to control their disease.
The 'GeparQuattro' trial shows that combining anthracycline and taxane chemotherapy with trastuzumab improves HER2 breast cancer response rates to 41.3%, compared to 19.5% without trastuzumab. The regimen also minimizes cardiac toxicity, making it a promising treatment option.
A study found that follow-up care for breast cancer patients costs less when led by nurses rather than physicians, with significant savings potential for healthcare budgets. Specialist nurse-led follow-up resulted in €866 per patient over a five-year period, making it a cost-effective alternative.
Research suggests mammograms are effective for women aged 70-75, with a lower mortality rate compared to earlier age groups. The best interval for screening is every three years, which has been shown to be an appropriate upper age limit and saves lives without causing harm.
A study found that acupuncture reduces hot flushes in breast cancer patients taking tamoxifen by 50%, with a sustained effect after treatment cessation. Acupuncture also improves overall well-being and has the advantage of being cheap and side-effect-free compared to other treatments.
A study of 1,394 women found that those with low vitamin D levels had a significantly increased breast cancer risk. Carriers of certain polymorphisms in the vitamin D receptor gene also showed an increased risk of developing breast tumors.
Researchers at Fox Chase Cancer Center have identified a molecule, IPA-3, that can shut down PAK1, an enzyme involved in pathways leading to breast cancer. The molecule achieves high selectivity for PAK1 by binding to its auto-regulatory arm, preventing the enzyme from becoming active.
Researchers found that breast cancers behave differently before and after age 70. Women aged under 70 are less likely to have aggressive tumors spreading to lymph nodes as they age, but the opposite occurs for women over 70. Decreased immune defense mechanisms may play a role in this change.
A study found that aromatase inhibitors (AIs) do not increase the risk of heart problems in women who take them, contrary to previous fears. The research suggests AIs are superior to tamoxifen in reducing breast cancer recurrence and do not significantly worsen cardiovascular health.
A recent study found that women with BRCA2-associated breast cancer had a higher response rate and longer overall survival when treated with anthracycline-based regimens. Researchers believe this may be due to the lack of functional BRCA1/2 proteins, which impair DNA repair after chemotherapy.
A new drug, lapatinib, has been shown to significantly shrink primary breast cancer tumors in just six weeks by targeting cancer stem cells. This breakthrough finding suggests a possible new therapy for eliminating tumor-causing cells and achieving long-term cancer eradication.
A new chemotherapy combination of docetaxel and capecitabine showed no improved efficacy in early breast cancer treatment, but increased non-haematological toxicities. The study found that the addition of capecitabine produced more side effects, such as hand-foot syndrome and diarrhoea.
A new study suggests that pregnant breast cancer patients can benefit from the same treatment as non-pregnant women with minimal health risks to the baby. The research collected data from 122 patients and found that most received surgery and chemotherapy without significant harm to the newborn.
Researchers found that common versions of FGFR2 and TNRC9 genes increase breast cancer risk in women carrying damaged BRCA2 gene. The study suggests that knowledge of a BRCA mutation is necessary but not sufficient to fully understand cancer risk.
Researchers present data on new role for MRI in brain cancer and lapatinib's promise for stabilizing disease in patients with liver cancer. Functional diffusion mapping can provide earlier assessment of response for patients with glioma, a notoriously hard-to-treat cancer.