Articles tagged with Breast Cancer
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A study found that genetic variations in the vitamin D receptor gene are associated with an increased risk of estrogen receptor-positive breast cancer in postmenopausal women. Vitamin D has been shown to play a role in preventing cancer, but its effects on specific genetic variants and breast cancer risk were unclear until this research.
Studies found obese breast cancer patients have poorer disease-free and overall survival rates compared to non-obese counterparts. Obesity also affects diagnostic characteristics, including stage at diagnosis, surgical delay, and hospital stay.
A study of 249 patients with breast cancer found that using MRI before surgery can lead to better-adapted treatment, including changing surgical approaches for multiple tumors. The technique reduced the need for mastectomies and improved treatment outcomes in 22 patients.
Researchers are developing a blood test to detect aggressive breast cancer using a comprehensive tissue collection and advanced proteomics technology. The project aims to identify proteins that indicate aggressive cancer and can be detected in blood, adding to the tools available to fight the disease.
Breast cancer incidence rates in US women over 50 declined sharply in 2002 and 2003, but only among Caucasians. For African Americans, there was virtually no change in invasive breast cancer rates. The study suspects genetic variations in estrogen metabolism may play a role in how women of African ancestry respond to hormonal therapies.
A study by Michigan State University found that media coverage of breast cancer prioritizes treatments over prevention. The research highlights the importance of promoting cancer-prevention techniques through media awareness, as it can have a significant impact on women's perceptions and behaviors.
Two studies suggest that chemotherapy is not the cause of memory problems in breast cancer patients, but rather stress and quality of life factors. Women with recent diagnoses performed similarly on cognitive tests to those without cancer, while those who had completed treatment showed better scores.
Researchers have found genetic differences in breast tumors between African-American and Caucasian women that may contribute to the more aggressive clinical features of breast cancer in African-American women. These differences were also seen in prostate cancer, suggesting a possible link to viral involvement and genetic factors.
A study of 250 BRCA carriers found that prophylactic mastectomy significantly reduces the risk of developing breast cancer, with only one case detected. The cost of ongoing surveillance is high and can be stressful for patients, while intensive screening may not always detect cancer at an early stage.
A study found that women's perceived risk of colon cancer is associated with their screening behavior, with higher risks detected in Latinas and lower risks in Asian women. Women with a family history of cancer were more likely to undergo screenings.
A study found that moderate drinking in women increases the risk of developing ER+/PR+ breast cancer, with higher risks observed for those who consumed more alcohol. Researchers also identified a link between specific genetic variations and increased breast cancer risk among postmenopausal drinkers.
Researchers have identified two potential biomarkers that could help doctors monitor the effectiveness of treatment with sunitinib or bevacizumab for kidney and non-small cell lung cancer. A study found that circulating endothelial progenitor cells (ccEPCs) increase in patients who respond to therapy, while those who do not respond hav...
Researchers found that a tumor protein present in aggressive breast cancers correlates with poor prognosis and growth/spread of disease. GRB-7 protein is related to HER-2/Neu gene, influencing treatment response and potentially informing clinical predictions and new therapies.
Research found that medial breast tumors primarily receive blood from internal mammary vessels, while lateral tumors have a more complex blood supply. This study supports the use of MRI for analyzing breast cancer's impact on surrounding anatomy, particularly vascular supply and lymphatic drainage.
A new study of 145 triple-negative breast cancers found that moderate or low-grade lesions were present in 23% of cases, with only a small percentage showing lymph node metastasis. The findings suggest that triple-negative breast cancers are a heterogeneous group and may not always be associated with cancer spread.
Elderly patients over 70 years old benefit from frequent mammograms, which can detect breast cancers earlier and reduce surgical procedures. The study found that 19 of 24 cases of breast malignancy were initially identified on screening mammography.
A recent study found that USFNA of axillary lymph nodes in patients with newly diagnosed breast cancer improves diagnostic accuracy while minimizing negative results. The procedure, which measures cortical thickness, is safe and minimally invasive.
A study found that MRI examinations before surgical treatment changed the treatment plan in 28% of cases, with 15 patients opting for mastectomy. The delay caused by MRI screenings also increased treatment time by 14 days on average.
A study by Baystate Health found that using mammography and sonography together can exclude breast cancer in 98% of patients. However, some cases may remain undiagnosed due to dense tissue or late detection.
A randomized controlled trial found that conjugated equine estrogen increased the risk of benign proliferative breast disease by more than two-fold. Women taking estrogen supplements had 155 cases of benign disease compared to 77 in the placebo group.
Researchers discovered a molecular pathway underlying low-grade forms of brain tumor known as astrocytoma, suggesting new therapeutic targets. Additionally, studies revealed that microRNAs regulate female mouse fertility by controlling the functioning of the corpus luteum, which is essential for pregnancy.
Research suggests that genistein in soy foods reduces the risk of breast cancer by controlling cell growth and death in young women. The exact mechanism is not yet fully understood, but studies suggest a link between soy consumption during puberty and reduced breast cancer risk.
A study by researchers at the University of Mississippi found that consuming green tea's EGCG significantly inhibits breast tumor growth and angiogenesis in female mice. The results suggest that EGCG may provide protection against breast cancer by targeting tumor blood vessels and cells.
Researchers discovered T-cadherin's role in promoting tumor vascularization, slowing down tumor growth and improving survival. However, the absence of this protein also led to more aggressive disease in the long run.
A recent study found that the human breast tumor microenvironment can prime cells for metastasis, particularly to the lungs. Researchers discovered a correlation between TGFß exposure and increased risk of lung cancer in ER- tumors.
A study of over 3,000 adult women found that those with the highest intake of choline had a 24% lower risk of developing breast cancer. Choline is an essential nutrient found in eggs, coffee, and skim milk, and increasing its intake may be particularly important for women.
A recent study found that patients who received a discussed breast reconstruction had higher odds of undergoing the procedure. Researchers recommend improving communication between physicians and patients to reduce disparities in breast reconstruction rates.
A new study combines clinical characteristics with genomic profiles to predict breast cancer prognosis and guide treatment. By matching the right drugs with the right patients, researchers aim to provide more personalized treatment strategies.
A study integrating genetic information with breast cancer risk factors refines estimates of relapse-free survival and predicts response to chemotherapy. Gene expression signatures provide valuable insights into breast cancer heterogeneity, enabling more precise clinical outcomes.
Researchers at the University of Missouri found that synthetic hormone replacement therapy can promote breast cancer growth, but an antibody and small molecular drug may prevent tumor cell expansion. The study suggests a potential link between hormone replacement therapy and breast cancer progression.
A comprehensive review of breast cancer research identifies key gaps in treatment and patient care, calling for increased attention on prevention, detection, and spread. The charity Breast Cancer Campaign is already funding innovative projects to fill these gaps and improve survival rates.
A new study has found that hormone replacement therapy (HRT) increases the risk of breast cancer recurrence in women who have survived breast cancer. The HABITS trial, which followed over 200 breast cancer survivors for four years, found that HRT significantly increased the risk of disease recurrence.
The use of sentinel lymph node biopsy (SLNB) increased substantially from 1998 to 2005, but disparities persist in access to the procedure. Non-white women, older women, and those living in poorer areas were less likely to receive SLNB than their counterparts, highlighting uneven access to this less-invasive breast cancer staging test.
A new study found that while MRI has a high false positive rate, it still detects genuine breast cancer cases effectively. However, the rate of false positives does not impact a woman's decision to undergo prophylactic mastectomy.
Researchers at Harvard Medical School have identified proteins that promote tumor growth in certain types of cancer, including breast and ovarian cancer. Targeting these proteins with small molecules may lead to new therapeutic options for patients.
Researchers found that tumour relapse rates were similar between lower dose regimens (50Gy, 41.6Gy, 39Gy) and the standard schedule. Both photographic and patient self-assessments suggested lower late adverse effects after these lower dose regimens.
Researchers found unsuspected treatable tumors in Li-Fraumeni syndrome patients using full-body PET/CT scanning. The study suggests that periodic scans could catch more tumors at a curable stage, but further studies are needed to confirm the benefits and risks.
A new study found that family discussions about cancer history significantly impact knowledge and attitudes about genetic counseling and testing for moderate-risk women. Women who discussed their family's cancer history with relatives had greater knowledge and more positive attitudes towards testing.
A study by the University of Chicago's Center for Interdisciplinary Health Disparities Research links early onset breast cancer in black women to neighborhood conditions, including social isolation and stress. The research aims to inform policy makers on creating cost-effective interventions to reduce women's vulnerability.
Women with breast cancer who are obese experience more aggressive disease, including higher rates of inflammatory breast cancer and increased risk of recurrence. Obesity can lead to weight gain during treatment, further increasing the risk of recurrence.
A study found two gene variants in the AKAP protein family to be linked to an elevated breast cancer risk, particularly in women from breast cancer families. These variants, located on the AKAP9 gene, were found to increase the risk by 17% and 27% respectively.
Researchers discovered that SATB1 protein promotes tumor growth and metastasis in breast cancer. High levels of SATB1 expression are associated with poor prognosis, and reducing SATB1 can prevent the formation of invasive cells.
Researchers found that COX-2 expression is a marker for cancer development in some benign breast biopsies, with higher levels associated with increased risk. The study's results may lead to targeted treatments using COX-2 inhibiting agents.
A study of Hiroshima and Nagasaki bombing survivors found that radiation exposure in utero and early childhood increases the risk of adult solid cancers. Individuals carrying a rare genetic variant of AKAP9 gene also have an increased risk of breast cancer.
The American Association for Cancer Research (AACR) is honoring world-class cancer researchers for their significant contributions to the fight against cancer. The AACR Awards Program recognizes outstanding achievements in basic cancer research, clinical care, therapeutics, and prevention.
Treatment with letrozole initiated one to seven years after stopping tamoxifen therapy cuts the risk of breast cancer recurrence in half and metastasis by 60%. The chance that a new tumor develops in the unaffected breast is also significantly reduced. These findings suggest aromatase inhibition can still offer preventive benefits.
A new study has demonstrated a lower risk of cardiac toxicity with dose-dense chemotherapy in early-stage HER2-positive breast cancer patients. The regimen, which administers standard doses of chemotherapy agents more frequently, pairs safely with trastuzumab and resulted in only 1.4% cardiac events after 28 months of follow-up.
A comprehensive review of 21 studies covering over 37,000 women found that anti-inflammatory drugs like aspirin may reduce breast cancer risk and provide a useful addition to treatment for existing sufferers
A follow-up study of women who stopped taking hormone therapy after a clinical trial found an increased risk of cancer, with higher rates of invasive breast cancer and other cancers. Cardiovascular events were comparable between the two groups.
A follow-up study of the Women's Health Initiative confirms that long-term use of combination hormone therapy in healthy postmenopausal women increases risks of heart disease, stroke, and blood clots. After stopping hormone therapy, cardiovascular disease risk decreases but overall risks remain high.
Researchers at UCSF have developed a new model for estimating breast cancer risk, incorporating breast density and ethnicity, which is well-calibrated and reasonably accurate across risk factor subgroups. The model may one day be used to calculate a woman's risk for breast cancer during mammograms.
A new guideline for treating dementia emphasizes the importance of individualized assessment and treatment based on a patient's specific medication regimen. Researchers also developed two new blood tests to diagnose latent tuberculosis, finding that one test is more sensitive than traditional methods.
Researchers at Memorial Sloan-Kettering Cancer Center have discovered a new genetic marker that increases breast cancer risk by 1.4 times in women with the DNA variation. The study used genome-wide association mapping to identify a gene locus on chromosome 6 associated with breast cancer risk.
Researchers have identified a new target for cancer therapy by targeting the non-malignant cells surrounding tumors, which can stop tumor growth in mice. This approach has shown promise in reducing tumor size and slowing growth of well-established cancers after a single injection of T cells.
A new study, ALTTO, is testing two targeted medications to treat aggressive breast cancer in 8,000 participants across 50 countries. The trial will compare four different regimens of targeted therapy and provide insights into individualized patient care.
The American Association of Physicists in Medicine celebrates its 50th anniversary, highlighting key contributions of medical physicists to medicine. Medical physicists have developed technologies such as MRI, CT scanning, and PET scanning, which have transformed imaging and cancer treatment.
A Weill Cornell team discovered that EP2 and EP4 receptors play a key role in boosting estrogen production in fat and breast cancer cells. This pathway increases the risk of hormone receptor-positive breast cancer. The study's findings suggest new targets for pharmaceutical research, including drugs that target these receptors.
A new study from the American Cancer Society reveals that breast cancer death rates among African American women are decreasing in only 11 US states and remain flat or increase in at least half. The disparity is attributed to access issues, regional variations in treatment quality, and limited screening services.
Patients with HER2-positive tumours who receive trastuzumab treatment after diagnosing brain metastases have improved survival rates. The study found a correlation between triple receptor status and the incidence of brain metastases, as well as survival time.
A study of 829 Canadian women diagnosed with early breast cancer found that they lost an average of 27% of their typical income during the first 12 months after diagnosis. The researchers also discovered that wage losses were more common among less educated women, those with more serious disease, and those with less social support.