Articles tagged with Breast Cancer
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The ATAC trial confirms anastrozole's superior efficacy over tamoxifen, with increased disease-free survival and reduced cancer recurrence. Long-term benefits of anastrozole treatment persist even after completion.
A new study reveals secretoneurin's neuroprotective role in a rat model of stroke. SN treatment improved survival of primary brain cell cultures and reduced cerebral tissue death in rats with ischemia-induced stroke.
A new survey from Michigan Medicine suggests that when women are told their risk of breast cancer is above average, they're more likely to take a hypothetical pill and overestimate its benefits. The study highlights the importance of considering individual risk information when making medical decisions.
The CTRC-AACR San Antonio Breast Cancer Symposium combines basic, translational, and clinical research to advance breast cancer research. The symposium aims to attract thought-leaders and high-quality papers in basic and translational breast cancer research.
Researchers discovered a genetic switch that regulates critical properties of cancer stem cells using microRNAs. Activating this switch, let-7, can push cancer stem cells to differentiate and lose their tumorigenic abilities, offering a novel approach to targeting these cells with therapeutic RNAs.
A definitive study of 15 randomized trials found that high-dose chemotherapy and autologous stem cell transplantation had no overall survival benefit for women with node-positive breast cancer. However, there was a slight benefit in relapse-free survival.
A nationwide study found that diagnostic mammogram accuracy depends on the radiologist reading it, with varying sensitivity and false-positive rates. Radiologists based at academic medical centers or spending most time on breast imaging performed more accurately.
A study published in the Journal of the National Cancer Institute found that diagnostic mammogram readings vary extensively by radiologist, with no explanation for the variation. Radiologists' performance was influenced by their experience, affiliation, and time spent interpreting mammograms.
A recent study has identified a link between BRCA1 mutations and the loss of the tumor suppressor gene PTEN in breast cancer. This discovery opens up new avenues for treating aggressive forms of breast cancer by targeting proteins in the PTEN pathway.
Research from the American Association for Cancer Research links weight gain and diabetes to increased risks of various cancers. Women with diabetes are 1.5 times more likely to develop colorectal cancer, while those with high C-peptide levels face a risk of death nearly three times higher than women with lower levels.
In a study of 79 women with breast cancer, breast MRI revealed important diagnostic information altering treatment plans in 20 percent of cases. The imaging modality detected additional cancers, discovered cancer in the opposite breast, or determined tumors were larger than expected.
Researchers have found that exposure to a common household chemical, butyl benzyl phthalate (BBP), can cause genomic changes in the mammary gland of rats. The study suggests that this could potentially lead to breast cancer, highlighting the need for further research.
A new marker, ALDH1, has been identified that can be used to detect and characterize cancer stem cells in breast tumors. These cells are responsible for fueling a tumor's growth and are linked to worse outcomes.
A study by American Cancer Society researchers found significant disparities in breast cancer diagnosis, particularly among uninsured and African American women. They are more likely to miss axillary lymph node assessments, which help determine stage and guide treatment decisions.
Researchers at Karolinska Institute have identified a new source of dopamine cells that provided marked benefit when transplanted into mice with Parkinson's-like disease. Wnt5a-treated neural stem cells may be an efficient and safe source for DA cell replacement therapy in individuals with PD.
Direct-to-consumer genetic testing poses risks of misleading patients and physicians due to lack of regulation. Physicians recommend consulting with doctors before ordering tests, as results may not be clinically valid or accurately interpreted.
A recent study found racial discrepancies in breast cancer tumor gene profiles, suggesting inflammation plays a stronger role in development and progression in African-American women. African-American breast cancer patients tend to have a greater prevalence of an aggressive form of cancer less likely to respond to hormone therapy.
A recent study by McGill researchers found that the enzyme focal adhesion kinase (FAK) is crucial for tumour progression from a pre-malignant to a malignant state in the mammary tumour system. The discovery opens up new avenues for developing targeted treatments against breast cancer.
Scientists at Jefferson Medical College have used PET imaging to observe hyperactive breast cancer genes in laboratory animals, marking a breakthrough in detecting and classifying cancer. This technology may help physicians identify breast tumors as early as possible and determine the appropriate treatment.
Researchers present findings on how poverty affects cancer prognosis, ethnicity influences medical care, and genetics impact survival rates among different groups of women. A study reveals African-American women face poorer disease-free survival rates due to racial-specific biology, prompting a reevaluation of screening guidelines. Mea...
Leslie Bernstein, a renowned researcher on hormone effects and physical activity on cancer risk, has been selected for the AACR-Prevent Cancer Foundation Award. Her work has vast implications on quality of life after cancer, challenging previous paradigms on breast cancer risk factors.
Researchers used PET/CT to diagnose and stage inflammatory breast cancer, detecting disease earlier than traditional methods. The study achieved a 95% accuracy rate in identifying cancerous areas and involved 41 women with the aggressive form of breast cancer.
Male BRCA1 and BRCA2 mutation carriers have a higher risk of developing breast cancer compared to noncarriers. A high carbohydrate diet may also promote prostate tumor growth in mice, while infection with human papillomavirus (HPV) is associated with an increased risk of head and neck cancers but does not further increase the risk when...
A new risk prediction model for African American women has been developed and tested, providing more accurate estimates of breast cancer risk compared to the widely used Gail model. The model, known as CARE, accurately predicted the number of cancers observed in African American women in most subgroups.
The Institute of Genetics and Molecular Medicine (IGMM) brings together researchers in human biology to develop non-toxic cancer treatments that could prevent tumours from spreading. The institute aims to learn lessons from each condition to inform others and develop personalized medical treatment.
A study by Nicholas M. Perry found that urban women have denser breasts and are nearly four times more likely to develop breast cancer than rural women. Regular breast screening with digital mammography is advised for all women, especially those with dense breast tissue.
A survey of 1,011 women found that ethnic background influences preferences regarding breast cancer screening for early detection. Black and Hispanic women tend to prefer recall over earlier detection, while Caucasian women prioritize earlier detection.
A study published in CANCER found that non-white women with metastatic breast cancer experience poorer pain control, with a higher risk of severe pain. The researchers also found that inactive performance status and previous radiation treatment were associated with greater pain.
A team of experts prioritized key issues in breast cancer research, including molecular signatures to spare chemotherapy and optimal chemotherapy regimens. The study aims to focus translational research resources on these critical areas, ensuring better patient management and treatment outcomes.
A study published in the Journal of Cancer Epidemiology, Biomarkers, and Prevention found that pre-malignant mammary lesions in dogs and humans display similar characteristics. The research, conducted by Purdue University scientists, could lead to better understanding of breast cancer progression and prevention for both people and pets.
A study found a 150% increase in women choosing contralateral prophylactic mastectomy when cancer is confined to one breast. Despite this, researchers caution that the procedure may not improve overall survival and raise concerns about unnecessary invasive treatment.
A new model for predicting estrogen receptor-positive breast cancer risk in postmenopausal women performs almost as well as the standard Gail model and could be used to identify high-risk women. Smoking is associated with rectal cancer, while drugs like ZD6126 may cause heart damage due to cardiovascular changes.
Researchers found that the Wwox protein keeps ErbB-4 on the cell surface, associated with better survival in breast-cancer patients. The absence of Wwox is linked to shorter survival, particularly in triple-negative breast cancers.
Researchers found that gene signatures can predict which chemotherapy regimens are most effective for breast cancer patients. The study showed a significant improvement in response rates when using gene signatures to select treatments, suggesting a potential breakthrough in personalized medicine.
A new model for predicting breast cancer risk in postmenopausal women is as accurate as the Gail Model, but easier to use. The model uses only three factors: age, family history of breast cancer, and previous breast biopsy.
Researchers identified distinct molecular markers predicting subsequent invasive cancer after noninvasive breast cancer diagnosis. These biomarkers can stratify women's individual risk and guide aggressive therapy decisions.
A novel molecular switch controls protein synthesis to promote tumor growth and survival in locally advanced breast cancer. The switch is regulated by two factors, 4E-BP1 and eIF4G, which are strongly over-expressed in human large advanced breast tumors.
Locally advanced breast cancer (LABC) may account for 50% of breast cancers in developing countries and 30% among socially disadvantaged women. A new study identifies a molecular switch essential for LABC development, which could be targeted for new therapies.
Researchers have identified a molecule, osteopontin-c, that appears more accurate than existing biomarkers in predicting which breast cancers will develop into advanced forms. The discovery could one day influence therapy decisions and prevent patients from undergoing aggressive treatments.
The Center for Biological Interfaces of Engineering at Clemson University will create identical tissue samples using inkjet printing to study breast cancer causes and progression. The multi-disciplinary research team aims to understand how environmental conditions stimulate breast cancer development.
Researchers found that routine mammograms for breast cancer screening in older women on dialysis are unlikely to outweigh the costs, given their reduced life expectancy. The study suggests that breast cancer screening may not provide significant benefits for this population.
A rare hereditary disorder, Li-Fraumeni syndrome, has been identified in an Asian female with early onset breast cancer. Genetic testing may help diagnose LFS in young women with a family history of the condition, which increases the risk of developing multiple primary tumors.
Researchers found that children of parents who died from these cancers have significantly worse survival rates than those with good parental survival. The risk of death was increased by 75% for breast cancer and 107% for prostate cancer.
Mayo Clinic researchers found that 2ME2 can effectively target breast cancer cells, prevent the spread of breast cancer to bone and protect bone from osteolysis. The study's findings suggest that 2ME2 could be a new therapy in treating advanced breast cancer.
Researchers have found that a new estrogen-derived drug, 2-methoxyestradiol (meth-oxy-es-tra-di-ol), effectively targets breast cancer cells, prevents their spread to bone, and protects against osteolysis. This discovery has significant implications for the treatment of breast cancer.
Researchers at Mayo Clinic Jacksonville found that partial breast irradiation can expose as much lung and heart tissue to potentially toxic radiation as whole breast irradiation. This suggests that both methods carry equivalent risks and benefits.
A recent study found that African-American women with early-stage breast cancer are more likely to experience cancer recurrence 10 years after diagnosis compared to Caucasian counterparts. The research also revealed that younger African-American women tend to have larger tumors and more aggressive tumors than their Caucasian peers, hig...
African American women are diagnosed with breast cancer at a younger age and have larger tumors than Caucasian women. The study found higher relapse rates in African American patients after treatment.
A large European study found that an extra high-dose radiation boost after breast-conserving surgery significantly reduces the risk of breast cancer recurrence in young women. The study also showed that women of all ages benefited from the boost dose, but younger women were most likely to be free of cancer 10 years after treatment.
A study of 6,162 breast cancer patients found that smoking does not lead to more aggressive or advanced breast cancers at diagnosis. Researchers analyzed data from 1970 to 2006 and discovered no correlation between tobacco use and tumor stage or aggressiveness.
Researchers found that women with early-stage breast cancer who received intensity-modulated radiation therapy (IMRT) had significantly fewer cases of serious dermatitis compared to those receiving conventional radiation. The study also showed that patients treated with IMRT experienced a shorter duration of dermatitis.
Three Einstein researchers have received $700,000 in grants from the Breast Cancer Research Foundation to study gene expression profiling, epigenetic changes, and metastasizing tumor cells. The studies aim to predict clinical outcomes, identify drug-resistant breast cancer cells, and develop new treatments.
Researchers used transparent zebrafish to study inflammatory breast cancer, discovering how two proteins interact to facilitate metastasis. The study reveals that vascular endothelial growth factor (VEGF) and RhoC work together to promote rapid intravasation of cancer cells into blood vessels.
Research suggests that weight gain throughout adulthood, rather than maintaining a stable weight, may increase the risk of breast cancer after menopause. Women who gained weight during certain life stages were more likely to develop breast cancer compared to those with stable weights.
A study found that increased sunlight exposure reduces the risk of advanced breast cancer in women with light skin color. The researchers measured skin color and compared sun exposure between women with breast cancer and those without, finding a significant difference.
Stefanie LaRue, a 30-year-old LA resident, was diagnosed with Stage-4 Advanced/Metastatic Breast Cancer in 2005. She has since devoted her time to educating men and women about diagnosing breast cancer and preventing misdiagnoses in young women under 40.
The report found that cancer death rates declined by an average of 2.1 percent per year from 2002 to 2004, nearly twice the annual decrease of 1.1 percent per year from 1993 to 2002. Cancer incidence rates among American Indians and Alaska Natives varied two-fold across six geographic regions.
Scientists from the University of Chicago and Kyoto University suggest that a DNA-repair mechanism normally prevents tumor growth may instead contribute to poor-prognosis breast cancer in BRCA1 carriers. Elevated RAD51 levels may help cells compensate for the defect, but also lead to genetic instability and increased tumor risk.
Researchers from UC San Diego have developed a more accurate method for predicting breast cancer metastasis by analyzing protein interactions. Their approach, which uses a network of genes rather than individual genes, improves metastasis prediction accuracy to around 72%.
A new study provides insight into trastuzumab resistance in breast cancer by identifying the PI3K pathway as a key factor. The research found that tumor suppressor PTEN and activating mutations of the PIK3CA gene contribute to trastuzumab resistance, suggesting a potential strategy for treating resistant patients.