Articles tagged with Breast Cancer
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Researchers at the University of Michigan Comprehensive Cancer Center have identified a gene, FOXP3, that suppresses tumor growth in breast cancer. The study found that when FOXP3 is normal, it keeps HER-2 levels low; however, when FOXP3 is missing or mutated, HER-2 levels are likely to rise.
A new Kaiser Permanente study suggests a possible link between breast cancer incidence and postmenopausal hormone therapy (HT) use, but concludes that the association is complex and influenced by various factors, including mammography screening rates. Long-term HT may slightly increase breast cancer risk, particularly in younger women.
A study published in the Journal of the National Cancer Institute found that adding readings by non-physician technologists to standard mammograms read by two radiologists increased breast cancer detection rates by 6.8%. This improvement was achieved with a minimal increase in false positives.
A recent study found a significant decline in breast cancer incidence in 2003, coinciding with a drop in hormone therapy use. Breast density and sex hormone levels are also independent risk factors for breast cancer in postmenopausal women.
A Stanford University School of Medicine researcher led by David Spiegel showed that support groups improved quality of life for participants with metastatic breast cancer, but didn't extend overall survival. However, a subgroup of patients with an aggressive form of breast cancer did experience a survival benefit from the therapy.
A new study published in CANCER journal found that group therapy does not prolong the lives of women with metastatic breast cancer. However, women with estrogen receptor-negative tumors showed a survival benefit from group therapy.
A new study published in CANCER found that newer drug therapies, particularly aromatase inhibitors, have improved the survival of women with metastatic breast cancer. Survival rates increased by approximately 30% as these drugs became more widely used between 1991 and 2001.
A study by the Cancer Research Network found that regular post-therapy surveillance lowers the rate of death from breast cancer in older women. The researchers examined nearly 2,000 patients age 65 and older with stage I and II breast cancer and found that annual mammograms can decrease death rates.
A new study published in JAMA found that intensively following a high-vegetable diet beyond recommended guidelines did not reduce breast cancer recurrence or death in early stage survivors. Despite significant changes in dietary patterns, the study observed no difference in outcomes between groups.
A study of 3,088 women with early-stage breast cancer found that a high-fruit-and-vegetable diet did not reduce the risk of breast cancer recurrence. Despite increased consumption of fiber and fat reduction, there was no significant benefit in preventing cancer progression or death.
A large randomized clinical trial found that eating double the recommended daily amount of fruits and vegetables does not reduce the likelihood of breast cancer recurrence in women who have completed treatment for early-stage breast cancer. The study involved nearly 3,100 women and followed them for an average of 7.3 years.
Researchers found that Src inhibitors can target aggressive breast cancers, which lack estrogen receptors and are more prone to growth. By inhibiting the protein Src, these treatments show promise in improving patient outcomes.
Researchers found that Src, a protein that cooperates with estrogen to break down ER-alpha, is overexpressed in ER-alpha–negative breast cancers. Src inhibition was shown to impair estrogen-stimulated ER-alpha proteolysis, suggesting that Src may stimulate estrogen-dependent ER-alpha degradation in these tumors.
Postmenopausal Asian women who consume a meat-sweet Western diet are at higher risk of developing breast cancer compared to those on a vegetable-soy diet, according to the study. The researchers found that high intake of the meat-sweet pattern increased estrogen-receptor-positive breast cancer among overweight postmenopausal women.
A study found a significant association between the Western-style 'meat-sweet' diet and an increased risk of breast cancer among postmenopausal Chinese women, particularly those with estrogen receptor-positive tumors. The research suggests that low consumption of this dietary pattern may protect against breast cancer.
Researchers at Biodesign Institute have received nearly $9 million in grants to develop a preventive vaccine against breast cancer. The team aims to identify common signatures across various breast tumors using genomics, proteomics, and immunology.
Research at Thomas Jefferson University shows that African American women with breast cancer tend to have more advanced disease and poorer outcomes. The study found that these tumors are more often estrogen-receptor negative and express growth-promoting genes, leading to aggressive and invasive disease.
A recent meta-analysis confirms that combining trastuzumab with chemotherapy reduces mortality by -34% and increases disease-free survival by 38% in women with operable HER-2 positive breast cancer. This treatment strategy also decreases the risk of locoregional and distant recurrences.
A novel mutation of the AKT1 gene has been found in breast, colorectal, and ovarian cancers, which may contribute to tumor cell proliferation. The mutation is believed to play a role in making cells resistant to certain therapies.
The Netherlands Cancer Institute received the ESMO Lifetime Achievement Award for its outstanding contributions to translational research in breast cancer. The team's discovery of a gene-signature has led to improved prognostic testing and reduced adjuvant chemotherapy in pre-menopausal patients.
A new $3.5 million program aims to train the immune system to detect and destroy cancerous tumors. Researchers will develop vaccines, enhance immune responses, and create imaging technologies to monitor the treatment's effectiveness.
Researchers from USC identified a technique for determining a tumor's 'immune signature,' which could lead to personalized medicine and improved diagnosis. The analysis revealed that a small subset of genes is integral in explaining immunological behavior, and may be useful for matching tumors with available therapies.
Women with endometriosis face a higher risk of certain cancers, including ovarian, kidney, and thyroid cancer. However, the risk is not affected by whether or not they have given birth. Conversely, women with endometriosis are less likely to develop cervical cancer.
A recent study published in the Journal of Clinical Oncology found that women with atypia in their breast tissue are nearly eight times more likely to develop breast cancer. The study, led by Mayo Clinic, improved risk prediction by taking into account age at diagnosis and multiple sites of atypical hyperplasia.
A Swedish study found that women who develop breast cancer are more likely to die from the disease if their daughters or sisters also have it. Research suggests a woman's breast cancer prognosis predicts survival of her first-degree relatives, with those whose mothers died within five years having a 70% chance of survival.
Researchers found that following ultrasound diagnosis of probably benign breast masses is a safe alternative to biopsy for stable masses. The study showed an overall negative predictive value of 99.8%, indicating only 0.2% risk of cancer development.
Two new studies found that switching to exemestane and adding trastuzumab improves disease-free survival and life expectancy in early breast cancer patients, at minimal additional cost. The treatments have been projected to save thousands of dollars per patient over their lifetime.
A new study found that software enhancement of breast MRI scans reduces false positive identifications by 23 percent, improving the accuracy of radiologists. The software analyzes multiple imaging series to provide detailed data on lesion morphology and kinetic features.
A new study suggests that women who suffer from morning sickness during pregnancy may be less likely to develop breast cancer later in life. The study found a 30% lower risk of breast cancer among women with nausea and vomiting compared to those without, suggesting potential protective effects against cancer cells.
A study found that women with a smaller family history of breast cancer are more likely to carry the BRCA gene mutation, challenging breast cancer prediction models. This may lead to reevaluation of genetic testing guidelines and improved individualized risk management advice.
Michael Garwood, a University of Minnesota professor, has been awarded the 2007 Gold Medal Award for his pioneering work on incorporating MRI with MRS technology to non-invasively diagnose cancer. His research improves the accuracy of cancer diagnosis and monitoring treatment response.
Scientists at Dana-Farber Cancer Institute used a three-part screening process to identify the IKBKE gene, which is made inappropriately in about a third of all breast cancers. The mutation arises during a woman's life and spurs cell growth and proliferation.
A new technique called Fluorescence Diffuse Optical Tomography has been developed to image breast cancer in patients with high contrast. The method uses fluorophore molecules that re-radiate fluorescent light, providing richer information about tumor physiology.
Simple steps like an exercise workbook or step pedometer can improve breast cancer survivors' quality of life and fatigue levels. More active women reported better quality of life, while those who used these tools had higher activity levels than recommended-only groups.
A survey by CancerCare found that while many women know about breast cancer, few are aware of recent treatment advances. The majority would actively work with their doctor to identify proper treatment, but 86% were uncertain about what questions to ask.
BRCA2 mutation carriers have a higher risk of developing aggressive and lethal prostate cancer, with younger onset and advanced-stage disease, according to a study published in the Journal of the National Cancer Institute. The study suggests that studying gene expression patterns in prostate cancers may help predict progression.
Two new studies find that the uninsured and people with certain types of public health insurance are more likely to be diagnosed with more advanced cancer compared to those with private insurance. The strongest predictors of advanced disease were health insurance status and type, according to the studies published in CANCER journal.
A new UCSD study found that eating at least five servings of vegetables and fruits a day and walking briskly for 30 minutes, six days a week, can reduce breast cancer mortality by 50%. The study also showed that this combined lifestyle pattern is effective for both obese and non-obese women.
A new study suggests that increasing calcium and vitamin D intake can lower the risk of breast, colon, lung, and other cancers in women. The four-year clinical trial found a significant protective effect with a 77% reduced risk for those taking calcium and vitamin D.
Researchers at Dartmouth College have developed three new electromagnetic imaging techniques that can effectively distinguish between healthy breast tissue and abnormal tissue. The study, which involved 150 women, found that the new methods offered a high contrast and increased accuracy in detecting breast cancer compared to convention...
Cedars-Sinai researchers presented innovative insights into the pituitary gland's link to systemic illness, mental disorders, and aging. They also showcased advancements in subcellular mechanisms and treatment outcomes for patients with acromegaly, a growth hormone disorder.
A prospective study found that aspirin use was associated with lower risk of cancer incidence and mortality, particularly among former and non-smokers. In contrast, integrin α7 gene mutations were identified in various cancers, including prostate and liver cancer, suggesting a potential role in cancer development.
Four-year data from two large clinical trials found that trastuzumab significantly improves disease-free survival and overall survival rates in women with HER2-positive breast cancer. The study showed a 52% decrease in the risk of disease recurrence and a 35% reduction in mortality rates compared to chemotherapy alone.
Women with early-stage breast cancer who reported hot flashes while on tamoxifen therapy had a lower risk of recurrent breast cancer than those without hot flashes. Hot flashes were a stronger predictor of outcome than age or hormone receptor status.
A five-year study found no significant increase in congestive heart failure among women treated with Herceptin and chemotherapy. The research team developed a prediction model to assess individual cardiac risk factors and personalize treatment.
Researchers have identified novel genetic mutations linked to hereditary diffuse gastric cancer, which are due to both independent mutational events and common ancestry. The study found that between 30% and 40% of families with a positive family history of gastric cancer will carry germline mutations in the CDH1 gene.
Researchers found a widening disparity in life expectancy between white and black women with advanced breast cancer, with median survival rates differing by up to 8.8% over the last two decades. Socio-economic factors, such as access to healthcare and treatment options, are suspected to be contributing factors.
Researchers discovered patterns of cellular activity that confer poorer prognoses in younger women with breast cancer, highlighting the need for age-appropriate targeted therapies. The study aims to identify effective treatments targeting these tumor cell activities in premenopausal women.
The drug lapatinib has modest but real activity against brain metastases, shrinking tumors and slowing disease progression in some breast cancer patients. The study's findings suggest that the drug should undergo further testing as a treatment for breast cancer with brain metastases.
A multicenter Phase II study of enzastaurin as a second- or third-line treatment for NSCLC found a median progression-free survival of 1.9 months and an overall survival rate of 46.3% at 12 months. The most common toxicity was fatigue.
Recent studies conducted at Mayo Clinic have found that MRI is superior to mammography in detecting additional tumors in the same breast and identifying new tumors in the healthy breast. The technology has also revealed distinct patterns between ipsilateral and contralateral tumors, guiding its use.
A study by Dana-Farber Cancer Institute found that exercising lower insulin levels in breast cancer survivors, potentially improving prognosis. The research suggests exercise may also improve insulin sensitivity and reduce hip circumference, leading to improved health outcomes.
A recent Phase II study evaluating the addition of GEMZAR to standard chemotherapy regimens showed promising results in treating stage II-III breast cancer. The treatment regimen demonstrated a high pathologic complete response rate, with additional benefits for HER-2 positive patients who received trastuzumab. These findings support t...
Dr. Gianni Bonadonna's innovative adjuvant treatment of breast cancer using CMF chemotherapy significantly reduced disease recurrence and death over 30 years. The new Gianni Bonadonna Breast Cancer Award and Fellowship supports emerging researchers in breast cancer, honoring his legacy and impact on the field.
The partnership aims to create programs and provide grants that support tangible improvements in access to and delivery of cancer care, particularly for disparities and clinical trials. The initiative also focuses on solutions to the projected shortfalls of the oncology workforce and addresses the unique needs of cancer survivors.
Research found that higher intakes of calcium and vitamin D in premenopausal women were associated with a lower risk of developing breast cancer. The study also suggested that the antioxidant effects of these nutrients may be linked to reduced tumor growth in younger women.
An international team of scientists has uncovered five common genetic variants that increase an individual's risk for breast cancer. The genes code for proteins crucial to biological activities and have a moderate impact on disease prevalence across a large population.
A new database developed by researchers at the Howard Hughes Medical Institute provides a detailed portrait of the army of over 700 proteins that helps maintain DNA's integrity. The study reveals that two critical enzymes, ATM and ATR, act as sensors to detect trouble and initiate repair pathways.
Researchers identified Rap80 as a new candidate breast-cancer susceptibility gene required for normal BRCA1 DNA-repair function. This discovery provides insights into the molecular mechanism of BRCA1 recognizing sites of DNA damage, shedding light on cancer-causing mutations in BRCA1.
A recent survey found that three-quarters of women with breast cancer were not informed about their risk of recurrence, despite 96% relying on their healthcare provider for information. The study highlights the need for better communication between healthcare professionals and patients to ensure they receive life-saving information.