Articles tagged with Breast Cancer
A large study of Norwegian women with cancer found that pregnancy did not affect survival rates, except for breast cancer diagnosed during lactation where mortality was higher. The study tracked 45,511 women over eight years and compared their survival rates to non-pregnant patients.
A large study found that drinking three or more alcoholic drinks a day increases breast cancer risk by 10-30% compared to light drinkers. The researchers discovered no difference in risk between wine, beer, and spirits consumption.
A Kaiser Permanente study found that the amount of alcohol consumed, regardless of type, is associated with an increased risk of breast cancer. Women who drank between one and two drinks per day had a 10% increased risk, while those who drank more than three drinks daily had a 30% increased risk.
A study presented at the European Cancer Conference found that axitinib shrank tumours and delayed disease progression in patients with advanced kidney cancer. The drug, which is also being tested in other types of cancer, showed promising results in a group of heavily pre-treated patients.
A recent study shows that overabundance of a single microRNA, microRNA-10b, can cause tumors to spread to distant tissues in mice. Researchers found that this microRNA disrupts the normal migration process of cancer cells by targeting the HoxD10 gene.
Women with metastatic breast cancer who have endured previous traumatic or stressful events see their cancer recur nearly twice as fast as others, according to a study. The median disease-free interval was 2.5 years for those with traumatic experiences, compared to 5 years for those without.
In a surprising study, married esophageal cancer patients reported worsening physical wellbeing and increasing pain frequency over time. However, they showed less improvement in their legal worries compared to single patients.
A survey of 543 breast cancer survivors found that women's knowledge about actions to reduce recurrence is low, despite being optimistic about their future. The majority reported feeling stronger and more hopeful after diagnosis.
Research shows PET scans with fluorodeoxyglucose (FDG) can predict a breast tumor's response to chemotherapy and a patient's likelihood of survival. Women with high initial FDG uptake and significant reduction after treatment are more likely to achieve complete response.
The American Cancer Society report shows a decline in breast cancer mortality rates, but African American women and women of other racial and ethnic groups have benefited less from advances. The report highlights the importance of increased mammography screening and reduced obesity to combat breast cancer.
A study using MR spectroscopy with MRI has successfully identified breast cancers in non-mass enhancing lesions without invasive biopsies. By measuring choline compounds, MR spectroscopy provides specific and sensitive results, reducing the need for unnecessary biopsies.
A survey of elderly Spaniards found poor knowledge about cancer, with many believing it's contagious or a punishment. The study highlights the importance of improving cancer education programs for older adults.
Scientists have developed a method to detect circulating tumour cells (CTCs) in blood before and after chemotherapy treatment, potentially identifying patients at risk of cancer recurrence. The study found that CTCs persisted in the blood of patients who were more likely to experience recurrence.
Italian scientists have discovered a new target for anti-tumor therapy in cancer, finding that the Trop-2 gene is expressed in the vast majority of human cancers. The gene's over-expression was found in between 65% and 90% of tumor types analyzed.
A two-year study from the University of Pittsburgh School of Medicine found that women who took a weekly dose of risedronate lost significantly less bone than those who did not take the drug. Risedronate improved bone density and prevented excess bone loss in breast cancer survivors, even among those on aromatase inhibitors.
Researchers at the University of Iowa have discovered a gene called AP2C that plays a linchpin role in estrogen signaling pathways. Silencing this gene significantly decreased tumor growth and delayed establishment of tumors in mice.
A study by Georgetown University researchers found that estrogen is necessary for breast cancer development but tumors become unresponsive to estrogen and anti-estrogen therapies after they form. This explains why oophorectomies help prevent breast cancer in women with BRCA1 mutations
A new American Cancer Society study reveals that having at least some education beyond high school is associated with a decreased risk of cancer death. The study found stronger associations between higher education levels and lower cancer mortality among black men, white men, and white women.
A study published in the Journal of the National Cancer Institute found that higher education levels are associated with decreased cancer mortality rates among black and white men and women. The difference in mortality was greatest between those with 12 or fewer years of education and those with more than 12 years. This association is ...
Researchers will present novel findings on personalized medicine, including new biomarkers for early detection, advanced imaging technologies, and proteomics applications. Key advances include a blood test for liver cancer and a protein target for lung cancer diagnosis.
A new study finds breast cancer survivors who received both chemotherapy and radiotherapy reported the most severe and prolonged fatigue. The study, published in CANCER, a peer-reviewed journal of the American Cancer Society, found women who received both treatments experienced more days with reported fatigue at each assessment.
The probe, which binds to active proteases in cancerous cells, beams out near-infrared light that passes through skin and is detectable with a special camera. The technique has the potential to provide a less harmful method of detecting cancer, especially in early stages.
A new study from the University of Michigan Comprehensive Cancer Center found that nearly half of women with breast cancer experience musculoskeletal issues while taking aromatase inhibitors. Up to 15% of patients stop treatment due to these side effects, highlighting a need for interventions to manage symptoms.
Scientists have developed a new 'knock-out' gene model that provides molecular clues to breast cancer, focusing on the role of estrogen receptors in mammary gland development. The study suggests that estrogen expression is essential for normal duct development during puberty, pregnancy and lactation.
A common molecular pathway called retinoblastoma (RB) tumor suppressor could help predict which lung cancer patients will benefit from chemotherapy drugs. Researchers found that turning off the RB pathway resulted in an altered response to chemotherapy agents and more cancer cell death.
Researchers identified a region on chromosome 5p associated with dense breast tissue, a known risk factor for breast cancer. Women with dense breasts are three to five times more likely to develop breast cancer than those with less dense breasts.
A recent study published in the Journal of the National Cancer Institute found that hypnosis prior to breast cancer surgery reduced the amount of anesthesia used during the operation, as well as levels of pain and other side effects reported afterwards. This resulted in shorter hospital stays, fewer readmissions, and lower surgical costs.
A study found that increasing vitamin D levels can prevent 250,000 cases of colorectal cancer and 350,000 cases of breast cancer worldwide. Researchers recommend optimal vitamin D serum levels to be around 24-32 nanograms per milliliter for prevention.
A symposium exploring acrylamide's health effects and ways to reduce its content in food will be held. Experts from around the world will provide new insights into the compound and its biological effects.
A new study involving 100,000 U.S. women found no association between acrylamide intake and breast cancer risk, contradicting prior animal studies. Researchers estimated daily acrylamide intake and tracked incidence of breast cancer over 20 years, concluding that levels in foods are unlikely to cause cancer.
Researchers found that dense breasts and high hormone levels increase breast cancer risk by 400% and 200%, respectively. The study also showed additive effects, where women with both dense breasts and excess hormones face a 600% increased risk.
Research published in The Journal of Clinical Investigation shows that tumors use the enzyme IDO to directly activate existing regulatory T cells, which become strongly suppressive within a day. This discovery defines a tumor's survival strategy and suggests potential new leverage points for therapies.
A study by University of Toronto researchers found significant differences in breast cancer prevention practices among Canadian women carrying the BRCA1 or BRCA2 genetic mutation. Women in Quebec were the least likely to use preventive measures, with only 38% opting for surgery or medication.
A recent decline in breast cancer incidence is attributed to a drop in postmenopausal hormone therapy use. This finding contradicts the assumption that decreased mammography screening is responsible for the decline.
Researchers have created cancer stem cells in a Petri dish from human breast tissue, which can initiate tumors and metastasize. The new study provides clues about the trajectory of cancer cells and offers a boon to researchers studying these elusive cells.
A new study found that racial differences in breast cancer survival are most apparent in advanced stages of the disease, with African American women having poorer outcomes than white women. After adjusting for clinical factors, the disparities persisted, indicating non-clinical factors may contribute to survival differences.
Scientists at Georgetown University Medical Center have discovered a new gene, XBP1, that contributes to Tamoxifen resistance in breast cancer cells. This finding may enable oncologists to screen women for responsiveness to these treatments and provide a clue for reversing resistance.
A study found that MRI outperformed mammography in detecting breast cancer in its earliest stage. Women diagnosed with ductal carcinoma in situ (DCIS) using MRI had a higher sensitivity than those detected by mammography.
A study by researchers at the University of Texas M.D. Anderson Cancer Center has identified a link between inflammatory protein Tumor Necrosis Factor alpha (TNFa) and breast cancer, highlighting a new pathway for potential clinical interventions. The research found that TNFa activates an enzyme that inactivates tumor-suppressing genes...
Researchers developed a novel technology using light to probe tissue architecture, enabling subtle changes in tissue to be detected. The technique produced an optic fingerprint from altered tissue, distinguishing patients with cancer at an accuracy approaching 100 percent.
A multicenter study compared screening methods in high-risk women, finding that MRI accurately identifies tumors missed by mammography and ultrasound. The study suggests that women at high risk for breast cancer can benefit from undergoing screening MRI to detect more cancers.
Researchers at the University of Michigan Comprehensive Cancer Center have identified a gene, FOXP3, that suppresses tumor growth in breast cancer. The study found that when FOXP3 is normal, it keeps HER-2 levels low; however, when FOXP3 is missing or mutated, HER-2 levels are likely to rise.
A new Kaiser Permanente study suggests a possible link between breast cancer incidence and postmenopausal hormone therapy (HT) use, but concludes that the association is complex and influenced by various factors, including mammography screening rates. Long-term HT may slightly increase breast cancer risk, particularly in younger women.
A study published in the Journal of the National Cancer Institute found that adding readings by non-physician technologists to standard mammograms read by two radiologists increased breast cancer detection rates by 6.8%. This improvement was achieved with a minimal increase in false positives.
A recent study found a significant decline in breast cancer incidence in 2003, coinciding with a drop in hormone therapy use. Breast density and sex hormone levels are also independent risk factors for breast cancer in postmenopausal women.
A Stanford University School of Medicine researcher led by David Spiegel showed that support groups improved quality of life for participants with metastatic breast cancer, but didn't extend overall survival. However, a subgroup of patients with an aggressive form of breast cancer did experience a survival benefit from the therapy.
A new study published in CANCER journal found that group therapy does not prolong the lives of women with metastatic breast cancer. However, women with estrogen receptor-negative tumors showed a survival benefit from group therapy.
A new study published in CANCER found that newer drug therapies, particularly aromatase inhibitors, have improved the survival of women with metastatic breast cancer. Survival rates increased by approximately 30% as these drugs became more widely used between 1991 and 2001.
A study by the Cancer Research Network found that regular post-therapy surveillance lowers the rate of death from breast cancer in older women. The researchers examined nearly 2,000 patients age 65 and older with stage I and II breast cancer and found that annual mammograms can decrease death rates.
A new study published in JAMA found that intensively following a high-vegetable diet beyond recommended guidelines did not reduce breast cancer recurrence or death in early stage survivors. Despite significant changes in dietary patterns, the study observed no difference in outcomes between groups.
A study of 3,088 women with early-stage breast cancer found that a high-fruit-and-vegetable diet did not reduce the risk of breast cancer recurrence. Despite increased consumption of fiber and fat reduction, there was no significant benefit in preventing cancer progression or death.
A large randomized clinical trial found that eating double the recommended daily amount of fruits and vegetables does not reduce the likelihood of breast cancer recurrence in women who have completed treatment for early-stage breast cancer. The study involved nearly 3,100 women and followed them for an average of 7.3 years.
Researchers found that Src inhibitors can target aggressive breast cancers, which lack estrogen receptors and are more prone to growth. By inhibiting the protein Src, these treatments show promise in improving patient outcomes.
Researchers found that Src, a protein that cooperates with estrogen to break down ER-alpha, is overexpressed in ER-alpha–negative breast cancers. Src inhibition was shown to impair estrogen-stimulated ER-alpha proteolysis, suggesting that Src may stimulate estrogen-dependent ER-alpha degradation in these tumors.
Postmenopausal Asian women who consume a meat-sweet Western diet are at higher risk of developing breast cancer compared to those on a vegetable-soy diet, according to the study. The researchers found that high intake of the meat-sweet pattern increased estrogen-receptor-positive breast cancer among overweight postmenopausal women.
A study found a significant association between the Western-style 'meat-sweet' diet and an increased risk of breast cancer among postmenopausal Chinese women, particularly those with estrogen receptor-positive tumors. The research suggests that low consumption of this dietary pattern may protect against breast cancer.
Researchers at Biodesign Institute have received nearly $9 million in grants to develop a preventive vaccine against breast cancer. The team aims to identify common signatures across various breast tumors using genomics, proteomics, and immunology.
Research at Thomas Jefferson University shows that African American women with breast cancer tend to have more advanced disease and poorer outcomes. The study found that these tumors are more often estrogen-receptor negative and express growth-promoting genes, leading to aggressive and invasive disease.
A recent meta-analysis confirms that combining trastuzumab with chemotherapy reduces mortality by -34% and increases disease-free survival by 38% in women with operable HER-2 positive breast cancer. This treatment strategy also decreases the risk of locoregional and distant recurrences.
A novel mutation of the AKT1 gene has been found in breast, colorectal, and ovarian cancers, which may contribute to tumor cell proliferation. The mutation is believed to play a role in making cells resistant to certain therapies.