Articles tagged with Breast Cancer
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Researchers mapped the human genome for breast and colon cancers, finding that most cancer-causing gene mutations are diverse and vary from person to person. The study suggests that personalized medicine may focus on complex pathways linking less-commonly mutated genes.
Researchers at Jefferson University have discovered a tumor-blocking protein, pp32, that may be missing in aggressive forms of pancreatic cancer. The absent protein could eventually serve as a biomarker for the disease and a potential therapeutic target.
Researchers analyzed over 18,000 genes from breast and colorectal tumors to identify genetic diversity between tumor types. The study highlights the need for individualized cancer treatment targeting specific mutant genes in each patient.
Women who overcome breast cancer are at a higher risk of developing cardiovascular disease due to therapies that damage the heart and blood vessels. Exercise is crucial in maintaining heart health during treatment, and early evaluation of cardiovascular risk factors can help prevent complications.
A recent study found that women with HER-2 positive breast cancer who receive Taxol alongside chemotherapy experience improved survival rates. In contrast, estrogen-receptor-positive and HER-2-negative patients do not benefit from the added treatment, offering a targeted approach to personalized medicine.
Scientists discover that mouse mammary tumor virus (MMTV) can replicate in cultured human breast cells, leading to rapid spread and potential role in human breast cancer. Researchers plan further investigation into the link between MMTV and breast cancer.
Research suggests that young women with estrogen receptor-positive (ER+) breast cancer who undergo adjuvant chemotherapy do not experience higher survival rates than those with ER-negative tumors. The study, published in Breast Cancer Research, found a 5% difference in survival rates between the two groups.
A novel gene called HMMR has been identified as a potential breast cancer susceptibility gene, according to researchers at Dana-Farber Cancer Institute. The gene's connections to BRCA1 and its role in centrosome formation have led scientists to believe it may contribute to an increased risk of breast cancer.
A new study found that white women are almost five times more likely to take tamoxifen and three times more likely to have adjuvant chemotherapy for advanced breast cancer. Women with government health insurance were less likely to receive combination breast conserving surgery and radiation.
A recent study published by Oregon Health & Science University discovered a strong correlation between the size and shape of a woman's hips and her daughter's risk of breast cancer. Women with wider, rounder hips were found to be more than three times as likely to have daughters with breast cancer.
A study published in CANCER found racial differences in the use of breast cancer therapy among African-American and white women. African-Americans were less likely to receive adjuvant cancer therapy, while white women were more likely to take Tamoxifen and have chemotherapy.
A new study has identified a gene, HMMR, that may increase a woman's risk of breast cancer by more than a third. The research found that HMMR interacts with the well-known breast cancer gene BRCA1, suggesting a potential new pathway for further research.
Researchers found a link between childbirth and reduced breast cancer risk, suggesting that fetal cells may play a role. The study discovered that women with male DNA in their bloodstream had a lower risk of developing breast cancer.
Researchers aim to improve breast cancer screening by developing new anatomical imaging methods, including MRI and PET, and sensitive histopathologic detection techniques. The goal is to identify precancerous lesions and map their extent for precise surgery.
A new survey reveals that 14-45% of cancer patients suffer from severe cognitive deficits, leading to a 'loss of self' and significant problems at home and in the workplace. The study also found that doctors are often dismissive or indifferent to patients' concerns.
Researchers at Fred Hutchinson Cancer Center found that fetal microchimerism, the presence of residual fetal cells in a woman's body, is significantly more common in healthy women than those with breast cancer. The study suggests that these cells may provide immune surveillance and reduce breast cancer risk.
Researchers have discovered that Notch gene stimulates breast cancer stem cells, which can cause the disease to recur. A potential new drug therapy targeting this gene could lead to a faster treatment in hospital clinics within a few years.
The American College of Physicians (ACP) has issued comprehensive guidelines for treating low back pain, recommending that clinicians avoid routine imaging and diagnostic tests. The ACP also found that the newer drug telbivudine is more effective than adefovir in suppressing hepatitis B virus levels.
Scientists at Jefferson University have found a new molecular evidence of the role of prolactin in breast cancer. The hormone stimulates a signaling pathway that may regulate the growth and survival of breast cancer cells. Inhibiting the Jak1 protein could represent a new drug target for treating breast cancer.
A large study of Norwegian women with cancer found that pregnancy did not affect survival rates, except for breast cancer diagnosed during lactation where mortality was higher. The study tracked 45,511 women over eight years and compared their survival rates to non-pregnant patients.
A large study found that drinking three or more alcoholic drinks a day increases breast cancer risk by 10-30% compared to light drinkers. The researchers discovered no difference in risk between wine, beer, and spirits consumption.
A Kaiser Permanente study found that the amount of alcohol consumed, regardless of type, is associated with an increased risk of breast cancer. Women who drank between one and two drinks per day had a 10% increased risk, while those who drank more than three drinks daily had a 30% increased risk.
A study presented at the European Cancer Conference found that axitinib shrank tumours and delayed disease progression in patients with advanced kidney cancer. The drug, which is also being tested in other types of cancer, showed promising results in a group of heavily pre-treated patients.
A recent study shows that overabundance of a single microRNA, microRNA-10b, can cause tumors to spread to distant tissues in mice. Researchers found that this microRNA disrupts the normal migration process of cancer cells by targeting the HoxD10 gene.
Women with metastatic breast cancer who have endured previous traumatic or stressful events see their cancer recur nearly twice as fast as others, according to a study. The median disease-free interval was 2.5 years for those with traumatic experiences, compared to 5 years for those without.
In a surprising study, married esophageal cancer patients reported worsening physical wellbeing and increasing pain frequency over time. However, they showed less improvement in their legal worries compared to single patients.
A survey of 543 breast cancer survivors found that women's knowledge about actions to reduce recurrence is low, despite being optimistic about their future. The majority reported feeling stronger and more hopeful after diagnosis.
Research shows PET scans with fluorodeoxyglucose (FDG) can predict a breast tumor's response to chemotherapy and a patient's likelihood of survival. Women with high initial FDG uptake and significant reduction after treatment are more likely to achieve complete response.
The American Cancer Society report shows a decline in breast cancer mortality rates, but African American women and women of other racial and ethnic groups have benefited less from advances. The report highlights the importance of increased mammography screening and reduced obesity to combat breast cancer.
A study using MR spectroscopy with MRI has successfully identified breast cancers in non-mass enhancing lesions without invasive biopsies. By measuring choline compounds, MR spectroscopy provides specific and sensitive results, reducing the need for unnecessary biopsies.
A survey of elderly Spaniards found poor knowledge about cancer, with many believing it's contagious or a punishment. The study highlights the importance of improving cancer education programs for older adults.
Scientists have developed a method to detect circulating tumour cells (CTCs) in blood before and after chemotherapy treatment, potentially identifying patients at risk of cancer recurrence. The study found that CTCs persisted in the blood of patients who were more likely to experience recurrence.
Italian scientists have discovered a new target for anti-tumor therapy in cancer, finding that the Trop-2 gene is expressed in the vast majority of human cancers. The gene's over-expression was found in between 65% and 90% of tumor types analyzed.
A two-year study from the University of Pittsburgh School of Medicine found that women who took a weekly dose of risedronate lost significantly less bone than those who did not take the drug. Risedronate improved bone density and prevented excess bone loss in breast cancer survivors, even among those on aromatase inhibitors.
Researchers at the University of Iowa have discovered a gene called AP2C that plays a linchpin role in estrogen signaling pathways. Silencing this gene significantly decreased tumor growth and delayed establishment of tumors in mice.
A study by Georgetown University researchers found that estrogen is necessary for breast cancer development but tumors become unresponsive to estrogen and anti-estrogen therapies after they form. This explains why oophorectomies help prevent breast cancer in women with BRCA1 mutations
A new American Cancer Society study reveals that having at least some education beyond high school is associated with a decreased risk of cancer death. The study found stronger associations between higher education levels and lower cancer mortality among black men, white men, and white women.
A study published in the Journal of the National Cancer Institute found that higher education levels are associated with decreased cancer mortality rates among black and white men and women. The difference in mortality was greatest between those with 12 or fewer years of education and those with more than 12 years. This association is ...
Researchers will present novel findings on personalized medicine, including new biomarkers for early detection, advanced imaging technologies, and proteomics applications. Key advances include a blood test for liver cancer and a protein target for lung cancer diagnosis.
A new study finds breast cancer survivors who received both chemotherapy and radiotherapy reported the most severe and prolonged fatigue. The study, published in CANCER, a peer-reviewed journal of the American Cancer Society, found women who received both treatments experienced more days with reported fatigue at each assessment.
The probe, which binds to active proteases in cancerous cells, beams out near-infrared light that passes through skin and is detectable with a special camera. The technique has the potential to provide a less harmful method of detecting cancer, especially in early stages.
A new study from the University of Michigan Comprehensive Cancer Center found that nearly half of women with breast cancer experience musculoskeletal issues while taking aromatase inhibitors. Up to 15% of patients stop treatment due to these side effects, highlighting a need for interventions to manage symptoms.
Scientists have developed a new 'knock-out' gene model that provides molecular clues to breast cancer, focusing on the role of estrogen receptors in mammary gland development. The study suggests that estrogen expression is essential for normal duct development during puberty, pregnancy and lactation.
A common molecular pathway called retinoblastoma (RB) tumor suppressor could help predict which lung cancer patients will benefit from chemotherapy drugs. Researchers found that turning off the RB pathway resulted in an altered response to chemotherapy agents and more cancer cell death.
Researchers identified a region on chromosome 5p associated with dense breast tissue, a known risk factor for breast cancer. Women with dense breasts are three to five times more likely to develop breast cancer than those with less dense breasts.
A recent study published in the Journal of the National Cancer Institute found that hypnosis prior to breast cancer surgery reduced the amount of anesthesia used during the operation, as well as levels of pain and other side effects reported afterwards. This resulted in shorter hospital stays, fewer readmissions, and lower surgical costs.
A study found that increasing vitamin D levels can prevent 250,000 cases of colorectal cancer and 350,000 cases of breast cancer worldwide. Researchers recommend optimal vitamin D serum levels to be around 24-32 nanograms per milliliter for prevention.
A symposium exploring acrylamide's health effects and ways to reduce its content in food will be held. Experts from around the world will provide new insights into the compound and its biological effects.
A new study involving 100,000 U.S. women found no association between acrylamide intake and breast cancer risk, contradicting prior animal studies. Researchers estimated daily acrylamide intake and tracked incidence of breast cancer over 20 years, concluding that levels in foods are unlikely to cause cancer.
Researchers found that dense breasts and high hormone levels increase breast cancer risk by 400% and 200%, respectively. The study also showed additive effects, where women with both dense breasts and excess hormones face a 600% increased risk.
Research published in The Journal of Clinical Investigation shows that tumors use the enzyme IDO to directly activate existing regulatory T cells, which become strongly suppressive within a day. This discovery defines a tumor's survival strategy and suggests potential new leverage points for therapies.
A study by University of Toronto researchers found significant differences in breast cancer prevention practices among Canadian women carrying the BRCA1 or BRCA2 genetic mutation. Women in Quebec were the least likely to use preventive measures, with only 38% opting for surgery or medication.
A recent decline in breast cancer incidence is attributed to a drop in postmenopausal hormone therapy use. This finding contradicts the assumption that decreased mammography screening is responsible for the decline.
Researchers have created cancer stem cells in a Petri dish from human breast tissue, which can initiate tumors and metastasize. The new study provides clues about the trajectory of cancer cells and offers a boon to researchers studying these elusive cells.
A new study found that racial differences in breast cancer survival are most apparent in advanced stages of the disease, with African American women having poorer outcomes than white women. After adjusting for clinical factors, the disparities persisted, indicating non-clinical factors may contribute to survival differences.
Scientists at Georgetown University Medical Center have discovered a new gene, XBP1, that contributes to Tamoxifen resistance in breast cancer cells. This finding may enable oncologists to screen women for responsiveness to these treatments and provide a clue for reversing resistance.
A study found that MRI outperformed mammography in detecting breast cancer in its earliest stage. Women diagnosed with ductal carcinoma in situ (DCIS) using MRI had a higher sensitivity than those detected by mammography.
A study by researchers at the University of Texas M.D. Anderson Cancer Center has identified a link between inflammatory protein Tumor Necrosis Factor alpha (TNFa) and breast cancer, highlighting a new pathway for potential clinical interventions. The research found that TNFa activates an enzyme that inactivates tumor-suppressing genes...
Researchers developed a novel technology using light to probe tissue architecture, enabling subtle changes in tissue to be detected. The technique produced an optic fingerprint from altered tissue, distinguishing patients with cancer at an accuracy approaching 100 percent.
A multicenter study compared screening methods in high-risk women, finding that MRI accurately identifies tumors missed by mammography and ultrasound. The study suggests that women at high risk for breast cancer can benefit from undergoing screening MRI to detect more cancers.