Articles tagged with Breast Cancer
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Researchers found that IGF-I stimulates aggressive tumor growth and DNA repair regulation, leading to poor outcomes. The study identifies a gene signature linked to patient responses to breast cancer treatments, offering potential biomarkers for targeted therapies.
Researchers at Cold Spring Harbor Laboratory discovered an enzyme called Brk that accelerates HER2-positive tumor growth and contributes to drug resistance. The team found that targeting Brk may provide a safe strategy for treating ErbB2-positive tumors.
A study found that reproductive and hormonal factors influence the risk of developing different subtypes of breast cancer. Breastfeeding for 6 months or longer was associated with a lower risk of luminal and triple-negative cancers, while late age at menopause and estrogen therapy were linked to increased risks.
A prospective cohort study of 6107 Chinese patients with type 2 diabetes found a V-shaped risk relation between LDL cholesterol and cancer. Patients with low LDL cholesterol (below 2.80 mmol/L) or high levels (above 3.90 mmol/L) had significantly elevated risks of various cancers.
A recent study published in BMC Cancer found that women who experienced multiple negative life events are at a higher risk of developing breast cancer. The research, conducted by Professor Ronit Peled and her team, suggests that a general feeling of happiness and optimism can play a protective role against the disease.
Research finds that dense breast tissue promotes aggressive cancer cells, as breast cancer cells in denser surroundings step up their invasive activities. The study suggests a cellular mechanism linking human breast tissue density and tumor aggressiveness.
A study by Deborah A. Small and Uri Simonsohn found that people become more sympathetic towards victims suffering from the same misfortune as a close relationship, leading to increased donations to charities supporting those causes. The researchers recreated this phenomenon in an experiment where participants formed new friendships and...
A new study found that young women with positive emotional states and high levels of happiness are less likely to develop breast cancer. However, women who have experienced multiple severe or mild negative life events are at higher risk for the disease. The researchers suggest that a general feeling of happiness can play a protective r...
Concomitant zoledronic acid prevents bone loss and improves bone-mineral density in premenopausal women with breast cancer during adjuvant endocrine therapy. After treatment, zoledronic acid even increases bone-mineral density.
Despite five years of systemic therapy, breast cancer patients remain at risk for disease recurrence. Women with hormone receptor-positive cancer have a higher risk of relapse, highlighting an unmet clinical need for new strategies to reduce this risk.
Researchers identified specific HBV genotypes and mutations associated with increased liver cancer risk, including genotype C and basal core promoter mutation A1762T/G1764A. A combination of doxorubicin and zoledronic acid was found to reduce tumor size substantially in a mouse model of breast cancer.
A study led by M. D. Anderson Cancer Center found that risk assessment can help determine the probability of breast cancer recurrence, allowing clinicians to make informed decisions about extended therapy. The research analyzed data from 2,838 women diagnosed with Stage I-III breast cancers and treated with adjuvant systemic therapy.
Researchers at the University of Chicago Medical Center found that targeted radiation therapy can eradicate all signs of disease in up to 21% of patients with stage-IV cancer who have only a few sites of metastasis. The treatment was well-tolerated, with limited side effects, and showed promising results in controlling tumor growth.
Research reveals that breast cancer survivors must navigate the vulnerabilities of loved ones as they share their diagnosis. Women typically face challenges in asking for help from others while also being perceived as caregivers.
Minority women were significantly less likely to be aware of their odds of survival after five years, regardless of surgeon volume or hospital setting. Women who asked about treatment options had better knowledge, highlighting the need for clear communication from surgeons.
A new study finds that patient age, predisposition to heart disease, and prior treatments are associated with an individual's risk of developing heart problems following epirubicin treatment. The researchers recommend lowering the cumulative dose recommended for most patients, with maximum doses ranging from 300 mg/m2 to 900 mg/m2.
A study comparing two breast cancer screening strategies in Norway and Vermont found that both approaches were equally sensitive for detecting cancer, with similar age-adjusted screening detection rates. However, the recall rate for abnormal mammograms was lower in Norway, while the rate of interval cancers was higher in Vermont.
A recent study published in the American Cancer Society's journal found that hip bone mineral density can provide additional information for predicting breast cancer risk. Women with higher bone mineral density scores had a 25% increased risk of developing breast cancer, while those with high Gail scores had a 35% increased risk.
A study of 10,000 postmenopausal women found that higher bone mineral density was associated with a 25% increased risk of developing breast cancer. Adding bone mineral density tests to current risk assessments may improve the prediction of breast cancer risk in older women.
A recent study published in BMC Cancer reveals that a family history of breast cancer does not significantly increase the likelihood of developing the disease at an early age. The research suggests that applying strict screening criteria can help reduce unnecessary testing and alleviate psychological harm.
A new study finds that a topical application of 4% lidocaine gel significantly reduces breast discomfort during mammography. Women who received the gel reported less pain and were more likely to undergo regular screening, with 88% indicating they would definitely get a mammogram the following year.
Researchers at Duke University Medical Center have identified 48 'poised gene cassette' genes that are tightly controlled in tumors, making them potential targets for cancer treatment. These genes showed subtle yet significant differences in expression between highly metastatic and non-metastatic cells.
Researchers emphasize the need to investigate ethnic differences in breast cancer treatment response due to genetic variations. Studies have shown that certain drugs benefit people from specific ethnic groups more than others.
A worldwide study found significant differences in cancer survival rates between rich and poor countries, as well as between black and white men and women in the US. Cancer survival varies widely across regions, with some countries having much higher or lower survival rates than others.
A comprehensive study of 31 countries found significant variations in cancer survival rates, with the US and Europe experiencing lower survival rates compared to other regions. The study reveals a racial gap in cancer survival between black and white populations in the US, with blacks facing a 7-14% lower survival rate.
A study published in the Journal of Communication found that access to an integrated system of internet health resources significantly improved quality of life, perceived social support, and health information management for breast cancer patients. In contrast, providing only a list of URLs or standard care offered little benefit.
Researchers at Georgetown University Medical Center have discovered that vitamin A can push stem cells in breast cancer tumors to form endothelial cells, leading to the creation of new blood vessels. This finding supports the 'vasculogenic mimicry' theory, which proposes that tumors build their own blood pipelines.
Researchers at Johns Hopkins Medicine identified a deadly combination of gene activity in breast and colon cancers, leading to poor patient outcomes. The study found that epigenetic changes contribute to cancer aggressiveness by disrupting normal biochemical pathways.
A new study from the University of Michigan Comprehensive Cancer Center found that HER2-positive breast cancers have four to five times more cancer stem cells than HER2-negative cancers. The drug Herceptin was shown to reduce cancer stem cell numbers by 80 percent, targeting and destroying these cells.
A U-M study found that breast asymmetry after cancer treatment significantly impacts a woman's quality of life, increasing the likelihood of depression, fear, and feelings of being less healthy. Women who experienced significant breast asymmetry were twice as likely to fear their cancer recurring than those with little to no asymmetry.
A Swedish study found that more than 40% of widowers were never informed about their wives' incurable cancer or received the news in the last week of her life. The study suggests room for improvement in healthcare provider communication with husbands, particularly those who did not receive information before the wife's death.
Researchers found that adding single nucleotide polymorphisms (SNPs) to clinical models did not significantly improve the accuracy of breast cancer risk predictions. In fact, SNPs were less able to accurately discriminate risk than established models using clinical factors.
Researchers discovered young women's breast cancers share unique genomic traits, including activated gene sets that distinguish them from older woman's tumors. These findings may lead to the development of targeted therapies for younger patients.
Scientists at Thomas Jefferson University have discovered a key mechanism of breast cancer metastasis, where a gene dubbed 'Dachshund' (DACH1) regulates the production of IL-8, a common inflammatory protein. Blocking this protein with an antibody completely halted breast cancer spread in mice.
Researchers identified resveratrol as a substance with anti-breast cancer properties by blocking estrogen DNA adducts. The study suggests that resveratrol may play a crucial role in preventing breast cancer.
Research conducted by University of Melbourne's Dr Anne Cust and colleagues found that overweight and insulin-resistant women are about 50% more likely to be diagnosed with an advanced stage of breast cancer. The study, published in Breast Cancer Research and Treatment, tracked over 60,000 Swedish women for 20 years.
A recent ASPS study found that women who have breast reconstruction after an elective mastectomy are satisfied with their decision and have low complication rates. The study revealed a 98% satisfaction rate among patients who had bilateral prophylactic mastectomy, with 100% willing to undergo the procedure again.
Men with breast cancer often experience poor outcomes due to delayed diagnoses, with 50% of cases reaching advanced stages. Early detection and treatment are crucial, as hormone therapy can be highly effective in treating the disease.
Researchers found that female mice who became pregnant had significantly fewer bladder cancers than their counterparts, with an average tumor volume about 15 times greater in non-pregnant females. The study suggests a possible role for hormones in bladder cancer protection.
Researchers identified CHD5 as a tumor suppressor gene associated with better outcomes in neuroblastoma patients. Intestinal proteins were found to be effective anti-tumor antigens in mice, potentially reducing autoimmune complications.
A new study by the American Cancer Society finds that individuals with low socioeconomic status have more advanced cancers at diagnosis, receive less aggressive treatment, and have a higher risk of dying in the five years following cancer diagnosis. The study supports the need to focus on socioeconomic status as an important underlying...
Researchers from the University of Navarra and Applied Medical Research Centre have identified five genes that play a crucial role in the metastasis of breast tumors to the lung. These genes were found to be common to both animal models and human patients with breast cancer, offering new insights into the complex process of tumor sprea...
A recent study published by Dr. Nicolas Christou of the McGill University Health Centre (MUHC) suggests that bariatric surgery reduces the risk of developing cancer by up to 80% in morbidly obese patients. The research, which compared over 1,000 patients who underwent bariatric surgery with those who did not, found significant decrease...
Researchers at the University of Missouri have developed a new non-toxic treatment that targets both tumor cells and blood vessels, effectively reducing breast cancer cell growth. The combination of PRIMA-1 and 2aG4 has been shown to improve responses and reduce side effects in pre-clinical trials.
A University of Alberta study found that obese Canadian women are 30-40% less likely to receive recommended cervical cancer screening, with fear of pain or embarrassment cited as a reason for non-screening. In contrast, breast and colon cancer screening rates remained unchanged.
Researchers have identified HLA-G dimer as a powerful immune molecule that can help prevent organ rejection. This molecule works by down-regulating the immune response and has potential applications in treating autoimmune diseases and cancer.
Researchers at the University of Illinois have identified a new family of agents that inhibit the growth of estrogen-dependent breast cancer cells. These compounds specifically target the binding of estrogen-receptor complex to regulatory regions of genes, effectively retarding protein production and cell proliferation.
The new scanner enables physicians to determine stages of breast cancer in patients already diagnosed, rather than as a mammography screening tool. It also helps plan breast cancer surgeries and detect early whether drug treatments are effective.
Researchers have identified a new family of compounds that can effectively treat estrogen receptor-positive breast cancers resistant to tamoxifen. The compounds, including TPBM and related agents, work by inhibiting the growth of cancer cells stimulated by estrogen.
Researchers found that primary tumors can encourage the growth of stray cancer cells elsewhere in the body, which may have therapeutic implications. Osteopontin secretion by instigating tumor cells plays a key role in this process.
A new analysis of raloxifene, a medication approved for osteoporosis prevention and treatment, found it reduces the risk of invasive, estrogen-receptor positive breast cancer in postmenopausal women by at least 50% for up to 8 years. The drug is also effective in reducing the risk of spine fractures.
The cost of cancer care for elderly patients in the US increased significantly between 1991 and 2002 due to rising costs of radiation therapy and chemotherapy. The average cost per patient for lung, colorectal, and breast cancers rose substantially during this period.
A randomized controlled trial found that raloxifene reduced the risk of invasive ER-positive breast cancer by 44% in postmenopausal women. The drug did not affect non-invasive cancers or those with osteoporosis without high breast cancer risk.
A novel small molecule inhibitor reduced both endogenous and drug-induced resistance to chemotherapy in a mouse model of melanoma. Low melatonin levels are associated with an increased risk of breast cancer in postmenopausal women, according to a prospective case-control study.
A new study suggests that CT lung cancer screening can increase lung cancer detection by 37% and reduce mortality by 28%, but has limited impact on all-cause mortality. Quitting smoking is still the most effective way to reduce risk of death from various causes.
A study of 246 long-term breast cancer survivors found that poor sleep is a significant problem for many women, with hot flashes, physical functioning, and depressive symptoms being key predictors. The American Academy of Sleep Medicine recommends getting between seven and eight hours of nightly sleep to enhance overall quality of life.
Researchers found that solid tumor cells can adapt to chemotherapy and radiation by increasing a regulatory factor called HIF1, which drives oxygen production and growth. Blocking HIF1 may provide a clear mechanism for killing resistant tumor cells.
A study published by the American Academy of Sleep Medicine found that women worrying about breast cancer are more likely to experience sleep disturbances, even without a diagnosis. The research highlights the importance of addressing sleep-related complaints in this population through cognitive behavioral therapy.
A new study from the University of Melbourne found that Kylie Minogue's breast cancer diagnosis led to a significant increase in breast imaging and biopsies among low-risk women, particularly those aged 25-34. Despite the surge in screening activity, the rates of breast cancer detection did not change significantly.
Researchers found that metformin significantly increased pathologic complete response rates in diabetic women with early-stage breast cancer who took the drug during chemotherapy. The study showed a 24% response rate, three times higher than non-diabetic patients. Further investigation is needed to understand the mechanism of the drug.