Articles tagged with Breast Cancer
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Postmenopausal women with a deficiency in the CYP2D6 gene have a nearly fourfold higher risk of early breast cancer recurrence when taking tamoxifen. Mayo Clinic researchers recommend testing for the gene before starting therapy.
Researchers at Mayo Clinic found a strong association between dense breasts and increased breast cancer risk, citing tissue composition differences between dense and non-dense tissue. Dense breast tissue contains more epithelium and stroma, and higher aromatase enzyme levels than non-dense tissue.
Researchers found that Tau expression is predictive of survival, but in an unexpected way. Low Tau levels were linked to a good response to pre-operative chemotherapy and higher sensitivity to paclitaxel, but also a relatively poor overall survival rate.
Mayo Clinic researchers found that young women with atypical hyperplasia had a relative risk of developing breast cancer almost six times greater than those without BBD. A strong family history of breast cancer slightly increased the risk in two other forms of benign breast disease, but only marginally.
A planned safety analysis of a breast cancer prevention study using exemestane found an acceptable level of bone loss in postmenopausal women. The study also suggests that the long-term clinical impact of this decrease is not yet known, and further research is needed.
Researchers discover new biomarkers that can predict breast cancer risk, respond to tamoxifen treatment, and identify patients who may benefit from anthracycline chemotherapy. A genetic model also improves diagnostic accuracy in high-risk populations.
Studies show hormone supplements, such as estrogen-progestin and letrozole, can reduce breast cancer mortality risk by up to 63% and improve overall survival. Meanwhile, tamoxifen is found to be superior for quality of life measures, with patients paying a price in quality of life when switching from anastrozole.
A large study found that early-stage HER2-positive breast cancer patients with tumors one centimeter or smaller have a 23% chance of recurrence, highlighting the need for additional therapy. The study's findings suggest that physicians should consider offering Herceptin-based therapy to these patients.
Mayo Clinic researchers found that endoxifen, a tamoxifen metabolite, degrades estrogen receptors and inhibits the growth of breast cancer cells. The study suggests that an agent mimicking endoxifen might be a more effective treatment than tamoxifen.
Researchers are studying new treatments, including zoledronic acid, aromatase inhibitors and monoclonal antibodies, with encouraging results. Exemestane has been shown to be more effective in postmenopausal women than current treatment with tamoxifen.
A study found that estrogen therapy can stop the growth of tumors or cause them to shrink in about a third of women with metastatic breast cancer that has developed resistance to standard estrogen-lowering therapy. The high-dose regimen had significant side effects, while the low-dose regimen was well tolerated.
Two meta-analyses of global trials confirm aromatase inhibitors are more effective in preventing breast cancer recurrence and reducing mortality risk compared to tamoxifen. Patients using aromatase inhibitors had a 3% lower cancer recurrence rate and a 1.6% reduced risk of death from the disease, according to researchers.
Easton's work on BRCA1 and BRCA2 gene mutations has significantly impacted breast cancer research. He established the Breast Cancer Linage Consortium, providing estimates of breast and ovarian cancer risk in BRCA1 mutation carriers.
A meta-analysis of 128 clinical trials has found that nonhormonal treatment regimens, including anthracycline-based regimens and taxanes, have improved overall survival in women with advanced breast cancer. The use of these regimens led to a significant relative risk reduction in overall mortality.
Researchers found that among women under 40, black women have a higher breast cancer incidence rate than white women. However, this trend reverses among women over 40, with white women having a higher incidence rate. The study confirms the age-related crossover effect in breast cancer incidence rates between black and white ethnic groups.
Two studies estimate the economic burden of cancer mortality using lost years of work and willingness-to-pay approaches. The estimated cost of cancer mortality in the US is high, with lung cancer accounting for 25% or more of costs.
Joan Massagué was honored with the inaugural AACR Distinguished Leadership Award in Breast Cancer Research for his work on transforming growth hormone factor-Beta and its role in metastasis. His research identified organ-specific metastatic characteristics that predict cancer cell spread.
Researchers found that patients in distressed marriages had higher levels of stress, less physical activity, slower recovery and more symptoms of illness compared to those with good marriages. Women in strong marriages also maintained better dietary habits and physical activity, leading to a poorer recovery from cancer.
Researchers have developed a new method to track down the cause of hereditary diseases more quickly and efficiently. This technique allows for genetic tests that take months today to be carried out in just a few weeks, providing a faster and more cost-effective solution.
A new study from Michigan Medicine found that a commonly used tool for estimating breast cancer recurrence risk is not effective at explaining risk to patients. Women with early-stage breast cancer may struggle to understand the benefits and risks of chemotherapy, leading to poor treatment choices.
The University of Texas M. D. Anderson Cancer Center is hosting its first international conference on inflammatory breast cancer to bring together clinicians and scientists to share new clinical discoveries and educational workshops. The conference aims to improve diagnosis and management of this rare but deadly disease through joint i...
A recent Ontario study found that only 19% of women with invasive ovarian cancer were referred for genetic testing of BRCA1 and BRCA2 genes, highlighting a lack of awareness about the risks and benefits of genetic testing. This omission puts family members at risk as they are unaware of their potential cancer risk.
A new angled gantry approach to coronary CT angiography significantly reduced breast radiation exposure by half. Researchers found that imaging the heart with an angled gantry acquisition reduced the overlap with the lower breast from 6.5cm to 3.2cm, warranting further machine development.
Researchers found that tamoxifen promotes aggressive cell behavior in ER+ breast cancer cells with poor intercellular adhesion. The study suggests that oestrogen deprivation may be a more appropriate treatment for these patients.
A University of California, Berkeley study has identified a key enzyme target for indole-3-carbinol, a broccoli compound that slows down rapidly advancing breast cancer cell growth. The research provides a basis for designing more effective anti-cancer drugs and could lead to breakthroughs in treating prostate tumors.
Lapatinib shows improved progression-free survival for women with HER2-positive metastatic breast cancer compared to chemotherapy alone. However, high-volume laboratories misclassify some patients, preventing them from receiving optimal therapy.
New research from Harvard University finds that improvements in behavior and screening are primarily responsible for the decline in cancer mortality. Screening has proven especially effective in early detection of colorectal and breast cancer, while behavioral changes have had the greatest impact on lung cancer.
Hormones produced by fat cells stimulate breast cancer cell migration and invasion, while a class of drugs called EGFR inhibitors can block these effects, potentially blunting aggressive tumor behavior in triple negative breast cancer patients.
Researchers at Boston University have found that consuming choline from eggs during pregnancy may affect breast cancer outcomes for a mother's offspring. The study suggests that genetic changes caused by prenatal choline exposure can impact tumor growth rates and survival rates.
A dual-headed dedicated gamma camera used during molecular breast imaging (MBI) can accurately detect small breast tumors less than 2 cm in size. The sensitivity rate of dual-head MBI was found to be 90%, detecting 128 cancers in 88 patients with suspicious lesions smaller than 2 cm.
A study found that male breast cancer presents as irregular masses with spiculated margins, often accompanied by armpit lymph node involvement. Doctors stress the importance of imaging and early treatment for accurate diagnosis.
A new study presents a promising alternative to traditional treatments for women with breast implants who develop early-stage cancer. Brachytherapy, a targeted radiation treatment, offers better cosmetic outcomes and avoids the risk of implant hardening compared to whole-breast radiation therapy.
A new statistical model, developed by researchers at the Seattle Cancer Care Alliance, uses three key characteristics to predict malignancy in breast lesions. The model identifies patients and lesions that are highly likely to be benign, allowing for reduced unnecessary biopsies.
The report found declines in both cancer incidence and death rates, as well as wide variations in lung cancer trends from state to state. Tobacco control measures are key to reducing the risk of lung cancer.
A tracking and feedback system reduced racial disparities in adjuvant therapy among women with early-stage breast cancer, increasing consultations with medical oncologists by 14 percentage points. The study found a decrease in underuse of adjuvant treatment, particularly among black and Hispanic women.
Researchers analyzed data from 13 prospective studies involving over half a million participants and found no link between fat, protein, or meat intake and kidney cancer. The study's findings suggest that the cause of increasing kidney cancer incidence worldwide remains unclear.
A study found breast cancer rates increased in women screened every two years compared to those screened once, suggesting some cancers may spontaneously regress. The findings raise concerns about the value of mammography and highlight the need for further research into breast cancer's natural history.
Four Americans, including US Senators Edward Kennedy and Mina Bissell, are being honored with the American Cancer Society's Medal of Honor for their outstanding contributions to cancer research and control. The recipients have made significant impact in funding, legislation, and awareness campaigns.
A study found that 78% of breast cancer patients had at least one other cause of bone loss besides cancer drugs. Vitamin D deficiency was the most common factor, affecting 38% of breast cancer patients compared to 51% of non-cancer patients.
A program called Project Early Awareness teaches high school girls about breast health and self-exams, resulting in a 39% increase in comfort with performing a self-exam and a 69% increase in correct answers to breast cancer questions. The goal is for breast self-exams to become routine among young women.
A recent study found that Latina women are 5.6 times more likely to express regret over their breast cancer treatment compared to white women. The researchers discovered that despite similar treatment, Latinas reported higher dissatisfaction and a desire for more culturally tailored information.
A home-based intervention improved body weight, diet quality, and physical function in older long-term cancer survivors. The RENEW trial found significant strength improvements and increased physical activity among participants.
ER/PR negative tumors associated with higher risk of poorer prognosis and limited treatment options. African-American women have higher risk due to race, socioeconomic characteristics and other tumor characteristics.
A recent study found that patients from higher-income and more educated communities are more likely to undergo immediate breast reconstruction after mastectomy. The research highlights the importance of community demographics in influencing access to this life-changing procedure.
A study found that women with a strong family history of breast cancer but without BRCA1 or BRCA2 mutations are at increased risk for developing the disease. These women had a four-fold higher risk than average, highlighting the importance of genetic testing and preventive measures.
Researchers at Mayo Clinic have discovered a 'two-faced' protein, p120 catenin, that promotes both tumor growth and metastasis in breast cancer. The protein acts like a tumor suppressor when bound to E-cadherin but becomes a tumor promoter when it's not.
A randomized clinical trial found that breast cancer patients who participate in psychological intervention sessions experience reduced stress, improved mood, and altered health behaviors. This led to a significant decrease in cancer recurrence and death from breast cancer, as well as overall mortality.
A new study found that a psychological intervention program designed for breast cancer patients increases their chance of survival and reduces the risk of recurrence. Participants who received the program reduced their risk of dying from breast cancer by 56 percent and breast cancer recurrence by 45 percent.
A recent study found that regular physical activity can lower a woman's overall risk of cancer, but only if she gets a good night's sleep. The study, published by the American Association for Cancer Research, suggests that short duration sleep can undermine exercise's cancer prevention benefits.
A study by UNC researchers found that palladin, a protein expressed mostly in invasive breast cancer cells, plays a crucial role in their ability to migrate and spread. Knocking down palladin expression reduced the ability of breast cancer cells to metastasize.
Researchers have discovered a previously unknown cell pathway that drives a lethal subtype of breast cancer, disproportionately affecting African American women. The study may lead to the development of new targeted therapies for this aggressive cancer type.
A new cross-Canada study found that breast and prostate cancer treatment can cause significant bone loss, affecting up to 46,000 people each year. The researchers discovered that medications called bisphosphonates can help combat osteoporosis and fractures in cancer patients.
A new study found that many African-American women perceive disrespect and inadequate explanations when visiting healthcare facilities, leading them to skip mammograms. The study suggests training physicians in cultural sensitivity and community-based health educators can help address these concerns.
A recent study discovered that the Overexpressed in Lung Cancer 1 (OLC1) gene is consistently expressed at high levels in most lung cancers, particularly in smokers. OLC1 overexpression was also shown to induce tumor formation in tissue culture cells and mouse models of lung cancer.
A randomized trial of over 36,000 postmenopausal women found no association between calcium and vitamin D supplementation and reduced breast cancer risk. The findings challenge previous observational studies suggesting a potential link between vitamin D levels and breast cancer incidence.
Researchers aim to identify undiscovered genes involved in early breast cancer stages by studying genetic information from thousands of breast samples. The technique could help monitor women at higher risk due to inherited gene defects, reducing mortality from breast cancer.
A new radar breast imaging system has been developed at the University of Bristol, which uses radio waves to create a 3D image of the breast without radiation risk. The system has been trialled at North Bristol NHS Trust and shows promise in detecting abnormalities earlier than current methods.
A new study by Indiana University found that young female breast cancer survivors experience significant problems related to sexual arousal, desire, and orgasm. Many reported vaginal dryness, genital pain, premature menopause, fatigue, and fertility issues, highlighting the need for research on strategies to address these challenges.
Researchers found that dense networks of blood vessels thought to promote cancer growth may actually hinder tumor progression. Tumors fed by more normal vascular were also more vulnerable to chemotherapy drugs.
Research at Fred Hutchinson Cancer Center found that women who suffer from migraines have a 30% lower risk of breast cancer compared to those without migraines. The association is thought to be linked to hormonal fluctuations and estrogen levels.