Articles tagged with Breast Cancer
Researchers from Spain have discovered that extra virgin olive oil's polyphenols may help combat breast cancer by inhibiting the HER2 oncogene. The study confirms the anti-HER2 effect of fractions extracted from olive oil in breast cancer cell lines, suggesting a potential basis for new anti-HER2 compounds.
Researchers used contrast agents in liposomes to determine if they could breach breast tumors. Tumors with better images of the contrast agents showed better therapeutic results when treated with a cancer drug called liposomal doxorubicin.
A study from the Women's Health Initiative found that postmenopausal women who stopped taking combined estrogen plus progestin experienced a marked decline in breast cancer risk. The researchers also discovered that continued use of the hormone therapy after five years doubles subsequent breast cancer risk each year.
A new study by Stanford researchers finds that combined estrogen plus progestin hormone therapy increases the annual risk of breast cancer in postmenopausal women, with a doubling of risk after five years. Stopping hormone therapy can quickly reduce this risk, as observed in a follow-up study.
A study published in Crop Science found that dry bean consumption significantly reduces the risk of mammary cancer in laboratory animals. The research revealed varying levels of antioxidants and flavonoids among different market classes of beans, but no association between these compounds and cancer incidence was observed.
The ELLA Binational Breast Cancer Study reveals significant differences in breast cancer risk factors between Hispanic and non-Hispanic women. Hispanic women are at a higher risk of triple-negative breast cancer due to family history, while those born in Mexico exhibit increased risk due to geography and environment.
A new genomic signature has been developed to predict how breast cancer patients respond to chemotherapy. The study found that the magnitude of the tumor's microenvironment, or reactive stroma, is predictive of a response to treatment. Patients with strong stroma reactions are more likely to have a bad response.
A new study from the University of Michigan Comprehensive Cancer Center found that 19% of women eligible for post-mastectomy radiation were not treated. Researchers emphasize the importance of educating patients and improving doctor-patient communication about this potentially lifesaving treatment.
A new study found that PET/CT can identify precise location and extent of metastasis, offering a better prognosis for patients with inflammatory breast cancer. The imaging modality provides information on both primary disease site and disease involvement throughout the body.
Researchers identified a DNA region controlling HGF gene activity and found shortened regions in most breast cancer patients, who were younger than those with normal lengths. This discovery suggests a potential marker for increased breast cancer risk and may be linked to other cancers overexpressing HGF.
Researchers describe a technique to determine tumor blood vessel leakiness using digital mammography, allowing prediction of chemotherapy efficacy. The method is closely correlated with the ability of clinically approved chemotherapy agents to enter tumors.
Mammography utilization in the US declined slightly between 2000 and 2006, with 34 states showing a decrease, according to a CDC study. The decline ranged from -0.3% to -5.3%, with no clear pattern among states by region, age, income or population density.
Researchers found a genetic variation in the HGF gene that increases breast cancer risk, suggesting shortening of a DNA region called DATE could be a useful marker. A study also revealed that high-fat diets can lead to insulin resistance by damaging mitochondria and increasing oxidative stress, but antioxidants may mitigate this effect.
Researchers at Mount Sinai Hospital have developed a new technology tool called DyNeMo that analyzes breast cancer tumors to determine the best treatment options. The tool predicts patient recovery with over 80% accuracy and may be used to analyze other types of cancer.
Researchers at UC San Diego have developed an automated image screening process to distinguish breast cancer cells from normal cells. The technique, which uses computer software and microscopy, has shown promise in correctly identifying invasive breast cancer cells in 83% of tumor specimens.
A team of researchers at the University of California, Davis, has recorded and visualized the human DNA repair process using fluorescent microscopy. The study reveals key differences between human and bacterial DNA repair mechanisms, including the regulation of Rad51 protein's growth.
A study found that many young women who received chest radiation for a childhood cancer are not getting regular mammography screenings, despite being at an increased risk of breast cancer. Women aged 25-50 with a history of pediatric malignancy and chest radiation showed low rates of screening mammograms.
A study found a potential genetic link between a germ-line mutation in the TTF-1 gene and an increased risk of developing multi-nodular goiter (MNG) and papillary thyroid cancer (PTC). The researchers also explored the effects of early mammography on breast cancer risk in BRCA mutation carriers.
A new study has identified certain patient and tumor characteristics that may indicate which breast cancer patients are at high risk of developing contralateral breast cancer. These include histologic invasive characteristics, multiple quadrants affected, and a high Gail risk score or age over 50 at diagnosis.
Researchers at Tel Aviv University have refined breast cancer identification using a combination of MRI and ultrasound, allowing for earlier detection and personalized treatment. The new approach measures metabolism rates of cancer cells, helping determine which tumors will metastasize and how they should be treated.
Researchers at Rice University, Texas Children's Hospital, and The Methodist Hospital Research Institute will investigate the mysteries of tuberculosis, breast cancer, and childhood cancer. They plan to develop novel treatments using lasers for deaf patients and create an auditory prosthetic superior to existing cochlear implants.
A recent study by Oregon Health and Science University and the University of Colorado School of Medicine found that fetal heath is affected by mother's diet, with high-fat diets increasing the risk of developing NAFLD and obesity-related diseases in offspring. Researchers suggest a healthy maternal diet is crucial for preventing these ...
National Lung Cancer Partnership awards I-Ching Wang a Career Development Award to study FoxM1, a protein linked to aggressive lung cancer growth. The grant aims to support protein-directed therapies and control the leading US cancer killer. Dr. Wang's research will help combat underfunding in federal lung cancer research.
Canadian researchers have identified a new protein, ARF1, that plays a critical role in breast cancer cell growth and tumour spread. Targeting this protein with drug therapy may provide hope to women with invasive breast cancers.
Researchers found that lapatinib delayed tumor development and reduced the number of tumors in a mouse model of hormone receptor-negative breast cancer. Lapatinib is a small-molecule inhibitor that blocks tyrosine kinase activities associated with tumor formation.
A meta-analysis of 10 studies confirms that risk-reducing salpingo-oophorectomy significantly reduces the risk of breast and ovarian cancers in women with BRCA mutations. The procedure is associated with a 51% relative reduction in breast cancer risk and an 79% relative reduction in ovarian cancer risk.
Researchers have developed a novel technique using photoacoustic tomography (PAT) and gold nanocages to noninvasively image sentinel lymph nodes (SLN) in breast cancer patients. This method reduces the need for invasive surgical biopsies and minimizes patient radiation exposure, offering a promising alternative for cancer diagnosis.
Research at Albert Einstein College of Medicine found that high insulin levels in postmenopausal women are associated with a higher risk of developing breast cancer. Women with the highest insulin levels were nearly 50% more likely to develop breast cancer compared to those with lower insulin levels.
Dr. Debashis Ghosh's groundbreaking work has determined the three-dimensional structure of aromatase, a key enzyme in estrogen production. This breakthrough opens doors to customized, comprehensive medical treatment for breast cancer patients.
Researchers discovered abnormally high copy numbers of chromosomal region 8q22 in more than 30% of breast cancers, associated with shorter survival times. The metadherin gene (MTDH) was found to play a dual role in cancer metastasis and resistance to chemotherapy.
A team of scientists at Princeton University has identified a long-sought gene, Metadherin, that is responsible for the aggressive behavior of poor-prognosis tumors and makes them resistant to chemotherapy. The discovery paves the way for new drugs to inhibit the gene's diabolical actions and may have significant health implications.
Research suggests cisplatin ototoxicity is due to higher platinum concentration in inner ear, while high insulin levels are an independent risk factor for breast cancer. Studies found significant correlations between fasting insulin and increased breast cancer risk.
Researchers found that irradiation damages fat tissue in mice, reducing its weight and size, and altering its ability to support reconstruction. Additionally, a study on multiple sclerosis found that CXCL1 decreases disease severity by promoting remyelination. A new molecule, FPR-2, has been identified as a potential anti-inflammatory ...
Researchers used PHIFU with short duty cycle and high intensity combined with ultrasound contrast agent (UCA) to damage rabbit liver VX2 tumour by non-thermal effect. The study found that PHIFU combination with UCA can enhance non-thermal effects of ultrasound, promoting tumor cell apoptosis and inhibiting proliferation.
A new study finds that obesity increases the risk of developing lymphedema by 40-60% in breast cancer survivors.MU researchers recommend increased health education for high-BMI patients to reduce lymphedema risk and promote optimal BMI maintenance.
The Comprehensive SDSU-UC San Diego Cancer Center Partnership aims to explain and eliminate cancer disparities in the San Diego region. The partnership will support research, education, and community outreach programs focused on minority populations.
A secondary analysis of a large clinical trial found that a diet high in fruits, vegetables, and fiber reduces the risk of breast cancer recurrence by approximately 31 percent in women without hot flashes. Women with estrogen receptor-positive cancers often receive hormone therapy to combat circulating estrogen levels.
A recent study published in Genome Research has mapped genomic translocations to base pair resolution, revealing a heavily rearranged genetic blueprint in breast cancer cells. The research highlights the importance of DNA repair machinery and identifies potential prognostic markers and therapeutic targets.
A diet rich in fruits, vegetables, and fiber has been shown to reduce the risk of recurrence in early-stage breast cancer survivors who do not experience hot flashes. This subgroup of patients typically faces higher recurrence rates and lower survival rates compared to those with hot flashes.
Researchers identified gene subnetworks that distinguished patient groups and uncovered new genes associated with breast cancer. These findings may lead to more accurate diagnostics and prognosis for various types of cancer, including leukemia, prostate cancer, and lung cancer.
Scientists use a special glass 'window' to visualize individually-labeled tumor cells as they move through the body's microenvironments. The technique allows researchers to identify critical interactions driving intravasation and develop microenvironment-specific drugs.
Postmenopausal women with a deficiency in the CYP2D6 gene have a nearly fourfold higher risk of early breast cancer recurrence when taking tamoxifen. Mayo Clinic researchers recommend testing for the gene before starting therapy.
Researchers at Mayo Clinic found a strong association between dense breasts and increased breast cancer risk, citing tissue composition differences between dense and non-dense tissue. Dense breast tissue contains more epithelium and stroma, and higher aromatase enzyme levels than non-dense tissue.
Researchers found that Tau expression is predictive of survival, but in an unexpected way. Low Tau levels were linked to a good response to pre-operative chemotherapy and higher sensitivity to paclitaxel, but also a relatively poor overall survival rate.
Mayo Clinic researchers found that young women with atypical hyperplasia had a relative risk of developing breast cancer almost six times greater than those without BBD. A strong family history of breast cancer slightly increased the risk in two other forms of benign breast disease, but only marginally.
A planned safety analysis of a breast cancer prevention study using exemestane found an acceptable level of bone loss in postmenopausal women. The study also suggests that the long-term clinical impact of this decrease is not yet known, and further research is needed.
Researchers discover new biomarkers that can predict breast cancer risk, respond to tamoxifen treatment, and identify patients who may benefit from anthracycline chemotherapy. A genetic model also improves diagnostic accuracy in high-risk populations.
Studies show hormone supplements, such as estrogen-progestin and letrozole, can reduce breast cancer mortality risk by up to 63% and improve overall survival. Meanwhile, tamoxifen is found to be superior for quality of life measures, with patients paying a price in quality of life when switching from anastrozole.
A large study found that early-stage HER2-positive breast cancer patients with tumors one centimeter or smaller have a 23% chance of recurrence, highlighting the need for additional therapy. The study's findings suggest that physicians should consider offering Herceptin-based therapy to these patients.
Mayo Clinic researchers found that endoxifen, a tamoxifen metabolite, degrades estrogen receptors and inhibits the growth of breast cancer cells. The study suggests that an agent mimicking endoxifen might be a more effective treatment than tamoxifen.
Researchers are studying new treatments, including zoledronic acid, aromatase inhibitors and monoclonal antibodies, with encouraging results. Exemestane has been shown to be more effective in postmenopausal women than current treatment with tamoxifen.
A study found that estrogen therapy can stop the growth of tumors or cause them to shrink in about a third of women with metastatic breast cancer that has developed resistance to standard estrogen-lowering therapy. The high-dose regimen had significant side effects, while the low-dose regimen was well tolerated.
Two meta-analyses of global trials confirm aromatase inhibitors are more effective in preventing breast cancer recurrence and reducing mortality risk compared to tamoxifen. Patients using aromatase inhibitors had a 3% lower cancer recurrence rate and a 1.6% reduced risk of death from the disease, according to researchers.
Easton's work on BRCA1 and BRCA2 gene mutations has significantly impacted breast cancer research. He established the Breast Cancer Linage Consortium, providing estimates of breast and ovarian cancer risk in BRCA1 mutation carriers.
A meta-analysis of 128 clinical trials has found that nonhormonal treatment regimens, including anthracycline-based regimens and taxanes, have improved overall survival in women with advanced breast cancer. The use of these regimens led to a significant relative risk reduction in overall mortality.
Researchers found that among women under 40, black women have a higher breast cancer incidence rate than white women. However, this trend reverses among women over 40, with white women having a higher incidence rate. The study confirms the age-related crossover effect in breast cancer incidence rates between black and white ethnic groups.
Two studies estimate the economic burden of cancer mortality using lost years of work and willingness-to-pay approaches. The estimated cost of cancer mortality in the US is high, with lung cancer accounting for 25% or more of costs.
Joan Massagué was honored with the inaugural AACR Distinguished Leadership Award in Breast Cancer Research for his work on transforming growth hormone factor-Beta and its role in metastasis. His research identified organ-specific metastatic characteristics that predict cancer cell spread.
Researchers found that patients in distressed marriages had higher levels of stress, less physical activity, slower recovery and more symptoms of illness compared to those with good marriages. Women in strong marriages also maintained better dietary habits and physical activity, leading to a poorer recovery from cancer.
Researchers have developed a new method to track down the cause of hereditary diseases more quickly and efficiently. This technique allows for genetic tests that take months today to be carried out in just a few weeks, providing a faster and more cost-effective solution.