Articles tagged with Breast Cancer
Researchers at Georgetown University Medical Center found that hormone levels in blood do not accurately reflect breast cancer risk. The study suggests that measuring hormones in blood may give a false impression of breast cancer risk and an imprecise picture of how these hormones affect breast cancer development.
Researchers found that lymphocytes, a type of immune system cell, produce the inflammatory protein RANKL when breast cancer cells are present. This leads to increased lung metastases. Blocking RANKL can halt cancer progression and may be a potential target for drug therapy.
Innate Therapeutics' novel microparticle-based immune response modifier MIS416 significantly inhibited tumor growth and metastasis in lung and breast cancers. Administered as an adjunct to localized tumor irradiation, MIS416 demonstrated synergistic activity against recurrent lung tumors.
Preclinical studies highlight PS-targeting antibodies' ability to reverse immune suppressing effects of tumors, change tumor microenvironment, and mobilize immune cells. These findings suggest that PS-targeting antibodies facilitate a cytokine shift in the tumor environment, encouraging multiple types of immune system cells to mount an...
A study by Elaine Hardman found that walnut consumption can reduce breast tumor incidence in laboratory mice. Walnut consumption delayed tumors by at least three weeks, with molecular analysis showing increased omega-3 fatty acid intake contributing to the decline.
A study of 227 breast cancer patients found that those with greater depressive symptoms and lower emotional quality of life were less likely to exercise as part of their recovery. Despite initial increases, physical activity declined over time, suggesting the need for future interventions to support long-term engagement.
Researchers at University of Texas M. D. Anderson Cancer Center found that overexpressing PEA-15 in breast cancer grafts in mice resulted in nearly undetectable tumor levels after 35 days. This suggests PEA-15 as a new, important target for therapy.
Researchers at Fox Chase Cancer Center found that smaller doses of human chorionic gonadotropin (hCG) can prevent breast cancer in rats. The study suggests that even shorter exposure to hCG may offer protective benefits against the disease.
A new nanoparticle has been developed to deliver a tumor suppressor gene to cancer cells, restoring normal gene function and bypassing healthy tissue. This breakthrough method shows promise in reducing the probability of recurrent tumors.
Researchers found that brain metastases subvert astrocytes, tricking them into protecting tumors and resisting chemotherapy. Surgery is effective when tumor removal is done intact, reducing the risk of cancer spreading to the spinal fluid.
A large US-based study found that nearly 26% of women with breast cancer have p53 gene mutations, leading to poorer outcomes. Postmenopausal women with higher body mass index (BMI) were more likely to develop these high-grade tumors.
Researchers from Loyola University Health System warn that the surgical gel FloSeal may cause microcalcifications on mammograms after breast cancer surgery. The study highlights the need for caution when using FloSeal in lumpectomies to avoid misdiagnosis.
Researchers found racial disparities in cancer survival rates disappear when analyzing smaller geographic areas like neighborhoods. The study suggests that modifiable factors such as socioeconomic differences and access to medical care contribute to these disparities.
Researchers found SIRT1 curbs cell division by speeding up the destruction of the tumor promoter c-Myc, a key finding that may aid cancer treatment. This study supports previous research suggesting SIRT1's anti-cancer effects while also identifying its role in regulating c-Myc levels.
A recent study found a 188% increase in women with ductal carcinoma in situ (DCIS) undergoing contralateral prophylactic mastectomy (CPM) between 1998 and 2005. The surgery is typically recommended for women with invasive breast cancer, but not for those with DCIS, which has a 98-99% 10-year survival rate.
Researchers at the University of Texas M.D. Anderson Cancer Center have discovered a gene that helps protect PTEN, a major tumor-suppressor protein, from degradation in breast cancer. Rak's protective effect is linked to its ability to stabilize PTEN protein, preventing breast cancer development.
A computer-based model has been developed to aid radiologists in diagnosing breast cancer by analyzing mammogram images. The model was trained on 48,744 mammograms and found that it could detect 41 more cancers than routine practice, with potential benefits including reduced unnecessary biopsies.
Duke University researchers developed a light-based system to analyze tumor oxygen levels, helping oncologists choose effective treatments. The system uses diffuse reflectance spectroscopy and can provide immediate feedback during biopsies.
Researchers found that Muc4 promotes release of breast cancer cells from primary tumor, allowing them to survive and resist treatment. The study suggests that targeting Muc4 could lead to new treatments for breast and potentially other cancers.
Researchers at Caltech develop a targeted cancer therapy using a gallium corrole that can detect and eliminate breast cancer tumors in mice, with fewer side effects than traditional treatments. The therapy shows promise for treating aggressive HER2+ breast cancers with lower toxicity.
Three Editorials in The Lancet focus on inadequate conditions for US migrant detainees, the need for tailored disease-prevention programs, and the recent Danish decision to award compensation to breast cancer sufferers who worked night shifts. Pope Benedict XVI's comments on AIDS are also criticized for distorting scientific evidence.
Researchers have engineered a new version of the tumour-inhibiting protein VHL that can target hypoxic areas in tumours, reducing HIF levels and causing tumours to regress. This breakthrough has implications for treating various types of cancer, particularly those resistant to conventional therapies.
A study found that quality of life determines the use of coping strategies among younger women with breast cancer. Positive cognitive restructuring and seeking social support were common coping strategies.
A study found that black women are 3 times more likely to develop aggressive triple negative breast tumours compared to non-black women. The study also revealed that the prevalence of these tumours is not limited to pre-menopausal black women, but is also common in those diagnosed before or after age 50 and across all body mass indexes.
A new surgical technique, lymphaticovenular bypass, shows promise in reducing lymphedema fluid by up to 39% in breast cancer patients. The minimally invasive procedure is a viable option for managing the condition, which affects up to 30% of women after surgery and radiation therapy.
A new UCLA study analyzes data from the Surveillance and Epidemiology End Result (SEER) cancer registry and the National Health Interview Survey (NHIS), finding that African Americans are more likely to get cancer in the first place, contributing to a life expectancy disparity of 1.47 years for men and 0.91 years for women.
A recent study published in Annals of Oncology found that a biopsy of suspected recurrent breast cancer can lead to significant changes in treatment. In some cases, the biopsy showed that the woman did not have an advanced cancer, but a benign condition.
A new study from University of Pennsylvania School of Medicine identifies genes associated with the BRCA1 protein and their involvement in the DNA repair pathway. MERIT40, a previously unknown protein, was found to work with BRCA1-RAP80 complex to achieve DNA repair.
A recent study found that early detection of second breast cancers in women who have already had the disease can significantly improve their chances of survival. The research revealed that mammography was more sensitive than clinical examination for detecting second cancers, with a sensitivity of 86%. Early detection at an asymptomatic...
Researchers at the University of Nebraska Medical Center discovered that certain estrogen metabolites can damage DNA, initiating breast and prostate cancer. A new dietary supplement called Preventium combines natural compounds to block this mechanism, potentially reducing cancer risk.
Researchers have developed nanoscale probes that can pinpoint tumors and deliver drugs directly to cancer cells using antibodies and magnetic particles. These probes offer a promising approach for more precise cancer treatment, expanding the possibilities of MRI-based tracking and optical luminescence.
Research finds that obese women, especially white ones, are less likely to have undergone a recent mammography compared to normal weight women. The study highlights poor self-esteem, body image issues, and racial disparities in obesity-related body image as reasons for the disparity.
Systematic literature reviews and meta-analyses support the use of risk assessment models combined with breast density information to identify high-risk postmenopausal women. Lifestyle factors such as exercise, weight reduction, and reduced alcohol intake also show promise in reducing breast cancer risk.
A new study published in Cancer Epidemiology, Biomarkers and Prevention found that red wine had no effect on breast cancer risk. Women who consumed moderate amounts of alcohol had a higher risk of breast cancer, regardless of the type of drink.
Women with BRCA gene mutations strongly favor preventive mastectomy as the most effective way to reduce their risk and fears of developing breast cancer. The study found that over 80% of these women ultimately underwent the procedure, highlighting the significant impact of genetic testing on medical decision-making.
A study published in Cancer found that women with BRCA mutations are more likely to choose prophylactic mastectomies due to emotional worry and fear of developing the disease. The research suggests that clinicians should consider a patient's lifestyle and quality of life when counseling them about prophylactic mastectomies.
The grocery chain has increased its contribution to TGen by 37% over 2008, with the donation representing a significant boost to breast cancer research. The funds will be used to develop treatments and eventually find a cure for breast cancer.
African-American breast cancer patients with high blood pressure have a higher mortality rate than their white counterparts, controlling for age, tumor characteristics, and treatment. Hypertension accounts for approximately 30 percent of the survival disparity between the two groups.
A new technique called stereotactic body radiotherapy (SBRT) has been shown to significantly improve survival rates for early-stage lung cancer patients, with a median survival range of over 32 months. The treatment doubles the odds of surviving and can even cure at least half of the patients, offering hope without the need for surgery.
A UT nanoscientist has developed a targeted new delivery system for breast cancer drugs, aiming to increase the efficiency of drug delivery and reduce side effects. The innovative approach uses nanocarriers engineered to search out and release their payload at tumor sites.
A new guide from Northwestern University helps doctors navigate fertility preservation strategies for cancer patients. The guide aims to increase awareness and improve treatment options for adolescents and younger adults facing cancer diagnosis.
A new study found that goserelin treatment reduced the risk of disease recurrence and deaths by 13.9% and 8.5% respectively in premenopausal women with early breast cancer. The benefits were comparable to those seen with tamoxifen treatment, suggesting goserelin may be a viable alternative for some patients.
A Million Women Study found that low to moderate alcohol consumption among women increases cancer risk for breast, liver, rectum, and upper aero-digestive tract cancers. The risk is highest after one drink per day, with an excess of about 15 cancers per 1000 women.
A randomized study found yoga significantly improved mental health aspects in women with breast cancer, including reduced depression and increased feelings of peace, compared to the control group. The gentle practice provided a wide range of benefits, particularly for those with higher negative emotions and lower emotional well-being.
Women with higher calcium intake have a lower risk of cancer overall and specific digestive system cancers like colorectal cancer, according to the study. Calcium consumption was inversely associated with an increased risk of these types of cancers in both men and women.
A study by Boston Children's Hospital researchers has identified lipocalin 2 as a protein that triggers the epithelial to mesenchymal transition in human breast cancer cells, increasing invasiveness and metastasis. The protein is detectable in urine samples, suggesting it may be used for prognostic testing.
Death rates for all cancers combined have decreased faster in African American men than white men, primarily due to rapid declines in lung and prostate cancer deaths. However, African Americans continue to be diagnosed at more advanced stages and have lower survival rates compared to whites for most cancer sites.
A study found that women with a history of breast cancer who use synthetic steroid tibolone are at a 40% increased risk of recurrence. The drug was linked to distant metastases, which are often fatal. Tibolone should not be prescribed to breast cancer patients.
A meta-analysis of 36 studies found that cancer survivors are 1.37 times more likely to be unemployed than healthy control participants, with higher risks for breast and gastrointestinal cancers. Long-term medical and psychological effects may cause social functioning impairments, including employment difficulties.
Recent studies by Cornell researcher Rui Hai Liu found that fresh apple extracts significantly inhibited the size of mammary tumors in rats, with greater inhibition seen at higher doses. The findings highlight the potential health benefits of consuming more fruits and vegetables, including apples, to reduce breast cancer risk.
Researchers at University of Cincinnati discovered that estrogen receptors are present in medulloblastoma, the most common type of pediatric brain tumor. This finding suggests that anti-estrogen drug treatments may be beneficial in limiting tumor progression and improving patient outcomes.
The new guidelines recommend using breast MRI to supplement standard imaging tools like mammography and ultrasound, particularly for detecting cancer in the contralateral breast. The guidelines also highlight the importance of clear standards for technical parameters and performance measures for clinical sites offering MRI services.
Researchers found that breast cancer cells can be made to express a transporter, allowing pyruvate to enter and induce cell death. The study aims to develop a new therapeutic target for fighting breast cancer.
A new genetic 'hotspot' for breast cancer susceptibility has been found on chromosome 6 in Asian women. This genetic locus may help guide efforts to identify specific genes linked with sporadic forms of the disease.
A new test can predict which women with breast cancer are likely to respond to chemotherapy and which type of chemotherapy will work best for them. The test, known as the Breast Bioclassifier, has been validated on thousands of women and can help doctors prescribe targeted treatments that may not require chemotherapy.
Researchers at M.D. Anderson Cancer Center found no difference in breast cancer survival rates for pregnant women compared to non-pregnant women, but those with Pregnancy Associated Breast Cancer (PABC) were more likely to be diagnosed late with advanced stages of the disease, leading to delayed treatment.
A new study published in Cancer found that pregnancy does not affect breast cancer severity or survival rates, but can delay diagnosis and treatment. Women who develop breast cancer while pregnant or shortly after have similar outcomes to those without a history of pregnancy.
Researchers developed a 50-gene set to identify the four known types of breast cancer, allowing for personalized treatment. The test was found to be highly sensitive and predictive for chemotherapy response, particularly for poor-prognosis tumor types.
Scientists tested atorvastatin and lovastatin in animal models but found no efficacy in preventing breast cancer. In contrast, tamoxifen and bexarotene showed significant reduction in mammary tumors when combined with statins.
A Michigan State University study reveals that nearly 70% of minority women trust healthcare organizations, leading to lower breast cancer screening rates. The study found that African-American women had the highest levels of mistrust, with 39% strongly agreeing that health-care organizations don't keep information private.