Articles tagged with Breast Cancer
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Researchers used PET scans to image HER2 protein levels in breast cancer cells before and after treatment. The study showed a significant reduction in HER2 expression, indicating the treatment's effectiveness.
A new study found that estrogen action through GPR30 promotes breast tumor cell survival, rather than growth, and activates integrin α5β1 to create a provisional extracellular matrix. This suggests that targeting GPR30 may be an important step in controlling ER-positive breast cancer.
A study published in JNCI found that carrying one allele of SNP 2q35-rs13387042 increases the risk of breast cancer, particularly in ER-positive and -negative cases. The association was observed in over 31,000 women with invasive breast cancer and those without the disease.
A new MRI technique developed by UW-Madison researchers has the potential to reduce breast biopsies in high-risk women. The technology allows radiologists to visually identify cancerous lesions based on characteristics such as shape and smoothness of edges. This could lead to fewer unnecessary biopsies and improved patient outcomes.
A recent study published in the American Journal of Roentgenology suggests that breast ultrasound examinations can eliminate the need for excisional biopsies in many cases. The study found that 15 out of 21 lumps were benign and did not require biopsy, highlighting the potential benefit of using ultrasound as a diagnostic tool.
Researchers from the University of Chicago discovered a 'yin-yang' effect between estrogen and retinoic acid on gene expression in breast cancer cells. This balanced control can lead to new ways of preventing and treating breast cancer, including more precise diagnoses and novel anti-cancer drugs.
A study of 577 breast cancer patients found that routine use of MRI scans was associated with delays in starting treatment and increased mastectomy rates. The study suggests that more research is needed to determine the benefits of MRI scans in evaluating breast cancer, as their disadvantages may outweigh any potential advantages.
Researchers found breast cancer incidence fell 13.2% nationwide, with greater reductions among women in urban (-13.8%) versus rural (-7.5%) areas. The decline may be linked to HT discontinuation, which was more pronounced in rich/urban areas.
A new study found that increased growth factor activation is associated with poor prognosis and tamoxifen-insensitivity in luminal-B breast cancers. Targeting this pathway may lead to a new therapeutic strategy for these patients.
Researchers are exploring how targeting Hsp90's helpers could lead to therapies for hormone-driven cancers like breast and prostate cancer. Understanding how these interactions work may allow for modulation of the function of steroid receptors, Hsp90, or both.
Scientists have discovered a protein called prosaposin that inhibits tumor metastasis by blocking blood vessel growth. The study found that prosaposin significantly reduces lung and lymph node metastases in mice, increasing survival time.
A polyomavirus known as MCPyV is associated with fewer metastases and better survival in patients with Merkel cell carcinoma. Long-term survivors of childhood central nervous system malignancies remain at risk for death and are at increasing risk for developing subsequent cancers and chronic medical conditions over time.
The report emphasizes the importance of identifying specific types of breast cancer and tailoring treatment to individual patients. It recommends adjuvant endocrine therapy for most patients with oestrogen receptor-positive tumours, anti-HER2 therapy for HER2-positive disease, and chemotherapy for triple-negative disease.
Researchers at SNM's 56th Annual Meeting present a prototype breast imaging system combining positron emission tomography (PET) and magnetic resonance imaging (MRI) technologies. The system aims to provide highly sensitive and specific breast cancer examinations while compensating for the shortcomings of individual PET or MRI systems.
Researchers at Whitehead Institute for Biomedical Research discovered a microRNA, miR-31, that inversely correlates with metastasis in breast cancer. Increasing miR-31 levels can help predict patient prognoses and potentially aid in the development of targeted therapies.
Research by Sabrina McCormick links everyday products to breast cancer, citing industrial pollution and agricultural pesticides as contributing factors. Experts urge policymakers to ban cancer-causing chemicals in everyday products, promoting prevention over a cure.
Researchers have identified a key gene, eIF4G1, overexpressed in the majority of cases of IBC, leading to rapid metastasis and high mortality rates. The study's findings could lead to new approaches and therapies for treating IBC.
Researchers found that a shorter form of the protein AIB1 alters breast tissue, making it more fibrous and potentially increasing tumor growth. The study suggests that this change may be related to dense breast tissue, a known risk factor for breast cancer.
A review of nearly 6,000 women found that lack of information and misconceptions about breast and cervical cancer significantly contribute to screening fear. The study recommends promoting education and targeting specific fears to increase uptake rates.
A waste disposal protein called p62 is responsible for disposing of damaged proteins in cells, preventing the accumulation of toxic waste that can promote cancer tumor growth. Researchers discovered that controlling p62 levels can stimulate autophagy and lead to tumor suppression.
Researchers discovered a protein profile that may accurately predict tamoxifen resistance in breast cancer patients. The study found that the extracellular matrix metalloproteinase inducer (EMMPRIN) was significantly associated with an earlier tumor progression and poor clinical outcome.
A team of scientists at The University of Texas M. D. Anderson Cancer Center has identified four new targets for breast cancer treatment, including three lysophosphatidic acid receptors and the enzyme autotaxin. These targets are found to be abnormally expressed in many types of cancer and have been shown to cause cancer.
Researchers at UNC Lineberger Comprehensive Cancer Center found a new protein SFRP2 that stimulates angiogenesis in various tumor sites. The discovery provides a potential target for developing new drugs to starve tumors of blood supply and destroy them.
A new study found that many breast cancer patients use antioxidant supplements, including high doses, during treatment. However, the effects on health and survival are poorly understood and the findings are mixed.
A study found that many women with breast cancer use antioxidant supplements during treatment, which may have mixed effects on their health and survival. Researchers recommend further research to determine the impact of antioxidant supplementation on breast cancer outcomes.
Researchers at U-M Comprehensive Cancer Center found that PTEN pathway affects growth of breast cancer stem cells and discovered a 90% reduction in stem cell population with perifosine treatment. This study suggests that targeting this pathway may improve current therapies for breast cancer
PTEN is often inactivated in breast cancer, leading to poor patient outcomes. Researchers found that a drug called perifosine specifically targets the breast cancer stem cell population by inhibiting the Akt pathway, reducing tumor-forming cells by up to 90%.
Researchers found a distinct link between the ABCC11 gene and excessively smelly armpits, wet earwax, and breast cancer risk. The study discovered that a specific SNP in the ABCC11 gene determines earwax type.
The I-SPY trial offers critical insights into locally advanced breast cancer, emphasizing the importance of not ignoring growing breast masses. The study found that most interval cancers are discovered between routine mammogram exams, suggesting a need for better screening strategies.
A study has identified a breast cancer gene called AGTR1 that is overexpressed in up to 20% of breast cancers and can be blocked by the blood pressure drug losartan. The researchers found that treatment with losartan shrunk tumors by 30% in mice, suggesting a potential new treatment option for women with AGTR1-positive breast tumors.
A new study found that taking a short break from postmenopausal hormone therapy does not lower the risk of false-positive mammogram results. However, it may help reduce breast density, making tumors harder to detect on X-rays.
Researchers have identified a molecule called PHD2 that regulates blood vessel growth and is often found at lower-than-normal levels in human tumors. Blocking PHD2 expression allows human cancer cells to grow more quickly, increasing tumor blood vessel formation.
In a phase I/II trial, combining trastuzumab and neratinib induced clinically meaningful responses in women with HER2-positive metastatic breast cancer who had progressed on previous trastuzumab-based therapies. Nine out of 33 patients (27%) achieved an objective response to the combination therapy.
A team of scientists and clinicians co-led by Joe Gray and Dennis Slamon will study three subtypes of breast cancer: estrogen receptor positive, HER2 positive, and triple negative. Their goal is to match a tumor's genetic profile with the best therapy, using cutting-edge biological, genomic, and computational techniques.
Five multi-disciplinary research teams will pursue innovative cancer treatments, combining laboratory scientists and physicians with a focus on rapid progress and collaboration. The funding model aims to eliminate barriers to creativity and collaboration, enabling diverse experts from institutions across the US to work together.
V. Craig Jordan, a renowned breast cancer scientist, has assembled a team of top researchers to tackle the complexities of breast cancer through a $73.7 million grant from Stand Up To Cancer. The 'Dream Team' aims to accelerate cancer treatment within three years by understanding the molecular diversity of human breast cancer.
Research from Northwestern University found Abraxane effectively prevents metastatic breast cancer progression and has fewer side effects compared to Taxotere. The study prolonged progression-free survival by almost seven months.
Researchers at Fred Hutchinson Cancer Center identified two proteins associated with chronic inflammation linked to long-term survival in breast cancer patients. Elevated levels of C-reactive protein and serum amyloid A are associated with reduced overall survival, regardless of patient age or tumor stage.
Researchers at Boston University School of Medicine found that conventional methods to adjust for confounding, such as restriction and multivariable regression, leave residual confounding because of unmeasured factors. Propensity scores and instrumental variable methods have limitations in resolving confounding by indication.
Breast cancer patients with high levels of C-reactive protein (CRP) and serum amyloid A (SAA) are more likely to die sooner or have their cancer return. Elevated CRP is also linked to increased risk of heart disease.
Two studies in the American Journal of Pathology demonstrate stromal caveolin-1 as a prognostic marker for breast cancer progression, correlating with reduced metastasis levels. Additionally, researchers have identified novel biomarkers for chronic kidney disease progression, predicting progressive renal fibrosis and glomerular filtrat...
A new study reveals that nearly one in four African American women with late-stage breast cancer refuse chemotherapy and radiation therapy. The authors emphasize the need for improved healthcare access and education to encourage treatment adherence. Further research is necessary to understand the factors contributing to this disparity.
A study at Dartmouth Hitchcock Medical Center found that nearly 20% of patients with recent breast cancer diagnoses had additional malignant tumors detected only by Breast MRI. The detection of these 'unsuspected' cancers is critical for patient health and survival.
Research suggests different invasive breast cancer subtypes have distinct etiologic pathways and prognoses. Patients with specific subtypes exhibit varying demographics, lifestyle traits, and risk factors, highlighting the need for refined tumor subtyping to elucidate development patterns.
A new study published in Journal of General Internal Medicine found that few women with family histories of hereditary breast or ovarian cancer are discussing genetic testing with their physicians. Most high-risk women are unaware of the available test or have not discussed it with their clinician.
A recent study published in Epidemiology found that hormone replacement therapy does not increase breast cancer risk for women with or without a family history. The research analyzed data from the Women's Health Initiative randomized trial and suggests that estrogen sensitivity may not be the causal pathway based on family history.
Vanderbilt University researchers have identified a gene signature linked to reduced relapse-free survival in breast cancer patients, especially those with estrogen receptor-positive tumors. The discovery suggests that assessing TGF-β signaling may aid in determining breast cancer prognosis and guiding treatment.
A new mathematical model developed at the University of Texas Health Science Center at Houston suggests that tumor growth and invasion can be predicted using biophysical laws. The model, which links molecular and cellular properties to tumor behavior, consistently reproduced patterns of tumor invasion observed in experiments and patien...
Researchers have identified a molecular link between sleep and weight gain, suggesting that targeting T-type calcium channels could be beneficial for weight loss. Additionally, studies on glucocorticoid hormones have revealed their protective effects on the heart during ischemia/reperfusion injury.
A study by Duke University Medical Center found that only 64% of low-income women with hormone receptor-positive breast cancer filled any prescriptions for hormonal therapy within 12 months after diagnosis. The researchers also discovered that 40% of the women stopped taking their medication regularly, and 20% stopped using it altogether.
The Pathfinder program, which focuses on body, mind, and spirit, has been found to improve distress and despair in women with metastatic breast cancer. The program provides patient navigation, counseling, and coping skills training, resulting in a higher quality of life for participants.
A study by M. D. Anderson Cancer Center researchers found that over one-third of metastatic breast cancer patients receive chemotherapy off-label, with 34.9% of women treated with an unapproved drug at some point during their care. The most common off-label chemotherapies noted were vinorelbine and gemcitabine, both shown to be efficac...
Researchers at the Mayo Clinic have found a triple drug combination to be an effective and tolerable option for treating metastatic HER2+ breast cancer. The regimen, which combines capecitabine, vinorelbine, and trastuzumab, has shown promising results in reducing tumor size and improving survival rates compared to traditional treatments.
Researchers identified cancer stem cells in breast cancer patients' bone marrow, which correlated with tumor's lymph node involvement and worse prognosis. The study suggests a need for novel biological therapies targeting these cells, and may lead to better monitoring of patients needing additional treatment.
A recent study found that chemotherapy in addition to surgery or radiation improves survival rates among older women with early-stage breast cancer. Combination therapy showed significantly better outcomes than single-drug treatment, with a 17% higher relapse-free survival rate at three years.
A review of phase I clinical trial designs and the association between lymphovascular invasion and breast cancer recurrence, highlighting the need for new methods to expedite drug development and improve patient outcomes.
A home-based diet and exercise program reduced the rate of functional decline among older, overweight long-term cancer survivors. The intervention group showed significant improvements in targeted behaviors and overall health-related quality of life compared to the control group.
Researchers at UNC identified the p18 gene as a potential cause of luminal-type breast cancers, which account for 70-80% of all cases. The study found that defects in this gene lead to uncontrolled cell growth and cancer.
Researchers have identified a genetic signature that can predict which breast cancer patients will respond well to treatment with epirubicin, a widely used form of chemotherapy. This signature may help ensure fewer women are exposed to severe side effects by identifying those most likely to benefit from treatment.
A new molecular biology-based technique has been shown to detect potential breast cancer spread with high accuracy, speed, and specificity. The Lymphoseek molecule binds to lymph node white blood cells, allowing for targeted detection of nearby 'sentinel nodes' that are most likely to contain cancer.