Articles tagged with Breast Cancer
A recent review suggests that using MRI before surgery to assess the extent of early breast cancer may not improve surgical planning or reduce follow-up surgeries. In fact, it could lead to more women being treated with mastectomy without evidence of improvement in outcomes.
A new study from the University of Pennsylvania School of Medicine found that weightlifting can help reduce lymphedema symptoms in breast cancer survivors. The research challenges traditional advice and suggests a slowly progressive weight-lifting routine can be beneficial for women with lymphedema.
A public survey in Europe found that most people overestimate the life-saving benefits of breast and prostate cancer screening. The study's findings highlight the need for accurate screening messages to include risks associated with overdiagnosis and overtreatment.
Nanobees, nano-sized spheres carrying the toxic melittin from bee venom, successfully delivered and killed tumor cells in mice. By targeting cancerous tissue with precision, nanobees showed promise in treating established and early-stage cancers.
A new molecule known as soluble VEGFR-2 has been identified that selectively blocks lymphatic vessel growth but not blood vessel growth. This breakthrough could lead to targeted treatments for diseases such as lymphedema, transplant rejection, and tumor metastasis.
Women with a family history of breast cancer who have ever breastfed may have a reduced risk of developing the disease before menopause. Additionally, breastfeeding was associated with a lower risk of breast cancer among women without a family history and those using lactation suppression.
Women with a family history of breast cancer who breastfed had a 59% lower risk of developing the disease. The study suggests breastfeeding can lower cancer risk without medication.
New commentary published in JNCI Journal of the National Cancer Institute discusses treatment options for metastatic breast cancer. The European School of Oncology Metastatic Breast Cancer Task Force recommends sequential chemotherapy with a single agent for patients without rapid progression or life-threatening metastasis.
Adding anesthetic lidocaine to radiocolloid injection improves patient comfort without compromising SLN identification, reducing pain and discomfort for patients with early breast cancer. The study concludes that this practice should be introduced as standard.
A study at UPMC in Pittsburgh, PA found that combining digital breast tomosynthesis and full-field digital mammography can decrease recall rates by 30% for cancer-free examinations. This could alleviate patient stress and economic burden on imaging facilities.
Researchers have discovered a gene signature in breast cancer stem cells that could be used to develop new drugs. The study found that this gene signature is enriched in human breast tumors after hormone treatment, making it a promising target for therapeutic intervention.
A recent study found that digital mammography significantly increases breast cancer detection rates, outperforming film-screen technology. The switch led to a notable rise in cancers detected at San Luis Diagnostic Center, averaging 7.9 cancers per 1,000 women imaged.
A study by Walter and Eliza Hall Institute scientists suggests that luminal progenitor cells, the 'daughters' of breast stem cells, are likely responsible for basal-like breast tumours in women with BRCA1 mutations. The research, published in Nature Medicine, represents a major shift in understanding how breast cancer develops.
A global breast cancer trial has recruited Chinese patients for the first time, evaluating the treatment's impact on cancer recurrence after mastectomy. Researchers aim to identify molecular fingerprints of each patient's cancer to determine the most likely candidates for radiotherapy.
UCLA researchers developed a new way to scan brain tumors and predict which ones will respond to the drug Avastin before treatment. By linking high water movement in tumors to positive drug response, they predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after therapy.
The Latino/a population is projected to triple by 2050, leading to a significant increase in cancer diagnoses. Improvements are needed in knowledge and access to services, particularly for breast and cervical cancers among Latinas.
A team of researchers at the University of Chicago has designed a computer program that uses artificial intelligence to analyze ultrasound images and predict whether a woman's breast cancer has metastasized. The pilot study, which analyzed 50 women with suspected breast cancer, found that the AI tool accurately identified 20 cases of m...
A new study uses mathematical models to analyze the change in concentrations of biological entities and found that quantitative PTEN protein expression is a key determinant of who will be resistant or sensitive to Herceptin. The absence of PTEN was more predictive than standard multivariate analysis.
A study of nearly 1,600 tumor samples found that CT-X genes are expressed in half of ER-negative and triple-negative breast cancers. This suggests a potential new therapy approach for these aggressive breast cancer types. Researchers plan to initiate clinical trials based on the findings.
A breakthrough technology developed by the US Navy is being adapted for breast cancer detection, offering improved reliability in early detection. The technology complements existing radiology devices by yielding more detailed images of faint cancerous lesions.
Researchers at Yale University School of Medicine and the University of California Davis have discovered a protein, PRCP, that regulates appetite suppression by breaking down alpha-MSH in mice. Administration of PRCP inhibitors reduced food intake in both normal and obese mice.
A new gene, RCP, has been identified as a potential breast cancer-promoting gene, with overexpression causing tumor cell characteristics and metastasis. Targeting RCP may provide a way to inhibit the known tumor-promoting pathway through activation of the RAS signaling pathway.
A new drug compound Salirasib has shown positive results against pancreatic cancer, almost doubling the life expectancy of those who received it. The drug works by inhibiting a protein called Ras, which is abnormally activated in one-third of human cancers.
Researchers at Genome Institute of Singapore identify RCP as a novel breast cancer promoting gene that functionsally contributes to aggressive breast cancer behaviour. Over-expression of RCP is positively correlated with cancer recurrence in patients, and silencing the gene significantly diminishes tumour formation and metastasis.
Researchers propose a novel two-agent combination therapy that selectively kills tumors while sparing healthy cells. The approach leverages the frequent absence of methylthioadenosine phosphorylase in various lethal cancers, allowing for increased doses and reduced toxic side effects.
Two matrix metalloproteinase (MMP) proteins contribute to bone metastasis in advanced breast cancer by degrading extracellular matrix and stimulating osteoclast activity. This discovery supports therapeutic targeting of MMP1 and ADAMTS1, potentially mitigating bone complications in advanced metastatic breast cancers.
Researchers at Thomas Jefferson University identified DACH1 as a protein that prevents cancer cell proliferation by repressing estrogen receptors in ER+ breast cancer. As DACH1 expression decreases in breast cancer, estrogen receptor presence increases, suggesting its potential as a therapeutic target.
Researchers at LSUHSC have been awarded a $1.3 million grant to develop a new cancer vaccine targeting melanoma and breast cancer. The grant will support the creation of a novel signaling pathway in T lymphocytes, which can detect cancer and boost tumor destruction.
A Kaiser Permanente study found that a reminder program using electronic health records and personalized outreach increased mammography rates among women aged 50-69. Mammography rates jumped from 63% to over 80%, with 75% of women completing their screenings within 10 months.
Cells experiencing DNA damage send signals to neighboring cells, triggering an inflammatory response that can lead to cancer and accelerated aging. The discovery provides a new target for preventing these processes.
Researchers found that curcumin delays tumor development and reduces multiplicity of progestin-accelerated tumors. Curcumin inhibits VEGF secretion from breast cancer cells, potentially reducing breast cancer risk for women exposed to hormone replacement therapy.
Researchers at Albert Einstein College of Medicine found a strong association between elevated insulin levels and increased breast cancer risk in postmenopausal women. Women with higher insulin levels were more than twice as likely to develop breast cancer compared to those with lower insulin levels, especially among lean women.
A follow-up study confirms a significant reduction in breast cancer risk among women with migraines, regardless of menopausal status or other factors. The association remains strong despite previous findings suggesting potential triggers like alcohol consumption and hormone replacement therapy.
A study published in the Journal of the National Cancer Institute found women with hormone receptor-negative first tumors have twice the risk of developing a second breast cancer compared to those with HR-positive tumors. The research also identified a five-fold increase in risk of a second hormone-receptor negative breast cancer.
A new study found that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races, even when controlling for medical treatment and socioeconomic factors. The analysis of over 20,000 patient records suggests a potential role for genetic factors in the survival gap.
Researchers have identified a potential therapeutic target for basal breast cancer, an aggressive form of the disease. The Met gene was found to play a critical role in its development, making it a promising drug target for patients with few treatment options.
A study of nearly 20,000 patient records found that African-American breast, ovarian, and prostate cancer patients die earlier than others with similar treatment, suggesting biological or host genetic factors as the cause. The survival gap persists even after controlling for socioeconomic factors.
Researchers found African Americans have lower survival rates for breast, prostate, and ovarian cancers due to biological factors, not socioeconomic ones. The study of 19,457 patients showed 49% more likelihood of death from early-stage breast cancer among African Americans.
Two studies found significant racial disparities in breast cancer survival rates, with black women having a higher hazard of death compared to white women. The disparity persists even when controlling for treatment factors and socioeconomic status.
The American Society of Plastic Surgeons reports nearly 70% of eligible women lack information on breast reconstruction procedures. To address this issue, ASPS is launching an awareness campaign to educate and empower patients to make informed decisions about their care.
A study by Columbia University's Mailman School of Public Health found that elderly women with localized breast cancer are less likely to receive chemotherapy, with only 15% receiving treatment. In contrast, younger women with nonmetastatic breast cancer received adjuvant chemotherapy at a rate of 70%.
Researchers used PET scans to image HER2 protein levels in breast cancer cells before and after treatment. The study showed a significant reduction in HER2 expression, indicating the treatment's effectiveness.
A new study found that estrogen action through GPR30 promotes breast tumor cell survival, rather than growth, and activates integrin α5β1 to create a provisional extracellular matrix. This suggests that targeting GPR30 may be an important step in controlling ER-positive breast cancer.
A study published in JNCI found that carrying one allele of SNP 2q35-rs13387042 increases the risk of breast cancer, particularly in ER-positive and -negative cases. The association was observed in over 31,000 women with invasive breast cancer and those without the disease.
A new MRI technique developed by UW-Madison researchers has the potential to reduce breast biopsies in high-risk women. The technology allows radiologists to visually identify cancerous lesions based on characteristics such as shape and smoothness of edges. This could lead to fewer unnecessary biopsies and improved patient outcomes.
A recent study published in the American Journal of Roentgenology suggests that breast ultrasound examinations can eliminate the need for excisional biopsies in many cases. The study found that 15 out of 21 lumps were benign and did not require biopsy, highlighting the potential benefit of using ultrasound as a diagnostic tool.
Researchers from the University of Chicago discovered a 'yin-yang' effect between estrogen and retinoic acid on gene expression in breast cancer cells. This balanced control can lead to new ways of preventing and treating breast cancer, including more precise diagnoses and novel anti-cancer drugs.
A study of 577 breast cancer patients found that routine use of MRI scans was associated with delays in starting treatment and increased mastectomy rates. The study suggests that more research is needed to determine the benefits of MRI scans in evaluating breast cancer, as their disadvantages may outweigh any potential advantages.
Researchers found breast cancer incidence fell 13.2% nationwide, with greater reductions among women in urban (-13.8%) versus rural (-7.5%) areas. The decline may be linked to HT discontinuation, which was more pronounced in rich/urban areas.
A new study found that increased growth factor activation is associated with poor prognosis and tamoxifen-insensitivity in luminal-B breast cancers. Targeting this pathway may lead to a new therapeutic strategy for these patients.
Researchers are exploring how targeting Hsp90's helpers could lead to therapies for hormone-driven cancers like breast and prostate cancer. Understanding how these interactions work may allow for modulation of the function of steroid receptors, Hsp90, or both.
Scientists have discovered a protein called prosaposin that inhibits tumor metastasis by blocking blood vessel growth. The study found that prosaposin significantly reduces lung and lymph node metastases in mice, increasing survival time.
A polyomavirus known as MCPyV is associated with fewer metastases and better survival in patients with Merkel cell carcinoma. Long-term survivors of childhood central nervous system malignancies remain at risk for death and are at increasing risk for developing subsequent cancers and chronic medical conditions over time.
The report emphasizes the importance of identifying specific types of breast cancer and tailoring treatment to individual patients. It recommends adjuvant endocrine therapy for most patients with oestrogen receptor-positive tumours, anti-HER2 therapy for HER2-positive disease, and chemotherapy for triple-negative disease.
Researchers at SNM's 56th Annual Meeting present a prototype breast imaging system combining positron emission tomography (PET) and magnetic resonance imaging (MRI) technologies. The system aims to provide highly sensitive and specific breast cancer examinations while compensating for the shortcomings of individual PET or MRI systems.
Researchers at Whitehead Institute for Biomedical Research discovered a microRNA, miR-31, that inversely correlates with metastasis in breast cancer. Increasing miR-31 levels can help predict patient prognoses and potentially aid in the development of targeted therapies.
Research by Sabrina McCormick links everyday products to breast cancer, citing industrial pollution and agricultural pesticides as contributing factors. Experts urge policymakers to ban cancer-causing chemicals in everyday products, promoting prevention over a cure.
Researchers have identified a key gene, eIF4G1, overexpressed in the majority of cases of IBC, leading to rapid metastasis and high mortality rates. The study's findings could lead to new approaches and therapies for treating IBC.
Researchers found that a shorter form of the protein AIB1 alters breast tissue, making it more fibrous and potentially increasing tumor growth. The study suggests that this change may be related to dense breast tissue, a known risk factor for breast cancer.
A review of nearly 6,000 women found that lack of information and misconceptions about breast and cervical cancer significantly contribute to screening fear. The study recommends promoting education and targeting specific fears to increase uptake rates.