Articles tagged with Breast Cancer
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A clinical trial of mifepristone is being conducted to evaluate its effectiveness in treating symptoms of Gulf War illness, a condition affecting 25% of veterans who served in the 1990-1991 Gulf War. The study aims to determine if mifepristone can improve physical and mental health outcomes in Gulf War veterans.
A recent study by Universite de Montreal researchers found that weight gain after age 20 increases breast cancer risk, with gains of over 15.5 kilos seen in a 68% increase in risk. Regular physical activity was also shown to decrease cancer risks by 52 percent for pre-menopausal and post-menopausal women.
A new study found that patients who were more involved in their treatment decisions were more likely to have a mastectomy, regardless of racial or ethnic group. Patient attitudes about surgery, family and friend opinions, concern about recurrence, and body image also influenced surgical choices.
A new study from the University of Michigan Comprehensive Cancer Center found that women's decisions on breast cancer surgery are often influenced by family and friends. The study discovered that when patients take a more active role in decision-making, they are more likely to choose mastectomy over breast-conserving surgery.
A new study published in the Journal of the National Cancer Institute found that adding clinical breast examination to mammography improves breast cancer detection rates and sensitivities, but also leads to higher false-positive rates. The study used a cohort of over 290,000 women screened between 2002 and 2003.
Researchers at Ohio State University found that a psychological therapy significantly relieved depressive symptoms and reduced markers of inflammation in breast cancer patients. The study published in Psychosomatic Medicine showed that treating depression can also lead to less inflammation, highlighting the importance of including psyc...
A recent analysis of 1.2 million Swedish hospital cases reveals that heart failure is associated with poor survival rates, more deaths, and premature life-years lost compared to common cancers. Heart failure affects more men and women than most cancer types, particularly in Sweden.
Researchers have discovered a small peptide that stops lung cancer tumors from growing by inhibiting blood vessel formation. The study showed significant reduction in tumor size and fewer blood vessels compared to untreated animals.
Research by Christopher Li and colleagues found a more than four-fold increased risk of ER-negative second cancers among breast cancer survivors taking long-term tamoxifen. The study confirms earlier findings suggesting a link between tamoxifen use and increased risk of aggressive second breast cancer.
A study published in Clinical Cancer Research found that a blood-flow metabolism mismatch in pancreatic tumors predicts poor patient outcome. The researchers used PET imaging to measure blood flow and glucose consumption, revealing a correlation between decreased blood flow and malignant tumors.
A new study published in JNCI finds that training methods for surgeons performing breast cancer sentinel lymph node resection are highly effective. The study evaluated three training methods and found a statistically significant positive association between procedural errors and false-negative rates.
Researchers found that Six1 protein is central to tumor development in breast cancer, linked to EMT, stem/progenitor cells, and poor prognosis. Overexpression of Six1 also enhanced ability to metastasize, indicating its role as a key player in aggressive breast cancer.
Researchers have created a robot-controlled palpating device that detects tumors with 40% more accuracy than humans, reducing tissue damage by over 35%. The device applies consistent force in each step, producing a complete map of the tissue.
A new study from the University of Michigan Comprehensive Cancer Center found that hospitals treating more black cancer patients have lower survival rates for breast and colon cancer, regardless of race. The researchers suggest that factors such as hospital resources and quality of care are key contributors to these disparities.
Researchers at LSUHSC have identified miR-27b as a major player in the development of invasive breast cancer, found to stimulate cell growth and invasion. Meanwhile, ST14 gene suppresses tumor cell growth and may serve as an early detection marker for breast cancer.
Progesterone exposure may increase breast cancer risk by activating genes involved in cell adhesion, survival, and inflammation. The study reveals targets for future work in reducing progesterone's influence on breast cancer development.
A recent study found that low-dose estrogen treatment can stop disease progression in patients with metastatic breast cancer, with 87% of those without PET flare reactions showing no response. The treatment was also well-tolerated, with fewer severe side effects compared to high doses.
A new study found that women with newly diagnosed breast cancer who receive MRI scans are more likely to undergo mastectomy than breast conserving therapy. This can lead to delays in treatment and unnecessary surgeries.
Recent studies published by the American Society for Nutrition provide no evidence that consuming animal foods increases breast cancer risk. In fact, researchers suggest that moderate and mindful consumption of these foods can be important in attaining optimal nutrition, particularly for women who may not consume enough iron and calcium.
A recent review suggests that using MRI before surgery to assess the extent of early breast cancer may not improve surgical planning or reduce follow-up surgeries. In fact, it could lead to more women being treated with mastectomy without evidence of improvement in outcomes.
A new study from the University of Pennsylvania School of Medicine found that weightlifting can help reduce lymphedema symptoms in breast cancer survivors. The research challenges traditional advice and suggests a slowly progressive weight-lifting routine can be beneficial for women with lymphedema.
A public survey in Europe found that most people overestimate the life-saving benefits of breast and prostate cancer screening. The study's findings highlight the need for accurate screening messages to include risks associated with overdiagnosis and overtreatment.
Nanobees, nano-sized spheres carrying the toxic melittin from bee venom, successfully delivered and killed tumor cells in mice. By targeting cancerous tissue with precision, nanobees showed promise in treating established and early-stage cancers.
A new molecule known as soluble VEGFR-2 has been identified that selectively blocks lymphatic vessel growth but not blood vessel growth. This breakthrough could lead to targeted treatments for diseases such as lymphedema, transplant rejection, and tumor metastasis.
Women with a family history of breast cancer who have ever breastfed may have a reduced risk of developing the disease before menopause. Additionally, breastfeeding was associated with a lower risk of breast cancer among women without a family history and those using lactation suppression.
Women with a family history of breast cancer who breastfed had a 59% lower risk of developing the disease. The study suggests breastfeeding can lower cancer risk without medication.
New commentary published in JNCI Journal of the National Cancer Institute discusses treatment options for metastatic breast cancer. The European School of Oncology Metastatic Breast Cancer Task Force recommends sequential chemotherapy with a single agent for patients without rapid progression or life-threatening metastasis.
Adding anesthetic lidocaine to radiocolloid injection improves patient comfort without compromising SLN identification, reducing pain and discomfort for patients with early breast cancer. The study concludes that this practice should be introduced as standard.
A study at UPMC in Pittsburgh, PA found that combining digital breast tomosynthesis and full-field digital mammography can decrease recall rates by 30% for cancer-free examinations. This could alleviate patient stress and economic burden on imaging facilities.
Researchers have discovered a gene signature in breast cancer stem cells that could be used to develop new drugs. The study found that this gene signature is enriched in human breast tumors after hormone treatment, making it a promising target for therapeutic intervention.
A recent study found that digital mammography significantly increases breast cancer detection rates, outperforming film-screen technology. The switch led to a notable rise in cancers detected at San Luis Diagnostic Center, averaging 7.9 cancers per 1,000 women imaged.
A study by Walter and Eliza Hall Institute scientists suggests that luminal progenitor cells, the 'daughters' of breast stem cells, are likely responsible for basal-like breast tumours in women with BRCA1 mutations. The research, published in Nature Medicine, represents a major shift in understanding how breast cancer develops.
A global breast cancer trial has recruited Chinese patients for the first time, evaluating the treatment's impact on cancer recurrence after mastectomy. Researchers aim to identify molecular fingerprints of each patient's cancer to determine the most likely candidates for radiotherapy.
UCLA researchers developed a new way to scan brain tumors and predict which ones will respond to the drug Avastin before treatment. By linking high water movement in tumors to positive drug response, they predicted with 70 percent accuracy which patients' tumors were the least likely to grow six months after therapy.
The Latino/a population is projected to triple by 2050, leading to a significant increase in cancer diagnoses. Improvements are needed in knowledge and access to services, particularly for breast and cervical cancers among Latinas.
A team of researchers at the University of Chicago has designed a computer program that uses artificial intelligence to analyze ultrasound images and predict whether a woman's breast cancer has metastasized. The pilot study, which analyzed 50 women with suspected breast cancer, found that the AI tool accurately identified 20 cases of m...
A new study uses mathematical models to analyze the change in concentrations of biological entities and found that quantitative PTEN protein expression is a key determinant of who will be resistant or sensitive to Herceptin. The absence of PTEN was more predictive than standard multivariate analysis.
A study of nearly 1,600 tumor samples found that CT-X genes are expressed in half of ER-negative and triple-negative breast cancers. This suggests a potential new therapy approach for these aggressive breast cancer types. Researchers plan to initiate clinical trials based on the findings.
A breakthrough technology developed by the US Navy is being adapted for breast cancer detection, offering improved reliability in early detection. The technology complements existing radiology devices by yielding more detailed images of faint cancerous lesions.
Researchers at Yale University School of Medicine and the University of California Davis have discovered a protein, PRCP, that regulates appetite suppression by breaking down alpha-MSH in mice. Administration of PRCP inhibitors reduced food intake in both normal and obese mice.
A new gene, RCP, has been identified as a potential breast cancer-promoting gene, with overexpression causing tumor cell characteristics and metastasis. Targeting RCP may provide a way to inhibit the known tumor-promoting pathway through activation of the RAS signaling pathway.
A new drug compound Salirasib has shown positive results against pancreatic cancer, almost doubling the life expectancy of those who received it. The drug works by inhibiting a protein called Ras, which is abnormally activated in one-third of human cancers.
Researchers at Genome Institute of Singapore identify RCP as a novel breast cancer promoting gene that functionsally contributes to aggressive breast cancer behaviour. Over-expression of RCP is positively correlated with cancer recurrence in patients, and silencing the gene significantly diminishes tumour formation and metastasis.
Researchers propose a novel two-agent combination therapy that selectively kills tumors while sparing healthy cells. The approach leverages the frequent absence of methylthioadenosine phosphorylase in various lethal cancers, allowing for increased doses and reduced toxic side effects.
Two matrix metalloproteinase (MMP) proteins contribute to bone metastasis in advanced breast cancer by degrading extracellular matrix and stimulating osteoclast activity. This discovery supports therapeutic targeting of MMP1 and ADAMTS1, potentially mitigating bone complications in advanced metastatic breast cancers.
Researchers at Thomas Jefferson University identified DACH1 as a protein that prevents cancer cell proliferation by repressing estrogen receptors in ER+ breast cancer. As DACH1 expression decreases in breast cancer, estrogen receptor presence increases, suggesting its potential as a therapeutic target.
Researchers at LSUHSC have been awarded a $1.3 million grant to develop a new cancer vaccine targeting melanoma and breast cancer. The grant will support the creation of a novel signaling pathway in T lymphocytes, which can detect cancer and boost tumor destruction.
A Kaiser Permanente study found that a reminder program using electronic health records and personalized outreach increased mammography rates among women aged 50-69. Mammography rates jumped from 63% to over 80%, with 75% of women completing their screenings within 10 months.
Cells experiencing DNA damage send signals to neighboring cells, triggering an inflammatory response that can lead to cancer and accelerated aging. The discovery provides a new target for preventing these processes.
Researchers found that curcumin delays tumor development and reduces multiplicity of progestin-accelerated tumors. Curcumin inhibits VEGF secretion from breast cancer cells, potentially reducing breast cancer risk for women exposed to hormone replacement therapy.
Researchers at Albert Einstein College of Medicine found a strong association between elevated insulin levels and increased breast cancer risk in postmenopausal women. Women with higher insulin levels were more than twice as likely to develop breast cancer compared to those with lower insulin levels, especially among lean women.
A follow-up study confirms a significant reduction in breast cancer risk among women with migraines, regardless of menopausal status or other factors. The association remains strong despite previous findings suggesting potential triggers like alcohol consumption and hormone replacement therapy.
A study published in the Journal of the National Cancer Institute found women with hormone receptor-negative first tumors have twice the risk of developing a second breast cancer compared to those with HR-positive tumors. The research also identified a five-fold increase in risk of a second hormone-receptor negative breast cancer.
A new study found that African-American patients with breast, ovarian, and prostate cancer tend to die earlier than patients of other races, even when controlling for medical treatment and socioeconomic factors. The analysis of over 20,000 patient records suggests a potential role for genetic factors in the survival gap.
Researchers have identified a potential therapeutic target for basal breast cancer, an aggressive form of the disease. The Met gene was found to play a critical role in its development, making it a promising drug target for patients with few treatment options.
A study of nearly 20,000 patient records found that African-American breast, ovarian, and prostate cancer patients die earlier than others with similar treatment, suggesting biological or host genetic factors as the cause. The survival gap persists even after controlling for socioeconomic factors.
Researchers found African Americans have lower survival rates for breast, prostate, and ovarian cancers due to biological factors, not socioeconomic ones. The study of 19,457 patients showed 49% more likelihood of death from early-stage breast cancer among African Americans.
Two studies found significant racial disparities in breast cancer survival rates, with black women having a higher hazard of death compared to white women. The disparity persists even when controlling for treatment factors and socioeconomic status.
The American Society of Plastic Surgeons reports nearly 70% of eligible women lack information on breast reconstruction procedures. To address this issue, ASPS is launching an awareness campaign to educate and empower patients to make informed decisions about their care.
A study by Columbia University's Mailman School of Public Health found that elderly women with localized breast cancer are less likely to receive chemotherapy, with only 15% receiving treatment. In contrast, younger women with nonmetastatic breast cancer received adjuvant chemotherapy at a rate of 70%.